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许多证据表明,线粒体在与衰老相关的神经退行性疾病中起着核心作用。线粒体是细胞死亡的关键调节剂,是神经退行性疾病的一个关键特征。线粒体 DNA 突变和氧化应激都会导致衰老,而衰老是神经退行性疾病的最大风险因素。在这些疾病的所有主要例子中,都有强有力的证据表明线粒体功能障碍发生在早期并在疾病发病机制中起因果作用。此外,大量疾病特异性蛋白质与线粒体相互作用。因此,针对基本线粒体过程的疗法,如能量代谢或自由基生成,或疾病相关蛋白质与线粒体的特定相互作用,具有广阔的前景