Leisure-time physical activity (LTPA) represents an important factor contributing to the development and management of osteoporosis yet research linking LTPA with perceived health markers has been limited in this cohort. The purpose of this study was to test the relationship between LTPA and perceived health controlling for select demographic factors and chronic conditions in people living with osteoporosis. Population-health survey data from cycle 2.2 of the Canadian Community Health Survey were used in conjunction with linear multiple regression models. Participants were 1538 (n female = 1371) adults who reported living with osteoporosis. Demographic factors, chronic conditions, and more frequent participation in LTPA accounted for variance in diverse indices representing perceived health. LTPA was the only predictor to account for unique variance in each marker of perceived health. Overall, it would appear that increased use of LTPA as an adjunct to therapeutic interventions may be a viable aid to enhancing self-perceived health amongst Canadians living with osteoporosis.