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Gijo George

user

City

Bangalore

Institution

Indian Institute of Science

Role

Student

External Ids

OrcId: 0000-0002-7487-7441
ResearcherId: A-3653-2010

Interests

Biological Sciences, Physical Sciences, Chemical Sciences

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Resources

article

Structural Dimorphism of Achiral α,γ‐Hybrid Peptide Foldamers: Coexistence of 12‐ and 15/17‐Helices

Rajkumar Misra, Abhijith Saseendran, Gijo George, Kuruva Veeresh, more

Chemistry – A European Journal > 23 > 15 > 3764 - 3772

Here, novel 12‐helices in α,γ‐hybrid peptides composed of achiral α‐aminoisobutyric acid (Aib) and 4‐aminoisocaproic acid (Aic, doubly homologated Aib) monomers in 1:1 alternation are reported. The 12‐helices were indicated by solution and crystal structural analyses of tetra‐ and heptapeptides. Surprisingly, single crystals of the longer nonapeptide displayed two different helix types: the novel...
article

Crystal‐Structure Analysis of cis‐X‐Pro‐Containing Peptidomimetics: Understanding the Steric Interactions at cis X‐Pro Amide Bonds

Damodara N. Reddy, Gijo George, Erode N. Prabhakaran

Angewandte Chemie International Edition > 52 > 14 > 3935 - 3939

Catch the twist: The cis Piv‐Pro conformer (Piv=pivaloyl) of peptides is no longer inaccessible. Any cis X‐Pro tertiary‐amide‐bond conformer can be stabilized in crystals of peptides by accommodating the unavoidable distortion of the dihedral angle of the peptide bond to the carbonyl group of the Pro residue (see picture), in this case through ni−1→πi* interactions. Steric clashes were not observed...
article

Crystal‐Structure Analysis of cis‐X‐Pro‐Containing Peptidomimetics: Understanding the Steric Interactions at cis X‐Pro Amide Bonds

Damodara N. Reddy, Gijo George, Erode N. Prabhakaran

Angewandte Chemie > 125 > 14 > 4027 - 4031

Konfliktfrei: Das cis‐Piv‐Pro‐Peptidkonformer (Piv=Pivaloyl) ist nicht länger unzugänglich. Alle cis‐X‐Pro‐Konformere mit tertiärer Amidbindung können sich in Peptidkristallen stabilisieren, indem die unvermeidliche Verzerrung des Diederwinkels der Peptidbindung bezüglich der Pro‐Carbonylgruppe kompensiert wird (siehe Bild) – in diesem Fall über ni−1→πi*‐Wechselwirkungen. Sterische Konflikte traten...

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