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Elevated levels of lactic acid can be deleterious to CNS tissue. Lactic acid is known to cause astroglial swelling and since glial swelling has been shown to inhibit l-glutamate (l-Glu) uptake, we examined whether one of the actions of lactic acid is to inhibit l-Glu uptake. Astrocyte cultures treated with lactic acid (25 mM; pH 6.1) showed an inhibition of l-Glu uptake by 65%. HCl (pH 6.1) also inhibited...
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