The hemolytic uremic syndrome (HUS) is most commonly associated with Escherichia coli, but has been associated with other infections such as Streptococcus pneumoniae. Pneumococcus-induced HUS carries an increased risk of mortality and renal morbidity compared with E. coli-induced HUS. The pneumococcal organism produces an enzyme, which can expose an antigen (T-antigen) present on erythrocytes, platelets,...
Monoclonal (MoAB) anti-N and anti-M were tested against normal, T-activated, and Tn-activated RBCs. In vivo T and Tn activation affects the sialic acid expression on the RBCs which may affect the binding of antibodies to the M and / or N antigens. The majority of MoAB anti-M and anti-N in this workshop demonstrated some effect from in vivo T and Tn activation.
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