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article

Transcriptomics of rhinovirus persistence reveals sustained expression of RIG‐I and interferon‐stimulated genes in nasal epithelial cells in vitro

Hsiao Hui Ong, Anand Kumar Andiappan, Kaibo Duan, Josephine Lum, more

Allergy > 77 > 9 > 2778 - 2793

Background Human rhinoviruses (HRVs) are frequently associated with asthma exacerbations, and have been found in the airways of asthmatic patients. While HRV‐induced acute infection is well‐documented, it is less clear whether the nasal epithelium sustains prolonged HRV infections along with the associated activation of host immune responses. Objective To investigate sustainably regulated host...

article

Metal–Protein Nanoparticles Facilitate Anti‐VSV and H1N1 Viruses Through the Coordinative Actions on Innate Immune Responses and METTL14

Xin‐Jie Zhu, Jin‐Qiu Feng, Meng‐Zhu Zheng, Ze‐Ruo Yang, more

Macromolecular Bioscience > 21 > 4 > n/a - n/a

Host defense systems can invade viral infection through immune responses and cellular metabolism. Recently, many studies have shown that cellular metabolism can be reprogrammed through N⁶‐methyladenosine (m⁶A) modifications during viral infection. Among of them, methyltransferase like‐14 enzyme (METTL14) plays an important role in m⁶A RNA modification, yet its antiviral function still remains unclear...

article

The effect of dietary fish meal replacement with blood meal on growth performance, metabolic activities, antioxidant and innate immune responses of fingerlings black carp, Mylopharyngodon piceus

Innocent Twahirwa, Chenglong Wu, Jinyun Ye, Qicun Zhou

Aquaculture Research > 52 > 2 > 702 - 714

This study was focused on evaluating the effect of dietary fish meal replacement with blood meal on growth performance, metabolic activities, antioxidant and innate immune responses of fingerlings black carp, Mylopharyngodon piceus. Six iso‐nitrogenous and iso‐caloric diets were formulated with varied blood meal (BM) inclusion levels to replace fish meal at 0%, 20%, 40%, 60%, 80% and 100% (designed...

article

Impaired immune responses to herpesviruses and microbial ligands in patients with MonoMAC

Maibritt Mardahl, Sofie Eg Jørgensen, Alon Schneider, Klas Raaschou‐Jensen, more

British Journal of Haematology > 186 > 3 > 471 - 476

MonoMAC is a complex primary immunodeficiency caused by mutations in the myeloid transcription factor GATA2, characterized by multilineage cytopenia with malignant complications and severe infections, including mycobacteria and herpesviruses. We describe the clinical presentation, genetics and antiviral inflammatory responses in a small case series. Two patients presented in childhood with mycobacterial...

article

Evidence of Aberrant Immune Response by Endogenous Double‐Stranded RNAs: Attack from Within

Sujin Kim, Yongsuk Ku, Jayoung Ku, Yoosik Kim

BioEssays > 41 > 7 > n/a - n/a

Many innate immune response proteins recognize foreign nucleic acids from invading pathogens to initiate antiviral signaling. These proteins mostly rely on structural characteristics of the nucleic acids rather than their specific sequences to distinguish self and nonself. One feature utilized by RNA sensors is the extended stretch of double‐stranded RNA (dsRNA) base pairs. However, the criteria for...

article

The dark side of organic vegetables: interactions of human enteropathogenic bacteria with plants

Sung Hee Jo, Jeong Mee Park

Plant Biotechnology Reports > 2019 > 13 > 2 > 105-110

Many recent studies reported that several pathogenic bacteria rely on multiple hosts during their life cycle. Specifically, Gram-negative enteropathogenic bacteria, such as Salmonella or Escherichia coli O157:H7, infect both human and plant hosts. These multi-kingdom pathogenic bacteria cause food-associated outbreaks in human by active invasion of the host. In the current review, we cover the interactions...

article

Effects of replacing fishmeal with fermented and non‐fermented rapeseed meal on the growth, immune and antioxidant responses of red sea bream (Pagrus major)

Serge Dossou, Shunsuke Koshio, Manabu Ishikawa, Saichiro Yokoyama, more

Aquaculture Nutrition > 25 > 2 > 508 - 517

The effect of rapeseed meal (RM) and Aspergillus oryzae fermented rapeseed meal (RM‐Koji) on red sea bream (Pagrus major) was examined. Three groups of fish (initial weight, 4.5 ± 0.02 g) were fed a basal diet (RM0) and two test diets where half of fishmeal was replaced by RM (RM50) and RM‐Koji (FRM50) for 56 days. The obtained results showed that fish fed RM0 and FRM50 exerted significantly higher...

article

IFI16 regulates HTLV‐1 replication through promoting HTLV‐1 RTI‐induced innate immune responses

Bo Yang, Di Song, Yue Liu, Yuhan Cui, more

FEBS Letters > 592 > 10 > 1693 - 1704

Interferon (IFN)‐inducible protein 16 (IFI16) regulates human immunodeficiency virus replication by inducing innate immune responses as a DNA sensor. Human T‐lymphotropic virus type 1 (HTLV‐1), a delta retrovirus family member, has been linked to multiple diseases. Here, we report that IFI16 expression is induced by HTLV‐1 infection or HTLV‐1 reverse transcription intermediate (RTI) ssDNA90 transfection...

article

Molecular identification and functional analysis of two variants of myeloid differentiation factor 88 (MyD88) from disk abalone (Haliotis discus discus)

Thanthrige Thiunuwan Priyathilaka, S.D.N.K. Bathige, Seongdo Lee, Jehee Lee

Developmental & Comparative Immunology > 2018 > 79 > C > 113-127

Myeloid differentiation factor 88 (MyD88) is a crucial adaptor protein of the Toll-like receptor (TLR)- and interleukin 1 receptor-mediated signaling pathways and is involved in a diverse array of inflammatory responses via NF-κB activation. In the present study, two MyD88 variants were identified from disk abalone (Haliotis discus discus) and designated AbMyD88-2 and AbMyD88-X. The deduced AbMyD88-2...

article

Effects of Cordyceps militaris spent mushroom substrate and Lactobacillus plantarum on mucosal, serum immunology and growth performance of Nile tilapia (Oreochromis niloticus)

Hien Van Doan, Seyed Hossein Hoseinifar, Mahmoud A.O. Dawood, Chanagun Chitmanat, more

Fish & Shellfish Immunology > 2017 > 70 > C > 87-94

An 8-weeks feeding trial was performed to investigate the possible effects of supplementation of Nile tilapia diet with Cordyceps militaris spent mushroom substrate (SMS) single or combined with Lactobacillus plantarum on immune parameters and growth performance. For this aim, Nile tilapia fingerlings were fed with four experimental diets namely: Diet 1 (0 – control), Diet 2 (10 g kg⁻¹ SMS), Diet...

article

Downregulated expression of miR-223 promotes Toll-like receptor-activated inflammatory responses in macrophages by targeting RhoB

Ningjie Zhang, Liyao Fu, Yanhong Bu, Yao Yao, more

Molecular Immunology > 2017 > 91 > C > 42-48

Toll-like receptors (TLRs) induced-inflammatory response must be tightly regulated to avoid impairment in host itself. Numerous factors have been identified in regulation of TLR-triggered inflammatory response. Among these, microRNAs (miRNAs) are small non-coding RNA molecules which have got much attention. MiR-223, which highly expresses in myeloid cells of the bone marrow, has reported to participate...

article

Differential expression of innate immune response genes in clinical phases of chronic hepatitis B infection

S. Romani, S. M. Hosseini, S. R. Mohebbi, A. Boonstra, more

Journal of Viral Hepatitis > 24 > 9 > 776 - 788

We investigated innate immune gene expression in clinical phases of chronic hepatitis B infection, including immune tolerant (IT), immune active (IA), inactive carrier (IC) and hepatitis B e antigen (HBeAg)‐negative phases, as well as healthy controls. Expression levels of interferon types I, II and III, their receptor subunits, IRFs, TLRs and other IFN‐induced genes in peripheral blood mononuclear...

article

The effects of dietary leucine on the growth performances, body composition, metabolic abilities and innate immune responses in black carp Mylopharyngodon piceus

Chenglong Wu, Lian Chen, Zhibin Lu, Jun’e Gao, more

Fish & Shellfish Immunology > 2017 > 67 > C > 419-428

The present study was focused on the growth, body composition, metabolic abilities and innate immune responses in juvenile black carp Mylopharyngodon piceus fed with six levels of dietary leucine (7.3, 12.4, 16.2, 21.9, 28.3 and 34.5 g kg⁻¹) for 9 weeks. Results showed that the highest weight gain (WG) and the lowest feed conversion ratio (FCR) was obtained at 23.5 and 23.9 g kg⁻¹ dietary leucine...

article

Effects of Cordyceps militaris spent mushroom substrate on mucosal and serum immune parameters, disease resistance and growth performance of Nile tilapia, (Oreochromis niloticus)

Hien Van Doan, Seyed Hossein Hoseinifar, Wanaporn Tapingkae, Chanagun Chitmanat, more

Fish & Shellfish Immunology > 2017 > 67 > C > 78-85

The aim of present study was determination effects of dietary administration of C. militaris spent mushroom substrate (SMS) on mucosal and serum immune parameters, disease resistance, and growth performance of Nile tilapia (Oreochromis niloticus). Two hundred twenty five fish of similar weight (37.28 ± 0.10 g) were assigned to the following diets [0 (T1- Control), 5 (T2), 10 (T3), 20 (T4) and 40 g kg...

article

Dietary cytidine monophosphate enhances the growth, blood characteristics, innate and adaptive immune functions and stress resistance of juvenile red sea bream, Pagrus major

Md. Sakhawat Hossain, Shunsuke Koshio, Manabu Ishikawa, Saichiro Yokoyama, more

Aquaculture > 2017 > 473 > Complete > 366-374

The present study was designed to evaluate the effects of dietary cytidine monophosphate on growth, blood characteristics, innate and adaptive immune functions and stress resistance of juvenile red sea bream, Pagrus major. A semi-purified basal diet supplemented with 0% (Control), 0.1% (CMP-0.1), 0.2% (CMP-0.2), 0.4% (CMP-0.4) and 0.8% (CMP-0.8) purified CMP to formulate five experimental diets. Each...

article

Commercial Bacillus probiotic supplementation of rainbow trout (Oncorhynchys mykiss) and brown trout (Salmo trutta): growth, immune responses and intestinal morphology

Maria Amélia Ramos, José F M Gonçalves, Benjamín Costas, Sónia Batista, more

Aquaculture Research > 48 > 5 > 2538 - 2549

Probiotic administration is associated with the enhancement of host resistance to environmental and nutritional stressors, improving survival and growth rates. This study was carried out to evaluate the effects of dietary supplementation of Bacillus subtilis and Bacillus cereus toyoi on growth performance, innate immune responses and gut morphology of two trout species feeding a commercial diet high...

article

Dietary administration of Pontogammarus maeoticus extract affects immune responses, stress resistance, feed intake and growth performance of caspian roach (Rutilus caspicus) fingerlings

Rudabeh Rufchaei, Seyed Hossein Hoseinifar, Alireza Mirzajani, Hien Van Doan

Fish & Shellfish Immunology > 2017 > 63 > C > 196-200

Dietary administration of immunostimulants showed promising results for elevation of immune responses and disease resistance. The aim of the present study was to investigate the effects of dietary Pontogammarus (Pontogammarus maeoticus) extract on innate immune response, stress resistance, feed intake and growth performance of the Caspian roach fingerling. Two levels of P. maeoticus extract dilution...

article

HTLV-1 Tax impairs K63-linked ubiquitination of STING to evade host innate immunity

Jie Wang, Shuai Yang, Lu Liu, Hui Wang, more

Virus Research > 2017 > 232 > C > 13-21

The cellular antiviral innate immune system is essential for host defense and viruses have evolved a variety of strategies to evade the innate immunity. Human T lymphotropic virus type 1 (HTLV-1) belongs to the deltaretrovirus family and it can establish persistent infection in human beings for many years. However, how this virus evades the host innate immune responses remains unclear. Here we report...

article

Testicular immunoregulation and spermatogenesis

Qiaoyuan Chen, Tingting Deng, Daishu Han

Seminars in Cell & Developmental Biology > 2016 > 59 > C > 157-165

The mammalian testis possesses a unique immune environment that is essential for testicular function. The testis is a remarkable immunoprivileged site that protects immunogenic germ cells from the detrimental effects of immune responses. However, the testis can be infected by various microbial pathogens. To overcome the immune privilege and enable testicular defense against microbes, the testis adopts...

article

Solute Carrier NTCP Regulates Innate Antiviral Immune Responses Targeting Hepatitis C Virus Infection of Hepatocytes

Eloi R. Verrier, Che C. Colpitts, Charlotte Bach, Laura Heydmann, more

Cell Reports > 2016 > 17 > 5 > 1357-1368

Chronic hepatitis B, C, and D virus (HBV, HCV, and HDV) infections are the leading causes of liver disease and cancer worldwide. Recently, the solute carrier and sodium taurocholate co-transporter NTCP has been identified as a receptor for HBV and HDV. Here, we uncover NTCP as a host factor regulating HCV infection. Using gain- and loss-of-function studies, we show that NTCP mediates HCV infection...

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Transcriptomics of rhinovirus persistence reveals sustained expression of RIG‐I and interferon‐stimulated genes in nasal epithelial cells in vitro

Metal–Protein Nanoparticles Facilitate Anti‐VSV and H1N1 Viruses Through the Coordinative Actions on Innate Immune Responses and METTL14

The effect of dietary fish meal replacement with blood meal on growth performance, metabolic activities, antioxidant and innate immune responses of fingerlings black carp, Mylopharyngodon piceus

Impaired immune responses to herpesviruses and microbial ligands in patients with MonoMAC

Evidence of Aberrant Immune Response by Endogenous Double‐Stranded RNAs: Attack from Within

The dark side of organic vegetables: interactions of human enteropathogenic bacteria with plants

Effects of replacing fishmeal with fermented and non‐fermented rapeseed meal on the growth, immune and antioxidant responses of red sea bream (Pagrus major)

IFI16 regulates HTLV‐1 replication through promoting HTLV‐1 RTI‐induced innate immune responses

Molecular identification and functional analysis of two variants of myeloid differentiation factor 88 (MyD88) from disk abalone (Haliotis discus discus)

Effects of Cordyceps militaris spent mushroom substrate and Lactobacillus plantarum on mucosal, serum immunology and growth performance of Nile tilapia (Oreochromis niloticus)

Downregulated expression of miR-223 promotes Toll-like receptor-activated inflammatory responses in macrophages by targeting RhoB

Differential expression of innate immune response genes in clinical phases of chronic hepatitis B infection

The effects of dietary leucine on the growth performances, body composition, metabolic abilities and innate immune responses in black carp Mylopharyngodon piceus

Effects of Cordyceps militaris spent mushroom substrate on mucosal and serum immune parameters, disease resistance and growth performance of Nile tilapia, (Oreochromis niloticus)

Dietary cytidine monophosphate enhances the growth, blood characteristics, innate and adaptive immune functions and stress resistance of juvenile red sea bream, Pagrus major

Commercial Bacillus probiotic supplementation of rainbow trout (Oncorhynchys mykiss) and brown trout (Salmo trutta): growth, immune responses and intestinal morphology

Dietary administration of Pontogammarus maeoticus extract affects immune responses, stress resistance, feed intake and growth performance of caspian roach (Rutilus caspicus) fingerlings

HTLV-1 Tax impairs K63-linked ubiquitination of STING to evade host innate immunity

Testicular immunoregulation and spermatogenesis

Solute Carrier NTCP Regulates Innate Antiviral Immune Responses Targeting Hepatitis C Virus Infection of Hepatocytes

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