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article

Efficacy of Rotundic Acid and Its Derivatives as Promising Natural Anticancer Triterpenoids: A Literature‐Based Study

Md. Shimul Bhuia, Raihan Chowdhury, Fatema Akter Sonia, Shrabonti Biswas, more

Chemistry & Biodiversity > 21 > 2 > n/a - n/a

Rotundic acid (RA) is a naturally occurring pentacyclic triterpene with a multitude of pharmacological activities. The primary emphasis of this study is on summarizing the anticancer properties with the underlying mechanisms of RA and its derivatives, as well as the pharmacokinetic features. Data was collected (up to date as of November 10, 2023) from various reliable and authentic literatures by...

article

Dual signaling evoked by oxidized LDLs in vascular cells

Anne Nègre-Salvayre, Nathalie Augé, Caroline Camaré, Titziana Bacchetti, more

Free Radical Biology and Medicine > 2017 > 106 > C > 118-133

The oxidative theory of atherosclerosis relies on the modification of low density lipoproteins (LDLs) in the vascular wall by reactive oxygen species. Modified LDLs, such as oxidized LDLs, are thought to participate in the formation of early atherosclerotic lesions (accumulation of foam cells and fatty streaks), whereas their role in advanced lesions and atherothrombotic events is more debated, because...

article

Single‐walled carbon nanotubes modulate cardiovascular control in rats

L. M. Shapoval, S. V. Prylutska, A. V. Kotsyuruba, O. V. Dmitrenko, more

Materialwissenschaft und Werkstofftechnik > 47 > 2-3 > 208 - 215

Effect of water dispersible single‐walled carbon nanotubes on the medullary cardiovascular control was studied in normotensive (control) and spontaneously hypertensive rats using physiological and biochemical approaches. We have shown for the first time the possible contribution of nitric oxide (NO) to single‐walled carbon nanotube‐induced effects in the cardiovascular nuclei of the medulla oblongata...

article

Effect of cytokine antibodies in the immunomodulation of inflammatory response and metabolic disorders induced by scorpion venom

Zahida Taibi-Djennah, Fatima Laraba-Djebari, Z. Taibi-Djennah, F. Laraba-Djebari

International Immunopharmacology > 2015 > 27 > 1 > 122-129

Androctonus australis hector (Aah) venom and its neurotoxins may affect the neuro-endocrine immunological axis due to their binding to ionic channels of axonal membranes. This binding leads to the release of neurotransmitters and immunological mediators accompanied by pathophysiological effects. Although the hyperglycemia induced by scorpion venom is clearly established, the involved mediators in...

article

Ultraviolet radiation does not increase oxidative stress in the lizard Psammodromus algirus along an elevational gradient

Senda Reguera, Francisco J. Zamora-Camacho, Elena Melero, Sergio García-Mesa, more

Comparative Biochemistry and Physiology, Part A > 2015 > 183 > Complete > 20-26

Lizards, as ectotherms, spend much time basking for thermoregulating exposed to solar radiation. Consequently, they are subjected to ultraviolet radiation (UVR), which is the most harmful component of solar radiation spectrum. UVR can provoke damages, from the molecular to tissue level, even cause death. Photooxidation triggered by UVR produces reactive oxidative species (ROS). When antioxidant machinery...

article

Assessment of hemodialysis impact by Polysulfone membrane on brain plasticity using BOLD-fMRI

R. Belaïch, S. Boujraf, A. Housni, M. Maaroufi, more

Neuroscience > 2015 > 288 > Complete > 94-104

Purpose: Hemodialysis (HD) is considered the most common alternative for overcoming renal failure. Studies have shown the involvement of HD membrane in the genesis of oxidative stress (OS) which has a direct impact on the brain tissue and is expected to be involved in brain plasticity and also reorganization of brain function control. The goal of this paper was to demonstrate the sensitivity of the...

article

Specioside ameliorates oxidative stress and promotes longevity in Caenorhabditis elegans

Jyotsna Asthana, A.K. Yadav, Aakanksha Pant, Swapnil Pandey, more

Comparative Biochemistry and Physiology, Part C > 2015 > 169 > Complete > 25-34

Specioside (6-O-coumaroylcatalpol) is an iridoid glucoside which possesses multifunctional activities viz. analgesic, antidyspeptic, astringent, liver stimulating and wound healing properties. The present study for the first time delineates stress alleviating and lifespan prolonging action of specioside (SPC), isolated from Stereospermum suaveolens in the free living, multicellular nematode model...

article

Molecular cloning and biochemical characterization of iron superoxide dismutase from the rodent malaria parasite Plasmodium vinckei

Kirtika Prakash, Manish Goyal, Awakash Soni, Arif Jamal Siddiqui, more

Parasitology International > 2014 > 63 > 6 > 817-825

Plasmodium parasite utilizes superoxide dismutase family proteins to limit the toxicity of reactive oxygen species, such as produced through hemoglobin degradation. These proteins play an important role in parasite survival during intra-erythrocytic phase. We have identified, and biochemically characterized a putative iron dependent superoxide dismutase from rodent malaria parasite Plasmodium vinckei...

article

P2X7 receptor blockade protects against cisplatin-induced nephrotoxicity in mice by decreasing the activities of inflammasome components, oxidative stress and caspase-3

Yuanyuan Zhang, Fahuan Yuan, Xuejiao Cao, Zhifang Zhai, more

Toxicology and Applied Pharmacology > 2014 > 281 > 1 > 1-10

Nephrotoxicity is a common complication of cisplatin chemotherapy and thus limits the use of cisplatin in clinic. The purinergic 2X7 receptor (P2X7R) plays important roles in inflammation and apoptosis in some inflammatory diseases; however, its roles in cisplatin-induced nephrotoxicity remain unclear. In this study, we first assessed the expression of P2X7R in cisplatin-induced nephrotoxicity in...

article

Gain in toxic function of stefin B EPM1 mutants aggregates: Correlation between cell death, aggregate number/size and oxidative stress

Mira Polajnar, Tina Zavašnik-Bergant, Nataša Kopitar-Jerala, Magda Tušek-Žnidarič, more

BBA - Molecular Cell Research > 2014 > 1843 > 9 > 2089-2099

EPM1 is a rare progressive myoclonus epilepsy accompanied by apoptosis in the cerebellum of patients. Mutations in the gene of stefin B (cystatin B) are responsible for the primary defect underlying EPM1. Taking stefin B aggregates as a model we asked what comes first, protein aggregation or oxidative stress, and how these two processes correlate with cell death.We studied the aggregation in cells...

article

Physiological responses of Manila clams Venerupis (=Ruditapes) philippinarum with varying parasite Perkinsus olseni burden to toxic algal Alexandrium ostenfeldii exposure

Malwenn Lassudrie, Philippe Soudant, Gaëlle Richard, Nicolas Henry, more

Aquatic Toxicology > 2014 > 154 > Complete > 27-38

Manila clam stock from Arcachon Bay, France, is declining, as is commercial harvest. To understand the role of environmental biotic interactions in this decrease, effects of a toxic dinoflagellate, Alexandrium ostenfeldii, which blooms regularly in Arcachon bay, and the interaction with perkinsosis on clam physiology were investigated. Manila clams from Arcachon Bay, with variable natural levels of...

article

Coptis chinensis Franch. exhibits neuroprotective properties against oxidative stress in human neuroblastoma cells

Thomas Friedemann, Benjamin Otto, Kristin Klätschke, Udo Schumacher, more

Journal of Ethnopharmacology > 2014 > 155 > 1 > 607-615

Ethnopharmacological relevance: The dried rhizome of Coptis chinensis Franch. (family Ranunculaceae) is traditionally used in Chinese medicine for the treatment of inflammatory diseases and diabetes. Recent studies showed a variety of activities of Coptis chinensis Franch. alkaloids, including neuroprotective, neuroregenerative, anti-diabetic, anti-oxidative and anti-inflammatory effects. However,...

article

Intranasal administration of a combination of choline chloride, vitamin C, and selenium attenuates the allergic effect in a mouse model of airway disease

Preeti Bansal, Sanjay Saw, Dhanapal Govindaraj, Naveen Arora, more

Free Radical Biology and Medicine > 2014 > 73 > Complete > 358-365

Respiratory allergic disease is an inflammatory condition accompanied by oxidative stress. Supplementation of an anti-inflammatory agent with antioxidants may have a therapeutic effect. In this study, the effects of choline chloride in combination with antioxidants were evaluated via the intranasal route in a mouse model of allergic airway disease. Balb/c mice were sensitized on days 0, 7, and 14...

article

Modulatory role of chelating agents in diet-induced hypercholesterolemia in rats

Heba M. Mahmoud, Hala F. Zaki, Gamal A. El Sherbiny, Hekma A. Abd El-Latif, more

Bulletin of Faculty of Pharmacy, Cairo University > 2014 > 52 > 1 > 27-35

Introduction: Hypercholesterolemia is a major risk factor for the development of atherosclerosis and endothelial dysfunction. Chelating agents may play a modulatory role in atherosclerosis by removal of calcium from atherosclerotic plaques. Aim: The present study aimed to explore the effects of calcium disodium ethylenediaminetetraacetic acid (CaNa ₂ EDTA) and meso-2,3-dimercaptosuccinic acid...

article

Oxidative stress and maternal obesity: Feto-placental unit interaction

N. Malti, H. Merzouk, S.A. Merzouk, B. Loukidi, more

Placenta > 2014 > 35 > 6 > 411-416

Objective: To determine oxidative stress markers in maternal obesity during pregnancy and to evaluate feto-placental unit interaction, especially predictors of fetal metabolic alterations. Patients and methods: 40 obese pregnant women (prepregnancy BMI > 30 kg/m ² ) were compared to 50 control pregnant women. Maternal, cord blood and placenta samples were collected at delivery. Biochemical...

article

Parabens. From environmental studies to human health

Dorota Błędzka, Jolanta Gromadzińska, Wojciech Wąsowicz, D. Bledzka, more

Environment International > 2014 > 67 > Complete > 27-42

Parabens are a group of substances commonly employed as preservatives, mainly in personal care products, pharmaceuticals and food. Scientific reports concerning their endocrine disrupting potential and the possible link with breast cancer raised wide discussion about parabens' impact and safety. This paper provides holistic overview of paraben usage, occurrence in the environment, methods of their...

article

Pretreatment with hydrogen-rich saline reduces the damage caused by glycerol-induced rhabdomyolysis and acute kidney injury in rats

Hongxia Gu, Min Yang, Xiaomin Zhao, Bing Zhao, more

Journal of Surgical Research > 2014 > 188 > 1 > 243-249

Background: Rhabdomyolysis is a leading cause of acute kidney injury. The pathophysiological process involves oxidative stress and inflammation. Hydrogen-rich saline (HRS) is an antioxidant and anti-inflammatory. This study explored the protective effect of pretreatment with HRS on the development of glycerol-induced rhabdomyolysis acute kidney injury. Materials and methods: Forty-eight rats were...

article

Antioxidative and blood pressure-lowering effects of Scurrula atropurpurea on deoxycorticosterone acetate–salt hypertensive rats

Nour Athiroh, Nur Permatasari, Djanggan Sargowo, M. Aris Widodo, more

Biomarkers and Genomic Medicine > 2014 > 6 > 1 > 32-36

This study aimed to investigate whether a methanolic extract of Scurrula atropurpurea (BL.) Dans. (MESA) was able to reduced oxidative stress and systolic blood pressure (SBP) in deoxycorticosterone acetate–salt hypertensive rats. Twenty-five male Wistar were divided into the control group and four hypertensive groups that received the MESA at a doses of 50 mg/kg, 100 mg/kg, or 200 mg/kg bodyweight,...

article

Triazophos induced oxidative stress and histomorphological changes in liver and kidney of female albino rats

Dharmender Sharma, Gurinder Kaur Sangha, D. Sharma, G.K. Sangha

Pesticide Biochemistry and Physiology > 2014 > 110 > Complete > 71-80

Organophosphate (OP) pesticides toxic manifestations have been associated with enhanced generation of reactive oxygen species (ROS) which culminates into oxidative stress (OS). Triazophos (TZ), a broad spectrum OP, was used in the present study to investigate toxic effects on liver and kidney of female albino rats at three sub-chronic dose levels of 1/10th, 1/20th and 1/40th of LD ₅₀ for 30days...

article

Metabolomics and transcriptomics demonstrate severe oxidative stress in both localized chemotherapy-treated and bystander tumors

Daniel Morvan, Aicha Demidem, D. Morvan, A. Demidem

BBA - General Subjects > 2014 > 1840 > 3 > 1092-1104

Background: Localized radiotherapy is long known to cause damages to not only targeted but also non-targeted cells, the so-called bystander (BS) effect. Recently, BS effect was demonstrated in response to chemotherapy. To get further insight into the mechanism of chemotherapy-induced BS effect in vivo, we investigated the response of normal tissues and untreated BS melanomas, at distance from localized...

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Search results

Efficacy of Rotundic Acid and Its Derivatives as Promising Natural Anticancer Triterpenoids: A Literature‐Based Study

Dual signaling evoked by oxidized LDLs in vascular cells

Single‐walled carbon nanotubes modulate cardiovascular control in rats

Effect of cytokine antibodies in the immunomodulation of inflammatory response and metabolic disorders induced by scorpion venom

Ultraviolet radiation does not increase oxidative stress in the lizard Psammodromus algirus along an elevational gradient

Assessment of hemodialysis impact by Polysulfone membrane on brain plasticity using BOLD-fMRI

Specioside ameliorates oxidative stress and promotes longevity in Caenorhabditis elegans

Molecular cloning and biochemical characterization of iron superoxide dismutase from the rodent malaria parasite Plasmodium vinckei

P2X7 receptor blockade protects against cisplatin-induced nephrotoxicity in mice by decreasing the activities of inflammasome components, oxidative stress and caspase-3

Gain in toxic function of stefin B EPM1 mutants aggregates: Correlation between cell death, aggregate number/size and oxidative stress

Physiological responses of Manila clams Venerupis (=Ruditapes) philippinarum with varying parasite Perkinsus olseni burden to toxic algal Alexandrium ostenfeldii exposure

Coptis chinensis Franch. exhibits neuroprotective properties against oxidative stress in human neuroblastoma cells

Intranasal administration of a combination of choline chloride, vitamin C, and selenium attenuates the allergic effect in a mouse model of airway disease

Modulatory role of chelating agents in diet-induced hypercholesterolemia in rats

Oxidative stress and maternal obesity: Feto-placental unit interaction

Parabens. From environmental studies to human health

Pretreatment with hydrogen-rich saline reduces the damage caused by glycerol-induced rhabdomyolysis and acute kidney injury in rats

Antioxidative and blood pressure-lowering effects of Scurrula atropurpurea on deoxycorticosterone acetate–salt hypertensive rats

Triazophos induced oxidative stress and histomorphological changes in liver and kidney of female albino rats

Metabolomics and transcriptomics demonstrate severe oxidative stress in both localized chemotherapy-treated and bystander tumors

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