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article

Prognostic significance of YY1 protein expression and mRNA levels by bioinformatics analysis in human cancers: A therapeutic target

Benjamin Bonavida, Samantha Kaufhold, B. Bonavida, S. Kaufhold

Pharmacology and Therapeutics > 2015 > 150 > Complete > 149-168

Conventional therapeutic treatments for various cancers include chemotherapy, radiotherapy, hormonal therapy and immunotherapy. While such therapies have resulted in clinical responses, they were coupled with non-tumor specificity, toxicity and resistance in a large subset of the treated patients. During the last decade, novel approaches based on scientific knowledge on the biology of cancer were...

article

Salt‐like transcription factor 4 promotes laryngeal cancer progression through transcriptional activation of ubiquitin‐specific protease 21 to stabilize Yin Yang 1

Qing‐Dong Wang, Li‐Li Liu, Di Li, Li Gao, more

Pathology International > 73 > 3 > 109 - 119

Laryngeal cancer (LC) is a rare and challenging clinical problem. Our aim was to investigate the mechanism of salt‐like transcription factor 4 (SALL4) in LC. LC tissue and paracancerous tissue were collected. Relative mRNA or protein levels were measured by quantitative real‐time polymerase chain reaction or Western blot. MTT, wound healing, and transwell assay were performed to evaluate cell proliferation,...

article

LINC01608 activated by YY1 facilitate hepatocellular carcinoma progression by modulating the EGFR/ERK axis

Mengzhen Han, Furong Liu, Xinxin Li, Hongwei Zhang, more

Liver International > 43 > 2 > 471 - 489

Background Long non‐coding RNAs (LncRNAs) have been demonstrated to associate with a variety of cancers. However, the mechanisms of LncRNAs in hepatocellular carcinoma (HCC) progression are still not fully clarified. Methods LINC01608 expression level in HCC and adjacent normal tissues was detected by real‐time‐quantitively PCR (RT‐qPCR) in clinical samples and in situ hybridization (ISH) in tissue...

article

Astrocytic Yin Yang 1 is critical for murine brain development and protection against apoptosis, oxidative stress, and inflammation

Edward Pajarillo, Ivan Nyarko‐Danquah, Alexis Digman, Cynthia Vied, more

Glia > 71 > 2 > 450 - 466

The transcription factor Yin Yang 1 (YY1) is ubiquitously expressed in mammalian cells, regulating the expression of a variety of genes involved in proliferation, differentiation, and apoptosis in a context‐dependent manner. While it is well‐established that global YY1 knockout (KO) leads to embryonic death in mice and that YY1 deletion in neurons or oligodendrocytes induces impaired brain function,...

article

microRNA‐497‐mediated Smurf2/YY1/HIF2α axis in tumor growth and metastasis of esophageal squamous cell carcinoma

Weijun Deng, Wei Fan, Peng Li, Juan Yao, more

Journal of Biochemical and Molecular Toxicology > 36 > 11 > n/a - n/a

Aberrant expression of microRNA‐497 (miR‐497) is associated with tumor progression, but the molecular mechanisms in tumorigenesis remain largely unknown. Here, we report that miR‐497 expression is downregulated in esophageal squamous cell carcinoma (ESCC) clinical samples. Consistently, upregulation of miR‐497 inhibits ESCC cell malignant properties and tumor growth in vivo. Importantly, we uncovered...

article

Transcription factor YY1 contributes to human melanoma cell growth through modulating the p53 signalling pathway

Shumin Zhou, Pin Li, Li Qin, Shuhong Huang, more

Experimental Dermatology > 31 > 10 > 1563 - 1578

Melanoma has a higher mortality rate than any other skin cancer, and its cases are increasing. The transcription factor YY1 has been proven to be involved in tumour progression; however, the role of YY1 in melanoma is not well understood. This study investigates how YY1 functions in melanoma progression, and it also elucidates the underlying mechanisms involved. We have found that in clinical human...

article

EWSR1::YY1 fusion positive peritoneal epithelioid mesothelioma harbors mesothelioma epigenetic signature: Report of 3 cases in support of an emerging entity

Josephine K. Dermawan, Dianne Torrence, Cheng‐Han Lee, Liliana Villafania, more

Genes, Chromosomes and Cancer > 61 > 10 > 592 - 602

Mesothelioma is a rare, aggressive malignant neoplasm of mesothelial origin. A small subset of peritoneal mesothelioma is driven by recurrent gene fusions, mostly EWSR1/FUS::ATF1 fusions, with predilection for young adults. To date, only two cases of mesothelioma harboring EWSR1::YY1 fusions have been described. We present three additional cases of EWSR1::YY1‐fused peritoneal mesotheliomas, two localized...

article

Mast cell‐derived exosomal miR‐181a‐5p modulated trophoblast cell viability, migration, and invasion via YY1/MMP‐9 axis

Yinfen Wang, Aner Chen

Journal of Clinical Laboratory Analysis > 36 > 7 > n/a - n/a

Background Mast cells regulate the process of preeclampsia (PE). Since we previously identified mast cells specifically expressing miR‐181a‐5p in the placenta of PE patients, it is plausible to examine the effect and mechanism of mast cell‐derived exosomal miR‐181a‐5p on trophoblast cells. Methods The miR‐181a‐5p and YY1 levels were determined by quantitative real‐time reverse transcription‐polymerase...

article

YY1: A New Gene for Childhood Onset Dystonia with Prominent Oromandibular‐Laryngeal Involvement?

Amy Ferng, Perla Thulin, Erin Walsh, Philip A. Weissbrod, more

Movement Disorders > 37 > 1 > 227 - 228

article

Clinical features of patients with Yin Yang 1 deficiency causing Gabriele‐de Vries syndrome: A new case and review of the literature

Hossein Jafari Khamirani, Sina Zoghi, Zahra Mehdipour Namdar, Neda Kamal, more

Annals of Human Genetics > 86 > 1 > 52 - 62

Background: Gabriele‐de Vries syndrome is a rare autosomal dominant genetic disease caused by de novo pathogenic variants in YY1. In this study, we report a 10‐year‐old boy with a de novo novel pathogenic variant in YY1, the first Iranian patient with Gabriele‐de Vries Syndrome. Methods: The novel de novo pathogenic variant detected in this study (NM_003403:c.690delA, p.Glu231Ilefs*25) was identified...

article

Circular RNA circ_0001588 sponges miR‐211‐5p to facilitate the progression of glioblastoma via up‐regulating YY1 expression

Qian Wang, Dahai Zheng, Yuhan Li, Ye Zhang, more

The Journal of Gene Medicine > 23 > 10 > n/a - n/a

Background As the most common and detrimental brain tumor with high invasiveness and poor prognosis, glioblastoma (GBM) has severely threatened people's health globally. Therefore, it is of great importance and necessary to identify the molecular mechanisms involved in tumorigenesis and development, thus contributing to potential therapeutic targets and strategies. Methods The level of circ_0001588...

article

Transcriptional regulation of human DUSP4 gene by cancer‐related transcription factors

Tatiana Varela, Natércia Conceição, Vincent Laizé, M. Leonor Cancela

Journal of Cellular Biochemistry > 122 > 10 > 1556 - 1566

Dual specificity phosphatase 4 (DUSP4), a member of the dual specificity phosphatase family, is responsible for the dephosphorylation and inactivation of ERK, JNK and p38, which are mitogen‐activated protein kinases involved in cell proliferation, differentiation and apoptosis, but also in inflammation processes. Given its importance for cellular signalling, DUSP4 is subjected to a tight regulation...

article

YY1‐Related Dystonia: Clinical Aspects and Long‐Term Response to Deep Brain Stimulation

Giovanna Zorzi, Ignacio Juan Keller Sarmiento, Federica Rachele Danti, Bernabe I. Bustos, more

Movement Disorders > 36 > 6 > 1461 - 1462

article

Transcription factor YY1 enhances the stemness of lung cancer cells by stabilizing hypoxia factor HIF‐1α under a hypoxic microenvironment

Xianping Huang, Weihe Zhou, Yuefeng Zhang

Environmental Toxicology > 36 > 1 > 114 - 122

The hypoxic microenvironment can facilitate the tumor progression, and transcription factor YY1 holds promoting effects in various tumors. This work aims to investigate whether YY1 is involved in hypoxia‐induced stemness of lung cancer cells. We showed that hypoxic microenvironment induced the expression of HIF‐1α and YY1, and the stemness of lung cancer cells, which was attenuated by YY1 knockdown...

article

LncRNA LINC00899 promotes progression of acute myeloid leukaemia by modulating miR‐744‐3p/YY1 signalling

XueMei Dong, Xin Xu, YanPing Guan

Cell Biochemistry and Function > 38 > 7 > 955 - 964

Long non‐coding RNA (lncRNA) LINC00899 is one kind cytoplasmic lncRNA, however, there is rarely little information about its function in physiological process. Here, we demonstrated that lncRNA LINC00899 was upregulated in acute myeloid leukaemia (AML) cells and was quite correlated with poor prognosis of AML patients. High expression of LINC00899 in AML cells could promote cell proliferation and...

article

HOXD3 was negatively regulated by YY1 recruiting HDAC1 to suppress progression of hepatocellular carcinoma cells via ITGA2 pathway

Lumin Wang, Yi Gao, Xiaoge Zhao, Chen Guo, more

Cell Proliferation > 53 > 8 > n/a - n/a

Objectives HOXD3 is associated with progression of multiple types of cancer. This study aimed to identify the association of YY1 with HOXD3‐ITGA2 axis in the progression of hepatocellular carcinoma. Materials and Methods Bioinformatics assay was used to identify the effect of YY1, HOXD3 and ITGA2 expression in HCC tissues. The function of YY1 and HOXD3 in HCCs was determined by qRT‐PCR, MTT, apoptosis,...

article

YY1 control of mitochondrial‐related genes does not account for regulation of immunoglobulin class switch recombination in mice

Satabdi Nandi, Guanxiang Liang, Vishal Sindhava, Rajesh Angireddy, more

European Journal of Immunology > 50 > 6 > 822 - 838

Immunoglobulin class switch recombination (CSR) occurs in activated B cells with increased mitochondrial mass and membrane potential. Transcription factor Yin Yang 1 (YY1) is critical for CSR and for formation of the DNA loops involved in this process. We therefore sought to determine if YY1 knockout impacts mitochondrial gene expression and mitochondrial function in murine splenic B cells, providing...

article

YY1‐mediated overexpression of long noncoding RNA MCM3AP‐AS1 accelerates angiogenesis and progression in lung cancer by targeting miR‐340‐5p/KPNA4 axis

Xuemei Li, Mei Yu, Caiyong Yang

Journal of Cellular Biochemistry > 121 > 3 > 2258 - 2267

Lung cancer is famous as an aggressive malignant tumor and is the main cause of cancer‐associated mortality globally. Tumor angiogenesis is a vital part in cancer, which influences cell proliferation and metastasis. Increasing studies have claimed that long noncoding RNAs (lncRNAs) were involved in the progression of several cancers. Based on previous studies, this study focused on the role and mechanism...

article

YY1 mediates TGF-β1-induced EMT and pro-fibrogenesis in alveolar epithelial cells

Chuyi Zhang, Xiaoping Zhu, Yifei Hua, Qian Zhao, more

Respiratory Research > 2019 > 20 > 1 > 1-11

Pulmonary fibrosis is a chronic, progressive lung disease associated with lung damage and scarring. The pathological mechanism causing pulmonary fibrosis remains unknown. Emerging evidence suggests prominent roles of epithelial–mesenchymal transition (EMT) of alveolar epithelial cells (AECs) in myofibroblast formation and progressive pulmonary fibrosis. Our previous work has demonstrated the regulation...

article

Yy1 regulates Senp1 contributing to AMPA receptor GluR1 expression following neuronal depolarization

Tao Wu, Mary E. Donohoe

Journal of Biomedical Science > 2019 > 26 > 1 > 1-15

Background Neuronal activity-induced changes in gene expression patterns are important mediators of neuronal plasticity. Many neuronal genes can be activated or inactivated in response to neuronal depolarization. Mechanisms that activate gene transcription are well established, but activity-dependent mechanisms that silence transcription are less understood. It is also not clear what is the significance...

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Search results

Prognostic significance of YY1 protein expression and mRNA levels by bioinformatics analysis in human cancers: A therapeutic target

Salt‐like transcription factor 4 promotes laryngeal cancer progression through transcriptional activation of ubiquitin‐specific protease 21 to stabilize Yin Yang 1

LINC01608 activated by YY1 facilitate hepatocellular carcinoma progression by modulating the EGFR/ERK axis

Astrocytic Yin Yang 1 is critical for murine brain development and protection against apoptosis, oxidative stress, and inflammation

microRNA‐497‐mediated Smurf2/YY1/HIF2α axis in tumor growth and metastasis of esophageal squamous cell carcinoma

Transcription factor YY1 contributes to human melanoma cell growth through modulating the p53 signalling pathway

EWSR1::YY1 fusion positive peritoneal epithelioid mesothelioma harbors mesothelioma epigenetic signature: Report of 3 cases in support of an emerging entity

Mast cell‐derived exosomal miR‐181a‐5p modulated trophoblast cell viability, migration, and invasion via YY1/MMP‐9 axis

YY1: A New Gene for Childhood Onset Dystonia with Prominent Oromandibular‐Laryngeal Involvement?

Clinical features of patients with Yin Yang 1 deficiency causing Gabriele‐de Vries syndrome: A new case and review of the literature

Circular RNA circ_0001588 sponges miR‐211‐5p to facilitate the progression of glioblastoma via up‐regulating YY1 expression

Transcriptional regulation of human DUSP4 gene by cancer‐related transcription factors

YY1‐Related Dystonia: Clinical Aspects and Long‐Term Response to Deep Brain Stimulation

Transcription factor YY1 enhances the stemness of lung cancer cells by stabilizing hypoxia factor HIF‐1α under a hypoxic microenvironment

LncRNA LINC00899 promotes progression of acute myeloid leukaemia by modulating miR‐744‐3p/YY1 signalling

HOXD3 was negatively regulated by YY1 recruiting HDAC1 to suppress progression of hepatocellular carcinoma cells via ITGA2 pathway

YY1 control of mitochondrial‐related genes does not account for regulation of immunoglobulin class switch recombination in mice

YY1‐mediated overexpression of long noncoding RNA MCM3AP‐AS1 accelerates angiogenesis and progression in lung cancer by targeting miR‐340‐5p/KPNA4 axis

YY1 mediates TGF-β1-induced EMT and pro-fibrogenesis in alveolar epithelial cells

Yy1 regulates Senp1 contributing to AMPA receptor GluR1 expression following neuronal depolarization

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