Search results

Items from 1 to 20 out of 4,755 results

article

Simulation-based partial volume correction for dopaminergic PET imaging: Impact of segmentation accuracy

Ye Rong, Ingo Vernaleken, Oliver H. Winz, Andreas Goedicke, more

Zeitschrift fuer Medizinische Physik > 2015 > 25 > 3 > 230-242

Partial volume correction (PVC) is an essential step for quantitative positron emission tomography (PET). In the present study, PVELab, a freely available software, is evaluated for PVC in ¹⁸F-FDOPA brain-PET, with a special focus on the accuracy degradation introduced by various MR-based segmentation approaches.Four PVC algorithms (M-PVC; MG-PVC; mMG-PVC; and R-PVC) were analyzed on simulated ¹⁸F-FDOPA...

article

Dynamic changes in dopamine neuron function after DNSP-11 treatment: Effects in vivo and increased ERK 1/2 phosphorylation in vitro

Joshua L. Fuqua, Ofelia M. Littrell, Martin Lundblad, Jadwiga Turchan-Cholewo, more

Peptides > 2014 > 54 > Complete > 1-8

Glial cell-line derived neurotrophic factor (GDNF) has demonstrated robust effects on dopamine (DA) neuron function and survival. A post-translational processing model of the human GDNF proprotein theorizes the formation of smaller, amidated peptide(s) from the proregion that exhibit neurobiological function, including an 11-amino-acid peptide named dopamine neuron stimulating peptide-11 (DNSP-11)...

article

Regulation of phosphorylation of synaptic and extrasynaptic GluA1 AMPA receptors in the rat forebrain by amphetamine

Li-Min Mao, Jesus A. Diaz, Eugene E. Fibuch, John Q. Wang

European Journal of Pharmacology > 2013 > 715 > 1-3 > 164-171

The AMPA receptor is regulated by phosphorylation. Two major phosphorylation sites (S831 and S845) are located in the intracellular C-terminal tail of GluA1 subunits. The phosphorylation on these sites controls receptor expression and function and is subject to the regulation by psychostimulants. In this study, we further characterized the regulation of S831 and S845 phosphorylation by amphetamine...

article

Nutritional Controls of Food Reward

Maria F. Fernandes, Sandeep Sharma, Cecile Hryhorczuk, Stephanie Auguste, more

Canadian Journal of Diabetes > 2013 > 37 > 4 > 260-268

The propensity to select and consume palatable nutrients is strongly influenced by the rewarding effects of food. Neural processes integrating reward, emotional states and decision-making can supersede satiety signals to promote excessive caloric intake and weight gain. While nutritional habits are influenced by reward-based neural mechanisms, nutrition and its impact on energy metabolism, in turn,...

article

The amygdala: An agent of change in adolescent neural networks

K. Suzanne Scherf, Joshua M. Smyth, Mauricio R. Delgado, K.S. Scherf, more

Hormones and Behavior > 2013 > 64 > 2 > 298-313

This article is part of a Special Issue ''Puberty and Adolescence''. A unique component of adolescent development is the need to master new developmental tasks in which peer interactions become primary (for the purposes of becoming autonomous from parents, forming intimate friendships, and romantic/sexual partnerships). Previously, it has been suggested that the ability to master these tasks requires...

article

Dopaminerge Modulation striataler Plastizität

Frieder Beck, Klaus Blischke, Birgit Abler

German Journal of Exercise and Sport Research > 2012 > 42 > 4 > 271-279

Der vorliegende Beitrag versucht, einen Überblick über die Neurobiologie der Automatisierung von Willkürbewegungen zu geben. Insbesondere wird aufgezeigt, dass eine zunehmende Bewegungsautomatisierung mit synaptischen Plastizitätsvorgängen im kortikokortikalen und kortikostriatalen System einhergeht, die vermutlich zu Veränderungen in den neuronalen Repräsentationen der geübten Bewegungen führen....

article

Die Bedeutung striataler Plastizitätsvorgänge und unerwarteten Bewegungserfolgs für sportmotorisches Lernen

Frieder Beck, Jürgen Beckmann

German Journal of Exercise and Sport Research > 2010 > 40 > 1 > 19-25

Menschliche Motorik wird wesentlich über die Schleifen zwischen Kortex und den Basalganglien organisiert. In diesem Beitrag werden Befunde und Überlegungen angeführt, wonach Plastizitätsvorgänge in diesen kortikostriatalen Schleifen und im Striatum überdauernde Reorganisationen kortikaler, motorischer Repräsentationen vermitteln und diese Vorgänge sportmotorische Relevanz besitzen. Die dargestellten...

article

Funktionelle Bildgebung kognitiver Prozesse bei M.-Huntington-Patienten und präsymptomatischen Mutationsträgern

R.C. Wolf, N. Vasic, C. Schönfeldt-Lecuona, D. Ecker, more

Der Nervenarzt > 2008 > 79 > 4 > 408-420

Kognitive Defizite gehören zu den Kernsymptomen der Huntington-Krankheit (Morbus Huntington, MH). Sie lassen sich in einem frühen Stadium der Erkrankung nachweisen und sind bereits bei präsymptomatischen Mutationsträgern häufig vorhanden. In dieser Übersicht sollen Untersuchungen kognitiver Funktionen von MH-Patienten und von präsymptomatischen Mutationsträgern mittels funktionell bildgebender Verfahren...

article

Neue Sicht des kortiko-striato-thalamo-kortikalen Regelkreises bei M. Parkinson

H. Braak, K. Del Tredici

Der Nervenarzt > 2008 > 79 > 12 > 1440-1445

Die traditionelle Darstellung des kortiko-striato-thalamo-kortikalen Regelkreises mit der Unterscheidbarkeit eines direkten und indirekten Weges erleichtert das Verständnis der im Verlauf des sporadischen Morbus Parkinson entstehenden motorischen Fehlfunktionen. Als krankheitsverursachende Veränderung wird lediglich die durch Ausfall von Neuronen der Substantia nigra bewirkte Reduktion von Dopamin...

article

Neurowissenschaftliche Aspekte der Emotionsregulation

Chantal Martin-Sölch

Psychotherapie Forum > 2004 > 12 > 2 > 71-78

Ziel dieses Beitrags ist es, beginnend mit einem Überblick über die Studien der Emotionsregulation im menschlichen Gehirn, die bis anhin vorliegenden Resultate in einen allgemeineren theoretischen Rahmen zwischen Psychologie und Neurobiologie zu integrieren. Nebst Forschungsarbeiten über die normale Regulierung von Emotionen werden hierbei auch Studien berücksichtigt, die mit Patienten gemacht wurden,...

article

Contributions of PET and SPECT to the understanding of the pathophysiology of Parkinson’s disease

S Thobois, S Guillouet, E Broussolle

Neurophysiologie Clinique / Clinical Neurophysiology > 2001 > 31 > 5 > 321-340

Positron emission tomography (PET) and single photon emission computed tomography (SPECT) provide the means to studying in vivo the neurochemical, hemodynamic or metabolic consequences of the degeneration of the nigrostriatal dopaminergic system in Parkinson’s disease (PD). The extent of striatal dopaminergic denervation can be quantified with radiotracers as 〚 ¹⁸ F〛FDopa for PET and 〚 ...

article

Striatal Blood Flow Changes by Middle Cerebral Artery Occlusion and Its Effect on Neurological Deficits in Mice

Miyuki Unekawa, Naoki Tsukada, Tsubasa Takizawa, Yutaka Tomita, more

Microcirculation > 31 > 6 > n/a - n/a

Objective We attempted to record the regional cerebral blood flow (CBF) simultaneously at various regions of the cerebral cortex and the striatum during middle cerebral artery (MCA) occlusion and to evaluate neurological deficits and infarct formation. Methods In male C57BL/6J mice, CBF was recorded in three regions including the ipsilateral cerebral cortex and the striatum with laser Doppler flowmeters,...

article

Activation of M₄ muscarinic receptors in the striatum reduces tic‐like behaviours in two distinct murine models of Tourette syndrome

Roberto Cadeddu, Giulia Braccagni, Caterina Branca, Easton R. Luik, more

British Journal of Pharmacology > 181 > 17 > 3064 - 3081

Background and Purpose Current pharmacotherapies for Tourette syndrome (TS) are often unsatisfactory and poorly tolerated, underscoring the need for novel treatments. Insufficient striatal acetylcholine has been suggested to contribute to tic ontogeny. Thus, we tested whether activating M₁ and/or M₄ receptors—the two most abundant muscarinic receptors in the striatum—reduced tic‐related behaviours...

article

Rethinking dopamine‐guided action sequence learning

Minryung R. Song, Sang Wan Lee

European Journal of Neuroscience > 60 > 1 > 3447 - 3465

As opposed to those requiring a single action for reward acquisition, tasks necessitating action sequences demand that animals learn action elements and their sequential order and sustain the behaviour until the sequence is completed. With repeated learning, animals not only exhibit precise execution of these sequences but also demonstrate enhanced smoothness and efficiency. Previous research has...

article

Behavioral dishonesty in multiscenes: Associations with trait honesty and neural patterns during (dis)honesty video‐watching

Xiaoli Guo, Lijun Yin

Human Brain Mapping > 45 > 8 > n/a - n/a

Cross‐situational inconsistency is common in the expression of honesty traits; yet, there is insufficient emphasis on behavioral dishonesty across multiple contexts. The current study aimed to investigate behavioral dishonesty in various contexts and reveal the associations between trait honesty, behavioral dishonesty, and neural patterns of observing others behave honestly or dishonestly in videos...

article

Cognitive outcome and its neural correlates after cardiorespiratory arrest in childhood

Sharon Geva, Aparna Hoskote, Maneet Saini, Christopher A. Clark, more

Developmental Science > 27 > 4 > n/a - n/a

Hypoxia‐ischaemia (HI) can result in structural brain abnormalities, which in turn can lead to behavioural deficits in various cognitive and motor domains, in both adult and paediatric populations. Cardiorespiratory arrest (CA) is a major cause of hypoxia‐ischaemia in adults, but it is relatively rare in infants and children. While the effects of adult CA on brain and cognition have been widely studied,...

article

Optimizing Screening for Intrastriatal Interventions in Huntington's Disease Using Predictive Models

Matthew J. Barrett, Ahmed Negida, Nitai Mukhopadhyay, Jin K. Kim, more

Movement Disorders > 39 > 5 > 855 - 862

Background Intrastriatal delivery of potential therapeutics in Huntington's disease (HD) requires sufficient caudate and putamen volumes. Currently, volumetric magnetic resonance imaging is rarely done in clinical practice, and these data are not available in large research cohorts such as Enroll‐HD. Objective The objective of this study was to investigate whether predictive models can accurately...

article

Ultrastructural analysis of nigrostriatal dopaminergic terminals in a knockin mouse model of DYT1 dystonia

Ke Pan, Hyder A. Jinnah, Ellen J. Hess, Yoland Smith, more

European Journal of Neuroscience > 59 > 7 > 1407 - 1427

DYT1 dystonia is associated with decreased striatal dopamine release. In this study, we examined the possibility that ultrastructural changes of nigrostriatal dopamine terminals could contribute to this neurochemical imbalance using a serial block face/scanning electron microscope (SBF/SEM) and three‐dimensional reconstruction to analyse striatal tyrosine hydroxylase‐immunoreactive (TH‐IR) terminals...

article

Sodium nitroprusside enhances stepping test performance and increases medium spiny neurons responsiveness to cortical inputs in a rat model of Levodopa‐induced dyskinesias

Danilo Leandro Ribeiro, Rayanne Poletti Guimarães, Keila Bariotto‐dos‐Santos, Elaine Del Bel, more

European Journal of Neuroscience > 59 > 7 > 1604 - 1620

Levodopa (L‐DOPA) is the classical gold standard treatment for Parkinson's disease. However, its chronic administration can lead to the development of L‐DOPA‐induced dyskinesias (LIDs). Dysregulation of the nitric oxide–cyclic guanosine monophosphate pathway in striatal networks has been linked to deficits in corticostriatal transmission in LIDs. This study investigated the effects of the nitric oxide...

article

Inhibition of striatal dopamine release by the L‐type calcium channel inhibitor isradipine co‐varies with risk factors for Parkinson's

Katherine R. Brimblecombe, Natalie Connor‐Robson, Carole J. R. Bataille, Bradley M. Roberts, more

European Journal of Neuroscience > 59 > 6 > 1242 - 1259

Ca²⁺ entry into nigrostriatal dopamine (DA) neurons and axons via L‐type voltage‐gated Ca²⁺ channels (LTCCs) contributes, respectively, to pacemaker activity and DA release and has long been thought to contribute to vulnerability to degeneration in Parkinson's disease. LTCC function is greater in DA axons and neurons from substantia nigra pars compacta than from ventral tegmental area, but this is...

Publication date

Last 3 months (4)
Last year (13)
Last 3 years (50)

Close

Date range setting

Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.

From:

To:
Set your own date range

Content availability

Available (4,329)
None (426)

Publication type

article (4,726)
book (29)

Publication language

English (4,748)
German (5)
French (1)
Undetermined (1)

Keywords

STRIATUM (4,755)
DOPAMINE (1,177)
BASAL GANGLIA (370)
HIPPOCAMPUS (354)
PARKINSON'S DISEASE (352)
SUBSTANTIA NIGRA (315)
NUCLEUS ACCUMBENS (279)
RAT (270)
MICRODIALYSIS (249)
GLUTAMATE (222)
PREFRONTAL CORTEX (217)
CORTEX (157)
SCHIZOPHRENIA (137)
SEROTONIN (133)
FMRI (131)
AGING (129)
REWARD (129)
ACETYLCHOLINE (123)
COCAINE (118)
HUNTINGTON'S DISEASE (118)
METHAMPHETAMINE (114)
PARKINSON’S DISEASE (113)
TYROSINE HYDROXYLASE (108)
6-HYDROXYDOPAMINE (101)
AMPHETAMINE (99)
AMYGDALA (97)
GABA (96)
ADDICTION (87)
FRONTAL CORTEX (85)
MPTP (84)
NEURODEGENERATION (80)
GLOBUS PALLIDUS (79)
CEREBELLUM (77)
THALAMUS (76)
DOPAMINE TRANSPORTER (74)
MEMORY (73)
DEVELOPMENT (72)
OXIDATIVE STRESS (72)
NEUROPROTECTION (71)
NEUROTOXICITY (71)
BRAIN (68)
CEREBRAL CORTEX (68)
MOUSE (68)
LEARNING (65)
EXCITOTOXICITY (64)
HALOPERIDOL (64)
IMMUNOHISTOCHEMISTRY (64)
DOPAMINE RELEASE (61)
ELECTROPHYSIOLOGY (61)
L-DOPA (60)
COGNITION (59)
STRESS (59)
MICE (58)
PUTAMEN (57)
APOPTOSIS (56)
C-FOS (56)
BEHAVIOR (54)
IN SITU HYBRIDIZATION (54)
NICOTINE (54)
NITRIC OXIDE (54)
CAUDATE (51)
POSITRON EMISSION TOMOGRAPHY (51)
DYSKINESIA (50)
DEPRESSION (48)
HYPOTHALAMUS (47)
SUBTHALAMIC NUCLEUS (46)
DOPAMINE RECEPTOR (45)
HUNTINGTON’S DISEASE (44)
SYNAPTIC PLASTICITY (43)
MICROGLIA (42)
QUINOLINIC ACID (42)
6-OHDA (41)
MORPHINE (41)
NMDA RECEPTOR (41)
SUBSTANCE P (41)
ACCUMBENS (40)
FUNCTIONAL MAGNETIC RESONANCE IMAGING (40)
PALLIDUM (40)
GENE EXPRESSION (39)
MRI (39)
NMDA (39)
STROKE (39)
LOCOMOTOR ACTIVITY (38)
VENTRAL TEGMENTAL AREA (38)
3-NITROPROPIONIC ACID (37)
CAUDATE NUCLEUS (37)
PET (37)
ENKEPHALIN (36)
ANXIETY (35)
VOLTAMMETRY (35)
DOPAMINE D2 RECEPTOR (34)
ETHANOL (34)
MOTIVATION (34)
ADENOSINE (32)
FUNCTIONAL CONNECTIVITY (32)
LOCOMOTION (32)
ALZHEIMER'S DISEASE (31)
CALCIUM (31)
ALCOHOL (29)
ANIMAL MODEL (29)
more

Data set

Elsevier (3,576)
Springer (641)
Wiley (497)
Agro (18)
ieee (17)
PSJD (6)

INFONA - science communication portal

Search results

Simulation-based partial volume correction for dopaminergic PET imaging: Impact of segmentation accuracy

Dynamic changes in dopamine neuron function after DNSP-11 treatment: Effects in vivo and increased ERK 1/2 phosphorylation in vitro

Regulation of phosphorylation of synaptic and extrasynaptic GluA1 AMPA receptors in the rat forebrain by amphetamine

Nutritional Controls of Food Reward

The amygdala: An agent of change in adolescent neural networks

Dopaminerge Modulation striataler Plastizität

Die Bedeutung striataler Plastizitätsvorgänge und unerwarteten Bewegungserfolgs für sportmotorisches Lernen

Funktionelle Bildgebung kognitiver Prozesse bei M.-Huntington-Patienten und präsymptomatischen Mutationsträgern

Neue Sicht des kortiko-striato-thalamo-kortikalen Regelkreises bei M. Parkinson

Neurowissenschaftliche Aspekte der Emotionsregulation

Contributions of PET and SPECT to the understanding of the pathophysiology of Parkinson’s disease

Striatal Blood Flow Changes by Middle Cerebral Artery Occlusion and Its Effect on Neurological Deficits in Mice

Activation of M₄ muscarinic receptors in the striatum reduces tic‐like behaviours in two distinct murine models of Tourette syndrome

Rethinking dopamine‐guided action sequence learning

Behavioral dishonesty in multiscenes: Associations with trait honesty and neural patterns during (dis)honesty video‐watching

Cognitive outcome and its neural correlates after cardiorespiratory arrest in childhood

Optimizing Screening for Intrastriatal Interventions in Huntington's Disease Using Predictive Models

Ultrastructural analysis of nigrostriatal dopaminergic terminals in a knockin mouse model of DYT1 dystonia

Sodium nitroprusside enhances stepping test performance and increases medium spiny neurons responsiveness to cortical inputs in a rat model of Levodopa‐induced dyskinesias

Inhibition of striatal dopamine release by the L‐type calcium channel inhibitor isradipine co‐varies with risk factors for Parkinson's

Filter options

Publication date

Content availability

Publication type

Publication language

Keywords

Data set

INFONA - science communication portal

Search results

Add recipient

Sending message cancelled

Are you sure you want to cancel sending this message?

Send message

Filter options

Publication date

Date range setting

Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.

Content availability

Publication type

Publication language

Keywords

Data set

Reporting an error / abuse

Sending the report failed

Accessibility options