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Items from 1 to 20 out of 147 results

article

Time‐Sequential and Multi‐Functional 3D Printed MgO₂/PLGA Scaffold Developed as a Novel Biodegradable and Bioactive Bone Substitute for Challenging Postsurgical Osteosarcoma Treatment

Cairong Li, Wei Zhang, Yangyi Nie, Xiangfu Du, more

Advanced Materials > 36 > 34 > n/a - n/a

Osteosarcoma (OS) is the most commonly occurring primary bone malignant tumor. The clinical postsurgical OS treatment faces big challenges for the staged therapeutic requirements of early anti‐tumor, anti‐bacterial, and long‐lasting osteogenesis. Herein, multi‐functional bioactive scaffolds with time‐sequential functions of preventing tumor recurrence, inhibiting bacterial infection, and promoting...

article

Time‐Sequential and Multi‐Functional 3D Printed MgO₂/PLGA Scaffold Developed as a Novel Biodegradable and Bioactive Bone Substitute for Challenging Postsurgical Osteosarcoma Treatment (Adv. Mater. 34/2024)

Cairong Li, Wei Zhang, Yangyi Nie, Xiangfu Du, more

Advanced Materials > 36 > 34 > n/a - n/a

Novel Time‐Sequential and Multi‐Functional Bone Substitute A time‐sequential and multi‐functional MgO₂/PLGA scaffold fabricated by 3D printed can release H₂O₂ and Mg²⁺ in a coordinated manner during degradation. The early‐stage release of H₂O₂ displays anti‐tumor and antibacterial effects, while the sustained release of Mg²⁺ promotes long‐term bone repair. This multi‐functional scaffold showcases...

article

Synthesis of composite corn starch/hydroxyapatite nanoparticle biomembranes and their effect on mineralization by osteoblasts

Lucas Santos Silva, Maryanne Trafani Melo, Pedro Augusto Invernizzi Sponchiado, Fernando Barbosa Júnior, more

Journal of Applied Polymer Science > 140 > 43 > n/a - n/a

Bone defects and injuries are challenging issues in regenerative medicine. Guided bone regeneration (GBR) techniques use biomaterials as scaffolds to support the healing of damaged bone tissue. In this context, there is growing interest in developing new biomaterials with bioabsorbable and bioactive properties to increase GBR effectiveness. In this study, composite corn starch/hydroxyapatite nanoparticle...

article

Smart Trap‐Capture‐Kill Antibacterial System for Infected Microenvironment Improvement and Vascularized Bone Regeneration via Magnetic Thermotherapy

Yanan Zhao, Liangcong Hu, Honglian Dai, Pengzhen Zhuang, more

Advanced Functional Materials > 33 > 23 > n/a - n/a

Infected bone defect has gradually become a disastrous complication in orthopedic surgery because of the bacterial biofilm formation both on the surface of the implants and surrounding tissues, which will cause antibiotic resistance and weak postoperative osseointegration. Herein, drug‐loaded hollow mesoporous ferrite nanoparticles coated by gelatin (GM/HMFNs) with pomegranate structure are prepared...

article

Bioactive glass air‐abrasion promotes healing around contaminated implant surfaces surrounded by circumferential bone defects: An experimental study in the rat

Faleh Abushahba, Nagat Areid, Mervi Gürsoy, Jaana Willberg, more

Clinical Implant Dentistry and Related Research > 25 > 2 > 409 - 418

Objectives The present study aimed to evaluate the healing of experimentally induced bone defects around contaminated dental implants after air‐abrasion using 45S5 or zinc oxide (ZnO)‐containing bioactive glasses (BAGs). Materials and Methods One maxillary first molar was extracted from each Sprague–Dawley rat (n = 30). After 4‐week healing, a titanium implant was placed in the extraction site...

article

Pedicled Double‐Barrel Fibular Transplantation Versus Bone Transport in the Treatment of Upper Tibial Osteomyelitis with Bone Defects: A Retrospective Study

Qiang Huang, Yao Lu, Teng Ma, Qian Wang, more

Orthopaedic Surgery > 14 > 11 > 2888 - 2896

Objective This study aimed to compare the clinical effects of using pedicled double‐barrel fibular transplantation (PDBFT) and bone transport (BT) for the treatment of upper tibial osteomyelitis with bone defects. Methods A total of 83 patients with upper tibial osteomyelitis and bone defects were selected and retrospectively studied in Xi'an Hong Hui Hospital from January 2009 to January 2019...

article

3D‐Printed composite scaffolds based on poly(ε‐caprolactone) filled with poly(glutamic acid)‐modified cellulose nanocrystals for improved bone tissue regeneration

Ilia Averianov, Mariia Stepanova, Olga Solomakha, Iosif Gofman, more

Journal of Biomedical Materials Research Part B: Applied Biomaterials > 110 > 11 > 2422 - 2437

The manufacturing of modern scaffolds with customized geometry and personalization has become possible due to the three‐dimensional (3D) printing technique. A novel type of 3D‐printed scaffolds for bone tissue regeneration based on poly(ε‐caprolactone) (PCL) filled with nanocrystalline cellulose modified by poly(glutamic acid) (PGlu‐NCC) has been proposed in this study. The 3D printing set‐ups were...

article

Reconstruction for Massive Proximal Tibial Bone Defects Using Patient‐Customized Three‐Dimensional‐Printed Metaphyseal Cones in Revision Total Knee Arthroplasty

Yang Li, Xinguang Wang, Hua Tian

Orthopaedic Surgery > 14 > 6 > 1071 - 1077

Objective To review the clinical outcomes of revision total knee arthroplasty (RTKA) with massive proximal tibial bone defects using patient‐customized three‐dimensional (3D) printed highly porous metaphyseal cones. Methods A retrospective study of all patients at our institution who underwent RTKA with the Anderson Orthopaedic Research Institute type III tibial defects using patient‐customized...

article

Enhanced Bone Regeneration Using a ZIF‐8‐Loaded Fibrin Composite Scaffold

Wentao Shi, Lu Bian, Yiqing Wu, Zhe Wang, more

Macromolecular Bioscience > 22 > 3 > n/a - n/a

In the present study, fibrin‐based biomaterials made of zeolite imidazole framework‐8 (ZIF‐8) and fibrin gel (Z‐FG) are fabricated with the aim of enhancing skull regeneration. X‐ray diffraction (XRD), scanning electron microscopy (SEM), ultraviolet (UV)–vis spectrophotometry, Fourier transform infrared spectroscopy, and rheometry are used to characterize ZIF‐8 and Z‐FG. The influences of ZIF‐8 on...

article

The efficacy of immediate implant placement in the anterior maxilla with dehiscence in the facial alveolar bone: A case series

Keiichiro Mizuno, Tamaki Nakano, Takuya Shimomoto, Yuya Fujita, more

Clinical Implant Dentistry and Related Research > 24 > 1 > 72 - 82

Background There is no clear evidence that immediate implant placement can be applied to cases with dehiscence in the facial alveolar bone prior to extraction. Purpose To evaluate the results of immediate implant placement in the anterior maxilla with facial alveolar bone dehiscence. Materials and Methods We super positioned pre‐ and post‐operative cone‐beam computed tomography (CBCT) three‐dimensional...

article

The morphological variation of acetabular defects in revision total hip arthroplasty—A statistical shape modeling approach

Alexander Meynen, Georges Vles, Amir A. Zadpoor, Michiel Mulier, more

Journal of Orthopaedic Research® > 39 > 11 > 2419 - 2427

Classification and evaluation of acetabular defects remain challenging and are primarily based on qualitative classification methods. That is because quantitative techniques describing variations of acetabular defects and accompanying bone loss volume are not available. This study introduces a new method based on statistical shape models (SSMs) to quantitively describe acetabular defects. This method...

article

Characteristics and frequency distribution of bone defect configurations in peri‐implantitis lesions—A series of 193 cases

Christian Wehner, Kristina Bertl, Gerlinde Durstberger, Christoph Arnhart, more

Clinical Implant Dentistry and Related Research > 23 > 2 > 178 - 188

Background Knowledge on peri‐implantitis bone defect characteristics and predictors is still limited. Purpose To describe peri‐implantitis bone defect characteristics and identify possible predictors. Methods Various parameters at patient‐ (age, gender, smoking, and supra‐structure), implant‐ (surface, type, connection, platform, and misfit), and site level (region, alveolar ridge position, defect...

article

Rat bone healing induced by natural nanocrystalline carbonated hydroxyapatite in combination with human amniotic fluid stem cells (AFSCs)

Lucia Centurione, Andrea Pantalone, Francesco Marchegiani, Ivana Antonucci, more

Journal of Cellular Physiology > 236 > 4 > 2782 - 2789

The present study was aimed at identifying a new scaffold/stem cell combination useful to treat large bone defects. Human amniotic fluid stem cells (AFSCs) were expanded in vitro, labeled with a fluorescent cell‐permeable dye (PKH26) and transplanted in vivo in a femoral injured rat model. The femoral defect was left untreated (control rats) or filled with hydroxyapatite (HA; natural nanocrystalline...

article

Chronic suppurative otitis media with cholesteatoma and chronic otitis media with granulation investigated by scanning electron microscope based on an analysis of 140 patients

Agnieszka Wiatr, Katarzyna Job, Jacek Składzień, Maciej Wiatr

Polish Journal of Otolaryngology > 2021 > 75 > 3 > 21-27

Introduction: Chronic purulent cholesteatoma of the middle ear, as well as to a lesser extent chronic granulomatous otitis media, lead to destruction of bone structures within the middle ear space. The above process is controlled by the OPG/RANKL/RANK system. Aim: The aim of the study is a comparative analysis of surgical material obtained from patients with diagnosed chronić cholesteatoma and...

article

Cup‐Cage Solution for Massive Acetabular Defects: A Systematic Review and Meta‐Analysis

Chao‐xin Wang, Zi‐da Huang, Bai‐jian Wu, Wen‐bo Li, more

Orthopaedic Surgery > 12 > 3 > 701 - 707

Our systematic review compiled multiple studies and evaluated survivorship and clinical outcomes of cup‐cage construct usage in the management of massive acetabular bone defects. This systematic review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) guidelines. Various combinations of “acetabular”, “pelvis”, “cup cage” and their corresponding...

article

Accelerating bone defects healing in calvarial defect model using 3D cultured bone marrow‐derived mesenchymal stem cells on demineralized bone particle scaffold

Jin Woo Kim, Jong Ho Park, Thangavelu Muthukumar, Eun Yeong Shin, more

Journal of Tissue Engineering and Regenerative Medicine > 14 > 4 > 563 - 574

Bone defects are usually difficult to be regenerated due to pathological states or the size of the injury. Researchers are focusing on tissue engineering approaches in order to drive the regenerative events, using stem cells to regenerate bone. The purpose of this study is to evaluate the osteogenic differentiation of bone marrow‐derived mesenchymal stem cells (BMSCs) on biologically derived Gallus gallus domesticus...

article

Skeletal abnormalities are common features in Aymé‐Gripp syndrome

Marcello Niceta, Domenico Barbuti, Neerja Gupta, Carlos Ruggiero, more

Clinical Genetics > 97 > 2 > 362 - 369

Aymé‐Gripp syndrome (AYGRPS) is a recognizable condition caused by a restricted spectrum of dominantly acting missense mutations affecting the transcription factor MAF. Major clinical features of AYGRPS include congenital cataracts, sensorineural hearing loss, intellectual disability, and a distinctive flat facial appearance. Skeletal abnormalities have also been observed in affected individuals,...

article

Extreme bone lengthening by bone transport with a unifocal tibial corticotomy: a case report

Hongjie Wen, Huagang Yang, Yongqing Xu

BMC Musculoskeletal Disorders > 2019 > 20 > 1 > 1-9

Background Bone transport is used for the treatment of extensive limb bone defects. The application of ring or unilateral external fixators combined with single or double corticotomy are well documented; however, there are few cases adopting a single corticotomy to repair bone defects > 24 cm. Case presentation The present case study describes an 18-year-old male, who was involved in a traffic...

article

Revision total knee arthroplasty (TKA): mid-term outcomes and bone loss/quality evaluation and treatment

Federica Rosso, Umberto Cottino, Federico Dettoni, Matteo Bruzzone, more

Journal of Orthopaedic Surgery and Research > 2019 > 14 > 1 > 1-9

Background Revision total knee arthroplasty (rTKA) is a demanding procedure, with a high complication and failure rate and a high rate of bone losses and poor bone quality. Different classifications for bone losses have been proposed, but they do not consider bone quality, which may affect implant fixation. The aim of this study is to describe the outcomes of a consecutive series of rTKA. Furthermore,...

article

Histological and histomorphometric analysis of bone tissue after guided bone regeneration with non‐resorbable membranes vs resorbable membranes and titanium mesh

Alessandro Cucchi, Maria Sartori, Annapaola Parrilli, Nicolò N. Aldini, more

Clinical Implant Dentistry and Related Research > 21 > 4 > 693 - 701

Background Guided bone regeneration (GBR) allows to achieve vertical ridge augmentation whether with nonresorbable membranes or resorbable membranes with Ti‐mesh, but till now no studies are published comparing histological and histomorphometrical outcomes of these two procedures. Materials and Methods Forty partially edentulous patients required vertical bone regeneration to place implants in...

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Time‐Sequential and Multi‐Functional 3D Printed MgO₂/PLGA Scaffold Developed as a Novel Biodegradable and Bioactive Bone Substitute for Challenging Postsurgical Osteosarcoma Treatment

Time‐Sequential and Multi‐Functional 3D Printed MgO₂/PLGA Scaffold Developed as a Novel Biodegradable and Bioactive Bone Substitute for Challenging Postsurgical Osteosarcoma Treatment (Adv. Mater. 34/2024)

Synthesis of composite corn starch/hydroxyapatite nanoparticle biomembranes and their effect on mineralization by osteoblasts

Smart Trap‐Capture‐Kill Antibacterial System for Infected Microenvironment Improvement and Vascularized Bone Regeneration via Magnetic Thermotherapy

Bioactive glass air‐abrasion promotes healing around contaminated implant surfaces surrounded by circumferential bone defects: An experimental study in the rat

Pedicled Double‐Barrel Fibular Transplantation Versus Bone Transport in the Treatment of Upper Tibial Osteomyelitis with Bone Defects: A Retrospective Study

3D‐Printed composite scaffolds based on poly(ε‐caprolactone) filled with poly(glutamic acid)‐modified cellulose nanocrystals for improved bone tissue regeneration

Reconstruction for Massive Proximal Tibial Bone Defects Using Patient‐Customized Three‐Dimensional‐Printed Metaphyseal Cones in Revision Total Knee Arthroplasty

Enhanced Bone Regeneration Using a ZIF‐8‐Loaded Fibrin Composite Scaffold

The efficacy of immediate implant placement in the anterior maxilla with dehiscence in the facial alveolar bone: A case series

The morphological variation of acetabular defects in revision total hip arthroplasty—A statistical shape modeling approach

Characteristics and frequency distribution of bone defect configurations in peri‐implantitis lesions—A series of 193 cases

Rat bone healing induced by natural nanocrystalline carbonated hydroxyapatite in combination with human amniotic fluid stem cells (AFSCs)

Chronic suppurative otitis media with cholesteatoma and chronic otitis media with granulation investigated by scanning electron microscope based on an analysis of 140 patients

Cup‐Cage Solution for Massive Acetabular Defects: A Systematic Review and Meta‐Analysis

Accelerating bone defects healing in calvarial defect model using 3D cultured bone marrow‐derived mesenchymal stem cells on demineralized bone particle scaffold

Skeletal abnormalities are common features in Aymé‐Gripp syndrome

Extreme bone lengthening by bone transport with a unifocal tibial corticotomy: a case report

Revision total knee arthroplasty (TKA): mid-term outcomes and bone loss/quality evaluation and treatment

Histological and histomorphometric analysis of bone tissue after guided bone regeneration with non‐resorbable membranes vs resorbable membranes and titanium mesh

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