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article

Using high resolution imaging to determine trafficking of corticotropin-releasing factor receptors in noradrenergic neurons of the rat locus coeruleus

B.A.S. Reyes, D.A. Bangasser, R.J. Valentino, E.J. Van Bockstaele, more

Life Sciences > 2014 > 112 > 1-2 > 2-9

Trafficking of G protein-coupled receptors (GPCRs) is a critical determinant of cellular sensitivity of neurons. To understand how endogenous or exogenous ligands impact cell surface expression of GPCRs, it is essential to employ approaches that achieve superior anatomical resolution at the synaptic level. In situations in which light and fluorescence microscopy techniques may provide only limited...

article

Association between stress and catecholamines with painful TMD in children

Claudia Restrepo‐Serna, Adriana Santamaría‐Villegas

International Journal of Paediatric Dentistry > 34 > 6 > 764 - 770

Background Studying biomarkers in children with temporomandibular disorders (TMD) such as epinephrine, norepinephrine, and dopamine may reveal factors like screen time or sleep loss that affect these biomarkers and predict TMD‐related pain, offering new research opportunities. Aim To determine the association between stress and catecholamines with myofascial pain and headache related to TMD in...

article

The use of injectable subcutaneous terbutaline and topical nitroglycerin ointment in the treatment of peripheral vasopressor extravasation in 3 dogs

Chele N. Lathroum, Hernan Lizardo Angulo Bracho, Kayla M. Alessandrino, Julie M. Walker

Journal of Veterinary Emergency and Critical Care > 34 > 4 > 393 - 398

Objective To describe the clinical course and treatment of 3 dogs with peripheral vasopressor extravasation. Case Series Summary Although vasopressor extravasation (VE) is a well‐documented complication in human medicine, literature describing VE and its management in veterinary patients is sparse. VE increases patient morbidity by causing local tissue injury and necrosis. The gold standard treatment...

article

Role of Phenylethanolamine‐N‐methyltransferase on Nicotine‐Induced Vasodilation in Rat Cerebral Arteries

Ming‐Wei Li, Shang‐Jen Chang, Hsi‐Hsien Chang, Stephen Shei‐Dei Yang

Microcirculation > 31 > 5 > n/a - n/a

Objective The sympathetic–parasympathetic (or axo–axonal) interaction mechanism mediated that neurogenic relaxation, which was dependent on norepinephrine (NE) releases from sympathetic nerve terminal and acts on β₂‐adrenoceptor of parasympathetic nerve terminal, has been reported. As NE is a weak β₂‐adrenoceptor agonist, there is a possibility that synaptic NE is converted to epinephrine by phenylethanolamine‐...

article

Are the P600 and P3 ERP components linked to the task‐evoked pupillary response as a correlate of norepinephrine activity?

Friederike Contier, Isabell Wartenburger, Mathias Weymar, Milena Rabovsky

Psychophysiology > 61 > 7 > n/a - n/a

During language comprehension, anomalies and ambiguities in the input typically elicit the P600 event‐related potential component. Although traditionally interpreted as a specific signal of combinatorial operations in sentence processing, the component has alternatively been proposed to be a variant of the oddball‐sensitive, domain‐general P3 component. In particular, both components might reflect...

article

Teleological reasoning bias is predicted by pupil dynamics: Evidence for the extensive integration account of bias in reasoning

Martin Jensen Mækelæ, Isabel V. Kreis, Gerit Pfuhl

Psychophysiology > 61 > 6 > n/a - n/a

Teleological reasoning is the tendency for humans to see purpose and intentionality in natural phenomena when there is none. In this study, we assess three competing theories on how bias in reasoning arises by examining performance on a teleological reasoning task while measuring pupil size and response times. We replicate that humans (N = 45) are prone to accept false teleological explanations. Further,...

article

Regulation of nociception threshold by norepinephrine through adrenergic α2 receptor in rat models of Parkinson's disease

Qing Gao, Yingying Zhang, Xiaoying Wang, Rui Wang, more

CNS Neuroscience & Therapeutics > 30 > 3 > n/a - n/a

Background The mechanism of pain symptoms in Parkinson's disease (PD) is unclear. Norepinephrine (NE) regulates neuropathic pain through ascending and descending pathways. However, the loss of NE neurons in the brain of patients with PD is obvious, it is speculated that NE is involved in the occurrence of PD pain symptoms. Aims To investigate the effect of NE on the activation of brain cells through...

article

Molecular signatures of attention networks

Hanna Schindler, Philippe Jawinski, Aurina Arnatkevičiūtė, Sebastian Markett

Human Brain Mapping > 45 > 3 > n/a - n/a

Attention network theory proposes three distinct types of attention—alerting, orienting, and control—that are supported by separate brain networks and modulated by different neurotransmitters, that is, norepinephrine, acetylcholine, and dopamine. Here, we explore the extent of cortical, genetic, and molecular dissociation of these three attention systems using multimodal neuroimaging. We evaluated...

article

HIV‐1 Tat and morphine interactions dynamically shift striatal monoamine levels and exploratory behaviors over time

Arianna R. S. Lark, Sara R. Nass, Yun K. Hahn, Benlian Gao, more

Journal of Neurochemistry > 168 > 3 > 185 - 204

Despite the advent of combination anti‐retroviral therapy (cART), nearly half of people infected with HIV treated with cART still exhibit HIV‐associated neurocognitive disorders (HAND). HAND can be worsened by co‐morbid opioid use disorder. The basal ganglia are particularly vulnerable to HIV‐1 and exhibit higher viral loads and more severe pathology, which can be exacerbated by co‐exposure to opioids...

article

Chiral acidic molecularly imprinted polymer for enantio‐separation of norepinephrine racemate

May Abdullah Abomuti

Chirality > 36 > 2 > n/a - n/a

We are looking into how well a copolymeric material made of poly (maleic acid–co‐4‐vinylpyridine) cross‐linked with divinylbenzene can separate L‐norepinephrine (L‐NEP) from (±)‐NEP. The initial step in this direction was the synthesis and subsequent analysis of L‐NEP‐maleimide chiral derivative. A 4‐vinylpyridine/divinylbenzene combination was copolymerized with the resultant chiral maleimide. After...

article

Hydrocortisone versus vasopressin for the management of adult patients with septic shock refractory to norepinephrine: A multicenter retrospective study

Steven Kulesza, Lindsey Gignac, C. Allis Colvin, Skyler Boll, more

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy > 43 > 8 > 787 - 794

Study Objective Significant practice variation exists when selecting between hydrocortisone and vasopressin as second line agents in patients with septic shock in need of escalating doses of norepinephrine. The goal of this study was to assess differences in clinical outcomes between these two agents. Design Multicenter, retrospective, observational study. Setting Ten Ascension Health hospitals...

article

Chronic administration of a norepinephrine antagonist prevents and partially reverses escalation of cocaine self‐administration

Hassiba Beldjoud, Alicia Avelar, Giordano Guglielmo, Marsida Kallupi, more

Addiction Biology > 28 > 9 > n/a - n/a

Anxiety is a critical component of the development and maintenance of drug addiction; however, anti‐anxiety medications such as benzodiazepines and beta‐blockers (β‐adrenergic receptor antagonists) are not used for the treatment of substance use disorder, except for the management of acute withdrawal syndrome. Preclinical studies have shown that beta‐blockers may reduce stress‐induced relapse; however,...

article

Functional neuroanatomy of monoaminergic systems in the basolateral nuclear complex of the amygdala: Neuronal targets, receptors, and circuits

Alexander Joseph McDonald

Journal of Neuroscience Research > 101 > 9 > 1409 - 1432

This review discusses neuroanatomical aspects of the three main monoaminergic systems innervating the basolateral nuclear complex (BNC) of the amygdala (serotonergic, noradrenergic, and dopaminergic systems). It mainly focuses on immunohistochemical (IHC) and in situ hybridization (ISH) studies that have analyzed the relationship of specific monoaminergic inputs and their receptors to specific neuronal...

article

Constraints of vigilance‐dependent noradrenergic signaling to mouse cerebellar Bergmann glia

Angelica Salinas‐Birt, Xiangyu Zhu, Eunice Y. Lim, Aryana J. Cruz Santory, more

Glia > 71 > 6 > 1451 - 1465

Behavioral state plays an important role in determining astroglia Ca²⁺ signaling. In particular, locomotion‐mediated elevated vigilance has been found to trigger norepinephrine‐dependent whole cell Ca²⁺ elevations in astroglia throughout the brain. For cerebellar Bergmann glia it has recently been found that locomotion‐induced transient Ca²⁺ elevations depend on their α_1A‐adrenergic receptors. With...

article

Can trajectory nor‐epinephrine infiltration reduce blood loss during percutaneous nephrolithotomy? A double‐blinded randomized controlled trial

Waleed El‐Shaer, Mohamed Salah Haggag, Alaa Elshaer, Islam Shaboob, more

International Journal of Urology > 29 > 12 > 1535 - 1542

Purpose To determine the efficacy and safety of trajectory infiltration with 1:150 000 Norepinephrine (NE) in reducing blood loss during percutaneous nephrolithotomy (PCNL). Materials and methods This is a prospective randomized double‐blinded placebo‐controlled trial. In all, 140 consecutive patients underwent PCNL for the management of large renal calculi. They were randomly assigned (1:1) to...

article

Use of vasopressors for treatment of vasodilatory hypotension in dogs and cats by Diplomates of the American College of Veterinary Emergency and Critical Care

Kellyann M. Murphy, Mark Rishniw, Deborah C. Silverstein

Journal of Veterinary Emergency and Critical Care > 32 > 6 > 714 - 722

Objective To identify the most common practices of Diplomates of the American College of Veterinary Emergency and Critical Care (DACVECCs) as they relate to the recognition and treatment of hypotension in dogs and cats, particularly concerning the use of vasopressors in vasodilatory shock states. Design A survey regarding vasopressor use was sent to all active DACVECCs using the Veterinary Information...

article

Front Cover: Mechanistic Aspects of the Asymmetric Transfer Hydrogenation in the Manufacture of Noradrenaline (Eur. J. Org. Chem. 36/2022)

Francesco Scorzelli, Giusy Tassone, Daniele Padula, Matteo Zacchè

European Journal of Organic Chemistry > 2022 > 36 > n/a - n/a

The Front Cover illustrates the main function of noradrenaline in the human body. In the background are represented the human brain and heart, which are the main target organs for this molecule. The image in the foreground shows a synapse exchanging noradrenaline molecules, an important neurotransmitter of all the sympathetic nerves. Cover design by M. Zacchè. More information can be found in the...

article

Mechanistic Aspects of the Asymmetric Transfer Hydrogenation in the Manufacture of Noradrenaline

Francesco Scorzelli, Giusy Tassone, Daniele Padula, Matteo Zacchè

European Journal of Organic Chemistry > 2022 > 36 > n/a - n/a

Mechanistic, stereochemical and stereoelectronic aspects of the asymmetric reduction (via hydrogen or transfer hydrogenation) for the manufacture of N‐benzyl‐noradrenaline from the ketone precursor are studied through catalyst screening and computational evaluations. This reaction provides an efficient and industrially suitable method for the manufacture of enantiomerically pure noradrenaline, an...

article

Sex differences in α‐adrenergic receptor function contribute to impaired hypothalamic metaplasticity following chronic intermittent ethanol exposure

Joseph J. Munier, Vincent N. Marty, Igor Spigelman

Alcoholism: Clinical and Experimental Research > 46 > 8 > 1384 - 1396

Background Individuals with alcohol use disorder (AUD) exhibit maladaptive responses of the hypothalamic–pituitary–adrenal (HPA) axis to stress, which has been linked to high rates of relapse to drinking among abstinent individuals. Corticotropin‐releasing factor (CRF) parvocellular neuroendocrine cells (PNCs) within the paraventricular nucleus of the hypothalamus (PVN) are critical to stress‐induced...

article

A double‐blind randomised feasibility trial of angiotensin‐2 in cardiac surgery^*

T. G. Coulson, L. F. Miles, A. Serpa Neto, D. Pilcher, more

Anaesthesia > 77 > 9 > 999 - 1009

Acute kidney injury is common after cardiac surgery. Vasoplegic hypotension may contribute to kidney injury, and different vasopressors may have variable effects on kidney function. We conducted a double‐blind, randomised feasibility trial comparing peri‐operative angiotensin‐2 with noradrenaline. We randomly allocated 60 patients at two centres to a blinded equipotent angiotensin‐2 or noradrenaline...

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Search results

Using high resolution imaging to determine trafficking of corticotropin-releasing factor receptors in noradrenergic neurons of the rat locus coeruleus

Association between stress and catecholamines with painful TMD in children

The use of injectable subcutaneous terbutaline and topical nitroglycerin ointment in the treatment of peripheral vasopressor extravasation in 3 dogs

Role of Phenylethanolamine‐N‐methyltransferase on Nicotine‐Induced Vasodilation in Rat Cerebral Arteries

Are the P600 and P3 ERP components linked to the task‐evoked pupillary response as a correlate of norepinephrine activity?

Teleological reasoning bias is predicted by pupil dynamics: Evidence for the extensive integration account of bias in reasoning

Regulation of nociception threshold by norepinephrine through adrenergic α2 receptor in rat models of Parkinson's disease

Molecular signatures of attention networks

HIV‐1 Tat and morphine interactions dynamically shift striatal monoamine levels and exploratory behaviors over time

Chiral acidic molecularly imprinted polymer for enantio‐separation of norepinephrine racemate

Hydrocortisone versus vasopressin for the management of adult patients with septic shock refractory to norepinephrine: A multicenter retrospective study

Chronic administration of a norepinephrine antagonist prevents and partially reverses escalation of cocaine self‐administration

Functional neuroanatomy of monoaminergic systems in the basolateral nuclear complex of the amygdala: Neuronal targets, receptors, and circuits

Constraints of vigilance‐dependent noradrenergic signaling to mouse cerebellar Bergmann glia

Can trajectory nor‐epinephrine infiltration reduce blood loss during percutaneous nephrolithotomy? A double‐blinded randomized controlled trial

Use of vasopressors for treatment of vasodilatory hypotension in dogs and cats by Diplomates of the American College of Veterinary Emergency and Critical Care

Front Cover: Mechanistic Aspects of the Asymmetric Transfer Hydrogenation in the Manufacture of Noradrenaline (Eur. J. Org. Chem. 36/2022)

Mechanistic Aspects of the Asymmetric Transfer Hydrogenation in the Manufacture of Noradrenaline

Sex differences in α‐adrenergic receptor function contribute to impaired hypothalamic metaplasticity following chronic intermittent ethanol exposure

A double‐blind randomised feasibility trial of angiotensin‐2 in cardiac surgery^*

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