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Items from 1 to 20 out of 2,280 results

article

Comparative characterization of phenolic and other polar compounds in Spanish melon cultivars by using high-performance liquid chromatography coupled to electrospray ionization quadrupole-time of flight mass spectrometry

C. Rodríguez-Pérez, R. Quirantes-Piné, A. Fernández-Gutiérrez, A. Segura-Carretero, more

Food Research International > 2013 > 54 > 2 > 1519-1527

Melon (Cucumis melo L.), belonging to the Cucurbitaceae family, is a significant source of phytochemicals which provide human health benefits. High-performance liquid chromatography coupled to electrospray ionization mass spectrometry quadropole-time of flight (HPLC–ESI-QTOF-MS) was used for the comprehensive characterization of 14 extracts from 3 Spanish varieties of melon (Galia, Cantaloupe, and...

article

Understanding Gold‐Alkyne Activation from Bond Dissociation Energies of Gold‐Alkyne Complexes

David Gatineau, Denis Lesage, Rodolphe Guéret, Samuel Danladi Mador, more

European Journal of Organic Chemistry > 27 > 29 > n/a - n/a

A detailed approach into electronic effects of ligands on gold‐alkyne interactions has been carried out in the gas phase using tandem mass spectrometry. A semi‐empirical method coupled to DFT calculations was used to quantify ligands effects on Au−CC bond strength. To this end, the critical energies of 16 [L−Au‐hex‐3‐yne]⁺ complexes with different L ligands were determined through collision induced...

article

Mass Spectrometry Identifies Taenia solium Proteins in Sera of Patients With and Without Parenchymal Neurocysticercosis

Betcy Evangeline Pamela, Chhaya Patole, Subashini Thamizhmaran, Ranjith K. Moorthy, more

Parasite Immunology > 46 > 7 > n/a - n/a

Neurocysticercosis (NCC), a major cause of global acquired epilepsy, results from Taenia solium larval brain infection. T. solium adult worms release large numbers of infective eggs into the environment contributing to high levels of exposure in endemic areas. This study identifies T. solium proteins in the sera of individuals with and without NCC using mass spectrometry to examine exposure in endemic...

article

Tandem Mass Spectrometry Approaches for Differentiation and Quantification Pidotimod and Its Three Isomers in the Gas Phase

Caiyu Zhang, Yang Liu, Lan He, Wei Li

Chirality > 36 > 8 > n/a - n/a

Pidotimod is a chiral drug that possesses two chiral centers, resulting in three isomeric impurities (analytes, A). This study employs electrospray ionization ion trap mass spectrometry (ESI‐MS) through collision‐induced dissociation (CID) to investigate the chiral recognition of pidotimod and its three isomers to eliminate chromatographic separation. Three approaches were explored: (1) Protonated...

article

Diversity in Pyracantha fortuneana fruits maturity stages enables discrepancy in the phenolic compounds, antioxidant activity, and tyrosinase inhibitory activity

Yan Wang, Qiju Shao, Xijin Yang, Ke Su, more

Journal of Food Science > 89 > 6 > 3469 - 3483

Abstract Pyracantha fortuneana (P. fortuneana) fruit is a wild fruit that is popular because of its delicious taste and numerous nutrients, and phenolic compounds are considered to be the main bioactive components in P. fortuneana fruits. However, the relationship between phenolic compounds and their antioxidant and tyrosinase (TYR) inhibitory activities during the ripening process is still unclear...

article

On the fate of protonated chloroformates in the gas phase: a competition between forming HCl and chloroformic acid

Malick Diedhiou, Paul M. Mayer

Journal of Mass Spectrometry > 59 > 6 > n/a - n/a

Chloroformates are prevalent in the atmosphere due to their utilization as fuel additives and industrial solvents. These species may undergo interactions with atmospheric water resulting in protonated chloroformates. This study delves into the gas‐phase dissociation of these protonated species. Tandem mass spectrometry was employed to scrutinize the unimolecular dissociation of protonated methyl (...

article

Rapid and simultaneous determination of curcuminoids and gingerols in food products containing turmeric and ginger using paper spray mass spectrometry

Lucia Bartella, Fabio Mazzotti, Ines Rosita Talarico, Ilaria Santoro, more

Journal of Mass Spectrometry > 59 > 6 > n/a - n/a

Turmeric and ginger are extensively employed as functional ingredients due to their high content of curcuminoids and gingerols, considered the key bioactive compounds found in these roots. In this study, we present an innovative and fast method for the assay of curcuminoids and gingerols in different foods containing the two spices, with the aim of monitoring the quality of products from a nutraceutical...

article

High‐throughput proteomic analysis of chronic inflammatory skin diseases: Psoriasis and atopic dermatitis

Tanel Traks, Paula Reemann, Kattri‐Liis Eskla, Aigar Ottas, more

Experimental Dermatology > 33 > 4 > n/a - n/a

Common characteristics in the pathogenesis of psoriasis (PS) and atopic dermatitis (AD) have been presumed, but only a few studies have clearly supported this. The current aim was to find possible similarities and differences in protein expression patterns between these two major chronic inflammatory skin diseases. High‐throughput tandem mass spectrometry proteomic analysis was performed using full...

article

A general, most basic rule for ion dissociation: Protonated molecules

Adriano Reis, Rodinei Augusti, Marcos N. Eberlin

Journal of Mass Spectrometry > 59 > 3 > n/a - n/a

Contrary to the common but potentially misleading belief that when a protonated molecule is excited, it is its most stable protomer that will mandatorily dissociate, we demonstrate herein that, when rationalizing or predicting the chemistry of such ions, we should always search for the most labile protomer. This “most labile protomer” rule, based on the mobile proton model, states therefore that when...

article

Exact p‐value calculation for XCorr scoring of high‐resolution MS/MS data

Kishankumar Bhimani, Arina Peresadina, Dmitrii Vozniuk, Attila Kertész‐Farkas

PROTEOMICS > 24 > 5 > n/a - n/a

Exact p‐value (XPV)‐based methods for dot product‐like score functions—such as the XCorr score implemented in Tide, SEQUEST, Comet or shared peak count‐based scoring in MSGF+ and ASPV—provide a fairly good calibration for peptide‐spectrum‐match (PSM) scoring in database searching‐based MS/MS spectrum data identification. Unfortunately, standard XPV methods, in practice, cannot handle high‐resolution...

article

A global LC–MS²‐based methodology to identify and quantify anionic phospholipids in plant samples

Manon Genva, Louise Fougère, Delphine Bahammou, Sébastien Mongrand, more

The Plant Journal > 117 > 3 > 956 - 971

Anionic phospholipids (PS, PA, PI, PIPs) are low‐abundant phospholipids with impactful functions in cell signaling, membrane trafficking and cell differentiation processes. They can be quickly metabolized and can transiently accumulate at defined spots within the cell or an organ to respond to physiological or environmental stimuli. As even a small change in their composition profile will produce...

article

Synthetic dyes: A mass spectrometry approach and applications

Zoe Millbern, Alison Trettin, Rachel Wu, Morgan Demmler, more

Mass Spectrometry Reviews > 43 > 2 > 327 - 344

Synthetic dyes are found in a wide variety of applications today, including but not limited to textiles, foods, and medicine. The analysis of these molecules is pertinent to several fields such as forensics, environmental monitoring, and quality control, all of which require the sensitivity and selectivity of analysis provided by mass spectrometry (MS). Recently, there has been an increase in the...

article

Uncommon posttranslational modifications in proteomics: ADP‐ribosylation, tyrosine nitration, and tyrosine sulfation

Aarti Bashyal, Jennifer S. Brodbelt

Mass Spectrometry Reviews > 43 > 2 > 289 - 326

Posttranslational modifications (PTMs) are covalent modifications of proteins that modulate the structure and functions of proteins and regulate biological processes. The development of various mass spectrometry‐based proteomics workflows has facilitated the identification of hundreds of PTMs and aided the understanding of biological significance in a high throughput manner. Improvements in sample...

article

Validation of a robust and rapid liquid chromatography tandem mass spectrometric method for the quantitative analysis of VK‐2019, a selective EBNA1 inhibitor

Michael T. Davis, Nicole M. Anders, A. Dimitrios Colevas, Troy E. Messick, more

Biomedical Chromatography > 38 > 2 > n/a - n/a

EBNA1 is an Epstein Barr virus (EBV) protein expressed in all EBV‐associated cancers. EBNA1 plays a critical role in the replication and maintenance of EBV episomes in latently infected cells. VK‐2019 was developed as a highly specific inhibitor of EBNA1 DNA binding activity and is currently in phase 1 development as a treatment for EBV‐associated carcinomas. A sensitive and reliable method was developed...

article

Pharmacokinetics and molecular docking of the cardioprotective flavonoids in Dalbergia odorifera

Canhong Wang, Bao Gong, Yulan Wu, Congwen Bai, more

Journal of Separation Science > 47 > 1 > n/a - n/a

The purpose of this research was to investigate the cardioprotective effects and pharmacokinetics of Dalbergia odorifera flavonoids. The cardioprotective effects were detected by hematoxylin‐eosin staining histopathological observations and the detection of myocardial enzymes by kits in serum, peroxidation and antioxidant levels and ATPase activities by kits in the homogenate supernatant, and antioxidant...

article

Quantitative analysis of the glutathione pathway cellular metabolites by targeted liquid chromatography‐tandem mass spectrometry

Kristian Serafimov, Yüsra Aydin, Michael Lämmerhofer

Journal of Separation Science > 47 > 1 > n/a - n/a

Glutathione, its biosynthesis intermediates, and other thiol metabolites are of central relevance for the redox homeostasis of cells. Their analysis is critical due to the facile interconversion of redox pairs during sampling, sample preparation, and data acquisition, in particular in the electrospray ionization interface. In this work, we propose a fast‐targeted liquid chromatography‐tandem mass...

article

Food allergen detection by mass spectrometry: From common to novel protein ingredients

Mariachiara Bianco, Giovanni Ventura, Cosima D. Calvano, Ilario Losito, more

PROTEOMICS > 23 > 23-24 > n/a - n/a

Food allergens are molecules, mainly proteins, that trigger immune responses in susceptible individuals upon consumption even when they would otherwise be harmless. Symptoms of a food allergy can range from mild to acute; this last effect is a severe and potentially life‐threatening reaction. The European Union (EU) has identified 14 common food allergens, but new allergens are likely to emerge with...

article

Mobility‐Modulated Sequential Dissociation Analysis Enables Structural Lipidomics in Mass Spectrometry Imaging

Yao Qian, Xiangyu Guo, Yunfang Wang, Zheng Ouyang, more

Angewandte Chemie International Edition > 62 > 52 > n/a - n/a

Spatial lipidomics based on mass spectrometry imaging (MSI) is a powerful tool for fundamental biology studies and biomarker discovery. But the structure‐resolving capability of MSI is limited because of the lack of multiplexed tandem mass spectrometry (MS/MS) method, primarily due to the small sample amount available from each pixel and the poor ion usage in MS/MS analysis. Here, we report a mobility‐modulated...

article

Mobility‐Modulated Sequential Dissociation Analysis Enables Structural Lipidomics in Mass Spectrometry Imaging

Yao Qian, Xiangyu Guo, Yunfang Wang, Zheng Ouyang, more

Angewandte Chemie > 135 > 52 > n/a - n/a

article

Single Spot Rb‐Sr Isochron Dating of Biotite by LA‐MC‐ICP‐MS/MS

Alicia M. Cruz‐Uribe, Grant Craig, Joshua M. Garber, Bence Paul, more

Geostandards and Geoanalytical Research > 47 > 4 > 795 - 809

Laser ablation tandem mass spectrometry is a burgeoning field for in situ Rb‐Sr geochronology. Here, we determined simultaneous isotope ratios of ⁸⁷Sr/⁸⁶Sr and ⁸⁷Rb/⁸⁶Sr in metamorphic biotite from western Maine, using an ESL™ imageGEO™193 excimer laser ablation system coupled to a Thermo Scientific™ Neoma™ MC‐ICP‐MS/MS. Measurements were made on Faraday cups with Rb⁺ at mass 87; Sr isotopes were...

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TANDEM MASS SPECTROMETRY (2,280)
LIQUID CHROMATOGRAPHY (267)
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NEWBORN SCREENING (94)
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MILK (17)
OLIGOSACCHARIDES (17)
PHOSPHOLIPIDS (17)
PROTEIN IDENTIFICATION (17)
SOLID PHASE EXTRACTION (17)
HIGH‐PERFORMANCE LIQUID CHROMATOGRAPHY (16)
HYDROPHILIC INTERACTION LIQUID CHROMATOGRAPHY (16)
ANTIBIOTICS (15)
FOOD (15)
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MALDI (12)
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Search results

Comparative characterization of phenolic and other polar compounds in Spanish melon cultivars by using high-performance liquid chromatography coupled to electrospray ionization quadrupole-time of flight mass spectrometry

Understanding Gold‐Alkyne Activation from Bond Dissociation Energies of Gold‐Alkyne Complexes

Mass Spectrometry Identifies Taenia solium Proteins in Sera of Patients With and Without Parenchymal Neurocysticercosis

Tandem Mass Spectrometry Approaches for Differentiation and Quantification Pidotimod and Its Three Isomers in the Gas Phase

Diversity in Pyracantha fortuneana fruits maturity stages enables discrepancy in the phenolic compounds, antioxidant activity, and tyrosinase inhibitory activity

On the fate of protonated chloroformates in the gas phase: a competition between forming HCl and chloroformic acid

Rapid and simultaneous determination of curcuminoids and gingerols in food products containing turmeric and ginger using paper spray mass spectrometry

High‐throughput proteomic analysis of chronic inflammatory skin diseases: Psoriasis and atopic dermatitis

A general, most basic rule for ion dissociation: Protonated molecules

Exact p‐value calculation for XCorr scoring of high‐resolution MS/MS data

A global LC–MS²‐based methodology to identify and quantify anionic phospholipids in plant samples

Synthetic dyes: A mass spectrometry approach and applications

Uncommon posttranslational modifications in proteomics: ADP‐ribosylation, tyrosine nitration, and tyrosine sulfation

Validation of a robust and rapid liquid chromatography tandem mass spectrometric method for the quantitative analysis of VK‐2019, a selective EBNA1 inhibitor

Pharmacokinetics and molecular docking of the cardioprotective flavonoids in Dalbergia odorifera

Quantitative analysis of the glutathione pathway cellular metabolites by targeted liquid chromatography‐tandem mass spectrometry

Food allergen detection by mass spectrometry: From common to novel protein ingredients

Mobility‐Modulated Sequential Dissociation Analysis Enables Structural Lipidomics in Mass Spectrometry Imaging

Mobility‐Modulated Sequential Dissociation Analysis Enables Structural Lipidomics in Mass Spectrometry Imaging

Single Spot Rb‐Sr Isochron Dating of Biotite by LA‐MC‐ICP‐MS/MS

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