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article

The effect of maternal sleep-disordered breathing on the infant’s neurodevelopment

Riva Tauman, Luba Zuk, Shimrit Uliel-Sibony, Jessica Ascher-Landsberg, more

American Journal of Obstetrics and Gynecology > 2015 > 212 > 5 > 656.e1-656.e7

Objective: We sought to examine the effect of maternal sleep-disordered breathing (SDB) on infant general movements (GMs) and neurodevelopment. Study Design: Pregnant women with uncomplicated full-term pregnancies and their offspring were prospectively recruited from a community and hospital low-risk obstetric surveillance. All participants completed a sleep questionnaire on second trimester and underwent...

article

Phthalate exposure and child development: The Polish Mother and Child Cohort Study

Kinga Polanska, Danuta Ligocka, Wojciech Sobala, Wojciech Hanke, more

Early Human Development > 2014 > 90 > 9 > 477-485

Background: Widespread phthalate exposure has prompted investigations concerning their potential adverse health effects. Aim: The objective of this study was to evaluate the impact of pre and early postnatal phthalate exposure on child psychomotor development based on the data from the prospective Polish Mother and Child Cohort Study (REPRO PL). Study design, subjects and outcome measures: Phthalate...

article

Early prediction of cerebral palsy after neonatal intensive care using motor development trajectories in infancy

Nathalie L. Maitre, James C. Slaughter, Judy L. Aschner, N.L. Maitre, more

Early Human Development > 2013 > 89 > 10 > 781-786

Neonatal intensive care unit (NICU) patients are at high risk for developmental disabilities such as cerebral palsy (CP). Early identification of CP is essential to effective rehabilitation, but diagnosis is often delayed, especially in preterm infants. We hypothesized that through the longitudinal evaluation of motor trajectories in the NICU follow-up clinic, we could distinguish infants who develop...

article

In support of the placental programming hypothesis: Placental endocrine insufficiency programs atypical behaviour in mothers and their offspring

Rosalind M. John

Experimental Physiology > 107 > 5 > 398 - 404

New Findings What is the topic of this review? More than half of all pregnancies in the UK are exposed to adversity linked to increased problems in pregnancy for mothers and adverse outcomes for their children, but we do not know the mechanism(s) underpinning these relationships. What advances does it highlight? Studies in mice prove that placental endocrine insufficiency driven by genetic manipulation...

article

The brain—from neurodevelopment to neurodegeneration

Andrey Y. Abramov

The FEBS Journal > 289 > 8 > 2010 - 2012

The brain is the organ that orchestrates the whole body. To do so, neurons and glia in different brain regions have evolved to be highly specialized and are regulated by diverse receptors and neuro‐ and gliotransmitters. Some of the features of the brain, including a protective brain–blood barrier, high‐energy demand, and electrical activity, mean that neurons and astrocytes are uniquely diverse components...

article

Brain‐specific functions of the endocytic machinery

Santiago Camblor‐Perujo, Natalia L. Kononenko

The FEBS Journal > 289 > 8 > 2219 - 2246

Endocytosis is an essential cellular process required for multiple physiological functions, including communication with the extracellular environment, nutrient uptake, and signaling by the cell surface receptors. In a broad sense, endocytosis is accomplished through either constitutive or ligand‐induced invagination of the plasma membrane, which results in the formation of the plasma membrane‐retrieved...

article

Soma‐to‐germline transformation in chromatin‐linked neurodevelopmental disorders?

Katherine M. Bonefas, Shigeki Iwase

The FEBS Journal > 289 > 8 > 2301 - 2317

Mutations in numerous chromatin regulators cause neurodevelopmental disorders (NDDs) with unknown mechanisms. Understandably, most research has focused on how chromatin regulators control gene expression that is directly relevant to brain development and function, such as synaptic genes. However, some NDD models surprisingly show ectopic expression of germline genes in the brain. These germline genes...

article

AMPK in the brain: its roles in glucose and neural metabolism

Ranjithmenon Muraleedharan, Biplab Dasgupta

The FEBS Journal > 289 > 8 > 2247 - 2262

The adenosine monophosphate‐activated protein kinase (AMPK) is an integrative metabolic sensor that maintains energy balance at the cellular level and plays an important role in orchestrating intertissue metabolic signaling. AMPK regulates cell survival, metabolism, and cellular homeostasis basally as well as in response to various metabolic stresses. Studies so far show that the AMPK pathway is associated...

article

Cortical myelination in toddlers and preschoolers with autism spectrum disorder

Bosi Chen, Annika Linke, Lindsay Olson, Jiwandeep Kohli, more

Developmental Neurobiology > 82 > 3 > 261 - 274

Intracortical myelin is thought to play a significant role in the development of neural circuits and functional networks, with consistent evidence of atypical network connectivity in children with autism spectrum disorder (ASD). However, little is known about the development of intracortical myelin in the first years of life in ASD, during the critical neurodevelopmental period when autism symptoms...

article

Segregation and integration of the functional connectome in neurodevelopmentally ‘at risk’ children

Jonathan S. Jones, The CALM Team, Duncan E. Astle

Developmental Science > 25 > 3 > n/a - n/a

Functional connectivity within and between Intrinsic Connectivity Networks (ICNs) transforms over development and is thought to support high order cognitive functions. But how variable is this process, and does it diverge with altered cognitive development? We investigated age‐related changes in integration and segregation within and between ICNs in neurodevelopmentally ‘at‐risk’ children, identified...

article

Development of functional organization within the sensorimotor network across the perinatal period

Sofia Dall'Orso, Tomoki Arichi, Sean P. Fitzgibbon, A. David Edwards, more

Human Brain Mapping > 43 > 7 > 2249 - 2261

In the mature human brain, the neural processing related to different body parts is reflected in patterns of functional connectivity, which is strongest between functional homologs in opposite cortical hemispheres. To understand how this organization is first established, we investigated functional connectivity between limb regions in the sensorimotor cortex in 400 preterm and term infants aged across...

article

Brain structural covariance network differences in adults with alcohol dependence and heavy‐drinking adolescents

Jonatan Ottino‐González, Hugh Garavan, The ENIGMA‐Addiction and IMAGEN consortiums, Matthew D. Albaugh, more

Addiction > 117 > 5 > 1312 - 1325

Background and aims Graph theoretic analysis of structural covariance networks (SCN) provides an assessment of brain organization that has not yet been applied to alcohol dependence (AD). We estimated whether SCN differences are present in adults with AD and heavy‐drinking adolescents at age 19 and age 14, prior to substantial exposure to alcohol. Design Cross‐sectional sample of adults and a cohort...

article

RDoC and the developmental origins of psychiatric disorders: How did we get here and where are we going?

Randy P. Auerbach

Journal of Child Psychology and Psychiatry > 63 > 4 > 377 - 380

About a decade ago, the National Institute of Mental Health (NIMH) proposed an innovative framework, the Research Domain Criteria (RDoC), to classify psychiatric disorders. This complementary approach has been used with existing diagnostic systems to identify transdiagnostic factors that inform early detection of mental health disturbances and critically, provide novel targets for interventions. An...

article

Social EEG: A novel neurodevelopmental approach to studying brain‐behavior links and brain‐to‐brain synchrony during naturalistic toddler–parent interactions

Elizabeth S. Norton, Brittany L. Manning, Emily M. Harriott, Julia I. Nikolaeva, more

Developmental Psychobiology > 64 > 3 > n/a - n/a

Despite increasing emphasis on emergent brain‐behavior patterns supporting language, cognitive, and socioemotional development in toddlerhood, methodologic challenges impede their characterization. Toddlers are notoriously difficult to engage in brain research, leaving a developmental window in which neural processes are understudied. Further, electroencephalography (EEG) and event‐related potential...

article

Elevated ghrelin alters the behavioral effects of perinatal acetaminophen exposure in rats

Joshua A. Herrington, Janet Guss Darwich, Christopher Harshaw, Alev M. Brigande, more

Developmental Psychobiology > 64 > 3 > n/a - n/a

A growing body of evidence links prenatal and early postnatal acetaminophen (APAP) exposure to atypical development of brain and behavior. In adult rodents, APAP is known to produce oxidative stress and lower anxiety‐related behavior following acute exposure. In models of early‐life exposure, APAP has also been shown to alter anxiety‐related and other behaviors. Since the neuropeptide ghrelin has...

article

Discrete white matter abnormalities at age 8–11 years in children born extremely preterm are not associated with adverse cognitive or motor outcomes

Daniela Nosko, Marika Strindberg, Jan Svoboda, Hedvig Kvanta, more

Acta Paediatrica > 111 > 3 > 566 - 575

Aim Little is known about the prevalence of discrete white matter abnormalities (WMA) beyond the first years in children born extremely preterm (EPT) and the relation to neurodevelopmental outcomes. Our aim was to investigate the prevalence of discrete WMA in children born EPT and the relationship to neonatal white matter injuries (WMI), white matter (WM) volume, WM diffusivity and neurodevelopment...

article

Clinical significance of assessing cerebral blood volume by time‐domain near‐infrared spectroscopy in children with congenital heart disease

Tomohiko Suemori, Tatsuya Nagano, Kohei Sunoki, Takako Shinohara, more

Pediatric Anesthesia > 32 > 3 > 413 - 420

Background Despite providing cerebral tissue oxygen saturation (StO₂), the lack of quantitative information for continuous wave near‐infrared spectroscopy (CW‐NIRS) is an obstacle in evaluating cerebral hemodynamic conditions. Time‐domain NIRS (TD‐NIRS) provides both StO₂ and cerebral blood volume and has recently become clinically available. Aim To investigate if the additional monitoring of cerebral...

article

Role of neddylation in neurological development and diseases

Xin He, Ainong Zhu, Jianguo Feng, Xiaobin Wang

Biotechnology and Applied Biochemistry > 69 > 1 > 330 - 341

Neddylation, a posttranslational protein modification, refers to the specific conjugation of NEDD8 to substrates, which is of great significance to various biological processes. Besides members of the cullin protein family, other key proteins can act as a substrate for neddylation modification, which remarkably influences neurodevelopment and neurodegenerative diseases. Normal levels of protein neddylation...

article

Capturing the complexity of autism: Applying a developmental cascades framework

Jessica Bradshaw, Amy J. Schwichtenberg, Jana M. Iverson

Child Development Perspectives > 16 > 1 > 18 - 26

Developmental change emerges from dynamic interactions among networks of neural activity, behavior systems, and experience‐dependent processes. A developmental cascades framework captures the sequential, multilevel, cross‐domain nature of human development and is ideal for demonstrating how interconnected systems have far‐reaching effects in typical and atypical development. Neurodevelopmental disorders...

article

Neurocognitive functioning in preschool children with sickle cell disease

Andrew M. Heitzer, Diana L. Cohen, Victoria I. Okhomina, Ana Trpchevska, more

Pediatric Blood & Cancer > 69 > 3 > n/a - n/a

Background Children with sickle cell disease (SCD) experience neurodevelopmental delays; however, there is limited research with preschool‐age children. This study examined neurocognitive risk and protective factors in preschoolers with SCD. Procedure Sixty‐two patients with SCD (60% HbSS/HbSβ⁰‐thalassemia; 40% HbSC/HbSβ⁺‐thalassemia) between the ages of 3 and 6 years (mean = 4.77 years) received...

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Search results

The effect of maternal sleep-disordered breathing on the infant’s neurodevelopment

Phthalate exposure and child development: The Polish Mother and Child Cohort Study

Early prediction of cerebral palsy after neonatal intensive care using motor development trajectories in infancy

In support of the placental programming hypothesis: Placental endocrine insufficiency programs atypical behaviour in mothers and their offspring

The brain—from neurodevelopment to neurodegeneration

Brain‐specific functions of the endocytic machinery

Soma‐to‐germline transformation in chromatin‐linked neurodevelopmental disorders?

AMPK in the brain: its roles in glucose and neural metabolism

Cortical myelination in toddlers and preschoolers with autism spectrum disorder

Segregation and integration of the functional connectome in neurodevelopmentally ‘at risk’ children

Development of functional organization within the sensorimotor network across the perinatal period

Brain structural covariance network differences in adults with alcohol dependence and heavy‐drinking adolescents

RDoC and the developmental origins of psychiatric disorders: How did we get here and where are we going?

Social EEG: A novel neurodevelopmental approach to studying brain‐behavior links and brain‐to‐brain synchrony during naturalistic toddler–parent interactions

Elevated ghrelin alters the behavioral effects of perinatal acetaminophen exposure in rats

Discrete white matter abnormalities at age 8–11 years in children born extremely preterm are not associated with adverse cognitive or motor outcomes

Clinical significance of assessing cerebral blood volume by time‐domain near‐infrared spectroscopy in children with congenital heart disease

Role of neddylation in neurological development and diseases

Capturing the complexity of autism: Applying a developmental cascades framework

Neurocognitive functioning in preschool children with sickle cell disease

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