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The vascular microenvironment is the scale at which microvascular transport, interstitial tissue properties and cell metabolism interact. The vascular microenvironment has been widely studied by means of quantitative approaches, including multi‐physics mathematical models as it is a central system for the pathophysiology of many diseases, such as cancer. The microvascular architecture is a key factor...
In article number 1902393, Charles G. Knutson, Roger D. Kamm, and co‐workers use microvascular networks self‐assembled from human cells within microfluid devices to directly measure trans‐capillary solute flux. Physiological fluid flow through the cell junctions, passive diffusion across the cell membrane, and active vesicular transport, recapitulate the in vivo mode and magnitude of transport for...
In vitro prediction of physiologically relevant transport of therapeutic molecules across the microcirculation represents an intriguing opportunity to predict efficacy in human populations. On‐chip microvascular networks (MVNs) show physiologically relevant values of molecular permeability, yet like most systems, they lack an important contribution to transport: the ever‐present fluid convection through...
We present a two‐phase model for microcirculation that describes the interaction of plasma with red blood cells. The model takes into account of typical effects characterizing the microcirculation, such as the Fahraeus‐Lindqvist effect and plasma skimming. Besides these features, the model describes the interaction of capillaries with the surrounding tissue. More precisely, the model accounts for...
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