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Items from 1 to 20 out of 83 results

article

Target validation using human tissue: from gene expression to function

Robert A. Coleman, Kenneth L. Clark

Targets > 2003 > 2 > 2 > 58-64

Arguably, one of the main reasons for the pharmaceutical industry's current poor performance in bringing successful new drugs to market is its over-reliance on animal data in the discovery and development processes. We propose that more use should be made of donated human tissues in order to identify and validate drug targets and to discover and develop novel drugs to act upon them. We review the...

article

A novel nonlinear afterload for ex vivo heart evaluation: Porcine experimental results

Henry Pigot, Kristian Soltesz, Audrius Paskevicius, Qiuming Liao, more

Artificial Organs > 46 > 9 > 1794 - 1803

Background Existing working heart models for ex vivo functional evaluation of donor hearts often use cardiac afterloads made up of discrete resistive and compliant elements. This approach limits the practicality of independently controlling systolic and diastolic aortic pressure to safely test the heart under multiple loading conditions. We present and investigate a novel afterload concept designed...

article

A pilot study on Italian eventing prospective olympic horse riders physiological, anthropometrical, functional and asymmetry assessment

S.D. Demarie, C. Galvani, B. Donatucci, A. Gianfelici

Central European Journal of Sport Sciences and Medicine > 2022 > 37 > 1

article

Comparison of quantitative flow ratio, Pd/Pa and diastolic hyperemia‐free ratio versus fractional flow reserve in non‐culprit lesion of patients with non ST‐segment elevation myocardial infarction

Matteo Tebaldi, Simone Biscaglia, Andrea Erriquez, Carlo Penzo, more

Catheterization and Cardiovascular Interventions > 98 > 6 > 1057 - 1065

Objectives To investigate the correlation between quantitative flow ratio (QFR), Pd/Pa, diastolic hyperemia‐free ratio (DFR) and fractional flow reserve (FFR, gold standard) in non‐culprit lesion (NCL) of patients with non ST‐segment elevation myocardial infarction (NSTEMI). Background The non‐hyperemic pressure ratio (NHPR) and the angiography‐based indexes have been developed to overcome the...

article

Epidemiological and ES cell‐based functional evaluation of BRCA2 variants identified in families with breast cancer

Teresa Sullivan, Eswary Thirthagiri, Chan‐Eng Chong, Stacey Stauffer, more

Human Mutation > 42 > 2 > 200 - 212

The discovery of high‐risk breast cancer susceptibility genes, such as Breast cancer associated gene 1 (BRCA1) and Breast cancer associated gene 2 (BRCA2) has led to accurate identification of individuals for risk management and targeted therapy. The rapid decline in sequencing costs has tremendously increased the number of individuals who are undergoing genetic testing world‐wide. However, given...

article

Digital planning workflow for partial maxillectomy using an osteotomy template and immediate rehabilitation of maxillary Brown II defects with prosthesis

Yang Wang, Xudong Yang, Ronglin Gan, Huifen Liu, more

Journal of Oral Rehabilitation > 46 > 12 > 1133 - 1141

Background There is increasing evidence of benefits for the rehabilitation of Brown II defects with prosthesis in surgery. However, the current literature is sparse for maxillary tumour resection using osteotomy templates. Objectives To assess the accuracy of maxillectomy using a custom fabricated osteotomy template and to evaluate the prosthesis for surgical accuracy, appearance and functioning...

article

Horizontal jumping biomechanics among elite female handball players with and without anterior cruciate ligament reconstruction: an ISU based study

Igor Setuain, Eder Bikandi, Francisco Antonio Amú Ruiz, Fernando Urtasun, more

BMC Sports Science, Medicine and Rehabilitation > 2019 > 11 > 1 > 1-9

Background Handball is a strenuous body-contact team sport that places high loads on the knee joint. Anterior cruciate ligament (ACL) tear is one of the most devastating injuries that any handball player can suffer, and female athletes are at particular risk due to their intrinsic anatomical, hormonal, neuromuscular and biomechanical characteristics. The purpose of this study was to analyze the horizontal...

article

Functional Evaluation Of Pedotransfer Functions For Simulation Of Soil Profile Drainage

Fatemeh Zakizadeh Abkenar, Ali Rasoulzadeh

Irrigation and Drainage > 68 > 3 > 573 - 587

Direct measurement of soil hydraulic properties is time consuming and costly. Therefore indirect methods, such as pedotransfer functions (PTFs), may provide an alternative. Some PTFs have been incorporated into stand‐alone computer programs like Rosetta and Soilpar, which are used in this study. The aim of this study was to compare different PTFs to use for modelling soil free drainage at three different...

article

Abstract need to be edited – Evaluation of functional discomfort in the thoracic outlet syndrome (TOS): A self-questionnaire

H. Quentin, V. Wieczorek, M. Wypych, A. Thevenon

Annals of Physical and Rehabilitation Medicine > 2018 > 61 > S > e145-e146

The compression of vascular and nerve structures for the upper limbs is the origin of TOS. If the clinical forms are variable (arterial, venous, neurological form), the functional discomfort in the activities of the daily life can be serious. Global scales (EN, DASH, CBSQ) can be used to evaluate the functional impact, but this evaluation is nonspecific. A specific scale was built and used during...

article

Assessment tools for functional independence and residual disability after stroke: Are they comparable?

Y.H. Kim, S.Y. Lee, M.K. Sohn, J. Lee, more

Annals of Physical and Rehabilitation Medicine > 2018 > 61 > S > e199-e200

The aim of this study was to investigate the correlations between the modified Rankin Scale (mRS) grades and Korean versions of the MBI (K-MBI) scores in assessing the residual functional status of stroke survivors.The Korean versions of the MBI and mRS scales were administered to 5759 ischemic stroke patients at 3 months after onset of stroke. The sensitivity and specificity were calculated at all...

article

Reproducibility analysis of upper limbs reachable workspace, and effects of acquisition protocol, sex and hand dominancy

Julien Clément, Maxime Raison, Dominique M. Rouleau

Journal of Biomechanics > 2018 > 68 > C > 58-64

None of the physical testing, nor the goniometers currently used to assess upper limb function have a high validity, sensitivity or reliability. The reachable workspace, i.e. the area covered by the farthest points a subject can reach by hand without moving his/her body, shows promise but has yet to be validated, particularly in terms of reproducibility. Therefore, this study aims to evaluate the...

article

Sprint mechanics return to competition follow-up after hamstring injury on a professional soccer player: A case study with an inertial sensor unit based methodological approach

Igor Setuain, Pablo Lecumberri, Mikel Izquierdo

Journal of Biomechanics > 2017 > 63 > C > 186-191

Background: The present research aimed to describe an inertial unit (IU)-based sprint mechanics evaluation model for assessing players’ readiness to return to competition after suffering a grade I hamstring injury. Methods: A professional male football player (age 19years; height 177cm; weight 70kg, midfielder, Spanish, 3° Division) with a grade 1 biceps femoris injury was evaluated at pre-season,...

article

Using game authoring platforms to develop screen-based simulated functional assessments in persons with executive dysfunction following traumatic brain injury

David Martínez-Pernía, Javier Núñez-Huasaf, Ángel del Blanco, Amparo Ruiz-Tagle, more

Journal of Biomedical Informatics > 2017 > 74 > C > 71-84

The assessment of functional status is a critical component of clinical neuropsychological evaluations used for both diagnostic and therapeutic purposes in patients with cognitive brain disorders. There are, however, no widely adopted neuropsychological tests that are both ecologically valid and easily administered in daily clinical practice. This discrepancy is a roadblock to the widespread adoption...

article

Three dimensional motion capture applied to violin playing: A study on feasibility and characterization of the motor strategy

Andrea Ancillao, Bernardo Savastano, Manuela Galli, Giorgio Albertini

Computer Methods and Programs in Biomedicine > 2017 > 149 > C > 19-27

Playing string instruments requires advanced motor skills and a long training that is often spent in uncomfortable postures that may lead to injuries or musculoskeletal disorders. Thus, it is interesting to objectively characterize the motor strategy adopted by the players. In this work, we implemented a method for the quantitative analysis of the motor performance of a violin player. The proposed...

article

Suitability of functional evaluation embedded in serious game rehabilitation exercises to assess motor development across lifespan

B. Bonnechère, V. Sholukha, L. Omelina, M. Van Vooren, more

Gait & Posture > 2017 > 57 > C > 35-39

The aim of this study was to determine if the results of activities performed using specially developed serious games for physical rehabilitation could be used as an indicator of the natural maturation and decline of motor control in healthy participants. Eighty-one participants (19 children (5–15 years old), 40 adults (18–65 years old) and 22 aged subjects (60–88 years old) participated in this study...

article

Absolute iron deficiency without anaemia in patients with chronic systolic heart failure is associated with poorer functional capacity

Joffrey Pozzo, Pauline Fournier, Clément Delmas, Paul-Louis Vervueren, more

Archives of Cardiovascular Diseases > 2017 > 110 > 2 > 99-105

Functional status is one of the main concerns in the management of heart failure (HF). Recently, the FAIR-HF and CONFIRM-HF trials showed that correcting anaemia using intravenous iron supplementation improved functional variables in patients with absolute or relative iron deficiency. Relative iron deficiency is supposed to be a marker of HF severity, as ferritin concentration increases with advanced...

article

Analysis of the impact of climate factors on the level of mechanical parameters of selected packaging films used for food products

A. Cholewa-Wojcik

Polish Journal of Natural Sciences > 2017 > 32 > 1

Plastic films are of key importance as a group of materials used for packaging food products. It is therefore crucial that they meet specific functional and durability requirements as well as comply with all regulations regarding food contact materials. A degree to which a set of properties of these materials satisfies the requirements connected with their usage determines their functional value....

chapter

Protective Effects of Hydrogen on Fetal Brain Injury During Maternal Hypoxia

Wenwu Liu, Oumei Chen, Chunhua Chen, Bihua Wu, more

Acta Neurochirurgica Supplements > Intracerebral Hemorrhage Research > Experimental Treatment for Cerebral Hemorrhage > 307-311

This study aimed to investigate the effects of hydrogen on fetal brain injury during maternal hypoxia. Pregnant rats (n = 12, at gestational day 17) were randomly assigned into three groups; air, hypoxia, and hypoxia plus hydrogen groups were put into a chamber and flushed with room air (21% O₂ and 79% N₂), hypoxia (8% O₂ and 92% N₂), and hypoxia with hydrogen mixture (2% H₂, 8% O₂ and 90% N₂), respectively,...

article

Intra- and inter-rater reliability of the Modified Frenchay Scale to measure active upper limb function in hemiparetic patients

Marjolaine Baude, Valentina Mardale, Catherine-Marie Loche, Emilie Hutin, more

Annals of Physical and Rehabilitation Medicine > 2016 > 59 > S > e59-e60

The Modified Frenchay Scale (MFS) measures active upper limb function in hemiparesis based on a video review of 10 everyday living tasks, each rated on a 10-point visual analogic scale. Six tasks are bimanual and four are unimanual performed with the paretic hand. We measured intra- and inter-rater reliability of MFS in hemiparetic patients among trained raters.After a group training session consisting...

article

Translation and transcultural adaptation of the Hip Fracture Recovery Score assessment tool

Francisco Costa Neto, Márcio Bezerra Gadelha Lopes, Felipe Veras Pereira de Oliveira, Francisco Robson de Vasconcelos Alves, more

Revista Brasileira de Ortopedia (English Edition) > 2016 > 51 > 3 > 353-365

The Hip Function Recovery Score questionnaire is an instrument that was developed for evaluating the functional recovery of patients over 60 years of age who undergo surgical treatment due to hip fractures. The objective of this study was to make a thorough transcultural translation of this questionnaire, with adaptation to the individual and cultural traits of the Brazilian population.This translation...

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Search results

Target validation using human tissue: from gene expression to function

A novel nonlinear afterload for ex vivo heart evaluation: Porcine experimental results

A pilot study on Italian eventing prospective olympic horse riders physiological, anthropometrical, functional and asymmetry assessment

Comparison of quantitative flow ratio, Pd/Pa and diastolic hyperemia‐free ratio versus fractional flow reserve in non‐culprit lesion of patients with non ST‐segment elevation myocardial infarction

Epidemiological and ES cell‐based functional evaluation of BRCA2 variants identified in families with breast cancer

Digital planning workflow for partial maxillectomy using an osteotomy template and immediate rehabilitation of maxillary Brown II defects with prosthesis

Horizontal jumping biomechanics among elite female handball players with and without anterior cruciate ligament reconstruction: an ISU based study

Functional Evaluation Of Pedotransfer Functions For Simulation Of Soil Profile Drainage

Abstract need to be edited – Evaluation of functional discomfort in the thoracic outlet syndrome (TOS): A self-questionnaire

Assessment tools for functional independence and residual disability after stroke: Are they comparable?

Reproducibility analysis of upper limbs reachable workspace, and effects of acquisition protocol, sex and hand dominancy

Sprint mechanics return to competition follow-up after hamstring injury on a professional soccer player: A case study with an inertial sensor unit based methodological approach

Using game authoring platforms to develop screen-based simulated functional assessments in persons with executive dysfunction following traumatic brain injury

Three dimensional motion capture applied to violin playing: A study on feasibility and characterization of the motor strategy

Suitability of functional evaluation embedded in serious game rehabilitation exercises to assess motor development across lifespan

Absolute iron deficiency without anaemia in patients with chronic systolic heart failure is associated with poorer functional capacity

Analysis of the impact of climate factors on the level of mechanical parameters of selected packaging films used for food products

Protective Effects of Hydrogen on Fetal Brain Injury During Maternal Hypoxia

Intra- and inter-rater reliability of the Modified Frenchay Scale to measure active upper limb function in hemiparetic patients

Translation and transcultural adaptation of the Hip Fracture Recovery Score assessment tool

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