Search results

Items from 1 to 20 out of 33 results

article

Subanalgesic morphine doses augment fentanyl analgesia by interacting with delta opioid receptors in male rats

Katherine E. Barker, Alynn J. Lecznar, Jill M. Schumacher, Jeffrey S. Morris, more

Journal of Neuroscience Research > 100 > 1 > 149 - 164

Opioids are commonly used for the treatment of postoperative and post‐traumatic pain; however, their therapeutic effectiveness is limited by undesirable and life‐threatening side effects. Researchers have long attempted to develop opioid co‐administration therapies that enhance analgesia, but the complexity of opioid analgesia and our incomplete mechanistic understanding has made this a daunting task...

article

Regulation of Cardiomyocyte Differentiation, Angiogenesis, and Inflammation by the Delta Opioid Signaling in Human Mesenchymal Stem Cells

L. Vinod Kumar Reddy, Dwaipayan Sen

Regenerative Engineering and Translational Medicine > 2019 > 5 > 3 > 252-262

Background Lack of angiogenesis, inflammation, and low differentiation of MSCs upon transplantation to ischemic site are major drawbacks in cell therapies for myocardial tissue regeneration. To overcome these problems, this study aimed to increase the angiogenesis, anti-inflammation, and differentiation of human umbilical cord MSCs (hMSCs) into cardiomyocytes by activating the delta opioid pathway...

article

Delta/mu opioid receptor interactions in operant conditioning assays of pain-depressed responding and drug-induced rate suppression: assessment of therapeutic index in male Sprague Dawley rats

Katherine Cone, Janell Lanpher, Abigail Kinens, Philomena Richard, more

Psychopharmacology > 2018 > 235 > 5 > 1609-1618

Rationale and objectives Although delta/mu receptor interactions vary as a function of behavioral endpoint, there have been no assessments of these interactions using assays of pain-depressed responding. This is the first report of delta/mu interactions using an assay of pain-depressed behavior. Methods A mult-cycle FR10 operant schedule was utilized in the presence of (nociception) and in the absence...

article

Prolonged morphine treatment alters δ opioid receptor post‐internalization trafficking

E W Ong, L Xue, M C Olmstead, C M Cahill

British Journal of Pharmacology > 172 > 2 > 615 - 629

Background and PurposeThe δ opioid receptor (DOP receptor) undergoes internalization both constitutively and in response to agonists. Previous work has shown that DOP receptors traffic from intracellular compartments to neuronal cell membranes following prolonged morphine treatment. Here, we examined the effects of prolonged morphine treatment on the post‐internalization trafficking of DOP receptors...

article

Synergistic activity between the delta-opioid agonist SNC80 and amphetamine occurs via a glutamatergic NMDA-receptor dependent mechanism

Kelly E. Bosse, Emily M. Jutkiewicz, Kristin N. Schultz-Kuszak, Omar S. Mabrouk, more

Neuropharmacology > 2014 > 77 > Complete > 19-27

Glutamate is known to cause the release of dopamine through a Ca ²⁺ -sensitive mechanism that involves activation of NMDA ionotropic glutamate receptors. In the current study, we tested the hypothesis that the delta opioid agonist SNC80 acts indirectly, via the glutamatergic system, to enhance both amphetamine-stimulated dopamine efflux from striatal preparations and amphetamine-stimulated...

article

δ‐Opioid receptor agonist SNC80 induces central antinociception mediated by Ca²⁺‐activated Cl^‐ channels

Daniela da Fonseca Pacheco, Cinthia Mara da Fonseca Pacheco, Igor Dimitri Gama Duarte

Journal of Pharmacy and Pharmacology > 64 > 8 > 1084 - 1089

Objectives The aim of this study was to determine whether Ca²⁺‐activated Cl^‐ channels (CaCCs) are involved in central antinociception induced by the activation of µ‐, δ‐ and κ‐opioid receptors. Methods The nociceptive threshold for thermal stimulation was measured using the tail‐flick test in Swiss mice. The drugs were administered via the intracerebroventricular route. Probabilities values of P...

article

Effects of the Delta Opioid Receptor Agonist SNC80 on Pain-Related Depression of Intracranial Self-Stimulation (ICSS) in Rats

S. Stevens Negus, Marisa B. Rosenberg, Ahmad A. Altarifi, Robert H. O’Connell, more

Journal of Pain > 2012 > 13 > 4 > 317-327

The delta opioid receptor agonist SNC80 produces both antinociceptive and antidepressant effects in rodents. This profile suggests that SNC80 may also reverse prodepressant effects of pain. Accordingly, this study compared SNC80 effects in complementary assays of pain-stimulated and pain-depressed behavior in rats. Intraperitoneal injection of dilute acid served as an acute noxious visceral stimulus...

article

Ovarian hormones influence corticotropin releasing factor receptor colocalization with delta opioid receptors in CA1 pyramidal cell dendrites

Tanya J. Williams, Keith T. Akama, Margarete G. Knudsen, Bruce S. McEwen, more

Experimental Neurology > 2011 > 230 > 2 > 186-196

Stress interacts with addictive processes to increase drug use, drug seeking, and relapse. The hippocampal formation (HF) is an important site at which stress circuits and endogenous opioid systems intersect and likely plays a critical role in the interaction between stress and drug addiction. Our prior studies demonstrate that the stress-related neuropeptide corticotropin-releasing factor (CRF) and...

article

Effects of the delta-opioid agonist SNC80 on the abuse liability of methadone in rhesus monkeys: a behavioral economic analysis

Matthew L. Banks, Peter G. Roma, John E. Folk, Kenner C. Rice, more

Psychopharmacology > 2011 > 216 > 3 > 431-439

Rationale Delta-opioid agonists enhance the antinociceptive efficacy of methadone and other mu-opioid agonists. However, relatively little is known about the degree to which delta agonists might enhance the abuse-related effects of mu agonists. Objective This study used a behavioral economic approach to examine effects of the delta agonist SNC80 [(+)-4-[(αR)-α-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-...

article

Effect of endothelin-A receptor antagonist on mu, delta and kappa opioid receptor-mediated antinociception in mice

Shaifali Bhalla, Zhong Zhang, Nicole Patterson, Anil Gulati

European Journal of Pharmacology > 2010 > 635 > 1-3 > 62-71

We have previously shown the involvement of central endothelin (ET) mechanisms in morphine analgesia and tolerance. Here we investigated the interaction of centrally administered endothelin ET _A receptor antagonist, BMS182874, with DAMGO (µ opioid receptor agonist), SNC80 (δ opioid receptor agonist), U50,488H (κ opioid receptor agonist), and oxycodone (µ and κ opioid receptor agonist) towards...

article

Modulation of delta opioid agonist-induced antinociception by repeated morphine pretreatment in rhesus monkeys

S.S. Negus, M.L. Banks, J.E. Folk, K.C. Rice

Life Sciences > 2010 > 86 > 11-12 > 385-392

Repeated treatment with morphine increases antinociceptive effects of delta opioid agonists in rodents by a mechanism that may involve increased cell-surface expression of delta receptors. The present study evaluated effects of repeated morphine treatment on behavioral effects of the delta agonist SNC80 and the mu agonist fentanyl in rhesus monkeys.In an assay of schedule-controlled responding, three...

article

A role for delta opioid receptors in the central nucleus of the amygdala in anxiety-like behaviors

Jovita F. Randall-Thompson, Karen A. Pescatore, Ellen M. Unterwald

Psychopharmacology > 2010 > 212 > 4 > 585-595

Rationale Compounds acting on delta opioid receptors (DOR) modulate anxiety-like behaviors, yet the site of action underlying this effect is unknown. DOR mRNA and protein are expressed in the central nucleus of the amygdala, a region that plays an important role in processing fear, stress, and anxiety. We hypothesized that this brain region may contribute to the modulation of anxiety by DOR drugs...

article

Opiate-agonist induced taste aversion learning in the Fischer 344 and Lewis inbred rat strains: Evidence for differential mu opioid receptor activation

Catherine M. Davis, Kenner C. Rice, Anthony L. Riley

Pharmacology, Biochemistry and Behavior > 2009 > 93 > 4 > 397-405

The Fischer 344 (F344) and Lewis (LEW) inbred rat strains react differently to morphine in a number of behavioral and physiological preparations, including the acquisition of aversions induced by this compound. The present experiment tested the ability of various compounds with relative selectivity at kappa, delta and mu receptor subtypes to assess the relative roles of these subtypes in mediating...

article

The selective non-peptidic delta opioid agonist SNC80 does not facilitate intracranial self-stimulation in rats

Gail Pereira Do Carmo, John E. Folk, Kenner C. Rice, Elena Chartoff, more

European Journal of Pharmacology > 2009 > 604 > 1-3 > 58-65

Delta opioid receptor agonists are under development for a variety of clinical applications, and some findings in rats raise the possibility that agents with this mechanism have abuse liability. The present study assessed the effects of the non-peptidic delta opioid agonist SNC80 in an assay of intracranial self-stimulation (ICSS) in rats. ICSS was examined at multiple stimulation frequencies to permit...

article

The selective delta opioid agonist SNC80 enhances amphetamine-mediated efflux of dopamine from rat striatum

Kelly E. Bosse, Emily M. Jutkiewicz, Margaret E. Gnegy, John R. Traynor

Neuropharmacology > 2008 > 55 > 5 > 755-762

The highly selective delta opioid agonist, SNC80, elicits dopamine-related behaviors including locomotor stimulation and conditioned place-preference. In contrast, it has been reported that SNC80 fails to promote dopamine efflux from the striatum of freely moving rats. However, SNC80 does enhance behavioral responses to the stimulants, amphetamine and cocaine, suggesting an interaction between delta...

article

Antidepressant-like effects of the delta-opioid receptor agonist SNC80 ([(+)-4-[(alphaR)-alpha-[(2S,5R)-2,5-dimethyl-4-(2-propenyl)-1-piperazinyl]-(3-methoxyphenyl)methyl]-N,N-diethylbenzamide) in an olfactory bulbectomized rat model

Akiyoshi Saitoh, Mitsuhiko Yamada, Misa Yamada, Kou Takahashi, more

Brain Research > 2008 > 1208 > Complete > 160-169

The responses of olfactory bulbectomized (OBX) rats to antidepressant treatment are similar to those of depressed patients since chronic administration of an antidepressant reverses OBX-induced behavioral and physiological changes. Previously, using several animal models, it was demonstrated that single treatment with delta-opioid receptor agonists produced an antidepressant-like effect. This study...

article

Withdrawal from chronic administration of cocaine decreases delta opioid receptor signaling and increases anxiety- and depression-like behaviors in the rat

Shane A. Perrine, Imran S. Sheikh, Chinwe A. Nwaneshiudu, Joseph A. Schroeder, more

Neuropharmacology > 2008 > 54 > 2 > 355-364

Chronic administration of cocaine has been shown to attenuate the functional capacity of delta opioid receptors to inhibit adenylyl cyclase activity. Abuse and withdrawal from cocaine in humans is associated with increases in anxiety and depression. Since recent research supports the role of delta opioid receptors in anxiety- and depression-like behaviors in rodents, we hypothesized that functional...

article

Effects of the selective delta opioid agonist SNC80 on cocaine- and food-maintained responding in rhesus monkeys

Gail Pereira Do Carmo, Nancy K. Mello, Kenner C. Rice, John E. Folk, more

European Journal of Pharmacology > 2006 > 547 > 1-3 > 92-100

Delta agonists such as SNC80 ((+)-4-[(aR)-a-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide) produce some cocaine-like behavioral effects and warrant evaluation as candidate “agonist” medications for cocaine abuse. The present study examined acute and chronic effects of the systemically active delta agonist SNC80 on cocaine- and food-maintained responding in rhesus...

article

Electroencephalographic and convulsant effects of the delta opioid agonist SNC80 in rhesus monkeys

Ingela Danielsson, Maciej Gasior, Glenn W. Stevenson, John E. Folk, more

Pharmacology, Biochemistry and Behavior > 2006 > 85 > 2 > 428-434

Non-peptidic delta opioid receptor agonists are being evaluated for a wide range of clinical applications; however, the clinical utility of piperazinyl benzamide delta agonists such as SNC80 may be limited by convulsant activity. The purpose of the present study was to evaluate the electroencephalographic and convulsant activity produced by a high dose of 10 mg/kg SNC80 IM in rhesus monkeys. EEG and...

article

Behavioral effects of opioid subtypes compared with benzodiazepines in the staircase paradigm

Anat Milman, Ronit Weizman, Tova Rigai, Kenner C. Rice, more

Behavioural Brain Research > 2006 > 170 > 1 > 141-147

Opioid abuse is frequently associated with the abuse of benzodiazepines (BZ). Despite the fact that benzodiazepines and opioids act at totally separate receptor sites and through different biochemical and pharmacological mechanisms, they obviously interact with each other at some level.The present study was designed to investigate the behavioral effects of agents with activity on the opioid system...

Publication date

Last 3 years (1)

Close

Date range setting

Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.

From:

To:
Set your own date range

Keywords

SNC80 (33)
MORPHINE (9)
DELTA OPIOID RECEPTOR (8)
ANTINOCICEPTION (5)
DEPRESSION (5)
NALTRINDOLE (4)
RAT (4)
AMPHETAMINE (3)
ANXIETY (3)
DAMGO (3)
DELTA OPIOID (3)
(+)BW373U86 (2)
BUPRENORPHINE (2)
BUTORPHANOL (2)
COCAINE (2)
CONDITIONED TASTE AVERSION (2)
CONVULSIONS (2)
DELTA OPIOIDS (2)
DELTORPHIN II (2)
DOPAMINE (2)
FENTANYL (2)
FORCED SWIM ASSAY (2)
MICE (2)
MONKEY (2)
MU OPIOIDS (2)
OPIOID RECEPTORS (2)
PERIPHERAL ANTINOCICEPTION (2)
RATS (2)
U50,488H (2)
Δ-OPIOID RECEPTOR AGONIST (2)
(RHESUS MONKEY) (1)
(−)-U50,488H (1)
-OPIOID RECEPTOR (1)
ADENYLYL CYCLASE (1)
AGONISTS (1)
ANALGESIA AUGMENTATION (1)
ANGIOGENESIS (1)
ANTIDEPRESSANT (1)
ANTIDEPRESSANTS (1)
ARM390 (1)
BEHAVIORAL ECONOMICS (1)
BMS182874 (1)
BREMAZOCINE (1)
CACC (1)
CAMP (1)
CARDIOMYOCYTES (1)
CENTRAL NUCLEUS OF THE AMYGDALA (1)
COCAINE SELF-ADMINISTRATION (1)
COMFA (1)
CONVULSION (1)
CORTICOTROPIN RELEASING HORMONE (1)
CTA (1)
DELTA (1)
DELTA OPIOID AGONIST (1)
DELTA OPIOID RECEPTOR AGONIST (1)
DELTA OPIOID RECEPTOR AGONISTS (1)
DELTA-OPIOID RECEPTOR (1)
DEMAND CURVE (1)
DEXTROMETHORPHAN (1)
DOP (1)
DORSAL ROOT GANGLIA (1)
DPDPE (1)
DRUG DISCRIMINATION LEARNING (1)
EEG (1)
ELEVATED PLUS MAZE (1)
ENDOTHELIN (1)
ESTROGEN (1)
F344 (1)
FLEXOR REFLEX (1)
FORCED SWIM TEST (1)
G PROTEIN ACTIVATION (1)
GABA (1)
GLUTAMATE (1)
HEROIN (1)
HIPPOCAMPUS (1)
HORMONES (1)
HOT-PLATE (1)
HUMAN UMBILICAL CORD MESENCHYMAL STEM CELL (1)
HYPERSENSITIVITY (1)
INFLAMMATION (1)
INFUSION RATE (1)
INTERNALIZATION (1)
INTRACRANIAL SELF-STIMULATION (1)
K+ CHANNEL (1)
KAPPA (1)
KETAMINE (1)
L-ARGININE/NO/CGMP PATHWAY (1)
LEW (1)
LOCOMOTOR ACTIVITY (1)
LORAZEPAM (1)
METHADONE (1)
MOP (1)
MU (1)
MU-OPIOID (1)
N4-PROTONATED FORMS (1)
NALORPHINE (1)
NG108-15 (1)
NIFLUMIC ACID (1)
NOCICEPTION (1)
NOTCH1 SIGNALING (1)
more

Data set

Elsevier (22)
Springer (8)
Wiley (3)

INFONA - science communication portal

Search results

Subanalgesic morphine doses augment fentanyl analgesia by interacting with delta opioid receptors in male rats

Regulation of Cardiomyocyte Differentiation, Angiogenesis, and Inflammation by the Delta Opioid Signaling in Human Mesenchymal Stem Cells

Delta/mu opioid receptor interactions in operant conditioning assays of pain-depressed responding and drug-induced rate suppression: assessment of therapeutic index in male Sprague Dawley rats

Prolonged morphine treatment alters δ opioid receptor post‐internalization trafficking

Synergistic activity between the delta-opioid agonist SNC80 and amphetamine occurs via a glutamatergic NMDA-receptor dependent mechanism

δ‐Opioid receptor agonist SNC80 induces central antinociception mediated by Ca²⁺‐activated Cl^‐ channels

Effects of the Delta Opioid Receptor Agonist SNC80 on Pain-Related Depression of Intracranial Self-Stimulation (ICSS) in Rats

Ovarian hormones influence corticotropin releasing factor receptor colocalization with delta opioid receptors in CA1 pyramidal cell dendrites

Effects of the delta-opioid agonist SNC80 on the abuse liability of methadone in rhesus monkeys: a behavioral economic analysis

Effect of endothelin-A receptor antagonist on mu, delta and kappa opioid receptor-mediated antinociception in mice

Modulation of delta opioid agonist-induced antinociception by repeated morphine pretreatment in rhesus monkeys

A role for delta opioid receptors in the central nucleus of the amygdala in anxiety-like behaviors

Opiate-agonist induced taste aversion learning in the Fischer 344 and Lewis inbred rat strains: Evidence for differential mu opioid receptor activation

The selective non-peptidic delta opioid agonist SNC80 does not facilitate intracranial self-stimulation in rats

The selective delta opioid agonist SNC80 enhances amphetamine-mediated efflux of dopamine from rat striatum

Antidepressant-like effects of the delta-opioid receptor agonist SNC80 ([(+)-4-[(alphaR)-alpha-[(2S,5R)-2,5-dimethyl-4-(2-propenyl)-1-piperazinyl]-(3-methoxyphenyl)methyl]-N,N-diethylbenzamide) in an olfactory bulbectomized rat model

Withdrawal from chronic administration of cocaine decreases delta opioid receptor signaling and increases anxiety- and depression-like behaviors in the rat

Effects of the selective delta opioid agonist SNC80 on cocaine- and food-maintained responding in rhesus monkeys

Electroencephalographic and convulsant effects of the delta opioid agonist SNC80 in rhesus monkeys

Behavioral effects of opioid subtypes compared with benzodiazepines in the staircase paradigm

Filter options

Publication date

Keywords

Data set

INFONA - science communication portal

Search results

Add recipient

Sending message cancelled

Are you sure you want to cancel sending this message?

Send message

Filter options

Publication date

Date range setting

Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.

Keywords

Data set

Reporting an error / abuse

Sending the report failed

Accessibility options