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Binder H33 is a small protein binder engineered by ribosome display to bind human interleukin 10. Crystals of binder H33 display severe diffraction anisotropy. A set of data files with correction for diffraction anisotropy based on different local signal‐to‐noise ratios was prepared. Paired refinement was used to find the optimal anisotropic high‐resolution diffraction limit of the data: 3.13–2.47...