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João Batista Júnior

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Role

Academic staff

External Ids

OrcId: 0000-0002-8972-8131

Interests

Computer and Information Sciences, Basic Medicine, Chemical Sciences and 5 other

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Keywords

SARS-CoV-2, Therapeutic Target, Molecular Recognition, TACE, Tumor Necrosis Factor Alpha Converting Enzyme, ARDS, Acute Respiratory Distress Syndrome, Interaction Energies, ACE2

Resources

article

Interaction Energies of the Human ACE2 Molecular Recognition by SARS-CoV-2

João Batista Júnior

The Coronaviridae family of viruses includes hundreds of viruses common in many different animal species and humans. Seven coronaviruses (CoVs) are known to cause disease in humans. Four of them show low pathogenicity and are endemic in humans and the other three CoV are particularly dangerous and highly pathogenic viruses, which underwent genetic changes rendering them able to jump the species barriers...
article

A Structure and Antioxidant Activity Study of Paracetamol and Salicylic Acid

Rosivaldo S. Borges, Tainá G. Barros, Glaécia A. N. Pereira, João Batista Júnior, more

1185-1191

The paracetamol has more antioxidant properties than the salicylic acid on the several oxidative stress-forced models and one possible mechanism is due to electron or hydrogen transfer by the evaluated hydroxyl radicals. The antioxidant mechanism for the compounds studied here was performed by molecular modeling using quantum chemical calculations at the B3LYP level of theory. Our results show that...
article

Clinical Oxidative Stress during Leprosy Multidrug Therapy: Impact of Dapsone Oxidation

Taysa Ribeiro Schalcher, Rosivaldo S. Borges, Michael D. Coleman, João Batista Júnior, more

e 85712-e 85712

This study aims to assess the oxidative stress in leprosy patients under multidrug therapy (MDT; dapsone, clofazimine and rifampicin), evaluating the nitric oxide (NO) concentration, catalase (CAT) and superoxide dismutase (SOD) activities, glutathione (GSH) levels, total antioxidant capacity, lipid peroxidation, and methemoglobin formation. For this, we analyzed 23 leprosy patients and 20 healthy...

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