Search results

Items from 1 to 20 out of 478 results

article

Association of telomere length and mitochondrial DNA copy number in a community sample of healthy adults

Audrey R. Tyrka, Linda L. Carpenter, Hung-Teh Kao, Barbara Porton, more

Experimental Gerontology > 2015 > 66 > Complete > 17-20

Cellular aging plays a role in longevity and senescence, and has been implicated in medical and psychiatric conditions, including heart disease, cancer, major depression and posttraumatic stress disorder. Telomere shortening and mitochondrial dysfunction are thought to be central to the cellular aging process. The present study examined the association between mitochondrial DNA (mtDNA) copy number...

article

Differential responses of white adipose tissue and brown adipose tissue to caloric restriction in rats

Naoyuki Okita, Yusuke Hayashida, Yumiko Kojima, Mayumi Fukushima, more

Mechanisms of Ageing and Development > 2012 > 133 > 5 > 255-266

Caloric restriction (CR) slows the aging process and extends longevity, but the exact underlying mechanisms remain debatable. It has recently been suggested that the beneficial action of CR may be mediated in part by adipose tissue remodeling. Mammals have two types of adipose tissue: white adipose tissue (WAT) and brown adipose tissue (BAT). In this study, proteome analysis using two-dimensional...

article

Restoring energy in a power crisis: mitochondrial targets for drug development

Neil Howell, Steven W. Taylor, Eoin Fahy, Anne Murphy, more

Targets > 2003 > 2 > 5 > 208-216

Mitochondria are the organelles responsible for energy production that 'house' many pathways of intermediary metabolism. It should not be surprising, therefore, that several human diseases involve mitochondrial dysfunction or dysregulation, although many of these diseases have complex etiologies that are not yet fully defined. For some of these diseases, there is evidence that ameliorating the mitochondrial...

article

Mitochondria‐Targeted Polyphenol‐Cysteine Nanoparticles Regulating AMPK‐Mediated Mitochondrial Homeostasis for Enhanced Bone Regeneration

Shufan Yu, Jing Du, Qun Zhang, Zhao Li, more

Advanced Functional Materials > 34 > 41 > n/a - n/a

Mitochondria are the energy source for basal cell functions as well as for tissue repair and regeneration. Excessive accumulation of reactive oxygen species (ROS) generated by bone tissue injury can cause cell oxidative stress and mitochondrial damage, negatively affecting osteogenic differentiation and tissue repair. However, efficient scavenging of mitochondrial ROS (mtROS) and restoration of mitochondrial...

article

Linoleic Acid Promotes Mitochondrial Biogenesis and Alleviates Acute Lung Injury

Jie Liu, Yu Jiang, Qiuhong Zhang, Yin Qin, more

The Clinical Respiratory Journal > 18 > 9 > n/a - n/a

Introduction Acute lung injury (ALI) is a critical and lethal medical condition. This syndrome is characterized by an imbalance in the body's oxidation stress and inflammation. Linoleic acid (LA), a polyunsaturated fatty acid, has been extensively studied for its potential health benefits, including anti‐inflammatory and antioxidant activities. However, the therapeutic effects of LA on ALI remain...

article

High‐concentration hydrogen inhalation mitigates sepsis‐associated encephalopathy in mice by improving mitochondrial dynamics

Yan Cui, Shuqi Meng, Nannan Zhang, Jingya Liu, more

CNS Neuroscience & Therapeutics > 30 > 9 > n/a - n/a

Background Sepsis‐associated encephalopathy (SAE) is a neuronal injury with poor prognosis. Mitochondrial dysfunction is critical in SAE development, and hydrogen gas (H₂) has a protective effect on septic mice. This study aimed to investigate the effect of high concentration (67%) of H₂ on SAE and whether it is related to mitochondrial biogenesis and mitochondrial dynamics. Methods A mouse sepsis...

article

Astaxanthin ameliorated isoproterenol induced myocardial infarction via improving the mitochondrial function and antioxidant activity in rats

Doaa Salah Eddin Mahmoud, Maher A. Kamel, Ibrahim El‐Tantawy El‐Sayed, Reem Binsuwaidan, more

Journal of Biochemical and Molecular Toxicology > 38 > 8 > n/a - n/a

The present study evaluated the cardioprotective effect of astaxanthin (ASX) against isoproterenol (ISO) induced myocardial infarction in rats via the pathway of mitochondrial biogenesis as the possible molecular target of astaxanthin. The control group was injected with normal physiological saline subcutaneously for 2 days. The second group was injected with ISO at a dose of 85 mg/kg bwt subcutaneously...

article

Mitochondrial biogenesis disorder and oxidative damage promote refractory apical periodontitis in rat and human

Jun Wang, Yuge Chen, Huina Yuan, Xuejia Zhang, more

International Endodontic Journal > 57 > 9 > 1326 - 1342

Aim To elucidate whether mitochondrial biogenesis disorder and damage from oxidative stress promote refractory apical periodontitis (RAP) in rat and human. Methodology Twenty Enterococcus faecalis‐induced RAPs were established in the maxillary first molars of male Wistar rats. Concurrently, 12 periapical lesion specimens from patients presenting with RAP were obtained by apicoectomy. Radiographic...

article

Mitochondrial regulation of erythropoiesis in homeostasis and disease

Vijay Menon, Mary Slavinsky, Olivier Hermine, Saghi Ghaffari

British Journal of Haematology > 205 > 2 > 429 - 439

Erythroid cells undergo a highly complex maturation process, resulting in dynamic changes that generate red blood cells (RBCs) highly rich in haemoglobin. The end stages of the erythroid cell maturation process primarily include chromatin condensation and nuclear polarization, followed by nuclear expulsion called enucleation and clearance of mitochondria and other organelles to finally generate mature...

article

Schizosaccharomyces pombe as a fundamental model for research on mitochondrial gene expression: Progress, achievements and outlooks

Nhu Dinh, Nathalie Bonnefoy

IUBMB Life > 76 > 7 > 397 - 419

Schizosaccharomyces pombe (fission yeast) is an attractive model for mitochondrial research. The organism resembles human cells in terms of mitochondrial inheritance, mitochondrial transport, sugar metabolism, mitogenome structure and dependence of viability on the mitogenome (the petite‐negative phenotype). Transcriptions of these genomes produce only a few polycistronic transcripts, which then undergo...

article

A hub for regulation of mitochondrial metabolism: Fatty acid and lipoic acid biosynthesis

Carol L. Dieckmann

IUBMB Life > 76 > 6 > 332 - 344

Having evolved from a prokaryotic origin, mitochondria retain pathways required for the catabolism of energy‐rich molecules and for the biosynthesis of molecules that aid catabolism and/or participate in other cellular processes essential for life of the cell. Reviewed here are details of the mitochondrial fatty acid biosynthetic pathway (FAS II) and its role in building both the octanoic acid precursor...

article

Effects of CuSO₄ on hepatic mitochondrial function, biogenesis and dynamics in mice

Yihan Wang, Yanqiu Zhu, Hengmin Cui, Huidan Deng, more

Environmental Toxicology > 39 > 4 > 2208 - 2217

Copper is an essential trace element for animal. Excessive intake of copper will cause a large accumulation of copper in the body, especially in the liver, and induce hepatotoxicity, however, there are few studies on the effects of copper on hepatic mitochondrial biogenesis and mitochondrial dynamics. In this study, mice were treated with different doses of CuSO₄ (0, 10, 20, and 40 mg/kg) for 21 and...

article

Mitophagy suppression by miquelianin‐rich lotus leaf extract induces ‘beiging’ of white fat via AMPK/DRP1‐PINK1/PARKIN signaling axis

Zhenyu Wang, Tian Yang, Maomao Zeng, Zhaojun Wang, more

Journal of the Science of Food and Agriculture > 104 > 5 > 2597 - 2609

Background Lotus (Nelumbo nucifera) leaf has been described to have anti‐obesity activity, but the role of white fat ‘browning’ or ‘beiging’ in its beneficial metabolic actions remains unclear. Here, 3T3‐L1 cells and high‐fat‐diet (HFD)‐fed mice were used to evaluate the effects of miquelianin‐rich lotus leaf extract (LLE) on white‐to‐beige fat conversion and its regulatory mechanisms. Results...

article

5‐Aza‐2′‐deoxycytidine‐mediated DNA hypomethylation with and without concurrent insulin resistance suppresses myotube mitochondrial capacity

Caroline N. Rivera, Madison M. Kamer, Norah E. Cook, Macey R. McGovern, more

Cell Biochemistry and Function > 41 > 8 > 1422 - 1429

Type 2 diabetes is characterized by elevated blood glucose and reduced insulin sensitivity in target tissues. Moreover, reduced mitochondrial metabolism and expressional profile of genes governing mitochondrial metabolism (such as peroxisome proliferator‐activated receptor gamma coactivator 1‐alpha [PGC‐1α]) are also reduced during insulin resistance. Epigenetic regulation via DNA methylation of genes...

article

Sulforaphane Mitigates High‐Fat Diet‐Induced Obesity by Enhancing Mitochondrial Biogenesis in Skeletal Muscle via the HDAC8‐PGC1α Axis

Hee Yang, Gihyun Hur, Tae Kyung Lee, Jong‐Eun Kim, more

Molecular Nutrition & Food Research > 67 > 23 > n/a - n/a

Scope Histone deacetylases (HDACs) play a crucial role in the transcriptional regulation of various genes which can contribute to metabolic disorders. Although sulforaphane (SFN), a natural HDAC inhibitor, has been reported to alleviate obesity in humans and mice, the specific mechanisms and how HDACs contribute to SFN's anti‐obesity effects remain unclear. Methods and results Oral administration...

article

Insights of mitochondrial involvement in alcoholic fatty liver disease

Nithyananthan Subramaiyam

Journal of Cellular Physiology > 238 > 10 > 2175 - 2190

Alcoholic liver disease (ALD) is a global concern affecting most of the population and leading to the development of end‐stage liver disease. Metabolic alterations due to increased alcohol consumption surge the hepatic accumulation of lipids and develop into a severe form of alcoholic steatohepatitis (ASH), depending on age and the consumption rate. The mitochondria in the hepatocyte actively regulate...

article

Pterostilbene Enhances Thermogenesis and Mitochondrial Biogenesis by Activating the SIRT1/PGC‐1α/SIRT3 Pathway to Prevent Western Diet‐Induced Obesity

Yen‐Chun Koh, Shin‐Jhih Lin, Kai‐Yu Hsu, Kalyanam Nagabhushanam, more

Molecular Nutrition & Food Research > 67 > 18 > n/a - n/a

Scope Sirtuin 1/peroxisome proliferator‐activated receptor gamma co‐activator 1 alpha (SIRT1/PGC‐1α) pathway activation is known to promote thermogenesis and mitochondrial biogenesis. Pterostilbene (PSB) and pinostilbene (PIN), the methylated analogs of resveratrol, are potential candidates to enhance thermogenesis and mitochondrial biogenesis. Method and results A model of Western diet‐induced...

article

The role of mitochondrial dysfunction in periodontitis: From mechanisms to therapeutic strategy

Wentao Jiang, Yujing Wang, Zelin Cao, Yifan Chen, more

Journal of Periodontal Research > 58 > 5 > 853 - 863

Periodontitis is an inflammatory and destructive disease of tooth‐supporting tissue and has become the leading cause of adult tooth loss. The most central pathological features of periodontitis are tissue damage and inflammatory reaction. As the energy metabolism center of eukaryotic cells, mitochondrion plays a notable role in various processes, such as cell function and inflammatory response. When...

article

Eicosapentaenoic Acid‐Enriched Phospholipids Alleviate Skeletal Muscle Atrophy in Lewis Lung Carcinoma Mouse Model

Zi‐Jian Wu, Wen‐Hong Li, Yu‐Hong Yang, Yan Zheng, more

Molecular Nutrition & Food Research > 67 > 13 > n/a - n/a

Scope Skeletal muscle atrophy is a critical feature of cancer‐associated cachexia (CAC) and it is responsible for poor quality of life and high mortality in cancer patients. The previous study demonstrates that eicosapentaenoic acid‐enriched phospholipids (EPA‐PL) prevent body weight loss in a mouse model of CAC. However, the role of EPA‐PL on cancer‐induced skeletal muscle atrophy remains unclear...

article

Nickel induces hepatotoxicity by mitochondrial biogenesis, mitochondrial dynamics, and mitophagy dysfunction

Hongrui Guo, Ling Wei, Yihan Wang, Hengmin Cui, more

Environmental Toxicology > 38 > 5 > 1185 - 1195

Nickel (Ni) is an important and widely hazardous chemical industrial waste. Excessive Ni exposure could cause multi‐organs toxicity in human and animals. Liver is the major target organ of Ni accumulation and toxicity, however, the precise mechanism is still unclear. In this study, nickel chloride (NiCl₂)‐treatment induced hepatic histopathological changes in the mice, and, transmission electron microscopy...

Publication date

Last 3 months (6)
Last year (13)
Last 3 years (24)

Close

Date range setting

Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.

From:

To:
Set your own date range

Content availability

Available (471)
None (7)

Publication type

article (477)
book (1)

Publication language

English (477)
Korean (1)

Keywords

MITOCHONDRIAL BIOGENESIS (478)
MITOCHONDRIA (47)
PGC-1Α (42)
OXIDATIVE STRESS (37)
MITOPHAGY (34)
AUTOPHAGY (30)
SKELETAL MUSCLE (29)
AMPK (22)
MITOCHONDRIAL DYNAMICS (22)
APOPTOSIS (19)
EXERCISE (18)
REACTIVE OXYGEN SPECIES (17)
OXIDATIVE PHOSPHORYLATION (13)
AGING (12)
MTDNA (12)
TFAM (12)
GENE EXPRESSION (11)
INSULIN RESISTANCE (11)
NITRIC OXIDE (11)
PGC‐1Α (11)
HYPOXIA (10)
SIRT1 (10)
MITOCHONDRIAL DYSFUNCTION (9)
PROTEIN IMPORT (9)
FREE RADICALS (8)
METABOLISM (8)
MITOCHONDRIAL DNA (8)
OBESITY (8)
RESVERATROL (8)
ROS (8)
ADIPOSE TISSUE (7)
ANTIOXIDANT (7)
ENERGY METABOLISM (7)
FATTY ACID OXIDATION (7)
LIVER (7)
ANTIOXIDANTS (6)
CALCIUM (6)
MITOCHONDRIAL DISEASE (6)
MITOCHONDRIAL FUNCTION (6)
NEURODEGENERATION (6)
PGC1Α (6)
THERMOGENESIS (6)
TRANSCRIPTIONAL REGULATION (6)
ALZHEIMER’S DISEASE (5)
CALORIE RESTRICTION (5)
EPIGENETICS (5)
FISSION (5)
HEART (5)
INFLAMMATION (5)
MITOCHONDRIAL QUALITY CONTROL (5)
MITOCHONDRIAL TRANSCRIPTION FACTOR A (5)
MITOCHONDRION (5)
RESPIRATION (5)
SEPSIS (5)
ADIPOGENESIS (4)
AMP-ACTIVATED PROTEIN KINASE (4)
BIOENERGETICS (4)
BREAST CANCER (4)
CALORIC RESTRICTION (4)
CANCER (4)
CREATINE KINASE (4)
DIABETES (4)
ENDURANCE EXERCISE (4)
ENDURANCE TRAINING (4)
EXERCISE TRAINING (4)
FUSION (4)
GLYCOLYSIS (4)
HYPERTROPHY (4)
METABOLIC SYNDROME (4)
MITOCHONDRIAL DISEASES (4)
MITOCHONDRIAL RESPIRATION (4)
MYOCARDIAL INFARCTION (4)
NRF2 (4)
OXPHOS (4)
OXYGEN CONSUMPTION (4)
P53 (4)
PARKINSON’S DISEASE (4)
PGC-1Β (4)
RESPIRATORY CHAIN (4)
ROTENONE (4)
SULFORAPHANE (4)
TYPE 2 DIABETES (4)
ACETYL-L-CARNITINE (3)
ADIPOCYTE (3)
AGEING (3)
ALZHEIMER'S DISEASE (3)
ATP SYNTHASE (3)
ATROPHY (3)
BEZAFIBRATE (3)
BIOFIELD ENERGY (3)
CARDIAC REMODELING (3)
CELL CYCLE (3)
CELL DEATH (3)
COPY NUMBER (3)
CREB (3)
DIABETIC CARDIOMYOPATHY (3)
DMEM (3)
DOWN SYNDROME (3)
DOXORUBICIN (3)
HEART FAILURE (3)
more

Data set

Elsevier (240)
Wiley (117)
Springer (113)
Agro (3)
Infona (3)
PSJD (2)

INFONA - science communication portal

Search results

Association of telomere length and mitochondrial DNA copy number in a community sample of healthy adults

Differential responses of white adipose tissue and brown adipose tissue to caloric restriction in rats

Restoring energy in a power crisis: mitochondrial targets for drug development

Mitochondria‐Targeted Polyphenol‐Cysteine Nanoparticles Regulating AMPK‐Mediated Mitochondrial Homeostasis for Enhanced Bone Regeneration

Linoleic Acid Promotes Mitochondrial Biogenesis and Alleviates Acute Lung Injury

High‐concentration hydrogen inhalation mitigates sepsis‐associated encephalopathy in mice by improving mitochondrial dynamics

Astaxanthin ameliorated isoproterenol induced myocardial infarction via improving the mitochondrial function and antioxidant activity in rats

Mitochondrial biogenesis disorder and oxidative damage promote refractory apical periodontitis in rat and human

Mitochondrial regulation of erythropoiesis in homeostasis and disease

Schizosaccharomyces pombe as a fundamental model for research on mitochondrial gene expression: Progress, achievements and outlooks

A hub for regulation of mitochondrial metabolism: Fatty acid and lipoic acid biosynthesis

Effects of CuSO₄ on hepatic mitochondrial function, biogenesis and dynamics in mice

Mitophagy suppression by miquelianin‐rich lotus leaf extract induces ‘beiging’ of white fat via AMPK/DRP1‐PINK1/PARKIN signaling axis

5‐Aza‐2′‐deoxycytidine‐mediated DNA hypomethylation with and without concurrent insulin resistance suppresses myotube mitochondrial capacity

Sulforaphane Mitigates High‐Fat Diet‐Induced Obesity by Enhancing Mitochondrial Biogenesis in Skeletal Muscle via the HDAC8‐PGC1α Axis

Insights of mitochondrial involvement in alcoholic fatty liver disease

Pterostilbene Enhances Thermogenesis and Mitochondrial Biogenesis by Activating the SIRT1/PGC‐1α/SIRT3 Pathway to Prevent Western Diet‐Induced Obesity

The role of mitochondrial dysfunction in periodontitis: From mechanisms to therapeutic strategy

Eicosapentaenoic Acid‐Enriched Phospholipids Alleviate Skeletal Muscle Atrophy in Lewis Lung Carcinoma Mouse Model

Nickel induces hepatotoxicity by mitochondrial biogenesis, mitochondrial dynamics, and mitophagy dysfunction

Filter options

Publication date

Content availability

Publication type

Publication language

Keywords

Data set

INFONA - science communication portal

Search results

Add recipient

Sending message cancelled

Are you sure you want to cancel sending this message?

Send message

Filter options

Publication date

Date range setting

Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.

Content availability

Publication type

Publication language

Keywords

Data set

Reporting an error / abuse

Sending the report failed

Accessibility options