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article

Challenges in harmonizing integrated healthcare network laboratories: Multi-center evaluation of the AccuTnI+3 troponin assay

Dina N. Greene, Daniel T. Holmes, Joy Liang, Shiu-Land Kwong, more

Clinical Biochemistry > 2015 > 48 > 4-5 > 268-274

Background: Beckman Coulter has recently introduced a new troponin assay manufactured for the Access2 and DxI platforms, releasing it under the name AccuTnI+3. Clinical laboratories are required to validate method performance before testing and reporting patient results. Methods: Beckman Coulter Access 2 instruments (n=42) across Kaiser Permanente Northern California were evaluated for their performance...

article

Harmonization and translation of crop modeling data to ensure interoperability

Cheryl H. Porter, Chris Villalobos, Dean Holzworth, Roger Nelson, more

Environmental Modelling and Software > 2014 > 62 > Complete > 495-508

The Agricultural Model Intercomparison and Improvement Project (AgMIP) seeks to improve the capability of ecophysiological and economic models to describe the potential impacts of climate change on agricultural systems. AgMIP protocols emphasize the use of multiple models; consequently, data harmonization is essential. This interoperability was achieved by establishing a data exchange mechanism with...

article

Unraveling schizophrenia replicable functional connectivity disruption patterns across sites

Xiaotong Du, Xiaotong Wei, Hao Ding, Ying Yu, more

Human Brain Mapping > 44 > 1 > 156 - 169

Functional connectivity (FC) disruption is a remarkable characteristic of schizophrenia. However, heterogeneous patterns reported across sites severely hindered its clinical generalization. Based on qualified nodal‐based FC of 340 schizophrenia patients (SZ) and 348 normal controls (NC) acquired from seven different scanners, this study compared four commonly used site‐effect correction methods in...

article

An improved algorithm to harmonize child overweight and obesity prevalence rates

Tim J. Cole, Tim Lobstein

Pediatric Obesity > 18 > 1 > n/a - n/a

Background Prevalence rates of child overweight and obesity for a group of children vary depending on the BMI reference and cut‐off used. Previously we developed an algorithm to convert prevalence rates based on one reference to those based on another. Objective To improve the algorithm by combining information on overweight and obesity prevalence. Methods The original algorithm assumed that...

article

Quality control validation for a veterinary laboratory network of six Sysmex XT‐2000iV hematology analyzers

Susan Daly, Peter A. Graham, Kathleen P. Freeman

Veterinary Clinical Pathology > 51 > 4 > 565 - 576

Background Quality control (QC) validation is an important step in the laboratory harmonization process. This includes the application of statistical QC requirements, procedures, and control rules to identify and maintain ongoing stable analytical performance. This provides confidence in the production of patient results that are suitable for clinical interpretation across a network of veterinary...

article

Reproducibility and postacquisition correction methods for quantitative magnetic resonance imaging of the anterior cruciate ligament (ACL)

Sean W. Flannery, Edward G. Walsh, Ryan M. Sanborn, Cynthia A. Chrostek, more

Journal of Orthopaedic Research® > 40 > 12 > 2908 - 2913

Quantitative magnetic resonance imaging has been used to evaluate the structural integrity of knee joint structures. However, variations in acquisition parameters between scanners pose significant challenges. Understanding the effect of small differences in acquisition parameters for quantitative sequences is vital to the validity of cross‐institutional studies, and for the harmonization of large,...

article

Designing international public sector accounting standards: An analysis of constituents’ participation through comment letters

Marco Bisogno, Francesca Manes‐Rossi, Mariafrancesca Sicilia

Financial Accountability & Management > 38 > 4 > 661 - 685

Harmonization of public sector accounting is attracting increasing attention from scholars and practitioners. A focal component of this phenomenon is the setting of accounting standards, whose legitimacy is paramount to their application. As participation by constituents is considered fundamental for ensuring this legitimacy, in this study, we focus on participation through comment letters in the...

article

From model selection to maps: A completely design‐based data‐driven inference for mapping forest resources

Rosa Maria Di Biase, Lorenzo Fattorini, Sara Franceschi, Mirko Grotti, more

Environmetrics > 33 > 7 > n/a - n/a

A completely data‐driven, design‐based sampling strategy is proposed for mapping a forest attribute within the spatial units tessellating a survey region. Based on sample data, a model is selected, and model parameters are estimated using least‐squares criteria for predicting the attribute of interest within units as a linear function of a set of auxiliary variables. The spatial interpolation of residuals...

article

Harmonizing platelet function analyzer testing and reporting in a large laboratory network

Emmanuel J. Favaloro, Soma Mohammed, Ronny Vong, Kent Chapman, more

International Journal of Laboratory Hematology > 44 > 5 > 934 - 944

Introduction The platelet function analyzer (PFA) is a popular platelet function screening instrument, highly sensitive to von Willebrand disease (VWD) and to aspirin therapy, with moderate sensitivity to defects in platelet function and/or deficiencies in platelet number. There are two models, the original PFA‐100 and the contemporary PFA‐200. Normal reference ranges (NRRs) provided by the manufacturer...

article

Harmonisierung in der Geotechnik – eine statistische Methode zur Ermittlung der repräsentativen Werte geotechnischer Kenngrößen unter Berücksichtigung von Vorinformationen

Elias Tafur, Martin Ziegler

geotechnik > 45 > 3 > 178 - 196

In der überarbeiteten Fassung des Eurocodes 7 (prEN 1997‐1:2021‐11) wird der für die Bemessung anzusetzende Wert für die geotechnische Kenngröße zukünftig als repräsentativer Wert bezeichnet, der sich aus dem charakteristischen Wert oder dem Nominalwert ableiten lässt. Während der Nominalwert mit den bisherigen konventionellen Schätzmethoden festgelegt wird und damit der bisherigen Definition des...

article

One Health Consensus Report Annotation Checklist (OH‐CRAC): A cross‐sector checklist to support harmonized annotation of surveillance data in reports

Estibaliz Lopez de Abechuco, Fernanda Dórea, Tasja Buschhardt, Nazareno Scaccia, more

Zoonoses and Public Health > 69 > 6 > 606 - 614

To facilitate cross‐sector integration of surveillance data it is necessary to improve and harmonize the meta‐information provided in surveillance data reports. Cross‐sector integration of surveillance results in sector‐specific reports is frequently difficult as reports with a focus on a single sector often lack aspects of the relevant meta‐information necessary to clarify the surveillance context...

article

Exploring an algorithm to harmonize International Obesity Task Force and World Health Organization child overweight and obesity prevalence rates

Tim J. Cole, Tim Lobstein

Pediatric Obesity > 17 > 7 > n/a - n/a

Background The International Obesity Task Force (IOTF) and World Health Organization (WHO) body mass index (BMI) cut‐offs are widely used to assess child overweight, obesity and thinness prevalence, but the two references applied to the same children lead to different prevalence rates. Objectives To develop an algorithm to harmonize prevalence rates based on the IOTF and WHO cut‐offs, to make them...

article

Video‐evoked fMRI BOLD responses are highly consistent across different data acquisition sites

Lisa Byrge, Dorit Kliemann, Ye He, Hu Cheng, more

Human Brain Mapping > 43 > 9 > 2972 - 2991

Naturalistic imaging paradigms, in which participants view complex videos in the scanner, are increasingly used in human cognitive neuroscience. Videos evoke temporally synchronized brain responses that are similar across subjects as well as within subjects, but the reproducibility of these brain responses across different data acquisition sites has not yet been quantified. Here, we characterize the...

article

ENIGMA HALFpipe: Interactive, reproducible, and efficient analysis for resting‐state and task‐based fMRI data

Lea Waller, Susanne Erk, Elena Pozzi, Yara J. Toenders, more

Human Brain Mapping > 43 > 9 > 2727 - 2742

The reproducibility crisis in neuroimaging has led to an increased demand for standardized data processing workflows. Within the ENIGMA consortium, we developed HALFpipe (Harmonized Analysis of Functional MRI pipeline), an open‐source, containerized, user‐friendly tool that facilitates reproducible analysis of task‐based and resting‐state fMRI data through uniform application of preprocessing, quality...

article

Digital soil assessment in support of a soil information system for monitoring salinization and sodification in agricultural areas

Christian Thine Omuto, Ronald Rojas Vargas, Abdelmagid Ali Elmobarak, Botle Esther Mapeshoane, more

Land Degradation & Development > 33 > 8 > 1204 - 1218

Salinization and sodification are types of degradation associated with the accumulation of salts and alkaline materials in the soil. They gradually advance unnoticed till severe degradation appears if not properly controlled. Relevant soil information is not routinely kept by many countries thus contributing to their advancement particularly in agricultural areas where their impacts have huge consequences...

article

Harmonization of Osteoporosis Guidelines: Paving the Way for Disrupting the Status Quo in Osteoporosis Management in the Asia Pacific

Manju Chandran, Peter R. Ebeling, Paul J Mitchell, Tuan V. Nguyen, more

Journal of Bone and Mineral Research > 37 > 4 > 608 - 615

In the Asia Pacific (AP) region, osteoporosis and its consequence of fragility fractures are not widely recognized as a major public health problem. Several challenges including underdiagnosis and undertreatment exist. The Asia Pacific Consortium on Osteoporosis (APCO) is a nonpartisan and apolitical organization comprising musculoskeletal experts and stakeholders from both private and public sectors...

article

Development of a harmonized method for antimicrobial susceptibility testing of Bordetella avium using broth microdilution and detection of resistance genes

Franziska Gütgemann, Anja Müller, Yury Churin, Arne Jung, more

Journal of Applied Microbiology > 132 > 3 > 1775 - 1787

Aims In response to a request from the Clinical and Laboratory Standards Institute (CLSI), the objective of this study was to develop a harmonized method for broth microdilution susceptibility testing of Bordetella (B.) avium, the major causative agent of infectious coryza in poultry. Methods and Results To find a suitable test medium, growth curves with four epidemiologically unrelated B. avium...

article

Deep Generative Medical Image Harmonization for Improving Cross‐Site Generalization in Deep Learning Predictors

Vishnu M. Bashyam, Jimit Doshi, Guray Erus, Dhivya Srinivasan, more

Journal of Magnetic Resonance Imaging > 55 > 3 > 908 - 916

Background In the medical imaging domain, deep learning‐based methods have yet to see widespread clinical adoption, in part due to limited generalization performance across different imaging devices and acquisition protocols. The deviation between estimated brain age and biological age is an established biomarker of brain health and such models may benefit from increased cross‐site generalizability...

article

Mitigating site effects in covariance for machine learning in neuroimaging data

Andrew A. Chen, Joanne C. Beer, Nicholas J. Tustison, Philip A. Cook, more

Human Brain Mapping > 43 > 4 > 1179 - 1195

To acquire larger samples for answering complex questions in neuroscience, researchers have increasingly turned to multi‐site neuroimaging studies. However, these studies are hindered by differences in images acquired across multiple sites. These effects have been shown to bias comparison between sites, mask biologically meaningful associations, and even introduce spurious associations. To address...

article

Why regulators assess risk differently: Regulatory style, business organization, and the varied practice of risk‐based food safety inspections across the EU

Olivier Borraz, Anne‐Laure Beaussier, Mara Wesseling, David Demeritt, more

Regulation & Governance > 16 > 1 > 274 - 292

This article advances scholarship on comparative regulation by moving beyond the conventional focus on formal law and EU comitology to assess the extent of ‘practice convergence’ in the implementation of EU regulation. Drawing on 50 key informant interviews, a survey, and policy document analysis, we compare how regulators in England, Germany, France and the Netherlands have implemented EU requirements...

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Search results

Challenges in harmonizing integrated healthcare network laboratories: Multi-center evaluation of the AccuTnI+3 troponin assay

Harmonization and translation of crop modeling data to ensure interoperability

Unraveling schizophrenia replicable functional connectivity disruption patterns across sites

An improved algorithm to harmonize child overweight and obesity prevalence rates

Quality control validation for a veterinary laboratory network of six Sysmex XT‐2000iV hematology analyzers

Reproducibility and postacquisition correction methods for quantitative magnetic resonance imaging of the anterior cruciate ligament (ACL)

Designing international public sector accounting standards: An analysis of constituents’ participation through comment letters

From model selection to maps: A completely design‐based data‐driven inference for mapping forest resources

Harmonizing platelet function analyzer testing and reporting in a large laboratory network

Harmonisierung in der Geotechnik – eine statistische Methode zur Ermittlung der repräsentativen Werte geotechnischer Kenngrößen unter Berücksichtigung von Vorinformationen

One Health Consensus Report Annotation Checklist (OH‐CRAC): A cross‐sector checklist to support harmonized annotation of surveillance data in reports

Exploring an algorithm to harmonize International Obesity Task Force and World Health Organization child overweight and obesity prevalence rates

Video‐evoked fMRI BOLD responses are highly consistent across different data acquisition sites

ENIGMA HALFpipe: Interactive, reproducible, and efficient analysis for resting‐state and task‐based fMRI data

Digital soil assessment in support of a soil information system for monitoring salinization and sodification in agricultural areas

Harmonization of Osteoporosis Guidelines: Paving the Way for Disrupting the Status Quo in Osteoporosis Management in the Asia Pacific

Development of a harmonized method for antimicrobial susceptibility testing of Bordetella avium using broth microdilution and detection of resistance genes

Deep Generative Medical Image Harmonization for Improving Cross‐Site Generalization in Deep Learning Predictors

Mitigating site effects in covariance for machine learning in neuroimaging data

Why regulators assess risk differently: Regulatory style, business organization, and the varied practice of risk‐based food safety inspections across the EU

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