Search results

Items from 1 to 9 out of 9 results

article

5-HT6 receptor blockade differentially affects scopolamine-induced deficits of working memory, recognition memory and aversive learning in mice

Virginie Silva Costa-Aze, Anne Quiedeville, Michel Boulouard, François Dauphin

Psychopharmacology > 2012 > 222 > 1 > 99-115

Rationale Blockade of 5-HT6 receptors (5-HT6R) is known to improve cognitive performances in the rodent. This improvement has been hypothesized to be the result, at least in part, of a modulation of the cholinergic neurotransmission. Objective We assessed the effects of 5-HT6R blockade on selected types of memory relevant to functional deficits of ageing and neurodegenerative diseases, in mice that...

article

Serotonin 5-HT6 receptor blockade reverses the age-related deficits of recognition memory and working memory in mice

Virginie Da Silva Costa-Aze, François Dauphin, Michel Boulouard

Behavioural Brain Research > 2011 > 222 > 1 > 134-140

Studies have shown that the blockade of 5-HT6 receptors (5-HT6R) can improve memory processes and reverse age-related spatial episodic like memory deficits. Since normal aging in the human is associated with a decline in episodic and working memory, we assessed the effect of the 5-HT6R blockade (SB-271046) on recognition memory (object recognition task) (a component of episodic like memory) in parallel...

article

The 5-HT6 serotonin receptor antagonist SB-271046 attenuates the development and expression of nicotine-induced locomotor sensitisation in Wistar rats

N.M.W.J. de Bruin, B.M. Kloeze, A.C. McCreary

Neuropharmacology > 2011 > 61 > 3 > 451-457

5-HT ₆ receptors are almost exclusively expressed in the central nervous system, particularly in areas relevant for addictive behaviour. Based on this, together with other data, this receptor may be a viable target for the control of drug abuse.The present study tested the ability of the 5-HT ₆ receptor antagonist SB-271046 to attenuate the development and expression of nicotine-induced...

article

The selective 5-HT6 receptor antagonists SB-271046 and SB-399885 potentiate NCAM PSA immunolabeling of dentate granule cells, but not neurogenesis, in the hippocampal formation of mature Wistar rats

Andrew G. Foley, Warren D. Hirst, Helen C. Gallagher, Claire Barry, more

Neuropharmacology > 2008 > 54 > 8 > 1166-1174

While there is now substantial evidence that 5-HT ₆ antagonism leads to significantly improved cognitive ability, the mechanism(s) and/or pathway(s) involved are poorly understood. We have evaluated the consequence of chronic administration of the 5-HT ₆ receptor antagonists SB-271046 and SB-399885 on neural cell adhesion molecule polysialylation state (NCAM PSA), a neuroplastic mechanism...

article

The effects of pharmacological blockade of the 5-HT6 receptor on formalin-evoked nociceptive behaviour, locomotor activity and hypothalamo–pituitary–adrenal axis activity in rats

David P. Finn, Kevin C.F. Fone, Simon R.G. Beckett, Jonathan A. Baxter, more

European Journal of Pharmacology > 2007 > 569 > 1-2 > 59-63

5-hydroxytryptamine (5-HT) mediates behavioural and neuroendocrine responses to noxious or stressful stimuli. 5-HT ₆ receptors are expressed in brain regions involved in nociceptive processing, however, their role in nociception is unknown. Here we demonstrate that acute, systemic administration of the 5-HT ₆ receptor antagonist, 5-chloro-N-(4-methoxy-3-benzothio-phenesulfonamide (SB-271046),...

article

5-HT ₆ receptor antagonists reverse delay-dependent deficits in novel object discrimination by enhancing consolidation-an effect sensitive to NMDA receptor antagonism

M.V. King, A.J. Sleight, M.L. Woolley, I.A. Topham, more

Neuropharmacology > 2004 > 47 > 2 > 195-204

5-HT ₆ receptors are expressed in brain regions associated with learning and memory, and blockade of their function increases central cholinergic and glutamatergic neurotransmission and enhances cognitive processes. This study examined the effects of acute systemic administration of two selective 5-HT ₆ receptor antagonists Ro 04-6790 and SB-271046 (10 mg kg ^- ¹ i.p.) on...

article

A 5-HT₇ Heteroreceptor-Mediated Inhibition of [³H]Serotonin Release in Raphe Nuclei Slices of the Rat: Evidence for a Serotonergic–Glutamatergic Interaction

Laszlo G. Harsing, Ibolya Prauda, Jozsef Barkoczy, Peter Matyus, more

Neurochemical Research > 2004 > 29 > 8 > 1487-1497

Midbrain slices containing the dorsal and medial raphe nuclei were prepared from rat brain, loaded with [³H]serotonin ([³H]5-HT), superfused, and the electrically induced efflux of radioactivity was determined. The nonselective 5-HT receptor agonist 5-carboxamido-tryptamine (5-CT; 0.001 to 1 μM) inhibited the electrically stimulated [³H]5-HT overflow from raphe nuclei slices (IC₅₀ of 3.34 ± 0.37 nM)...

article

Effects of the 5-HT ₆ receptor antagonist, SB-271046, in animal models for schizophrenia

B. Pouzet, M. Didriksen, J. Arnt

Pharmacology, Biochemistry and Behavior > 2002 > 71 > 4 > 635-643

The 5-HT ₆ receptor is targeted by several new antipsychotics such as clozapine, olanzapine, and sertindole. We studied the effect of SB-271046 [5-chloro-N-(4-methoxy-3-piperazin-1-yl-phenyl)-3-methyl-2-benzothiophenesul fonamide], a specific 5-HT ₆ receptor antagonist, in three models for the positive symptoms of schizophrenia-d-amphetamine-induced hyperactivity, and d-amphetamine-...

article

The 5-HT ₆ Receptor Antagonist SB-271046 Selectively Enhances Excitatory Neurotransmission in the Rat Frontal Cortex and Hippocampus

Lee A. Dawson, Huy Q. Nguyen, Ping Li

Neuropsychopharmacology > 2001 > 25 > 5 > 662-668

Preclinical evidence has suggested a possible role for the 5-HT ₆ receptor in the treatment of cognitive dysfunction. However, currently there is little neurochemical evidence suggesting the mechanism(s) which may be involved. Using the selective 5-HT ₆ antagonist SB-271046 and in vivo microdialysis, we have evaluated the effects of this compound on the modulation of basal neurotransmitter...

Filter options

Publication date

Set your own date range

Keywords

SB-271046 (9)
5-HT 6 RECEPTOR (2)
5-HT6 RECEPTOR (2)
COGNITION (2)
GLUTAMATE (2)
LOCOMOTOR ACTIVITY (2)
RECOGNITION MEMORY (2)
SPONTANEOUS ALTERNATION (2)
WORKING MEMORY (2)
5-HT 6 (1)
5-CARBOXAMIDOTRYPTAMINE (1)
5-HT1A RECEPTOR (1)
5-HT1B/1D RECEPTOR (1)
5-HT6 ANTAGONISTS (1)
5-HT7 RECEPTOR (1)
ACTIVITY (1)
AGING (1)
AVERSIVE LEARNING (1)
CATALEPSY (1)
CORTICOSTERONE (1)
DEVELOPMENT AND EXPRESSION OF NICOTINE SENSITISATION (1)
DORSAL HIPPOCAMPUS (1)
FRONTAL CORTEX (1)
MICRODIALYSIS (1)
MOUSE (1)
NCAM PSA (1)
NEUROGENESIS (1)
NUCLEUS ACCUMBENS (1)
OBJECT DISCRIMINATION (1)
OBJECT RECOGNITION (1)
PAIN (1)
PASSIVE AVOIDANCE (1)
PLACE RECOGNITION (1)
PREPULSE INHIBITION (1)
RAPHE NUCLEI (1)
RO 04-6790 (1)
SB-216641 (1)
SB-258719 (1)
SB-399885 (1)
SCHIZOPHRENIA (1)
SCOPOLAMINE (1)
SEROTONIN (1)
SEROTONIN 5-HT6 ANTAGONIST (1)
SOCIAL INTERACTION (1)
SPATIAL LEARNING (1)
STRESS (1)
STRIATUM (1)
WAY-100635 (1)
WISTAR RATS (1)
[3H]SEROTONIN RELEASE (1)
more

Data set

Elsevier (7)
Springer (2)

INFONA - science communication portal

Search results

Add recipient

Sending message cancelled

Are you sure you want to cancel sending this message?

Send message

Filter options

Publication date

Date range setting

Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.

Keywords

Data set

Reporting an error / abuse

Sending the report failed

Accessibility options