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Background β1 blockers increase the risk of cerebral hypoxia during acute anemia and apneic hypoxia. We hypothesized that β1 stimulants conversely increase cerebral tolerance to anemia and hypoxia. Methods After induction with isoflurane, twelve swine (mean ± SD: 25.2 ± 0.6 kg) received 200 µg kg−1 min−1 landiolol and 20 µg kg−1 min−1 dobutamine. Reversal of the order of drug administration was...
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