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Atrial fibrillation (AF) induces variations in channel characteristics of human atrial myocytes. Data from experimental AF studies was incorporated in a computational model It was used to investigate the effects of electrophysiological remodeling on myocardial behavior This model was integrated in a schematic 2D model of human right atrium including the sinoatrial node, crista terminalis, pectinate...
It has been recently shown that, in adult rat ventricular cardiomyocytes, functional muscarinic receptors (M-receptors) of the M3-subtype exist that mediate inositol phosphate (IP) formation. The aim of this study was to characterize the M-receptor subtype mediating IP formation in the human heart. For this purpose in [3H]-myo-inositol labeled slices of human right atria, carbachol-induced [3H]-IP...
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