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INTRODUCTION: Complete spinal cord transection (SCT) leads to loss of motor control due to disruption of supraspinal tracts and altered functioning of both central and peripheral synapses. We showed that SCT at low thoracic segments causes deficiency in cholinergic input to ankle extensor (soleus) motoneurons, whereas brain-derived neurotrophic factor (BDNF) overexpression below the lesion site increases...
INTRODUCTION: Complete spinal cord transection (SCT) disturbs the balance between inhibitory and excitatory inputs to motoneurons increasing their excitability. However SCT causes deficiency in excitatory cholinergic input to ankle extensor motoneurons, whereas brain-derived neurotrophic factor (BDNF) overexpression below the lesion site increases markers of spinal neurotransmission and improves locomotor...
BACKGROUND AND AIMS: Complete spinal cord transection (SCT) causes reorganization of spinal networks involving changes ofsynaptic terminals abutting on α-motoneurons(MNs).We showed that SCT impoverishes excitatory cholinergic input to ankle extensor but not to flexor MNs and locomotor training leads to its enrichment on both MNs groups (Skup et al. 2012). The opposite effect of training after SCT...
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