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Items from 1 to 20 out of 366 results

article

Three-Dimensional Palpography of Human Coronary Arteries

Johannes A. Schaar*, Chris L. Korte*, Frits Mastik, Luc C. A. Damme, more

Herz > 2005 > 30 > 2 > 125-133

Background: Rupture of thin-cap fibroatheroma is a major cause of acute myocardial infarction and stroke. Identification of these plaques is one of the major challenges in cardiovascular medicine. At present, techniques with sufficient sensitivity and specificity to identify these unstable plaques are not clinically available. This paper describes a new technique to identify these plaques. Methods and Results:...

article

Intravascular Palpography for High-Risk Vulnerable Plaque Assessment

Johannes A. Schaar, Chris L. de Korte, Frits Mastik, Radj Baldewsing, more

Herz > 2003 > 28 > 6 > 488-495

Background:. The composition of an atherosclerotic plaque is considered more important than the degree of stenosis. An unstable lesion may rupture and cause an acute thrombotic reaction. Most of these lesions contain a large lipid pool covered by an inflamed thin fibrous cap. The stress in the cap increases with decreasing cap thickness and increasing macrophage infiltration. Intravascular ultrasound...

article

Optical Coherence Tomography (OCT)Potential of a New High-Resolution Intracoronary Imaging Technique

Ulrich Gerckens, Lutz Buellesfeld, Edward McNamara, Eberhard Grube

Herz > 2003 > 28 > 6 > 496-500

Background:. It is believed that most myocardial infarctions result from the rupture of vulnerable plaques, that share certain common characteristics. These plaques typically consist of a lipid-rich core in the central portion of the thickened intima, covered by a thin friable fibrous cap. Today, one of the important challenges in the field of interventional cardiology is how to identify minor or...

article

Imaging diagnosis and research progress of carotid plaque vulnerability

Lianlian Zhang, Xia li, Qi Lyu, Guofu Shi

Journal of Clinical Ultrasound > 50 > 7 > 905 - 912

Ischemic stroke (IS) exhibits a high disability rate, mortality, and recurrence rate, imposing a serious threat to human survival and health. Its occurrence is affected by various factors. Although the previous research has demonstrated that the occurrence of IS is mainly associated with lumen stenosis caused by carotid atherosclerotic plaque (AP), recent studies have revealed that many patients will...

article

Optical coherence tomography predictors of target vessel myocardial infarction after provisional stenting in patients with coronary bifurcation disease

Xiaobo Li, Jing Kan, Liping She, Rajiv Shrestha, more

Catheterization and Cardiovascular Interventions > 97 > 7 > 1331 - 1340

Background Provisional side branch (SB) stenting is correlated with target vessel myocardial infarction (TVMI) in patients with coronary bifurcation lesions. However, the mechanisms underlying this association remain unknown. Objectives To determine the correlation between SB lesion length with vulnerable plaques and TVMI using optical coherence tomography (OCT). Background The correlation between...

article

Exploring the role of extracellular matrix proteins to develop biomarkers of plaque vulnerability and outcome

S. Holm Nielsen, L. Jonasson, K. Kalogeropoulos, M. A. Karsdal, more

Journal of Internal Medicine > 287 > 5 > 493 - 513

Cardiovascular disease (CVD) is the most common cause of death in industrialized countries. One underlying cause is atherosclerosis, which is a systemic disease characterized by plaques of retained lipids, inflammatory cells, apoptotic cells, calcium and extracellular matrix (ECM) proteins in the arterial wall. The biologic composition of an atherosclerotic plaque determines whether the plaque is...

article

Automated Detection of Vulnerable Plaque for Intravascular Optical Coherence Tomography Images

Ran Liu, Yanzhen Zhang, Yangting Zheng, Yaqiong Liu, more

Cardiovascular Engineering and Technology > 2019 > 10 > 4 > 590-603

Purpose Vulnerable plaque detection is important to acute coronary syndrome (ACS) diagnosis. In recent years, intravascular optical coherence tomography (IVOCT) imaging has been used for vulnerable plaque detection. Current automated detection methods adopt the traditional image classification and object detection algorithms, such as the logistic regression model, SVM, and Haar-Adaboost, to detect...

article

Triple-gated motion and blood pool clearance corrections improve reproducibility of coronary ¹⁸F-NaF PET

Martin Lyngby Lassen, Jacek Kwiecinski, Damini Dey, Sebastien Cadet, more

European Journal of Nuclear Medicine and Molecular Imaging > 2019 > 46 > 12 > 2610-2620

Purpose To improve the test–retest reproducibility of coronary plaque ¹⁸F-sodium fluoride (¹⁸F-NaF) positron emission tomography (PET) uptake measurements. Methods We recruited 20 patients with coronary artery disease who underwent repeated hybrid PET/CT angiography (CTA) imaging within 3 weeks. All patients had 30-min PET acquisition and CTA during a single imaging session. Five PET image-sets...

article

PET imaging of vulnerable coronary artery plaques

Lucia Leccisotti, P. Nicoletti, C. Cappiello, L. Indovina, more

Clinical and Translational Imaging > 2019 > 7 > 4 > 267-284

Purpose In the last years, the identification of vulnerable atherosclerotic plaques to prevent acute coronary events has been one of the main objectives of the cardiovascular science community. In this review, we provide an overview of vulnerable coronary artery plaque imaging by positron emission tomography (PET). Methods and results Relevant methodological and technical aspects of PET on coronary...

article

Data Processing Pipeline for Lipid Profiling of Carotid Atherosclerotic Plaque with Mass Spectrometry Imaging

Mirjam Visscher, Astrid M. Moerman, Peter C. Burgers, Heleen M. M. Beusekom, more

Journal of The American Society for Mass Spectrometry > 2019 > 30 > 9 > 1790-1800

Atherosclerosis is a lipid and inflammation-driven disease of the arteries that is characterized by gradual buildup of plaques in the vascular wall. A so-called vulnerable plaque, consisting of a lipid-rich necrotic core contained by a thin fibrous cap, may rupture and trigger thrombus formation, which can lead to ischemia in the heart (heart attack) or in the brain (stroke). In this study, we present...

article

Coronary Vessel Wall Imaging: State of the Art and Future Directions

Thomas Wurster, Ulf Landmesser, Leif-Christopher Engel, Boris Bigalke, more

Current Cardiovascular Imaging Reports > 2019 > 12 > 5 > 1-10

Purpose of Review The purpose of this paper is to review the latest advancements and developments in non-invasive coronary magnetic resonance (MR) and hybrid positron emission tomography (PET)/MR imaging. Recent Findings Coronary MRI has advanced in recent years in different aspects, especially regarding technical developments, scan protocols, and molecular probes. Recently introduced hybrid PET/MR...

article

Automated detection of vulnerable plaque in intravascular ultrasound images

Tae Joon Jun, Soo-Jin Kang, June-Goo Lee, Jihoon Kweon, more

Medical & Biological Engineering & Computing > 2019 > 57 > 4 > 863-876

Acute coronary syndrome (ACS) is a syndrome caused by a decrease in blood flow in the coronary arteries. The ACS is usually related to coronary thrombosis and is primarily caused by plaque rupture followed by plaque erosion and calcified nodule. Thin-cap fibroatheroma (TCFA) is known to be the most similar lesion morphologically to a plaque rupture. In this paper, we propose methods to classify TCFA...

article

Fractal dimension based carotid plaque characterization from three-dimensional ultrasound images

Ran Zhou, Yongkang Luo, Aaron Fenster, John David Spence, more

Medical & Biological Engineering & Computing > 2019 > 57 > 1 > 135-146

Irregularity of the plaque surface associated with previous plaque rupture plays an important role in the risk estimation of stroke caused by carotid atherosclerotic lesions. Thus, the aim of this study is to develop and validate novel vulnerability biomarkers from three-dimensional ultrasound (3DUS) images by analyzing the surface morphological characteristics of carotid plaque using fractal geometry...

article

Study of Serum CD147 Level in Patients with Transient Ischemic Attack and CD147 Expression in Atherosclerotic Plaque

Bin Xu, Chan Wu, Wenqing Wu, Yanguo Tan, more

Journal of Cardiovascular Translational Research > 2018 > 11 > 4 > 285-291

There is growing evidence that highlighted the potential effects of CD147 in atherosclerosis, but the potential implication of CD147 in diagnosis and treatment of transient ischemic attack (TIA) and acute cerebral infarction (ACI) is still unclear. In this work, we investigated the serum level of CD147 in patients with TIA and ACI, and CD147 expression in atherosclerotic plaque. The result showed...

article

A review in enormity of OCT and its enduring understanding of vulnerable plaque in coronary bifurcation lesion

Rajiv Shrestha, Aanchal Shrestha, Jing Kan, Shaoliang Chen

The International Journal of Cardiovascular Imaging > 2018 > 34 > 11 > 1679-1684

Optical coherence tomography (OCT) has emerged as one of the most promising tools to assist the optimization of percutaneous coronary intervention (PCI). Its ability to provide unique information on the plaque at high risk for rupture, plaque composition, the thickness of the fibrous cap, the presence of macrophage and thrombi has not only assisted simple PCI but also in many complex bifurcation lesions...

article

Endoplasmic reticulum stress in perivascular adipose tissue promotes destabilization of atherosclerotic plaque by regulating GM-CSF paracrine

Ru Ying, Sheng-Wei Li, Jia-Yuan Chen, Hai-Feng Zhang, more

Journal of Translational Medicine > 2018 > 16 > 1 > 1-13

Background Perivascular adipose tissue (PVAT) accelerates plaque progression and increases cardiovascular risk. We tested the hypothesis that PVAT contributed to plaque vulnerability and investigated whether endoplasmic reticulum stress (ER stress) in PVAT played an important role in vulnerable plaque. Methods We transplanted thoracic aortic PVAT or subcutaneous adipose tissue as a control, from...

article

Apelin‐13 treatment enhances the stability of atherosclerotic plaques

Rodrigo A. Fraga‐Silva, Hugo Seeman, Fabrizio Montecucco, Analina R. da Silva, more

European Journal of Clinical Investigation > 48 > 3 > n/a - n/a

Background Apelin is an endogenous peptidergic system which modulates cardiovascular function. Recent studies pointed out a fundamental contribution of apelin on atherosclerosis development; however, such reports revealed contradictory data, and to date, it is difficult to accurately define a beneficial or deleterious role. To better understand apelin function on atherosclerosis, we aimed to investigate...

article

The feedback loop of “EMMPRIN/NF-κB” worsens atherosclerotic plaque via suppressing autophagy in macrophage

Xing Liang, Xianhua Hou, Yang Yang, Hong Liu, more

Journal of Molecular and Cellular Cardiology > 2018 > 114 > C > 129-140

This study examined the significance of macrophage autophagy in extracellular matrix metalloproteinase inducer (EMMPRIN)-mediated atherosclerosis (AS).Apolipoprotein E-deficient (ApoE−/−) mice were fed a western diet to establish an AS model. EMMPRIN and p62/Sequestosome-1(SQSTM1) expression were evaluated in plaque macrophages from the AS mice using immunofluorescence. The EMMPRIN and p62/SQSTM1...

article

Plaque Rupture in Coronary Atherosclerosis Is Associated With Increased Plaque Structural Stress

Charis Costopoulos, Yuan Huang, Adam J. Brown, Patrick A. Calvert, more

JACC: Cardiovascular Imaging > 2017 > 10 > 12 > 1472-1483

The aim of this study was to identify the determinants of plaque structural stress (PSS) and the relationship between PSS and plaques with rupture.Plaque rupture is the most common cause of myocardial infarction, occurring particularly in higher risk lesions such as fibroatheromas. However, prospective intravascular ultrasound–virtual histology studies indicate that <10% higher risk plaques cause...

article

The Ongoing Quest to Predict Plaque Rupture∗

Habib Samady, David S. Molony

JACC: Cardiovascular Imaging > 2017 > 10 > 12 > 1484-1486

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VULNERABLE PLAQUE (366)
ATHEROSCLEROSIS (153)
CORONARY ARTERY DISEASE (34)
INTRAVASCULAR ULTRASOUND (34)
INFLAMMATION (33)
OPTICAL COHERENCE TOMOGRAPHY (31)
PLAQUE RUPTURE (30)
ACUTE CORONARY SYNDROME (24)
IMAGING (20)
CAROTID ARTERY (19)
MOLECULAR IMAGING (15)
MAGNETIC RESONANCE IMAGING (13)
MYOCARDIAL INFARCTION (13)
ULTRASONIC IMAGING (13)
STRAIN (12)
IVUS (11)
MACROPHAGE (11)
VASA VASORUM (11)
DISEASES (10)
THIN-CAP FIBROATHEROMA (10)
BIOMEDICAL ULTRASONICS (9)
BLOOD VESSELS (9)
ACUTE CORONARY SYNDROMES (8)
COMPUTED TOMOGRAPHY (8)
CORONARY ATHEROSCLEROSIS (8)
MACROPHAGES (8)
CARDIOVASCULAR DISEASE (7)
CORONARY ARTERY (7)
CORONARY DISEASE (7)
MRI (7)
THROMBUS (7)
ULTRASOUND (7)
VULNERABLE PATIENT (7)
ARTERIES (6)
BIOMARKERS (6)
CALCIFICATION (6)
INTRAVASCULAR ULTRASOUND ELASTOGRAPHY (6)
MICROBUBBLES (6)
NEOVASCULARIZATION (6)
NONINVASIVE IMAGING (6)
PET (6)
PRIMARY PREVENTION (6)
STROKE (6)
ACUTE MYOCARDIAL INFARCTION (5)
ATHEROSCLEROTIC PLAQUES (5)
CARDIOVASCULAR SYSTEM (5)
CAROTID ARTERIES (5)
CAROTID PLAQUE (5)
CORONARY CT ANGIOGRAPHY (5)
CORONARY HEART DISEASE (5)
HIGH-RISK PLAQUE (5)
HISTOLOGY (5)
INTRAVASCULAR IMAGING (5)
NEAR-INFRARED SPECTROSCOPY (5)
OCT (5)
PHANTOMS (5)
SHEAR STRESS (5)
SPECTROSCOPY (5)
STRAIN IMAGING (5)
THIN CAP FIBROATHEROMA (5)
TISSUE CHARACTERIZATION (5)
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ATHEROSCLEROTIC PLAQUE (4)
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PLACA VULNERABLE (4)
PLAQUE (4)
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PREVENTIVE CARDIOLOGY (4)
STRESS (4)
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Search results

Three-Dimensional Palpography of Human Coronary Arteries

Intravascular Palpography for High-Risk Vulnerable Plaque Assessment

Optical Coherence Tomography (OCT)Potential of a New High-Resolution Intracoronary Imaging Technique

Imaging diagnosis and research progress of carotid plaque vulnerability

Optical coherence tomography predictors of target vessel myocardial infarction after provisional stenting in patients with coronary bifurcation disease

Exploring the role of extracellular matrix proteins to develop biomarkers of plaque vulnerability and outcome

Automated Detection of Vulnerable Plaque for Intravascular Optical Coherence Tomography Images

Triple-gated motion and blood pool clearance corrections improve reproducibility of coronary ¹⁸F-NaF PET

PET imaging of vulnerable coronary artery plaques

Data Processing Pipeline for Lipid Profiling of Carotid Atherosclerotic Plaque with Mass Spectrometry Imaging

Coronary Vessel Wall Imaging: State of the Art and Future Directions

Automated detection of vulnerable plaque in intravascular ultrasound images

Fractal dimension based carotid plaque characterization from three-dimensional ultrasound images

Study of Serum CD147 Level in Patients with Transient Ischemic Attack and CD147 Expression in Atherosclerotic Plaque

A review in enormity of OCT and its enduring understanding of vulnerable plaque in coronary bifurcation lesion

Endoplasmic reticulum stress in perivascular adipose tissue promotes destabilization of atherosclerotic plaque by regulating GM-CSF paracrine

Apelin‐13 treatment enhances the stability of atherosclerotic plaques

The feedback loop of “EMMPRIN/NF-κB” worsens atherosclerotic plaque via suppressing autophagy in macrophage

Plaque Rupture in Coronary Atherosclerosis Is Associated With Increased Plaque Structural Stress

The Ongoing Quest to Predict Plaque Rupture∗

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