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Development and validation of HPLC–MS/MS procedure for determination of 3,4,4′,5-tetra-methoxystilbene (DMU-212) and its metabolites in ovarian cancer cells and culture medium

Agnieszka Klupczynska, Anna Maria Sulej-Suchomska, Hanna Piotrowska-Kempisty, Marcin Wierzchowski, more

Journal of Chromatography B > 2017 > 1060 > C > 30-35

The synthetic resveratrol analogue DMU-212 (3,4,4′,5-tetramethoxystilbene) has been shown to possess stronger anticancer activity than resveratrol in a variety of tumour cells. To date, there has been no appropriate procedure that would ensure a reliable data about levels of metabolic products of DMU-212 in cancer cell lines. The purpose of this study was to develop a new procedure for determination...

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Potential renoprotective effects of piceatannol in ameliorating the early-stage nephropathy associated with obesity in obese Zucker rats

Marta Llarena, Fernando Andrade, Mounia Hasnaoui, María P. Portillo, more

Journal of Physiology and Biochemistry > 2016 > 72 > 3 > 555-566

Obesity-associated nephropathy is considered to be a leading cause of end-stage renal disease. Resveratrol supplementation represents a promising therapy to attenuate kidney injury, but the poor solubility and limited bioavailability of this polyphenol limits its use in dietary intervention. Piceatannol, a resveratrol analogue, has been suggested as a better option. In this study, we aimed to provide...

article

Deprotometalation–iodolysis and computed CH acidity of 1,2,3- and 1,2,4-triazoles. Application to the synthesis of resveratrol analogues

Elisabeth Nagaradja, Ghenia Bentabed-Ababsa, Mathieu Scalabrini, Floris Chevallier, more

Bioorganic & Medicinal Chemistry > 2015 > 23 > 19 > 6355-6363

1-Aryl- and 2-aryl-1,2,3-triazoles were synthesized by N-arylation of the corresponding azoles using aryl iodides. The deprotometalations of 1-phenyl-1,2,3-triazole and -1,2,4-triazole were performed using a 2,2,6,6-tetramethylpiperidino-based mixed lithium–zinc combination and occurred at the most acidic site, affording by iodolysis the 5-substituted derivatives. Dideprotonation was noted from 1-(2-thienyl)-1,2,4-triazole...

article

Flavonoids and stilbenoids from Derris eriocarpa

Hong-Xia Zhang, Paul-Keilah Lunga, Zhi-Jian Li, Qin Dai, more

Fitoterapia > 2014 > 95 > C > 147-153

One new resveratrol analogue, 1-(3′,4′,5′-trimethoxyphenyl)-2-methoxy-2-(4″-methoxyphenyl)-ethane-1-ol (1), and two new prenylisoflavones, 4′-hydroxy-5,7-dimethoxy-6-(3-methyl-2-butenyl)-isoflavone (2), and derrubon 5-methyl ether (3), together with 17 known compounds including one new natural product, 5,7-dihydroxy-3-[4′-O-(3-methyl-2-butenyl)-phenyl]-isoflavone (4), were isolated from the stems...

article

HS-1793, a recently developed resveratrol analogue protects rat heart against hypoxia/reoxygenation injury via attenuating mitochondrial damage

Seung Hun Jeong, Tran My Hanh, Hyoung Kyu Kim, Sung Ryul Lee, more

Bioorganic & Medicinal Chemistry Letters > 2013 > 23 > 14 > 4225-4229

Resveratrol is known to exert a cardioprotective effect against hypoxia/reoxygenation (H/R) injury. HS-1793 is a novel, more stable resveratrol analog, but its cardioprotective effects were unknown. The present study aimed to test the cardioprotective effect of HS-1793 against H/R injury and investigate the role of mitochondria in Sprague Dawley rat heart damage using an ex vivo Langendorff system...

article

Potential of Resveratrol Analogues as Antagonists of Osteoclasts and Promoters of Osteoblasts

Katarzyna Kupisiewicz, Patrice Boissy, Basem M. Abdallah, Frederik Dagnaes Hansen, more

Calcified Tissue International > 2010 > 87 > 5 > 437-449

The plant phytoalexin resveratrol was previously demonstrated to inhibit the differentiation and bone resorbing activity of osteoclasts, to promote the formation of osteoblasts from mesenchymal precursors in cultures, and inhibit myeloma cell proliferation, when used at high concentrations. In the current study, we screened five structurally modified resveratrol analogues for their ability to modify...

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Search results

Development and validation of HPLC–MS/MS procedure for determination of 3,4,4′,5-tetra-methoxystilbene (DMU-212) and its metabolites in ovarian cancer cells and culture medium

Potential renoprotective effects of piceatannol in ameliorating the early-stage nephropathy associated with obesity in obese Zucker rats

Deprotometalation–iodolysis and computed CH acidity of 1,2,3- and 1,2,4-triazoles. Application to the synthesis of resveratrol analogues

Flavonoids and stilbenoids from Derris eriocarpa

HS-1793, a recently developed resveratrol analogue protects rat heart against hypoxia/reoxygenation injury via attenuating mitochondrial damage

Potential of Resveratrol Analogues as Antagonists of Osteoclasts and Promoters of Osteoblasts

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INFONA - science communication portal

Search results

Development and validation of HPLC–MS/MS procedure for determination of 3,4,4′,5-tetra-methoxystilbene (DMU-212) and its metabolites in ovarian cancer cells and culture medium

Potential renoprotective effects of piceatannol in ameliorating the early-stage nephropathy associated with obesity in obese Zucker rats

Deprotometalation–iodolysis and computed CH acidity of 1,2,3- and 1,2,4-triazoles. Application to the synthesis of resveratrol analogues

Flavonoids and stilbenoids from Derris eriocarpa

HS-1793, a recently developed resveratrol analogue protects rat heart against hypoxia/reoxygenation injury via attenuating mitochondrial damage

Potential of Resveratrol Analogues as Antagonists of Osteoclasts and Promoters of Osteoblasts

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