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article

Potential Etiologic Factors of Microbiome Disruption in Autism

Timothy Buie, T. Buie

Clinical Therapeutics > 2015 > 37 > 5 > 976-983

Purpose: The primary purpose of this article was to consider the candidate disruptors of the development of a healthy microbiome in patients with autism. The reported abnormalities in the microbiome of individuals with autism are discussed. Methods: This selected review used data from published articles related to the assessment of microbiota in autism. Evidence-based support of factors known to affect...

article

Near missed reversible cardiomyopathy: The value of the electrocardiogram

Majid Al-Fayyadh, Abdualah Alwadai, Abdulah Al Huzaimi, Zohair Al Halees, more

International Journal of Pediatrics and Adolescent Medicine > 2015 > 2 > 1 > 29-33

Dilated cardiomyopathy is a devastating disease affecting the myocardium that is characterized by cardiac chamber dilatation with contractile function impairment in the absence of structural heart disease. The majority of cases are idiopathic; these patients have a poor outcome. However, identifying a reversible etiology and instituting appropriate intervention could reverse the disease process and...

article

Unanticipated findings in pediatric neuroimaging research: Prevalence of abnormalities and process for reporting and clinical follow-up

Drew Kaiser, James Leach, Jennifer Vannest, Mark Schapiro, more

Brain Imaging and Behavior > 2015 > 9 > 1 > 32-42

MRI is a powerful tool to evaluate brain anatomy and function in normal children and its use in research applications has steadily increased. As imaging technology improves, and sensitivity to brain pathology increases, unanticipated (and potentially clinically important) findings on research neuroimaging studies will also increase. We evaluated the prevalence and type of unanticipated and...

article

The Birds, the Bees, and Technology : Four active research areas are boosting birth rates.

Leslie Mertz

IEEE Pulse > 2015 > 6 > 1 > 14 - 15

In 1978, "test tube baby" Louise Joy Brown became the first person born through the use of in vitro fertilization (IVF). Since then, the number of babies delivered with help from IVF or other assisted reproductive technology (ART) totaled about 2.5 million worldwide as of 2007, with another 2.5 million born through 2013, according to the International Committee for the Monitoring of Assisted...

article

A Review of Biomarkers and Physiomarkers in Pediatric Sepsis

Mashael F. Alqahtani, Lauren E. Marsillio, Ranna A. Rozenfeld, M.F. Alqahtani, more

Clinical Pediatric Emergency Medicine > 2014 > 15 > 2 > 177-184

Sepsis is a leading cause of morbidity and mortality in critically ill pediatric patients. The early diagnosis of sepsis is often difficult. Clinical signs and symptoms consistent with established criteria often occur late in the course of illness. In addition, early manifestations of sepsis are often nonspecific and can occur in many other disease processes, which confound the clinical picture. Therefore,...

article

Reflexions sur la pediatrie en France et aux Etats-Unis<space>:un appel aux etudes comparees

P.C. Sorum

Archives de pediatrie > 2001 > 8 > 5 > 465-468

article

Outcome of patients with undifferentiated embryonal sarcoma of the liver treated according to European soft tissue sarcoma protocols

Florent Guérin, Hélène Martelli, Timothy Rogers, Ilaria Zanetti, more

Pediatric Blood & Cancer > 70 > 7 > n/a - n/a

Background To assess the outcomes of pediatric patients with undifferentiated embryonal sarcoma of the liver (UESL) and treatment including at least surgery and systemic chemotherapy. Methods This study included patients aged up to 21 years with a pathological diagnosis of UESL prospectively enrolled from 1995 to 2016 in three European trials focusing on the effects of surgical margins, preoperative...

article

Acne incidence in preadolescents and association with increased body mass index: A population‐based retrospective cohort study of 643 cases with age‐ and sex‐matched community controls

Katinna E. Rodriguez Baisi, Amy L. Weaver, Hadir Shakshouk, Megha M. Tollefson

Pediatric Dermatology > 40 > 3 > 428 - 433

Background/Objectives Little is known about acne incidence in preadolescents and its potential association with body mass index (BMI). Our study aims to determine acne incidence in preadolescents and its association with BMI. Methods A population‐based retrospective cohort study identified 7‐ to ≤12 year‐olds with an initial acne diagnosis during 2010–2018, and incidence was calculated. Two age‐...

article

Cross‐sectional associations between physical fitness and biomarkers of inflammation in children—The PANIC study

Eero A. Haapala, Emmi Kuronen, Johanna K. Ihalainen, Niina Lintu, more

Scandinavian Journal of Medicine & Science in Sports > 33 > 6 > 1000 - 1009

Background Systemic low‐grade inflammation has been proposed as an underlying pathophysiological mechanism for cardiometabolic diseases. We investigated the associations of physical fitness with a systemic low‐grade inflammatory state in a population sample of children. Methods Altogether 391 children aged 6–9 years were examined. Cardiorespiratory fitness (maximal power output, W_max) was assessed...

article

Cryoprecipitate for the treatment of life‐threatening hemorrhage in children

Jennifer A. Horst, Philip C. Spinella, Julie C. Leonard, Cassandra D. Josephson, more

Transfusion > 63 > S3 > S10 - S17

Background Hypofibrinogenemia is an important risk factor for poor outcomes in children with severe bleeding. There is a paucity of data on the impact of cryoprecipitate transfusion on outcomes in pediatric patients with life‐threatening hemorrhage (LTH). Study Design and Methods This secondary analysis of a multicenter prospective observational study of children with LTH investigated subjects...

article

Machine learning models to predict and benchmark PICU length of stay with application to children with critical bronchiolitis

Colin M. Rogerson, Julia A. Heneghan, Joseph G. Kohne, Denise M. Goodman, more

Pediatric Pulmonology > 58 > 6 > 1777 - 1783

Objective To create models for prediction and benchmarking of pediatric intensive care unit (PICU) length of stay (LOS) for patients with critical bronchiolitis. Hypothesis We hypothesize that machine learning models applied to an administrative database will be able to accurately predict and benchmark the PICU LOS for critical bronchiolitis. Design Retrospective cohort study. Patients All...

article

Congenital lobar emphysema: A rare cause of respiratory failure in neonates

Paul Rose, Saim Rana, Cassie Abbey, Seth Deskins, more

Pediatric Pulmonology > 58 > 6 > 1821 - 1823

Congenital lobar overinflation, also known as congenital lobar emphysema (CLE), is an uncommon (1/20,000–30,000 live births) abnormality characterized by hyperinflation of one or more pulmonary lobes, usually with contralateral displacement of the mediastinum. While the etiology of most cases of CLE is poorly understood and labeled idiopathic, some cases are thought to be due to an intrinsic or extrinsic...

article

Diaphragm excursion correlates with performance and ventilation on the 6‐min walk test in children with sickle cell disease

Simon Ho, Kelly Rock, Victoria Marchese

Pediatric Pulmonology > 58 > 6 > 1665 - 1673

Introduction Diaphragm function may be impaired in children with sickle cell disease (SCD). We hypothesized that diaphragm function is related to performance and ventilation on the 6‐min walk test (6MWT). Methods Respiratory muscle testing, diaphragm ultrasonography, and the 6MWT with portable gas analysis were performed on children with SCD and age‐ and sex‐matched controls. Results Fourteen...

article

Reliability of 3D freehand ultrasound to assess lower limb muscles in children with spastic cerebral palsy and typical development

Britta Hanssen, Nicky Peeters, Tijl Dewit, Ester Huyghe, more

Journal of Anatomy > 242 > 6 > 986 - 1002

This study investigated the reliability of 3‐dimensional freehand ultrasound (3DfUS) to quantify the size (muscle volume [MV] and anatomical cross‐sectional area [aCSA]), length (muscle length [ML], tendon length [TL], and muscle tendon unit length [MTUL]), and echo‐intensity (EI, whole muscle and 50% aCSA), of lower limb muscles in children with spastic cerebral palsy (SCP) and typical development...

article

Hydroxyurea for children with sickle cell disease in sub‐Saharan Africa: A summary of the evidence, opportunities, and challenges

Daniel Dexter, Patrick T. McGann

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy > 43 > 5 > 430 - 441

Sickle cell disease (SCD) is a common and life‐threatening inherited blood disorder that affects more than 300,000 newborns per year. Because of the origins of the sickle gene mutation as a protective mechanism against malaria for those with sickle cell trait, more than 90% of annual SCD births are in sub‐Saharan Africa (sSA). Over the past several decades, there have been many important advances...

article

Ex situ heart perfusion for optimization of pediatric donor organ utilization: Attitudes and perceptions

Madeleine Townsend, Tara Pidborochynski, Michael Manen, Darren H. Freed, more

Artificial Organs > 47 > 5 > 864 - 869

Background Children with heart failure have the highest mortality while awaiting transplantation. Ex situ heart perfusion (ESHP), a method for continuous perfusion of the donor heart, has the potential to improve access to transplant by increasing travel distance between donor and recipient. An adult ESHP device is currently available, but as of yet there is no pediatric device. The aim of this study...

article

A case of neonatal thrombocytopenia due to maternal Helicobacter pylori‐associated immune thrombocytopenia

Naho Ikeda, Hiromichi Shoji, Tamaki Ikuse, Natsuki Ohkawa, more

Helicobacter > 28 > 3 > n/a - n/a

Many studies in adults have suggested an association between Helicobacter pylori (H. pylori) infection and chronic immune thrombocytopenia (ITP). In adults with ITP and H. pylori infection, eradicating H. pylori is recommended as the first‐line therapy. However, the association between ITP and H. pylori in children remains controversial. Diagnosing thrombocytopenia in pregnant women is challenging...

article

Clinical utility of colonic low‐amplitude propagating contractions in children with functional constipation

Kitzia Colliard, Dhiren Patel, Samuel Nurko, Leonel Rodriguez

Neurogastroenterology & Motility > 35 > 5 > n/a - n/a

Background Colonic high‐amplitude propagating contractions (HAPC) are generally accepted as a marker of neuromuscular integrity. Little is known about low‐amplitude propagating contractions (LAPCs); we evaluated their clinical utility in children. Methods Retrospective review of children with functional constipation undergoing low‐resolution colon manometry (CM) recording HAPCs and LAPCs (physiologic...

article

Similarities and controversies in imaging of pediatric renal tumors: A SIOP‐RTSG and COG collaboration

Justine N. Beek, Maddy Artunduaga, Jens‐Peter Schenk, Meryle J. Eklund, more

Pediatric Blood & Cancer > 70 > S2 > n/a - n/a

Malignant renal tumors are rare in children, and Wilms tumors (WTs) are the most common subtype. Imaging plays an essential role in the diagnosis, staging, and follow‐up of these patients. Initial workup for staging is mainly performed by cross‐sectional imaging modalities such as computed tomography (CT) and magnetic resonance imaging (MRI). Imaging approach within the two core international groups,...

article

Revaccination of children with acute lymphoblastic leukemia following completion of chemotherapy

Adi Anafy, Gil Gilad, Nadav Michaan, Ronit Elhasid, more

Pediatric Blood & Cancer > 70 > 6 > n/a - n/a

Background Intensive chemotherapy for acute lymphoblastic leukemia (ALL) may affect the immune system and potentially the immune memory causing antibodies provided by vaccination to disappear. There are disagreements regarding the guidelines for posttreatment immunization strategy. Methods Ninety‐six children (aged 1–18 years at diagnosis) who completed chemotherapy for ALL were recruited. Antibody...

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Search results

Potential Etiologic Factors of Microbiome Disruption in Autism

Near missed reversible cardiomyopathy: The value of the electrocardiogram

Unanticipated findings in pediatric neuroimaging research: Prevalence of abnormalities and process for reporting and clinical follow-up

The Birds, the Bees, and Technology : Four active research areas are boosting birth rates.

A Review of Biomarkers and Physiomarkers in Pediatric Sepsis

Reflexions sur la pediatrie en France et aux Etats-Unis<space>:un appel aux etudes comparees

Outcome of patients with undifferentiated embryonal sarcoma of the liver treated according to European soft tissue sarcoma protocols

Acne incidence in preadolescents and association with increased body mass index: A population‐based retrospective cohort study of 643 cases with age‐ and sex‐matched community controls

Cross‐sectional associations between physical fitness and biomarkers of inflammation in children—The PANIC study

Cryoprecipitate for the treatment of life‐threatening hemorrhage in children

Machine learning models to predict and benchmark PICU length of stay with application to children with critical bronchiolitis

Congenital lobar emphysema: A rare cause of respiratory failure in neonates

Diaphragm excursion correlates with performance and ventilation on the 6‐min walk test in children with sickle cell disease

Reliability of 3D freehand ultrasound to assess lower limb muscles in children with spastic cerebral palsy and typical development

Hydroxyurea for children with sickle cell disease in sub‐Saharan Africa: A summary of the evidence, opportunities, and challenges

Ex situ heart perfusion for optimization of pediatric donor organ utilization: Attitudes and perceptions

A case of neonatal thrombocytopenia due to maternal Helicobacter pylori‐associated immune thrombocytopenia

Clinical utility of colonic low‐amplitude propagating contractions in children with functional constipation

Similarities and controversies in imaging of pediatric renal tumors: A SIOP‐RTSG and COG collaboration

Revaccination of children with acute lymphoblastic leukemia following completion of chemotherapy

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