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Focal cortical dysplasia (FCD) is the most frequent etiology of operable pharmacoresistant epilepsy in children. There is burgeoning evidence that FCD‐related epilepsy is a disorder that involves distributed brain networks. Functional magnetic resonance imaging (fMRI) is a tool that allows one to infer neuronal activity and to noninvasively map whole‐brain functional networks. Despite its relatively...
Objective
Focal cortical dysplasia (FCD) is the most common etiology of surgically‐remediable epilepsy in children. Eighty‐seven percent of patients with FCD develop epilepsy (75% is pharmacoresistant epilepsy [PRE]). Focal to bilateral tonic–clonic (FTBTC) seizures are associated with worse surgical outcomes. We hypothesized that children with FCD‐related epilepsy with FTBTC seizures are more likely...
Objective
The purpose of this study was to evaluate if focal cortical dysplasia (FCD) co‐localization to cortical functional networks is associated with the temporal distribution of epilepsy onset in FCD.
Methods
International (20 center), retrospective cohort from the Multi‐Centre Epilepsy Lesion Detection (MELD) project. Patients included if >3 years old, had 3D pre‐operative T1 magnetic resonance...
Objective
Drug‐resistant focal epilepsy is often caused by focal cortical dysplasias (FCDs). The distribution of these lesions across the cerebral cortex and the impact of lesion location on clinical presentation and surgical outcome are largely unknown. We created a neuroimaging cohort of patients with individually mapped FCDs to determine factors associated with lesion location and predictors of...
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