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The cell wall of Gram-negative bacteria plays a crucial role in the bacteria resistance to certain antimicrobials and its adaptation to the host environment. The first line of cell defense is its outer membrane composed of glycerophos-pholipids in the inner monolayer, lipopolysaccharides (LPS) in the outer monolayer and integral proteins. To understand the details of the outer membrane structure we...
Electrical stimulation and vibration stimulation are two most investigated interfaces for sending the information to humans. It is well known that change in electrical stimulation is not linearly related to the perception of sensation that humans feel. This paper presents the experiment along with results that investigate the relationship between change in electrical stimulation parameters (e.g. pulse...
The objective of this study was to monitor changes in physiological indexes of alpha attenuation coefficient (AAC), high-frequency component (HF) and oxygenated hemoglobin (oxyHb) as objective parameters and Roken Arousal Scale (RAS) as a subjective parameter in experimental participants performing simple tasks related to motor skills, as necessary for safe driving. The oxyHb signal was monitored...
This paper presents a low-invasive framework for estimating changes in a cognitive performance using heart rate variability (HRV). Although HRV is a common physiological indicator of autonomous nerve activity or central nervous fatigue, there are individual differences in the relationship between HRV and such internal state. The new framework enables an estimation model to be determined using the...
In cranial radiotherapy highly accurate tumor localization is required to spare healthy tissue while delivering sufficient dose to the target. Here, marker-less optical tracking can support immobilization devices and monitor head motion. However, recent studies have shown that the spatial registration of the optically generated point cloud to a reference is not robust enough. It may suffer from misalignments...
An unsupervised methodology for the detection of Epileptic seizures in EEG recordings is proposed. The time-frequency content of the EEG signals is extracted using the Short Time Fourier Transform. The analysis focuses on the EEG energy distribution among the well-established delta, theta and alpha rhythms (2–13 Hz), as energy variations in these frequency bands are widely associated with seizure...
Dizziness is a common symptom for both benign and life-threatening disorders with subtle distinguishing features. This poses a clinical challenge for physicians dealing with patients suffering from dizziness and vertigo and managing them within primary care. The objective of the EMBalance project is to present a decision support system to assist general practitioners in the diagnosis and management...
A finite element model of a whole human head was developed to study sound transmission by bone conducted sound. The model comprises tissues as bone, brain and soft tissues. With this model, the motion of the bone surrounding the inner ear was investigated. This was done by defining an imaginary box encapsulating the inner ear and analyzing the motion of the opposing sides. According to this analysis,...
Alginate nanocomposite hydrogels with incorporated electrochemically synthesized silver nanoparticles were investigated regarding cytotoxicity in vitro. Direct contact test of Ag/alginate discs was applied in 2D monolayer cultures of bovine calf chondrocytes while a 3D culture of bovine articular cartilage explants pressed by the discs was established in a biomimetic bioreactor with dynamic compression...
The role of intraluminal thrombus (ILT) has special attention in these studies. One of the papers showed that asymmetrical intraluminal thrombus deposition (ATDI) has an important role in growth of the AAA. The aim of our study was to assess the asymmetrical thrombus deposition index in ruptured and symptomatic aneurysms. We collected data for 33 aneurysms, 21 (63.63%) asymptomatic and 12 (33.37%)...
Demand for analyzing very large datasets is increasing, especially with the introduction of chromatin immunoprecipitation sequencing which is a recent method of Next Generation Sequencing used to analyze protein interactions with DNA. The development of new technologies is revolutionizing genome-wide analysis and scientists' abilities to have a better understanding of the biological meaning but inferring...
Human hearing system in general, and particularly the cochlea, is very interesting for investigation. The most important reason for it is hearing loss — a health problem that affects a large part of the world's human population. The highest percentage of people with hearing problems are older people, but the problem also occurs in newborns. Experimental research in this area provides some information...
This paper presents computer analysis of how geometry of reconstructed gastrointestinal tract can influence outcome of Billroth II gastric resection. We performed three-dimensional computer simulation in order to predict duodenal stump blowout. For creation of initial three dimensional FE models of preoperative gastroduodenal region we used data from Multi Slice Computer Tomography (MSCT). Using the...
In this article we present a fusion architecture for the automatic classification of sleep stages. The architecture relies on time and frequency domain features which are processed by dissimilar classifiers. The initial predictions of each classifier are refined by using fusion of the prediction estimations together with temporal contextual information of the electroencephalographic signal. The experimental...
In this study, we propose a novel method for medical data classification, it is the integration of new heuristic algorithm that get inspired the black hole phenomenon called as Black Hole Algorithm (BHA) and decision tree (C4.5). To evaluate the effectiveness of our proposed method, it is implemented on 2 microarray dataset and 5 different medical data sets obtained from UCI machine learning databases...
The technological development in healthcare experienced in actual days has relationship with the integration of many knowledge areas, fundamentally by searching new solutions in order to improve the quality of life of the society. Examples of this reality appears in medicine and engineering areas, where the computer-assisted techniques works together to solve many healthcare problems. In the surgical...
The inner ear is physically inaccessible in living humans, which leads to unique difficulties in studying its normal function and pathology as in other human organs. Recently, biosimulation model has gained a significant attention to understand the exact causative factors that give rise to impairment in human organs. However, to build a biosimulation model for human organ concepts and their topological...
The objective of this paper is to demonstrate the creation process of the application ontology of scoliosis OBR-Scolio using the OBR reference ontology, which is spread over anatomy, physiology and pathology domains. Since OBR reference ontology exists only as a preliminary classification and does not possess taxonomy of pathological structure, we created the OBR-Scolio ontology by employing analogy...
Recently, there is an increasing motivation to develop telemonitoring systems that enable cost-effective screening of Parkinson's Disease (PD) patients. These systems are generally based on measuring the motor system disorders seen in PD patients by the help of non-invasive data collection tools. Vocal impairments one of the most commonly seen PD symptoms in the early stages of the disease, and building...
Transcranial Doppler (TCD) is a widely used, non-invasive, rapid and reproducible monitoring method for observing the condition of middle cerebral artery. Micro embolic signals, which appear in various clinical scenarios such as; carotid stenosis, aortic arch plaques, atrial fibrillation, myocardial infarction, patent foramen ovale and valvular stenosis, can be detected by the analysis of TCD signals...
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