Search results for: Pawel Szulc

Items from 1 to 20 out of 59 results

article

Machine‐Learning Assessed Abdominal Aortic Calcification is Associated with Long‐Term Fall and Fracture Risk in Community‐Dwelling Older Australian Women

Jack Dalla Via, Abadi K. Gebre, Cassandra Smith, Zulqarnain Gilani, more

Journal of Bone and Mineral Research > 38 > 12 > 1867 - 1876

Abdominal aortic calcification (AAC), a recognized measure of advanced vascular disease, is associated with higher cardiovascular risk and poorer long‐term prognosis. AAC can be assessed on dual‐energy X‐ray absorptiometry (DXA)‐derived lateral spine images used for vertebral fracture assessment at the time of bone density screening using a validated 24‐point scoring method (AAC‐24). Previous studies...

article

Dysregulation of MicroRNAs in Adult Osteogenesis Imperfecta: The miROI Study

Alexandre Mercier‐Guery, Marjorie Millet, Blandine Merle, Corinne Collet, more

Journal of Bone and Mineral Research > 38 > 11 > 1665 - 1678

As epigenetic regulators of gene expression, circulating micro‐RiboNucleic Acids (miRNAs) have been described in several bone diseases as potential prognostic markers. The aim of our study was to identify circulating miRNAs potentially associated with the severity of osteogenesis imperfecta (OI) in three steps. We have screened by RNA sequencing for the miRNAs that were differentially expressed in...

article

A Fracture Risk Assessment Tool for High Resolution Peripheral Quantitative Computed Tomography

Danielle E. Whittier, Elizabeth J. Samelson, Marian T. Hannan, Lauren A. Burt, more

Journal of Bone and Mineral Research > 38 > 9 > 1234 - 1244

Most fracture risk assessment tools use clinical risk factors combined with bone mineral density (BMD) to improve assessment of osteoporosis; however, stratifying fracture risk remains challenging. This study developed a fracture risk assessment tool that uses information about volumetric bone density and three‐dimensional structure, obtained using high‐resolution peripheral quantitative compute tomography...

article

Rapid Cortical Bone Loss at the Distal Radius Is Associated With Higher Risk of Fracture in Older Men – The STRAMBO Study

Elina Gunsing, Philippe P. Wagner, Danielle E. Whittier, Steven K. Boyd, more

Journal of Bone and Mineral Research > 38 > 6 > 841 - 850

Rapid loss of areal bone mineral density (aBMD) is associated with higher fracture risk after adjustment for confounders including initial aBMD. However, the link between bone microarchitecture decline and fracture is not clear. We studied the association between bone microarchitecture deterioration assessed prospectively over 4 years and the subsequent fracture risk in older men. Bone microarchitecture...

article

Association of Vitamin D and Parathyroid Hormone Status With the Aging‐Related Decline of Bone Microarchitecture in Older Men: The Prospective Structure of Aging Men's Bones (STRAMBO) Study

Audrey Bobillier, Philippe Wagner, Danielle E. Whittier, René Ecochard, more

Journal of Bone and Mineral Research > 37 > 10 > 1903 - 1914

Poor vitamin D status and high parathyroid hormone (PTH) level are associated with impaired bone microarchitecture, but these data are mainly cross‐sectional. We studied the association of the baseline PTH and 25‐hydroxycholecalciferol (25OHD) levels with the prospectively assessed deterioration of bone microarchitecture and in estimated bone strength in older men. Distal radius and tibia bone microarchitecture...

article

Body Composition in Patients With Psoriatic Arthritis and Changes During Interleukin‐12/Interleukin‐23 Inhibition

Julien Paccou, Wallis Bavière, Elisabeth Sornay‐Rendu, Pawel Szulc, more

Arthritis Care & Research > 74 > 10 > 1608 - 1613

Objective Little is known about body composition in patients with psoriatic arthritis (PsA). Our objective was to compare body composition parameters in PsA patients and healthy controls and then investigate the effects of ustekinumab (UST) on body composition in patients with PsA. Methods At baseline, 30 PsA patients were compared cross‐sectionally with 60 healthy controls without PsA, matched...

article

Bone Microarchitecture Phenotypes Identified in Older Adults Are Associated With Different Levels of Osteoporotic Fracture Risk

Danielle E Whittier, Elizabeth J Samelson, Marian T Hannan, Lauren A Burt, more

Journal of Bone and Mineral Research > 37 > 3 > 428 - 439

Prevalence of osteoporosis is more than 50% in older adults, yet current clinical methods for diagnosis that rely on areal bone mineral density (aBMD) fail to detect most individuals who have a fragility fracture. Bone fragility can manifest in different forms, and a “one‐size‐fits‐all” approach to diagnosis and management of osteoporosis may not be suitable. High‐resolution peripheral quantitative...

article

Joint Associations of Prevalent Radiographic Vertebral Fracture and Abdominal Aortic Calcification With Incident Hip, Major Osteoporotic, and Clinical Vertebral Fractures

John T Schousboe, Lisa Langsetmo, Pawel Szulc, Joshua R Lewis, more

Journal of Bone and Mineral Research > 36 > 5 > 892 - 900

Prevalent vertebral fractures (PVFx) and abdominal aortic calcification (AAC) are both associated with incident fractures and can be ascertained on the same lateral spine images, but their joint association with incident fractures is unclear. Our objective was to estimate the individual and joint associations of PVFx and AAC with incident major osteoporotic, hip, and clinical vertebral fractures in...

article

High Cardiovascular Risk in Older Men with Poor Bone Microarchitecture—The Prospective STRAMBO Study

Pawel Szulc, Dominique Foesser, Roland Chapurlat

Journal of Bone and Mineral Research > 36 > 5 > 879 - 891

Data on the association between bone microarchitecture and cardiovascular disease (CVD) in men are scarce. We studied the link of bone microarchitecture and areal bone mineral density (aBMD) with the risk of major adverse coronary event (MACE) in a cohort of men aged 60 to 87 years followed prospectively for 8 years. At baseline, aBMD was measured using a Hologic Discovery‐A device. Bone microarchitecture...

article

A Signature of Circulating miRNAs Associated With Fibrous Dysplasia of Bone: the mirDys Study

Mélanie A Legrand, Marjorie Millet, Blandine Merle, Jean‐Charles Rousseau, more

Journal of Bone and Mineral Research > 35 > 10 > 1881 - 1892

Fibrous dysplasia (FD) is a rare bone disease caused by activating mutations of GNAS encoding the Gsα protein, enhancing cyclic adenosine monophosphate (cAMP) production by overstimulation of adenylyl cyclase and impairing osteoblastic differentiation. The clinical presentation ranges from asymptomatic to polyostotic forms with severe disability, explained by the mosaic distribution of the GNAS mutation...

article

Relationship Between Sex Steroids and Deterioration of Bone Microarchitecture in Older Men: The Prospective STRAMBO Study

Anne Piot, Roland D Chapurlat, Bruno Claustrat, Pawel Szulc

Journal of Bone and Mineral Research > 34 > 9 > 1562 - 1573

In older men, low estrogen levels are associated with poor bone microarchitecture. Data on androgens are discordant. We studied the link between baseline sex steroid levels (total 17β ‐estradiol [17βE2], total testosterone [tT], calculated bioavailable 17βE2 [bio‐17βE2], and apparent free testosterone concentration [AFTC]) and bone microarchitecture deterioration assessed prospectively in a 820 older...

article

Algorithm for the Use of Biochemical Markers of Bone Turnover in the Diagnosis, Assessment and Follow-Up of Treatment for Osteoporosis

Mattias Lorentzon, Jaime Branco, Maria Luisa Brandi, Olivier Bruyère, more

Advances in Therapy > 2019 > 36 > 10 > 2811-2824

Introduction Increased biochemical bone turnover markers (BTMs) measured in serum are associated with bone loss, increased fracture risk and poor treatment adherence, but their role in clinical practice is presently unclear. The aim of this consensus group report is to provide guidance to clinicians on how to use BTMs in patient evaluation in postmenopausal osteoporosis, in fracture risk prediction...

article

Correction to: Is There Enough Evidence for Osteosarcopenic Obesity as a Distinct Entity? A Critical Literature Review

Jürgen M. Bauer, Alfonso J. Cruz-Jentoft, Roger A. Fielding, John A. Kanis, more

Calcified Tissue International > 2019 > 105 > 2 > 125-126

The original version of this article unfortunately contained a mistake in one of the co-author's name. The co-author Cyrus Cooper's degree “FMedSci” was incorrectly tagged as family name. This has been corrected with this erratum.

article

Is There Enough Evidence for Osteosarcopenic Obesity as a Distinct Entity? A Critical Literature Review

Jürgen M. Bauer, Alfonso J. Cruz-Jentoft, Roger A. Fielding, John A. Kanis, more

Calcified Tissue International > 2019 > 105 > 2 > 109-124

The co-existence of impaired bone health (osteopenia/osteoporosis), reduced muscle mass and strength (sarcopenia), and increased adiposity (obesity) in middle-aged and older people has been identified in recent studies, leading to a proposal for the existence of “osteosarcopenic obesity” as a distinct entity. Evidence for the pathophysiological overlap of these conditions is mounting, although a causal...

article

Low Muscle Strength and Mass Is Associated With the Accelerated Decline of Bone Microarchitecture at the Distal Radius in Older Men: the Prospective STRAMBO Study

Philippe Wagner, Roland Chapurlat, René Ecochard, Pawel Szulc

Journal of Bone and Mineral Research > 33 > 9 > 1630 - 1640

Low muscle mass and strength are associated with poor bone microarchitecture. We studied the association of muscle mass and strength with changes in bone microarchitecture of distal radius in 821 older men during an 8‐year prospective follow‐up. Bone microarchitecture was assessed by high resolution peripheral quantitative computed tomography (XtremeCT‐1, Scanco) at baseline, then after 4 and 8 years...

article

Osteoporotic Vertebral Fracture Prevalence Varies Widely: Reply Letter to the Editor

Pawel Szulc

Journal of Bone and Mineral Research > 33 > 8 > 1548 - 1549

article

Prediction of Fractures in Men Using Bone Microarchitectural Parameters Assessed by High‐Resolution Peripheral Quantitative Computed Tomography—The Prospective STRAMBO Study

Pawel Szulc, Stéphanie Boutroy, Roland Chapurlat

Journal of Bone and Mineral Research > 33 > 8 > 1470 - 1479

Areal bone mineral density (aBMD) poorly identifies men at high fracture risk. Our aim was to assess prediction of fractures in men by bone microarchitectural measures. At baseline, 825 men aged 60 to 87 years had the assessment of bone microarchitecture at distal radius and distal tibia by high‐resolution peripheral QCT (HR‐pQCT; XtremeCT‐I, Scanco Medical, Brüttisellen, Switzerland). Bone strength...

article

Vertebral Fracture: Diagnostic Difficulties of a Major Medical Problem

Pawel Szulc

Journal of Bone and Mineral Research > 33 > 4 > 553 - 559

article

Bone, muscle, and metabolic parameters predict survival in patients with synchronous bone metastases from lung cancers

Lauriane Chambard, Nicolas Girard, Edouard Ollier, Jean-Charles Rousseau, more

Bone > 2018 > 108 > C > 202-209

Lung adenocarcinoma regularly induces bone metastases that are responsible for impaired quality of life as well as significant morbidity, including bone pain and fractures. We aimed at identifying whether bone and metabolic biomarkers were associated with the prognosis of lung adenocarcinoma patients with synchronous bone metastases.POUMOS is a prospective cohort of patients diagnosed with lung adenocarcinoma...

article

Teenagers and young adults with nephropathic cystinosis display significant bone disease and cortical impairment

Aurélia Bertholet-Thomas, Debora Claramunt-Taberner, Ségolène Gaillard, Georges Deschênes, more

Pediatric Nephrology > 2018 > 33 > 7 > 1165-1172

Background Bone impairment appears to be a novel complication of nephropathic cystinosis despite cysteamine therapy. Its exact underlying pathophysiology is nevertheless unclear. The objective of this study was to evaluate bone status among patients included in the French Crystobs study. Methods In addition to clinical data, bone status was evaluated using biomarkers (ALP, PTH, 25-D, 1-25D, FGF23),...

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INFONA - science communication portal

Search results for: Pawel Szulc

Machine‐Learning Assessed Abdominal Aortic Calcification is Associated with Long‐Term Fall and Fracture Risk in Community‐Dwelling Older Australian Women

Dysregulation of MicroRNAs in Adult Osteogenesis Imperfecta: The miROI Study

A Fracture Risk Assessment Tool for High Resolution Peripheral Quantitative Computed Tomography

Rapid Cortical Bone Loss at the Distal Radius Is Associated With Higher Risk of Fracture in Older Men – The STRAMBO Study

Association of Vitamin D and Parathyroid Hormone Status With the Aging‐Related Decline of Bone Microarchitecture in Older Men: The Prospective Structure of Aging Men's Bones (STRAMBO) Study

Body Composition in Patients With Psoriatic Arthritis and Changes During Interleukin‐12/Interleukin‐23 Inhibition

Bone Microarchitecture Phenotypes Identified in Older Adults Are Associated With Different Levels of Osteoporotic Fracture Risk

Joint Associations of Prevalent Radiographic Vertebral Fracture and Abdominal Aortic Calcification With Incident Hip, Major Osteoporotic, and Clinical Vertebral Fractures

High Cardiovascular Risk in Older Men with Poor Bone Microarchitecture—The Prospective STRAMBO Study

A Signature of Circulating miRNAs Associated With Fibrous Dysplasia of Bone: the mirDys Study

Relationship Between Sex Steroids and Deterioration of Bone Microarchitecture in Older Men: The Prospective STRAMBO Study

Algorithm for the Use of Biochemical Markers of Bone Turnover in the Diagnosis, Assessment and Follow-Up of Treatment for Osteoporosis

Correction to: Is There Enough Evidence for Osteosarcopenic Obesity as a Distinct Entity? A Critical Literature Review

Is There Enough Evidence for Osteosarcopenic Obesity as a Distinct Entity? A Critical Literature Review

Low Muscle Strength and Mass Is Associated With the Accelerated Decline of Bone Microarchitecture at the Distal Radius in Older Men: the Prospective STRAMBO Study

Osteoporotic Vertebral Fracture Prevalence Varies Widely: Reply Letter to the Editor

Prediction of Fractures in Men Using Bone Microarchitectural Parameters Assessed by High‐Resolution Peripheral Quantitative Computed Tomography—The Prospective STRAMBO Study

Vertebral Fracture: Diagnostic Difficulties of a Major Medical Problem

Bone, muscle, and metabolic parameters predict survival in patients with synchronous bone metastases from lung cancers

Teenagers and young adults with nephropathic cystinosis display significant bone disease and cortical impairment

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