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Items from 1 to 20 out of 756 results

article

Rituximab for connective tissue disease‐associated interstitial lung disease: A systematic review and meta‐analysis

Yilin Wang, Liren Li

International Journal of Rheumatic Diseases > 26 > 2 > 225 - 235

Objective To assess the efficacy of rituximab (RTX) on lung function and the prevalence of adverse events (AEs) in connective tissue disease‐associated interstitial lung disease (CTD‐ILD) by meta‐analysis. Methods EMBASE, Web of Science, PubMed and ClinicalKey were searched up to July 16, 2021. The lung function (forced vital capacity, FVC% predicted, and diffusing capacity of the lung for carbon...

article

Persistent T‐cell exhaustion in relation to prolonged pulmonary pathology and death after severe COVID‐19: Results from two Norwegian cohort studies

Marius Trøseid, Tuva B. Dahl, Jan C. Holter, Anders B. Kildal, more

Journal of Internal Medicine > 292 > 5 > 816 - 828

Background T‐cell activation is associated with an adverse outcome in COVID‐19, but whether T‐cell activation and exhaustion relate to persistent respiratory dysfunction and death is unknown. Objectives To investigate whether T‐cell activation and exhaustion persist and are associated with prolonged respiratory dysfunction and death after hospitalization for COVID‐19. Methods Plasma and serum...

article

Mediators linking obesity to childhood asthma

Yang‐Ching Chen, Yen‐Tsung Huang, Wen‐Harn Pan, Yungling L. Lee

Pediatric Allergy and Immunology > 33 > 10 > n/a - n/a

Background Obesity and asthma are highly associated, but the mechanisms underlying the association remain unknown. We examined five mediators linking obesity with childhood asthma: (1) pulmonary function impairment, (2) airway inflammation, (3) physical fitness, (4) sleep‐disordered breathing (SDB), and (5) early puberty. Methods A Mendelian randomization (MR) study with mediation analysis of data...

article

Comparison of nasal intermittent positive pressure ventilation and bubble CPAP with an in‐line high‐frequency interrupter in a premature infant lung model

David M. Rub, Emidio M. Sivieri, Soraya Abbasi, William Sieberlich, more

Pediatric Pulmonology > 57 > 10 > 2356 - 2362

Introduction Noninvasive ventilation has become a staple in the care of premature infants. However, failure rates continue to be high in this population. Modifications to noninvasive support, such as nasal intermittent positive pressure ventilation (NIPPV), are used clinically to reduce such failure. Previous in vitro studies have shown improved CO₂ clearance when superimposing high‐frequency oscillations...

article

Delays in pulmonary decline in eteplirsen‐treated patients with Duchenne muscular dystrophy

Joel Iff, Charles Gerrits, Yi Zhong, Edward Tuttle, more

Muscle & Nerve > 66 > 3 > 262 - 269

Introduction/Aims Pulmonary decline is a major issue in patients with Duchenne muscular dystrophy (DMD). Eteplirsen is a United States–approved treatment for patients with DMD and exon 51 skip‐amenable mutations. Previous analyses have shown that eteplirsen is associated with a statistically significant attenuation of pulmonary decline. In this study we evaluate the effect of eteplirsen treatment...

article

Cord blood IgE predicts allergic sensitization, elevation of exhaled nitric oxide, and asthma in schoolchildren

Hsin‐Ju Lee, Hui‐Ju Tsai, Hsin‐Yi Huang, Chun‐Chun Gau, more

Pediatric Allergy and Immunology > 33 > 8 > n/a - n/a

Background Few data are available in Asian children regarding the validity of cord blood immunoglobulin E (IgE) in predicting allergic sensitization and pulmonary function. The relationship between cord blood IgE and fraction of exhaled nitric oxide (FeNO) remains unknown. This study investigated the associations of cord blood IgE with allergic sensitization, FeNO, pulmonary function, and allergic...

article

Neonatal rodent ventilation and clinical correlation in congenital diaphragmatic hernia

Vikas S. Gupta, Cory Wilson, Elizabeth C. Popp, Siqin Zhaorigetu, more

Pediatric Pulmonology > 57 > 7 > 1600 - 1607

Introduction Ventilator management is a critical part of managing congenital diaphragmatic hernia (CDH). We aimed to use a murine model and patient data to study CDH‐associated differences in oxygenation, airway resistance, and pulmonary mechanics by disease severity. Methods We used the nitrofen model of CDH. For control and CDH rodents, data were collected within the first hour of life. Oxygen...

article

Pooled analysis on image‐guided moderately hypofractionated thoracic irradiation in inoperable node‐positive/recurrent patients with non–small cell lung cancer with poor prognostic factors and severely limited pulmonary function and reserve

Chukwuka Eze, Julian Elias Guggenberger, Nina‐Sophie Schmidt‐Hegemann, Saskia Kenndoff, more

Cancer > 128 > 12 > 2358 - 2366

Background The objective of this study was to investigate the feasibility and efficacy of image‐guided moderately hypofractionated thoracic radiotherapy (hypo‐IGRT) in patients with non–small cell lung cancer (NSCLC) with poor performance status and severely limited pulmonary function and reserve. Methods Consecutive inoperable patients who had node‐positive, stage IIB‐IIIC (TNM, 8th edition) or...

article

Respiratory dysfunction three months after severe COVID‐19 is associated with gut microbiota alterations

Beate Vestad, Thor Ueland, Tøri Vigeland Lerum, Tuva Børresdatter Dahl, more

Journal of Internal Medicine > 291 > 6 > 801 - 812

Background Although coronavirus disease 2019 (COVID‐19) is primarily a respiratory infection, mounting evidence suggests that the gastrointestinal tract is involved in the disease, with gut barrier dysfunction and gut microbiota alterations being related to disease severity. Whether these alterations persist and are related to long‐term respiratory dysfunction remains unknown. Methods Plasma was...

article

Association between age, gender, body mass index, and pulmonary function in preoperative patients with lung cancer

Weicheng Xu, Yakang Liu, Bin Zeng, Xinping Li

The Clinical Respiratory Journal > 16 > 3 > 244 - 251

Introduction Many confounding factors such as sex, age, and body mass index (BMI) affect pulmonary function parameters, but there are limited data about the direct and/or indirect effects of small airway function on lung function for differences in confounding factors. Objectives This study aimed to use structural equation model (SEM) to explain the influence of the confounding factors (age, sex,...

article

Pulmonary function, muscle strength, and quality of life have differed between chronic kidney disease patients and healthy individuals

Patrícia Souza Rezende, Francini Porcher Andrade, Carolina Ferraro dos Santos Borba, Paula Maria Eidt Rovedder

Therapeutic Apheresis and Dialysis > 26 > 2 > 337 - 344

Chronic kidney disease (CKD) patients have lower pulmonary function, respiratory and peripheral muscle strength values when compared to the general population, which reflects negatively in the quality of life (QoL). The aim of this study was to compare the pulmonary function, respiratory and peripheral muscle strength, and QoL between CKD patients and healthy individuals. Cross‐sectional study with...

article

Impact of Achromobacter spp. isolation on clinical outcomes in children with cystic fibrosis

Birce Sunman, Nagehan Emiralioglu, Gülsen Hazirolan, Dilber Ademhan Tural, more

Pediatric Pulmonology > 57 > 3 > 658 - 666

Background The prevalence of Achromobacter spp. in cystic fibrosis (CF) has increased while its significance remains controversial. Our aim was to investigate the impact of Achromobacter spp. isolation on clinical outcomes in children with CF. Methods Children with Achromobacter spp. isolation were retrospectively included from the CF database of our center. Control groups of children with CF,...

article

Investigating obesity‐related risk factors for childhood asthma

Yang‐Ching Chen, Ming‐Wei Su, Ben M. Brumpton, Yungling L. Lee, more

Pediatric Allergy and Immunology > 33 > 1 > n/a - n/a

Background We tested the hypothesis that multiple obesity‐related risk factors (obesity, physical activity, cardiopulmonary physical fitness, sleep‐disorder breathing (SDB), and sleep quality) are associated with childhood asthma using a Mendelian randomization (MR) design. Furthermore, we aim to investigate whether these risk factors were associated with incident asthma prospectively. Methods...

article

Respiratory manifestations in the Ehlers–Danlos syndromes

Rebecca Bascom, Radha Dhingra, Clair A. Francomano

American Journal of Medical Genetics Part C: Seminars in Medical Genetics > 187 > 4 > 533 - 548

Persons with the Ehlers–Danlos syndromes (EDS) report a wide range of respiratory symptoms, most commonly shortness of breath, exercise limitation, and cough. Also reported are noisy breathing attributed to asthma, difficulty with deep inhalation, and inspiratory thoracic pain. The literature consists of case reports and small cross‐sectional and cohort studies. One case–control study estimated twofold...

article

Serum cadmium positively correlates with inflammatory cytokines in patients with chronic obstructive pulmonary disease

Ya‐Lin Jiang, Jun Fei, Peng Cao, Chen Zhang, more

Environmental Toxicology > 37 > 1 > 151 - 160

Background Cadmium is a ubiquitous toxic heavy metal and environmental toxicant. Inflammation exerts central roles in the process of chronic obstructive pulmonary disease (COPD). However, few epidemiological studies on the correlation between cadmium exposure and COPD are available. The aim of this study was to evaluate the correlations among serum cadmium, inflammatory cytokines and pulmonary function...

article

Protracted respiratory findings in children post‐SARS‐CoV‐2 infection

Shoshana C. Leftin Dobkin, Joseph M. Collaco, Sharon A. McGrath‐Morrow

Pediatric Pulmonology > 56 > 12 > 3682 - 3687

Introduction Although prolonged respiratory symptoms following severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection have been described in adults, data are emerging that children also experience long‐term sequelae of coronavirus disease 2019 (COVID‐19). The respiratory sequelae of COVID‐19 in children remain poorly characterized. In this study we describe health data and respiratory...

article

2020 year in review: Neonatal pulmonology

Richard L. Auten, Rita M. Ryan

Pediatric Pulmonology > 56 > 12 > 3577 - 3579

Pediatric Pulmonology publishes original research, reviews, and case reports related to a wide range of children's respiratory disorders. This review summarizes the past year's publications in the topic area of neonatal pulmonology, in the context of selected literature from other journals relevant to the discipline.

article

Effects of obesity on pulmonary function considering the transition from obstructive to restrictive pattern from childhood to young adulthood

Li Huang, Sen‐Te Wang, Han‐Pin Kuo, Christophe Delclaux, more

Obesity Reviews > 22 > 12 > n/a - n/a

Adults with obesity exhibit a restrictive pattern, whereas children with obesity exhibit an obstructive pattern. However, the transition process remains unclear. We performed a systematic search for studies reporting on body mass index and pulmonary function in children. The main outcomes were forced expiratory volume in 1 s (FEV₁), forced vital capacity (FVC), and their ratio (FEV₁/FVC). We compared...

article

Lung growth and pulmonary function after prematurity and bronchopulmonary dysplasia

Laura Moschino, Luca Bonadies, Eugenio Baraldi

Pediatric Pulmonology > 56 > 11 > 3499 - 3508

Bronchopulmonary dysplasia (BPD) still carries a heavy burden of morbidity and mortality in survivors of extreme prematurity. The disease is characterized by simplification of the alveolar structure, involving a smaller number of enlarged alveoli due to decreased septation and a dysmorphic pulmonary microvessel growth. These changes lead to persistent abnormalities mainly affecting the smaller airways,...

article

Influence of reduced diffusing capacity and FEV₁ on outcome after cardiac surgery

Emilie C. Risom, Katrine B. Buggeskov, René H. Petersen, Jann Mortensen, more

Acta Anaesthesiologica Scandinavica > 65 > 9 > 1221 - 1228

Background Impaired lung function is a well‐known risk factor in cardiac surgery patients and reduced forced expiratory volume in 1 second (FEV₁) is associated with increased mortality. However, there is limited knowledge regarding the influence of impaired diffusing capacity of the lungs for carbon monoxide (DLCO) in unselected cardiac surgery patients. The aim of this study was to investigate the...

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Search results

Rituximab for connective tissue disease‐associated interstitial lung disease: A systematic review and meta‐analysis

Persistent T‐cell exhaustion in relation to prolonged pulmonary pathology and death after severe COVID‐19: Results from two Norwegian cohort studies

Mediators linking obesity to childhood asthma

Comparison of nasal intermittent positive pressure ventilation and bubble CPAP with an in‐line high‐frequency interrupter in a premature infant lung model

Delays in pulmonary decline in eteplirsen‐treated patients with Duchenne muscular dystrophy

Cord blood IgE predicts allergic sensitization, elevation of exhaled nitric oxide, and asthma in schoolchildren

Neonatal rodent ventilation and clinical correlation in congenital diaphragmatic hernia

Pooled analysis on image‐guided moderately hypofractionated thoracic irradiation in inoperable node‐positive/recurrent patients with non–small cell lung cancer with poor prognostic factors and severely limited pulmonary function and reserve

Respiratory dysfunction three months after severe COVID‐19 is associated with gut microbiota alterations

Association between age, gender, body mass index, and pulmonary function in preoperative patients with lung cancer

Pulmonary function, muscle strength, and quality of life have differed between chronic kidney disease patients and healthy individuals

Impact of Achromobacter spp. isolation on clinical outcomes in children with cystic fibrosis

Investigating obesity‐related risk factors for childhood asthma

Respiratory manifestations in the Ehlers–Danlos syndromes

Serum cadmium positively correlates with inflammatory cytokines in patients with chronic obstructive pulmonary disease

Protracted respiratory findings in children post‐SARS‐CoV‐2 infection

2020 year in review: Neonatal pulmonology

Effects of obesity on pulmonary function considering the transition from obstructive to restrictive pattern from childhood to young adulthood

Lung growth and pulmonary function after prematurity and bronchopulmonary dysplasia

Influence of reduced diffusing capacity and FEV₁ on outcome after cardiac surgery

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