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Items from 1 to 20 out of 39 results

article

Pathology of explanted pediatric hearts: An 11‐year study. Population characteristics and implications for outcomes

Takato Yamasaki, Stephen P. Sanders, Robyn J. Hylind, Caitlin Milligan, more

Pediatric Transplantation > 28 > 4 > n/a - n/a

Background As more pediatric patients become candidates for heart transplantation (HT), understanding pathological predictors of outcome and the accuracy of the pretransplantation evaluation are important to optimize utilization of scarce donor organs and improve outcomes. The authors aimed to investigate explanted heart specimens to identify pathologic predictors that may affect cardiac allograft...

article

Sudden Cardiac Deaths in Adults with Congenital Heart Disease with Structural Abnormalities: A Retrospective Review of Cases in the Cook County Medical Examiner's Office

Lorenzo Gitto, Serenella Serinelli, Ponni Arunkumar, Steven M. White

Journal of Forensic Sciences > 65 > 1 > 117 - 127

Sudden cardiac death is a significant cause of mortality in adults with congenital heart disease (CHD). The Cook County Medical Examiner's Office database was queried for cases of CHD as a cause of death in the period between July 2008 and April 2019. Twenty‐two cases were identified, including 11 decedents with simple defects and 10 decedents with complex defects. All of the subjects were in apparent...

article

Cardiac morphology for the millennial cardiology fellow: Nomenclature and advances in morphologic imaging

Shankar Baskar, Seth B. Gray, Erica L. Del Grippo, Onyekachukwu Osakwe, more

Congenital Heart Disease > 13 > 5 > 808 - 810

Cardiology fellows‐in‐training, both in adult and pediatric hospitals, need structured education in regards to congenital heart disease (CHD) nomenclature. With improved survival of patients with CHD, it is not uncommon for these patients to seek care in multiple adult and pediatric hospitals. A deep understanding of CHD nomenclature would aid in providing accurate medical and surgical care for these...

article

Surgical repair of partial anomalous pulmonary venous return with intact atrial septum in a 65-year-old woman: a case report

Narihiro Ishida, Katsuya Shimabukuro, Shojiro Yamaguchi, Etsuji Umeda, more

Journal of Medical Case Reports > 2018 > 12 > 1 > 1-4

Background Partial anomalous pulmonary venous return is a rare congenital cardiac anomaly that usually involves the right pulmonary vein and an atrial septal defect. Isolated partial anomalous pulmonary venous return with an intact atrial septum is even rarer, and this condition is usually treated surgically in younger patients. We describe isolated partial anomalous pulmonary venous return in a 65-year-old...

article

Refractory ventricular tachycardia caused by inflow cannula mechanical injury in a patient with left ventricular assist device: Catheter ablation and pathological findings

Stefano Pedretti, Manlio Cipriani, Edgardo Bonacina, Sara Vargiu, more

Journal of Arrhythmia > 2017 > 33 > 5 > 494-496

In patients with left ventricular assist device (LVAD), a minority of post-operative ventricular tachycardias (VTs) is caused by contact between the inflow cannula and the endocardium. Currently, electrophysiologic characteristics and pathologic features of this condition are lacking. We report on a case of a successfully ablated mechanical VT. After VT recurrence, heart transplantation took place...

article

Melatonin: Protection against age-related cardiac pathology

Gaia Favero, Lorenzo Franceschetti, Barbara Buffoli, Mohammed H. Moghadasian, more

Ageing Research Reviews > 2017 > 35 > C > 336-349

Aging is a complex and progressive process that involves physiological and metabolic deterioration in every organ and system. Cardiovascular diseases are one of the most common causes of mortality and morbidity among elderly subjects worldwide. Most age-related cardiovascular disorders can be influenced by modifiable behaviours such as a healthy diet rich in fruit and vegetables, avoidance of smoking,...

article

Cardiac pathology in spinal muscular atrophy: a systematic review

C. A. Wijngaarde, A. C. Blank, M. Stam, R. I. Wadman, more

Orphanet Journal of Rare Diseases > 2017 > 12 > 1 > 1-10

Background Hereditary proximal spinal muscular atrophy (SMA) is a severe neuromuscular disease of childhood caused by homozygous loss of function of the survival motor neuron (SMN) 1 gene. The presence of a second, nearly identical SMN gene (SMN2) in the human genome ensures production of residual levels of the ubiquitously expressed SMN protein. Alpha-motor neurons in the ventral horns of the spinal...

article

Eosinophilic endomyocardial disease

Victor Y Liu, Raymundo A Quintana-Quezada, L Maximilian Buja

Cardiovascular Pathology > 2017 > 27 > C > 54-56

Eosinophilic granulomatosis with polyangiitis is the rarest of the antineutrophil cytoplasmic antibody-associated vasculitides. We describe the case of a 58-year-old woman with a history of asthma found to have a left ventricular apical thrombus. Cardiac catheterization with endomyocardial biopsy was consistent with eosinophilic endomyocardial disease. The disease affects several organ systems and...

article

Strenuous Exercise and Cardiovascular Disease Outcomes

Jonathan H. Kim, Aaron L. Baggish

Current Atherosclerosis Reports > 2017 > 19 > 1 > 1-8

Purpose of Review This review summarizes several issues at the forefront of recent controversies involving the appropriate exercise dose including epidemiologic data describing mortality trends in those who engage in high levels of physical activity and recent observational data suggesting adverse cardiovascular outcomes among long-term endurance athletes. Recent Findings The benefits of habitual...

article

Physical Activity, Endurance Exercise, and Excess—Can One Overdose?

Jonathan H. Kim, Aaron L. Baggish

Current Treatment Options in Cardiovascular Medicine > 2016 > 18 > 11 > 1-13

Opinion statement Although moderate levels of exercise reduce cardiovascular morbidity and mortality in the general population, recent data have questioned whether higher doses of physical activity are associated with diminished health benefits and adverse outcomes. This review focuses on several issues at the center of this controversy including epidemiologic data describing mortality trends in those...

article

Cardiovascular safety risk assessment for new candidate drugs from functional and pathological data: Conference report

Stephanie K. Klein, Will S. Redfern

Journal of Pharmacological and Toxicological Methods > 2015 > 76 > Complete > 1-6

This is a report on a 2-day joint meeting between the British Society of Toxicological Pathology (BSTP) and the Safety Pharmacology Society (SPS) held in the UK in November 2013. Drug induced adverse effects on the cardiovascular system are associated with the attrition of more marketed and candidate drugs than any other safety issue. The objectives of this meeting were to foster inter-disciplinary...

article

Transgenic over-expression of YY1 induces pathologic cardiac hypertrophy in a sex-specific manner

Brian L. Stauffer, Karen Dockstader, Gloria Russell, Jamie Hijmans, more

Biochemical and Biophysical Research Communications > 2015 > 462 > 2 > 131-137

YY1 can activate or repress transcription of various genes. In cardiac myocytes in culture YY1 has been shown to regulate expression of several genes involved in myocyte pathology. YY1 can also acutely protect the heart against detrimental changes in gene expression. In this study we show that cardiac over-expression of YY1 induces pathologic cardiac hypertrophy in male mice, measured by changes in...

chapter

Post‐Processing and Analysis of Dynamic Magnetic Resonance Images for Myocardial Perfusion Quantification

Bruno Neyran, Magalie Viallon

Multi‐Modality Cardiac Imaging > 103 - 139

This chapter details the methods allowing the modeling of signal variations observed in dynamic series of magnetic resonance imaging (MRI) and allowing a quantitative analysis of the perfusion. The quantification of myocardial perfusion and perfusion reserve, aims to improve the premature clinical diagnosis of cardiac pathologies and the longitudinal follow‐up of patients. The conversion of the MRI...

article

Primary cardiac tumors: 32 years of experience from a Spanish tertiary surgical center

Manuel Barreiro, Alfredo Renilla, Jaime M. Jimenez, María Martin, more

Cardiovascular Pathology > 2013 > 22 > 6 > 424-427

Primary cardiac tumors are rare entities with an autopsy frequency ranging between 0.001% and 0.3%. Our objective was to review 32 years of experience from a Spanish tertiary surgical center.We collected data on 73 patients with a histopathological diagnosis of a primary cardiac tumor in a retrospective analysis from 1979 to 2012. Tissue samples were obtained either at surgery or from necropsy and...

article

A model for cardiomyocyte cell death: Insights into mechanisms of oncosis

Priya Weerasinghe, Sarathi Hallock, Robert E. Brown, David S. Loose, more

Experimental and Molecular Pathology > 2013 > 94 > 1 > 289-300

It is now known that there are at least two basic patterns of cell injury progressing to cell death: cell injury with swelling, known as oncosis, and cell injury with shrinkage, known as apoptosis. Both types of cell death are “programmed” in the sense that the genetic information and many of the enzymes and other factors pre-exist in the cell. Previous investigation has pointed to cardiomyocyte ischemic...

article

Oncosis: An important non-apoptotic mode of cell death

Priya Weerasinghe, L. Maximilian Buja

Experimental and Molecular Pathology > 2012 > 93 > 3 > 302-308

It is now increasingly accepted that apoptosis may not be the only form of cell death seen in vitro and in vivo; hence there is a need to study novel forms of cell death. The explosion of cell death research that followed the recognition of apoptosis by Kerr and colleagues in the late 1960s completely obscured the fact that apoptosis is not the only form of cell death. Apoptosis manifests itself by...

article

Mixed self-assembled monolayer (mSAM) based impedimetric immunosensors for cardiac troponin I (cTnI) and soluble lectin-like oxidized low-density lipoprotein receptor-1 (sLOX-1)

Md. Morsaline Billah, Henry C.W. Hays, Christopher S. Hodges, Sreenivasan Ponnambalam, more

Sensors & Actuators: B. Chemical > 2012 > 173 > Complete > 361-366

Immunosensors depend on the specificity of the molecular recognition towards analytes of interest provided by the antibodies. In this study, electrochemical impedance spectroscopy (EIS) was used to monitor the sensor surface assembly and recognition of two different analytes of cardiac pathology, cardiac troponin I (cTnI) and soluble lectin-like oxidized LDL receptor-1 (sLOX-1) on surfaces based on...

article

Syncope in the Athletic Patient

Jeffrey L. Hastings, Benjamin D. Levine

Progress in Cardiovascular Diseases > 2012 > 54 > 5 > 438-444

Syncope is a common but concerning event in athletic patients. As such, efforts must be made to distinguish presyncope from syncope with a critical distinction of syncope during exercise and postexercise syncope. Syncope most often occurs just after exercise and is usually benign; however, syncope during exercise may be a sign of pathologic structural or electrical cardiac issues. Solving this diagnostic...

article

Exercise-Induced Cardiac Injury: Evidence From Novel Imaging Techniques and Highly Sensitive Cardiac Troponin Assays

Rob Shave, David Oxborough

Progress in Cardiovascular Diseases > 2012 > 54 > 5 > 407-415

Prolonged endurance exercise in humans has been associated with an acute impairment in diastolic and systolic cardiac function and the release of cardiac troponin. In this chapter, we review recent evidence from studies using novel echocardiographic parameters and highly sensitive cardiac troponin assays. We demonstrate that the mechanics of left and right ventricular functions are acutely impaired...

chapter

Auscultation based stethoscopic diagnostic device for cardiac murmur identification

D Kasun Prasanga, A H S Abeykoon, S Prasad, L Udawatta

2011 IEEE International Conference on Industrial Technology > 367 - 372

2011 IEEE International Conference on Industrial Technology (ICIT 2011)

In a healthy heart, there is no any abnormal blood flow takes place inside, in addition to the usual blood circulating pattern. However when the valves or tissues inside the heart are in diseased conditions, this usual blood flow pattern gets changed. As a result, abnormal sounds are produced with the normal heart beat sound. These abnormal sounds are known as cardiac murmurs. By identifying the murmur...

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Pathology of explanted pediatric hearts: An 11‐year study. Population characteristics and implications for outcomes

Sudden Cardiac Deaths in Adults with Congenital Heart Disease with Structural Abnormalities: A Retrospective Review of Cases in the Cook County Medical Examiner's Office

Cardiac morphology for the millennial cardiology fellow: Nomenclature and advances in morphologic imaging

Surgical repair of partial anomalous pulmonary venous return with intact atrial septum in a 65-year-old woman: a case report

Refractory ventricular tachycardia caused by inflow cannula mechanical injury in a patient with left ventricular assist device: Catheter ablation and pathological findings

Melatonin: Protection against age-related cardiac pathology

Cardiac pathology in spinal muscular atrophy: a systematic review

Eosinophilic endomyocardial disease

Strenuous Exercise and Cardiovascular Disease Outcomes

Physical Activity, Endurance Exercise, and Excess—Can One Overdose?

Cardiovascular safety risk assessment for new candidate drugs from functional and pathological data: Conference report

Transgenic over-expression of YY1 induces pathologic cardiac hypertrophy in a sex-specific manner

Post‐Processing and Analysis of Dynamic Magnetic Resonance Images for Myocardial Perfusion Quantification

Primary cardiac tumors: 32 years of experience from a Spanish tertiary surgical center

A model for cardiomyocyte cell death: Insights into mechanisms of oncosis

Oncosis: An important non-apoptotic mode of cell death

Mixed self-assembled monolayer (mSAM) based impedimetric immunosensors for cardiac troponin I (cTnI) and soluble lectin-like oxidized low-density lipoprotein receptor-1 (sLOX-1)

Syncope in the Athletic Patient

Exercise-Induced Cardiac Injury: Evidence From Novel Imaging Techniques and Highly Sensitive Cardiac Troponin Assays

Auscultation based stethoscopic diagnostic device for cardiac murmur identification

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