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article

Atractylodes macrocephala Koidz promotes intestinal epithelial restitution via the polyamine—Voltage-gated K+ channel pathway

Hou-Pan Song, Ru-Liu Li, Xu Chen, Yi-Yu Wang, more

Journal of Ethnopharmacology > 2014 > 152 > 1 > 163-172

Ethnopharmacological relevance: Atractylodes macrocephala Koidz (AMK) has been used widely as a digestive and tonic in traditional Chinese medicine. AMK has shown noteworthy promoting effect on intestinal epithelial cell migration, which might represent a promising candidate for the treatment of intestinal mucosa injury. The aim of this study was to investigate the efficacy of AMK on intestinal mucosal...

article

Preparation, characterization, biological activity, and transport study of polystyrene based calcium–barium phosphate composite membrane

Mohammad Mujahid Ali Khan, Rafiuddin, M.M.A. Khan, Rafiuddin

Materials Science & Engineering C > 2013 > 33 > 7 > 4228-4235

Calcium–barium phosphate (CBP) composite membrane with 25% polystyrene was prepared by co-precipitation method. Scanning electron microscopy (SEM), X-ray diffraction (XRD), Fourier transformed infrared (FTIR), and Thermogravimetric analysis (TGA) were used to characterize the membrane. The membrane was found to be crystalline in nature with consistent arrangement of particles and no indication of...

article

The green light gap: a window of opportunity for optogenetic control of stomatal movement

Jeffrey J. Jones, Shouguang Huang, Rainer Hedrich, Christoph‐Martin Geilfus, more

New Phytologist > 236 > 4 > 1237 - 1244

Green plants are equipped with photoreceptors that are capable of sensing radiation in the ultraviolet‐to‐blue and the red‐to‐far‐red parts of the light spectrum. However, plant cells are not particularly sensitive to green light (GL), and light which lies within this part of the spectrum does not efficiently trigger the opening of stomatal pores. Here, we discuss the current knowledge of stomatal...

article

Teaching an old dog new tricks: A lipid membrane‐based electric immunosensor for real‐time probing of the spike S₁ protein subunit from SARS‐CoV‐2

Alina Asandei, Loredana Mereuta, Irina Schiopu, Yoonkyung Park, more

PROTEOMICS > 22 > 5-6 > n/a - n/a

Fast, cheap, and easy to implement point‐of‐care testing for various pathogens constituted a game changer in past years due to its potential for early disease diagnosis. Herein, we report on the proof‐of‐concept of a simple method enabling in vitro detection of a structural spike protein subunit from the SARS‐CoV‐2 (S₁) in aqueous samples. At the core of this discovery lies the well‐known paradigm...

article

Toward absolute viability measurements for bacteria

Joy P. Dunkers, Hariharan Iyer, Brynna Jones, Charles H. Camp, more

Journal of Biophotonics > 14 > 12 > n/a - n/a

We aim to develop a quantitative viability method that distinguishes individual quiescent from dead cells and is measured in time (ns) as a referenceable, comparable quantity. We demonstrate that fluorescence lifetime imaging of an anionic, fluorescent membrane voltage probe fulfills these requirements for Streptococcus mutans. A random forest machine‐learning model assesses whether individual S. mutans...

article

Differential hyperpolarization to substance P and calcitonin gene‐related peptide in smooth muscle versus endothelium of mouse mesenteric artery

Charles E. Norton, Erika M. Boerman, Steven S. Segal

Microcirculation > 28 > 8 > n/a - n/a

Objective We sought to define how sensory neurotransmitters substance P and calcitonin gene‐related peptide (CGRP) affect membrane potential of vascular smooth muscle and endothelium. Methods Microelectrodes recorded membrane potential of smooth muscle from pressurized mouse mesenteric arteries (diameter, ~150 µm) and in endothelial tubes. Results Resting potential was similar (~ −45 mV) for...

article

Acid‐sensing ion channel 1 contributes to pulmonary arterial smooth muscle cell depolarization following hypoxic pulmonary hypertension

Nikki L. Jernigan, Jay S. Naik, Thomas C. Resta

The Journal of Physiology > 599 > 21 > 4749 - 4762

Abstract Pulmonary hypertension is characterized by sustained vasoconstriction and remodelling of the small pulmonary arteries, which is associated with persistent depolarization of the resting membrane potential (E_m) of pulmonary arterial smooth muscle cells (PASMCs). It is well‐known that the underlying mechanism of this depolarization includes inhibition of K⁺ channels; however, whether other...

article

Is neuronal inhibition or excitability controlled by Na⁺K⁺2CL^– transporters?

Andrea Ebersberger

The Journal of Physiology > 599 > 17 > 4013 - 4014

article

Electric Field Induced Biomimetic Transmembrane Electron Transport Using Carbon Nanotube Porins

Jacqueline M. Hicks, Yun‐Chiao Yao, Sydney Barber, Nigel Neate, more

Small > 17 > 32 > n/a - n/a

Cells modulate their homeostasis through the control of redox reactions via transmembrane electron transport systems. These are largely mediated via oxidoreductase enzymes. Their use in biology has been linked to a host of systems including reprogramming for energy requirements in cancer. Consequently, the ability to modulate membrane redox systems may give rise to opportunities to modulate underlying...

article

Electric Field Induced Biomimetic Transmembrane Electron Transport Using Carbon Nanotube Porins (Small 32/2021)

Jacqueline M. Hicks, Yun‐Chiao Yao, Sydney Barber, Nigel Neate, more

Small > 17 > 32 > n/a - n/a

Carbon Nanotube Porins In article number 2102517, Frankie J. Rawson and co‐workers report the use of carbon nanotube porins (CNTPs) as voltage dependant‐anion channel mimics. CNTPs are inserted into the membrane of neuronal cells. On applying an electric field, gold ions are reduced at the membrane interface containing the CNTPs via low voltage bipolar electrochemistry. Image credit: Dr. Leonora Martínez...

article

Complement activation by dialysis membranes and its association with secondary membrane formation and surface charge

Pascal Melchior, Ansgar Erlenkötter, Adam M. Zawada, Dirk Delinski, more

Artificial Organs > 45 > 7 > 770 - 778

Activation of the complement system may occur during blood‐membrane interactions in hemodialysis and contribute to chronic inflammation of patients with end‐stage renal disease. Hydrophilic modification with polyvinylpyrrolidone (PVP) has been suggested to increase the biocompatibility profile of dialysis membranes. In the present study we compared the complement activation of synthetic and cellulose‐based...

article

Effects Induced by a Weak Static Magnetic Field of Different Intensities on HT‐1080 Fibrosarcoma Cells

Hakki Gurhan, Rodolfo Bruzon, Sahithi Kandala, Ben Greenebaum, more

Bioelectromagnetics > 42 > 3 > 212 - 223

In this study, we investigated the effects of weak static magnetic fields (SMFs) on HT‐1080 human fibrosarcoma cells. Exposures to SMFs for four consecutive days were varied from 0.5 to 600 µT for treated units, while exposures to control units were held at 45 µT. Growth rates were measured by comparing cell counts, whereas membrane potentials, mitochondrial calcium, mitochondrial superoxide (O₂⁻),...

article

Voltage‐dependent conformational changes of Kv1.3 channels activate cell proliferation

Pilar Cidad, Esperanza Alonso, Marycarmen Arévalo‐Martínez, Enrique Calvo, more

Journal of Cellular Physiology > 236 > 6 > 4330 - 4347

The voltage‐dependent potassium channel Kv1.3 has been implicated in proliferation in many cell types, based on the observation that Kv1.3 blockers inhibited proliferation. By modulating membrane potential, cell volume, and/or Ca²⁺ influx, K⁺ channels can influence cell cycle progression. Also, noncanonical channel functions could contribute to modulate cell proliferation independent of K⁺ efflux...

article

Modulation of the Cell Membrane Potential and Intracellular Protein Transport by High Magnetic Fields

Vitalii Zablotskii, Tatyana Polyakova, Alexandr Dejneka

Bioelectromagnetics > 42 > 1 > 27 - 36

To explore cellular responses to high magnetic fields (HMF), we present a model of the interactions of cells with a homogeneous HMF that accounts for the magnetic force exerted on paramagnetic/diamagnetic species. There are various chemical species inside a living cell, many of which may have large concentration gradients. Thus, when an HMF is applied to a cell, the concentration‐gradient magnetic...

article

How potassium came to be the dominant biological cation: of metabolism, chemiosmosis, and cation selectivity since the beginnings of life

Nikolay Korolev

BioEssays > 43 > 1 > n/a - n/a

In the cytoplasm of practically all living cells, potassium is the major cation while sodium dominates in the media (seawater, extracellular fluids). Both prokaryotes and eukaryotes have elaborate mechanisms and spend significant energy to maintain this asymmetric K⁺/Na⁺ distribution. This essay proposes an original line of evidence to explain how bacteria selected potassium at the very beginning...

article

Hyaluronan and halogen‐induced airway hyperresponsiveness and lung injury

Ahmed Lazrak, Weifeng Song, Ting Zhou, Saurabh Aggarwal, more

Annals of the New York Academy of Sciences > 1479 > 1 > 29 - 43

Chlorine (Cl₂) and bromine (Br₂) are produced in large quantities throughout the world and used in the industry and the sanitation of water. These halogens can pose a significant threat to public health when released into the atmosphere during transportation and industrial accidents, or as acts of terrorism. In this review, we discuss the evidence showing that the activity of Cl₂ and Br₂, and of products...

article

‘Resistance is futile?’ – paradoxical inhibitory effects of K_ATP channel closure in glucagon‐secreting α‐cells

Quan Zhang, Haiqiang Dou, Patrik Rorsman

The Journal of Physiology > 598 > 21 > 4765 - 4780

By secreting insulin and glucagon, the β‐ and α‐cells of the pancreatic islets play a central role in the regulation of systemic metabolism. Both cells are equipped with ATP‐regulated potassium (K_ATP) channels that are regulated by the intracellular ATP/ADP ratio. In β‐cells, K_ATP channels are active at low (non‐insulin‐releasing) glucose concentrations. An increase in glucose leads to K_ATP channel...

article

TASK‐1 channel blockade by AVE1231 increases vasocontractile responses and BP in 1‐ to 2‐week‐old but not adult rats

Anastasia A. Shvetsova, Dina K. Gaynullina, Nadine Schmidt, Peter Bugert, more

British Journal of Pharmacology > 177 > 22 > 5148 - 5162

Background and Purpose The vasomotor role of K2P potassium channels during early postnatal development has never been investigated. We tested the hypothesis that TASK‐1 channel (K2P family member) contribution to arterial vascular tone and BP is higher in the early postnatal period than in adulthood. Experimental Approach We studied 10‐ to 15‐day‐old (“young”) and 2‐ to 3‐month‐old (“adult”) male...

article

Electrochemical communication in biofilm of bacterial community

Sounik Manna, Chandan Ghanty, Piyush Baindara, Tarun KR. Barik, more

Journal of Basic Microbiology > 60 > 10 > 819 - 827

Electrochemical communication during biofilm formation has recently been identified. Bacteria within biofilm‐adopt different strategies for electrochemical communication such as direct contact via membrane‐bound molecules, diffusive electron transfer via soluble redox‐active molecules, and ion channel‐mediated long‐range electrochemical signaling. Long‐range electrical signals are important to communicate...

article

Biophysical basis for Kv1.3 regulation of membrane potential changes induced by P2X4‐mediated calcium entry in microglia

Hai M. Nguyen, Jacopo Lucente, Yi‐Je Chen, Yanjun Cui, more

Glia > 68 > 11 > 2377 - 2394

Microglia‐mediated inflammation exerts adverse effects in ischemic stroke and in neurodegenerative disorders such as Alzheimer's disease (AD). Expression of the voltage‐gated potassium channel Kv1.3 is required for microglia activation. Both genetic deletion and pharmacological inhibition of Kv1.3 are effective in reducing microglia activation and the associated inflammatory responses, as well as...

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Search results

Atractylodes macrocephala Koidz promotes intestinal epithelial restitution via the polyamine—Voltage-gated K+ channel pathway

Preparation, characterization, biological activity, and transport study of polystyrene based calcium–barium phosphate composite membrane

The green light gap: a window of opportunity for optogenetic control of stomatal movement

Teaching an old dog new tricks: A lipid membrane‐based electric immunosensor for real‐time probing of the spike S₁ protein subunit from SARS‐CoV‐2

Toward absolute viability measurements for bacteria

Differential hyperpolarization to substance P and calcitonin gene‐related peptide in smooth muscle versus endothelium of mouse mesenteric artery

Acid‐sensing ion channel 1 contributes to pulmonary arterial smooth muscle cell depolarization following hypoxic pulmonary hypertension

Is neuronal inhibition or excitability controlled by Na⁺K⁺2CL^– transporters?

Electric Field Induced Biomimetic Transmembrane Electron Transport Using Carbon Nanotube Porins

Electric Field Induced Biomimetic Transmembrane Electron Transport Using Carbon Nanotube Porins (Small 32/2021)

Complement activation by dialysis membranes and its association with secondary membrane formation and surface charge

Effects Induced by a Weak Static Magnetic Field of Different Intensities on HT‐1080 Fibrosarcoma Cells

Voltage‐dependent conformational changes of Kv1.3 channels activate cell proliferation

Modulation of the Cell Membrane Potential and Intracellular Protein Transport by High Magnetic Fields

How potassium came to be the dominant biological cation: of metabolism, chemiosmosis, and cation selectivity since the beginnings of life

Hyaluronan and halogen‐induced airway hyperresponsiveness and lung injury

‘Resistance is futile?’ – paradoxical inhibitory effects of K_ATP channel closure in glucagon‐secreting α‐cells

TASK‐1 channel blockade by AVE1231 increases vasocontractile responses and BP in 1‐ to 2‐week‐old but not adult rats

Electrochemical communication in biofilm of bacterial community

Biophysical basis for Kv1.3 regulation of membrane potential changes induced by P2X4‐mediated calcium entry in microglia

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