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Items from 1 to 20 out of 1,382 results

article

Risk of lymph node metastasis in early gastric cancer for a Western population

Akie Watanabe, Geoffrey J. McKendry, Lily Yip, Fergal Donnellan, more

Journal of Surgical Oncology > 127 > 5 > 791 - 797

Introduction Endoscopic resection (ER) of early gastric cancer (EGC) is increasingly used in Eastern countries due to their low rates of lymph node metastasis (LNM); however, there is a paucity of evidence in Western countries. We investigated LNM and its effect on overall survival (OS) in Western patients with EGC. Methods Patients diagnosed with T1 gastric cancer between 2000 and 2017 were retrospectively...

article

Clinical and ultrasonic risk factors for high‐volume central lymph node metastasis in cN0 papillary thyroid microcarcinoma: A retrospective study and meta‐analysis

Zhiyuan Wang, Zhiqiang Gui, Zhihong Wang, Jiapeng Huang, more

Clinical Endocrinology > 98 > 4 > 609 - 621

Objective Papillary thyroid microcarcinoma (PTMC) comprises more than 50% of all newly detected cases of papillary thyroid carcinoma (PTC). High‐volume lymph node metastasis (involving >5 lymph nodes) (hv‐LNM) is associated with PTMC recurrence. In half of the clinically node‐negative (cN0) PTMC patients, central lymph node metastasis (CLNM) is pathologically present. However, clinical risk factors...

article

Fine needle aspiration cytology of metastatic SMARCA4‐deficient sinonasal teratocarcinosarcoma: First report in literature

Akhila Gopakumar, Aanchal Kakkar, Kavneet Kaur, Kapil Sikka, more

Diagnostic Cytopathology > 51 > 4 > E129 - E136

Inactivating mutations of SMARCA4 and accompanying loss of BRG1 immunoexpression were recently identified in majority of sinonasal teratocarcinosarcomas (TCS). These rare and aggressive neoplasms have potential for nodal metastasis, presenting opportunities for diagnosis on fine needle aspiration cytology (FNAC). However, their cytological features have not been described till date. A 22‐year‐old...

article

Impact of adjuvant therapy on outcomes after curative‐intent resection for distal cholangiocarcinoma

Jing‐Jing Hou, Shishir K. Maithel, Sharon M. Weber, George Poultsides, more

Journal of Surgical Oncology > 127 > 4 > 607 - 615

Background The benefit of adjuvant therapy (AT) after curative resection of distal cholangiocarcinoma (DCC) remains unclear. The objective of the current study was to investigate the impact of AT on long‐term survival of patients who underwent curative‐intent resection for DCC. Methods Patients who underwent curative‐intent resection for DCC between 2000 and 2020 were identified from a multi‐institutional...

article

Impact of lymphadenectomy in patients with locally recurrent or persistent cervical cancer treated with salvage hysterectomy

Seiji Mabuchi, Naoko Komura, Michiko Kodama, Shinya Matsuzaki, more

Journal of Obstetrics and Gynaecology Research > 49 > 2 > 717 - 724

Aim To investigate the role of lymphadenectomy (LND) in locally recurrent or persistent cervical cancer patients treated with salvage hysterectomy. Methods Locally recurrent or persistent cervical cancer patients treated with salvage hysterectomy, with or without LND, were identified. Patients were divided into two groups according to the status of radiologic evidence of lymph node metastasis,...

article

Exosomal hsa_circRNA_047733 integrated with clinical features for preoperative prediction of lymph node metastasis risk in oral squamous cell carcinoma

Qingrong Deng, Yujia Chen, Lisong Lin, Jing Lin, more

Journal of Oral Pathology & Medicine > 52 > 1 > 37 - 46

Background To evaluate whether exosomal circRNAs could serve as diagnostic biomarkers for the accurate preoperative prediction of lymph node metastasis (LNM) risk in oral squamous cell carcinoma (OSCC) patients. Methods A combinative strategy of exosomal circRNAs microarray and qRT‐PCR verification was employed to dig LNM‐related circRNA signatures. Then, a dynamic nomogram was developed based...

article

Deep learning radiomics of ultrasonography for comprehensively predicting tumor and axillary lymph node status after neoadjuvant chemotherapy in breast cancer patients: A multicenter study

Jionghui Gu, Tong Tong, Dong Xu, Fang Cheng, more

Cancer > 129 > 3 > 356 - 366

Background Neoadjuvant chemotherapy (NAC) can downstage tumors and axillary lymph nodes in breast cancer (BC) patients. However, tumors and axillary response to NAC are not parallel and vary among patients. This study aims to explore the feasibility of deep learning radiomics nomogram (DLRN) for independently predicting the status of tumors and lymph node metastasis (LNM) after NAC. Methods In...

article

Surgeon‐performed ultrasound changes surgical management in patients with thyroid cancer

Mario Tapia, Clemente Chia, Jamil Manji, Matthew J. R. Magarey, more

ANZ Journal of Surgery > 92 > 12 > 3268 - 3272

Background A comprehensive neck ultrasound (US) is essential in the operative planning of patients with thyroid disease. Recent literature has shown surgeon‐performed US (SUS) can be more accurate than radiology‐performed US for the purpose of surgical planning. Missed findings on radiology‐performed ultrasound may lead to inadequate surgical management. Methods A retrospective cohort study of...

article

Development and validation of a nomogram for the prediction of lymph node metastasis within 2‐year postoperatively in cT1‐T2N0 oral squamous cell carcinoma

Aoming Cheng, Zhen Wang, Xiaohong Yuan, Huan Liu, more

Head & Neck > 45 > 1 > 103 - 114

Background The current neck management for early oral squamous cell carcinoma (OSCC) has always been a controversial issue. A comprehensive model is necessary for predicting an individual's metastasis risk and appropriate patient counseling. Methods A nomogram for predicting 2‐year LNM in patients with cT1‐2N0 OSCC was developed and validated using clinicopathological data from 642 patients from...

article

Occult metastasis to the superficial level VI lymph nodes in papillary thyroid carcinoma

Ha Na Lee, Chang Myeon Song, Yong Bae Ji, Jae Kyung Myung, more

Head & Neck > 44 > 12 > 2796 - 2802

Background This study aimed to evaluate the incidence and risk factors of occult metastasis to superficial level VI, defined as the space anterior to the strap muscles, including the lymph nodes between the sternocleidomastoid and sternohyoid muscles and suprasternal space lymph nodes. Methods We studied 129 patients with papillary thyroid carcinoma who underwent thyroidectomy and neck dissection,...

article

Superiority of metastatic lymph node ratio over number of node metastases and TNM/AJCC N classification in predicting cancer‐specific survival in medullary thyroid cancer

Andreas Machens, Kerstin Lorenz, Frank Weber, Henning Dralle

Head & Neck > 44 > 12 > 2717 - 2726

Background In medullary thyroid cancer (MTC), it is unclear which nodal classification system, metastatic lymph node ratio (MLNR), number of node metastases, or TNM/AJCC N classification, predicts cancer‐specific survival best. Methods Kaplan–Maier analysis of cancer‐specific survival after operation at a tertiary center. Results Included were 505 MTC patients. The spread of the survival curves...

article

Prognosis of pancreatic head cancer with different patterns of lymph node metastasis

Seung Ki Min, Yunghun You, Dong Wook Choi, In Woong Han, more

Journal of Hepato‐Biliary‐Pancreatic Sciences > 29 > 9 > 1004 - 1013

Background The nodal stage of pancreatic ductal adenocarcinoma (PDAC) is revised in the AJCC 8th edition. Studies on the prognosis of PDAC according to lymph node metastasis (LNM) are still ongoing. We attempted to find the patterns of nodal involvement and to reveal its clinical significance to overall survival (OS). Methods We analyzed 585 patients who received pancreatic head cancer surgery...

article

Optimization of prostate cancer patient lymph node staging via the integration of neutrophil–lymphocyte ratios, platelet–lymphocyte ratios, and ⁶⁸Ga‐PSMA‐PET‐derived SUVmax values

Yinzhao Wang, Yongxiang Tang, Xiaomei Gao, Yu Gan, more

The Prostate > 82 > 15 > 1415 - 1421

Background At present, standardized parameters for quantitatively evaluating ⁶⁸Ga‐PSMA‐PET/CT outcomes when diagnosing lymph node metastasis in prostate cancer patients are lacking. Inflammatory hematological biomarkers offer value as robust predictors of certain cancer‐related outcomes. The present study was thus developed to explore approaches to improving the utility of ⁶⁸Ga‐PSMA‐PET/CT for diagnosing...

article

Development of a novel signature derived from single cell RNA‐sequencing for preoperative prediction of lymph node metastasis in head and neck squamous cell carcinoma

Yibin Dai, Ziyu Wang, Enshi Yan, Jin Li, more

Head & Neck > 44 > 10 > 2171 - 2180

Background Lymph node metastasis (LNM) is considered as an adverse prognostic indicator for cancer patients. Preoperative knowledge of LNM is valuable for pretreatment decision making. Here, we sought to develop and validate an LNM signature for preoperative prediction of LNM in patients with head and neck squamous cell carcinoma (HNSCC). Methods By studying single cell RNA‐sequencing data (scRNA‐seq),...

article

Single‐cell RNA‐seq dissecting heterogeneity of tumor cells and comprehensive dynamics in tumor microenvironment during lymph nodes metastasis in gastric cancer

Yan Qian, Ertao Zhai, Sile Chen, Yinan Liu, more

International Journal of Cancer > 151 > 8 > 1367 - 1381

Lymph node metastasis is the common metastasis route of gastric cancer. However, until now, heterogeneities of tumor cells and tumor microenvironment in primary tumors (PT) and metastatic lymph nodes (MLN) of gastric cancer (GC) remains uncharacterized. In our study, single cell RNA sequencing was performed on tissues from PT and MLN of gastric cancer. Trajectory analysis and function enrichment analyses...

article

SPP1 as a key gene in the lymph node metastasis and a potential predictor of poor prognosis in head and neck carcinoma

Shunli Feng, Wubin Yuan, Zhen Sun, Xiaopeng Guo, more

Journal of Oral Pathology & Medicine > 51 > 7 > 620 - 629

Background Lymph node metastasis (LNM) is an important cause leading to recurrence and development of head and neck carcinoma (HNC), with the precise mechanisms unclear. Thus, we aimed to identify the key genes involved in LNM and further evaluate their expressions and roles. Methods A cohort of HNC in the TCGA was analyzed. The study involved three phases (one screening and two validation phases)...

article

Preoperative Prediction of Axillary Lymph Node Metastasis in Breast Cancer Using CNN Based on Multiparametric MRI

Zijian Wang, Hang Sun, Jing Li, Jing Chen, more

Journal of Magnetic Resonance Imaging > 56 > 3 > 700 - 709

Background Multiparametric magnetic resonance imaging (MRI) is widely used in breast cancer screening. Accurate prediction of the axillary lymph nodes metastasis (ALNM) is essential for breast cancer surgery and treatment. However, there is no mature and effective discerning method for ALNM based on multiparametric MRI. Purpose To evaluate the ALNM using T1‐weighted imaging (T1WI), T2‐weighted...

article

A Nomogram of Combining IVIM‐DWI and MRI Radiomics From the Primary Lesion of Rectal Adenocarcinoma to Assess Nonenlarged Lymph Node Metastasis Preoperatively

Haodong Jia, Xueyan Jiang, Kaiyue Zhang, Jin Shang, more

Journal of Magnetic Resonance Imaging > 56 > 3 > 658 - 667

Background Lymph node (LN) staging plays an important role in treatment decision‐making. Current problem is that preoperative detection of LN involvement is always highly challenging for radiologists. Purpose To explore the value of the nomogram model combining intravoxel incoherent motion diffusion‐weighted imaging (IVIM‐DWI) and radiomics features from the primary lesion of rectal adenocarcinoma...

article

Prognostic and clinicopathological significance of cytocapsular tubes in oral squamous cell carcinoma

Wenjin Wang, Nan Xie, Chen Yi, Ming Zhang, more

Journal of Oral Pathology & Medicine > 51 > 6 > 520 - 528

Background Cytocapsular tubes (CTs) provide membranous channels for cancer cells interconnection and multidirectional locomotion, which facilitate cancer cell transportation and metastasis. However, the clinicopathological significance of CTs has not been documented in oral squamous cell carcinoma (OSCC). Herein, we aimed to identify CTs and assess their clinicopathological significance in OSCC....

article

Clinicopathological predictors of finding additional inguinal lymph node metastases in penile cancer patients after positive dynamic sentinel node biopsy: a European multicentre evaluation

Hielke M. Vries, Hack Jae Lee, Wayne Lam, Rosa S. Djajadiningrat, more

BJU International > 130 > 1 > 126 - 132

Objective To develop a predictive model for additional inguinal lymph node metastases (LNM) at inguinal lymph node dissection (ILND) after positive dynamic sentinel node biopsy (DSNB) using DSNB characteristics to identify a patient group in which ILND might be omitted. Patients and Methods We conducted a retrospective study of 407 inguinal basins with a positive DSNB in penile cancer patients...

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Risk of lymph node metastasis in early gastric cancer for a Western population

Clinical and ultrasonic risk factors for high‐volume central lymph node metastasis in cN0 papillary thyroid microcarcinoma: A retrospective study and meta‐analysis

Fine needle aspiration cytology of metastatic SMARCA4‐deficient sinonasal teratocarcinosarcoma: First report in literature

Impact of adjuvant therapy on outcomes after curative‐intent resection for distal cholangiocarcinoma

Impact of lymphadenectomy in patients with locally recurrent or persistent cervical cancer treated with salvage hysterectomy

Exosomal hsa_circRNA_047733 integrated with clinical features for preoperative prediction of lymph node metastasis risk in oral squamous cell carcinoma

Deep learning radiomics of ultrasonography for comprehensively predicting tumor and axillary lymph node status after neoadjuvant chemotherapy in breast cancer patients: A multicenter study

Surgeon‐performed ultrasound changes surgical management in patients with thyroid cancer

Development and validation of a nomogram for the prediction of lymph node metastasis within 2‐year postoperatively in cT1‐T2N0 oral squamous cell carcinoma

Occult metastasis to the superficial level VI lymph nodes in papillary thyroid carcinoma

Superiority of metastatic lymph node ratio over number of node metastases and TNM/AJCC N classification in predicting cancer‐specific survival in medullary thyroid cancer

Prognosis of pancreatic head cancer with different patterns of lymph node metastasis

Optimization of prostate cancer patient lymph node staging via the integration of neutrophil–lymphocyte ratios, platelet–lymphocyte ratios, and ⁶⁸Ga‐PSMA‐PET‐derived SUVmax values

Development of a novel signature derived from single cell RNA‐sequencing for preoperative prediction of lymph node metastasis in head and neck squamous cell carcinoma

Single‐cell RNA‐seq dissecting heterogeneity of tumor cells and comprehensive dynamics in tumor microenvironment during lymph nodes metastasis in gastric cancer

SPP1 as a key gene in the lymph node metastasis and a potential predictor of poor prognosis in head and neck carcinoma

Preoperative Prediction of Axillary Lymph Node Metastasis in Breast Cancer Using CNN Based on Multiparametric MRI

A Nomogram of Combining IVIM‐DWI and MRI Radiomics From the Primary Lesion of Rectal Adenocarcinoma to Assess Nonenlarged Lymph Node Metastasis Preoperatively

Prognostic and clinicopathological significance of cytocapsular tubes in oral squamous cell carcinoma

Clinicopathological predictors of finding additional inguinal lymph node metastases in penile cancer patients after positive dynamic sentinel node biopsy: a European multicentre evaluation

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