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Background
A serious adverse effect of long‐term bisphosphonate (BP) administration is bisphosphonate‐related osteonecrosis of the jaw (BRONJ). Among different proposed pathogenesis, suppression of immune cells is gaining interest. Because monocytes/macrophages could get access to BP since residing in the blood and bone microenvironment, the aim of this study was to analyze the behaviors of macrophages...
Observational evidence suggests association between periodontitis and atherosclerotic vascular disease (ASVD), however the cause–effect remains unclear. In this study, we investigated the mechanistic link of the two diseases by measuring production of interleukin (IL)-1β, a potent inflammatory cytokine, induced via inflammasome activation by a key periodontal pathogen – Porphyromonas gingivalis LPS...
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