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Merging gene expression datasets is a simple way to increase the number of samples in an analysis. However experimental and data processing conditions, which are proper to each dataset or batch, generally influence the expression values and can hide the biological effect of interest. It is then important to normalize the bigger merged dataset, as failing to adjust for those batch effects may adversely...
Background Non-invasive ventilation (NIV) tolerance is a key factor of NIV success. Hence, numerous sedative pharmacological or non-pharmacological strategies have been assessed to improve NIV tolerance. Music therapy in various health care settings has shown beneficial effects. In invasively ventilated critical care patients, encouraging results of music therapy on physiological parameters, anxiety,...
Stochastic neighbor embedding (SNE) and its variants are methods of dimensionality reduction (DR) that involve normalized softmax similarities derived from pairwise distances. These methods try to reproduce in the low-dimensional embedding space the similarities observed in the high-dimensional data space. Their outstanding experimental results, compared to previous state-of-the-art methods, originate...
Objective:The genetic variation underlying facioscapulohumeral muscular dystrophy (FSHD), 1 of the most common hereditary neuromuscular disorders, is complex, and associated with the contraction of a repeat array (D4Z4) at the subtelomeric end of chromosome 4q. Nonpathogenic variants of 4q and the presence of a homologous array on chromosome 10q make FSHD diagnosis extremely challenging, at least...
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