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article

Improved detection of Zika virus RNA in human and animal specimens by a novel, highly sensitive and specific real‐time RT‐PCR assay targeting the 5′‐untranslated region of Zika virus

Jasper Fuk‐Woo Chan, Cyril Chik‐Yan Yip, Kah‐Meng Tee, Zheng Zhu, more

Tropical Medicine & International Health > 22 > 5 > 594 - 603

Objective and Method We developed and evaluated five novel real‐time RT‐PCR assays targeting conserved regions in the 5′‐untranslated region (5′‐UTR), envelope (E'), non‐structural protein 2A (NS2A), NS5 and 3′‐UTR of the ZIKV genome. Results The ZIKV‐5′‐UTR assay exhibited the lowest in vitro limit of detection (5–10 RNA copies/reaction and 3.0 × 10⁻¹ plaque‐forming units/ml). Compared to the...

article

Digital detection of biomarkers assisted by nanoparticles: application to diagnostics

Marina Cretich, George G. Daaboul, Laura Sola, M. Selim Ünlü, more

Trends in Biotechnology > 2015 > 33 > 6 > 343-351

Single-molecule detection and counting is the new frontier in biomarker analysis. Here, we report on recent techniques for the digital detection of biomolecules for clinical application. First we highlight methods based on the immunocapture of proteins onto microparticles, followed by isolation of individual particles in microenvironments so that a sufficient signal is acquired for each binding event...

article

The impact of next generation sequencing technologies on haematological research – A review

Jessica S. Black, Manuel Salto-Tellez, Ken I. Mills, Mark A. Catherwood, more

Pathogenesis > 2015 > 2 > 1-2 > 9-16

Next-generation sequencing (NGS) technologies have begun to revolutionize the field of haematological malignancies through the assessment of a patient's genetic makeup with a minimal cost. Significant discoveries have already provided a unique insight into disease initiation, risk stratification and therapeutic intervention. Sequencing analysis will likely form part of the routine diagnostic testing...

article

Eliciting patients' preferences for epilepsy diagnostics: A discrete choice experiment

B.F.M. Wijnen, R.J.A. de Kinderen, A.J. Colon, C.D. Dirksen, more

Epilepsy & Behavior > 2014 > 31 > Complete > 102-109

Background: Diagnosing epilepsy is a lengthy and burdensome process for patients and their family. Although the need for a more patient-centered approach in clinical practice is widely acknowledged, empirical evidence regarding patient preferences for diagnostic modalities in epilepsy is missing. The objectives of this study were 1) to identify to what extent important attributes of diagnostic procedures...

article

Microchip-based detection of magnetically labeled cancer biomarkers

Melaku Muluneh, David Issadore, M. Muluneh, D. Issadore

Advanced Drug Delivery Reviews > 2014 > 66 > Complete > 101-109

Micro-magnetic sensing and actuation have emerged as powerful tools for the diagnosis and monitoring of cancer. These technologies can be miniaturized and integrated onto compact, microfluidic platforms, enabling molecular diagnostics to be performed in practical clinical settings. Molecular targets tagged with magnetic nanoparticles can be detected with high sensitivity directly in unprocessed clinical...

article

Model for blade diagnosis in a working rotor machine employing the method of virtual elimination of stochastic environment

Lindstedt, Paweł, Grądzki, Rafał, Lindstedt, Paweł, Grądzki, Rafał

Archive of Mechanical Engineering > 2011 > 58 > 3

article

Dynamic model of axial piston swash-plate pump for diagnostics of wear in elements

Łatas, Waldemar, Stojek, Jerzy, Łatas, Waldemar, Stojek, Jerzy

Archive of Mechanical Engineering > 2011 > 58 > 2

article

Strongly Diagnosable Systems under the Comparison Diagnosis Model

Sun-Yuan Hsieh, Yu-Shu Chen

IEEE Transactions on Computers > 2008 > 57 > 12 > 1720 - 1725

A system is t-diagnosable if all faulty nodes can be identified without replacement when the number of faults does not exceed t, where t is some positive integer. Furthermore, a system is strongly t-diagnosable if it is t-diagnosable and can achieve (t+1)-diagnosable except for the case where a node's neighbors are all faulty. In this paper, we propose some conditions for verifying whether a class...

article

Introduction to the Diagnostics in Periodontology and Implant Dentistry issue

Denis F. Kinane, Michael M. Bornstein

Periodontology 02000 > 95 > 1 > 7 - 9

Chronic inflammatory periodontal disease and its related condition, peri‐implant disease, are highly prevalent globally and require accurate and speedy diagnosis. The focus of this volume dedicated to diagnostics is to cover modern enhancements in accuracy, simplicity and speed. An international assortment of experts has been tasked with reviewing defined areas of current best practice as well innovation...

article

A Highly Stretchable, Conductive, and Transparent Bioadhesive Hydrogel as a Flexible Sensor for Enhanced Real‐Time Human Health Monitoring

Arpita Roy, Shea Zenker, Saumya Jain, Ronak Afshari, more

Advanced Materials > 36 > 35 > n/a - n/a

Real‐time continuous monitoring of non‐cognitive markers is crucial for the early detection and management of chronic conditions. Current diagnostic methods are often invasive and not suitable for at‐home monitoring. An elastic, adhesive, and biodegradable hydrogel‐based wearable sensor with superior accuracy and durability for monitoring real‐time human health is developed. Employing a supramolecular...

article

IL‐1β/DNA complex elevation distinguishes autoinflammatory disorders from autoimmune and infectious diseases

Anastasia‐Maria Natsi, Efstratios Gavriilidis, Christina Antoniadou, Evangelos Papadimitriou, more

Journal of Internal Medicine > 296 > 3 > 298 - 301

article

Damage Investigation of a Stork Wärtsilä 6SW280 Engine Valve Exhaust – A Case Study

Michał Kawiak, Sławomir Krajewski, Kamil Urbanowicz

Advances in Science and Technology. Research Journal > 2024 > Vol. 18, no 4 > 42--54

The loss of steerage in maritime vessels often stems from main engine failures, as expounded in the present article. The focal incident involves a cascading engine breakdown initiated by a single exhaust valve fault. Subsequent consequences encompass the fragmentation of the second exhaust valve, structural damage to the engine components, including the head and piston, cracking of valve seats, and...

article

Towards a better future for DNA barcoding: Evaluating monophyly‐ and distance‐based species identification using COI gene fragments of Dacini fruit flies

Camiel Doorenweerd, Michael San Jose, Luc Leblanc, Norman Barr, more

Molecular Ecology Resources > 24 > 6 > n/a - n/a

The utility of a universal DNA ‘barcode’ fragment (658 base pairs of the Cytochrome C Oxidase I [COI] gene) has been established as a useful tool for species identification, and widely criticized as one for understanding the evolutionary history of a group. Large amounts of COI sequence data have been produced that hold promise for rapid species identification, for example, for biosecurity. The fruit...

article

Reconsidering red blood cells as the diagnostic potential for neurodegenerative disorders

Somu Yadav, Deepika, Kareena Moar, Akshay Kumar, more

Biology of the Cell > 116 > 7 > n/a - n/a

Background Red blood cells (RBCs) are usually considered simple cells and transporters of gases to tissues. Hypothesis However, recent research has suggested that RBCs may have diagnostic potential in major neurodegenerative disorders (NDDs). Results This review summarizes the current knowledge on changes in RBC in Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and other...

article

Understanding bacterial pathogen diversity: A proteogenomic analysis and use of an array of genome assemblies to identify novel virulence factors of the honey bee bacterial pathogen Paenibacillus larvae

Tomas Erban, Bruno Sopko

PROTEOMICS > 24 > 14 > n/a - n/a

Mass spectrometry proteomics data are typically evaluated against publicly available annotated sequences, but the proteogenomics approach is a useful alternative. A single genome is commonly utilized in custom proteomic and proteogenomic data analysis. We pose the question of whether utilizing numerous different genome assemblies in a search database would be beneficial. We reanalyzed raw data from...

article

Diagnostic, Therapeutic, and Theranostic Multifunctional Microneedles

Yavuz Nuri Ertas, Derya Ertas, Ahmet Erdem, Farouk Segujja, more

Small > 20 > 26 > n/a - n/a

Microneedles (MNs) have maintained their popularity in therapeutic and diagnostic medical applications throughout the past decade. MNs are originally designed to gently puncture the stratum corneum layer of the skin and have lately evolved into intelligent devices with functions including bodily fluid extraction, biosensing, and drug administration. MNs offer limited invasiveness, ease of application,...

article

Diagnostic methods/parameters to monitor peri‐implant conditions

Alberto Monje, Giovanni E. Salvi

Periodontology 02000 > 95 > 1 > 20 - 39

The diagnostic accuracy of clinical parameters, including visual inspection and probing to monitor peri‐implant conditions, has been regarded with skepticism. Scientific evidence pointed out that primary diagnostic tools (chairside) seem to be highly specific, while their sensitivity is lower compared with their use in monitoring periodontal stability. Nonetheless, given the association between pocket...

article

Deciphering dermatological distinctions: Cornulin as a discriminant biomarker between basal cell carcinoma and squamous cell carcinoma detected through e‐biopsy and machine learning

Edward Vitkin, Julia Wise, Ariel Berl, Ofir Shir‐az, more

Experimental Dermatology > 33 > 6 > n/a - n/a

Clinical misdiagnosis between cutaneous squamous cell carcinoma (cSCC) and basal cell carcinoma (BCC) poses treatment challenges and carries risks of recurrence, metastases and increased morbidity and mortality. We aimed to identify discriminant proteins markers for cSCC and BCC using a minimally invasive proteome sampling method called e‐biopsy, employing electroporation for non‐thermal cell permeabilization...

article

Performance of the clarus Aspergillus galactomannan enzyme immunoassay prototype for the diagnosis of invasive pulmonary aspergillosis in serum

Johannes Boyer, Sarah Sedik, Matthias Egger, Karl Dichtl, more

Mycoses > 67 > 6 > n/a - n/a

Background Serum galactomannan (GM) testing is essential for diagnosing invasive aspergillosis (IA), particularly in immunocompromised individuals. The global lack of on‐site GM testing capacities necessitates cost‐effective alternatives, such as .the clarus Aspergillus GM enzyme immunoassay prototype (clarus AGM prototype). Methods This single‐centre, cross‐sectional study compared the diagnostic...

article

Microbial diagnostics in periodontal diseases

Daniel Manoil, Ana Parga, Nagihan Bostanci, Georgios N. Belibasakis

Periodontology 02000 > 95 > 1 > 176 - 193

Microbial analytical methods have been instrumental in elucidating the complex microbial etiology of periodontal diseases, by shaping our understanding of subgingival community dynamics. Certain pathobionts can orchestrate the establishment of dysbiotic communities that can subvert the host immune system, triggering inflammation and tissue destruction. Yet, diagnosis and management of periodontal...

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Search results

Improved detection of Zika virus RNA in human and animal specimens by a novel, highly sensitive and specific real‐time RT‐PCR assay targeting the 5′‐untranslated region of Zika virus

Digital detection of biomarkers assisted by nanoparticles: application to diagnostics

The impact of next generation sequencing technologies on haematological research – A review

Eliciting patients' preferences for epilepsy diagnostics: A discrete choice experiment

Microchip-based detection of magnetically labeled cancer biomarkers

Model for blade diagnosis in a working rotor machine employing the method of virtual elimination of stochastic environment

Dynamic model of axial piston swash-plate pump for diagnostics of wear in elements

Strongly Diagnosable Systems under the Comparison Diagnosis Model

Introduction to the Diagnostics in Periodontology and Implant Dentistry issue

A Highly Stretchable, Conductive, and Transparent Bioadhesive Hydrogel as a Flexible Sensor for Enhanced Real‐Time Human Health Monitoring

IL‐1β/DNA complex elevation distinguishes autoinflammatory disorders from autoimmune and infectious diseases

Damage Investigation of a Stork Wärtsilä 6SW280 Engine Valve Exhaust – A Case Study

Towards a better future for DNA barcoding: Evaluating monophyly‐ and distance‐based species identification using COI gene fragments of Dacini fruit flies

Reconsidering red blood cells as the diagnostic potential for neurodegenerative disorders

Understanding bacterial pathogen diversity: A proteogenomic analysis and use of an array of genome assemblies to identify novel virulence factors of the honey bee bacterial pathogen Paenibacillus larvae

Diagnostic, Therapeutic, and Theranostic Multifunctional Microneedles

Diagnostic methods/parameters to monitor peri‐implant conditions

Deciphering dermatological distinctions: Cornulin as a discriminant biomarker between basal cell carcinoma and squamous cell carcinoma detected through e‐biopsy and machine learning

Performance of the clarus Aspergillus galactomannan enzyme immunoassay prototype for the diagnosis of invasive pulmonary aspergillosis in serum

Microbial diagnostics in periodontal diseases

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