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The present study was designed to investigate the role of miR‐708‐5p/p38 mitogen‐activated protein kinase (MAPK) pathway during the mechanism of selenium nanoparticles (Nano‐Se) against nickel (Ni)‐induced testosterone synthesis disorder in rat Leydig cells. We conducted all procedures based on in vitro culture of rat primary Leydig cells. After treating Leydig cells with Nano‐Se and NiSO4 alone or...
The aim of this study was to investigate the protective effects of Nano‐Se against nickel (Ni)‐induced hepatotoxicity and the potential mechanism. Hence, we constructed in vivo and in vitro models of Ni‐induced hepatotoxicity. Sprague–Dawley (SD) rats were exposed to nickel sulfate (NiSO4, 5.0 mg/kg, i.p.) with or without Nano‐Se (0.5, 1, and 2 mg/kg, oral gavage) co‐administration for 14 days, and...
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