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article

N6‐methyladenosine functions and its role in skin cancer

Yanqin Ran, Zhuoxian Yan, Bimei Jiang, Pengfei Liang

Experimental Dermatology > 32 > 1 > 4 - 12

N6‐methyladenosine (m6A) methylation is the most abundant mammalian mRNA modification. m6A regulates RNA processing, splicing, nucleation, translation and stability by transferring, removing and recognizing m6A methylation sites, which are critical for cancer initiation, progression, metabolism and metastasis. m6A is involved in pathophysiological tumour development by altering m6A modification and...

article

Visible‐Light Facilitated Fluorescence “Switch‐On” Labelling of 5‐Formylpyrimidine RNA

Rui‐Li Wang, Xiao‐Yang Jin, De‐Long Kong, Zhi‐Gang Chen, more

Advanced Synthesis & Catalysis > 361 > 23 > 5406 - 5411

Labelling and detecting 5‐formylpyrimidine is essential to understand its biological function. Herein, we describe a visible‐light triggered and catalyst‐free reaction in which 5‐formylcytidine RNA can be selectively labelled with 2‐thioaniline under the irradiation of a commercial blue LED light to generate fluorogenic 5‐(benzothiazol‐2‐yl) cytidine.

article

To be or not to be modified: Miscellaneous aspects influencing nucleotide modifications in tRNAs

Pierre Barraud, Carine Tisné

IUBMB Life > 71 > 8 > 1126 - 1140

Transfer RNAs (tRNAs) are essential components of the cellular protein synthesis machineries, but are also implicated in many roles outside translation. To become functional, tRNAs, initially transcribed as longer precursor tRNAs, undergo a tightly controlled biogenesis process comprising the maturation of their extremities, removal of intronic sequences if present, addition of the 3′‐CCA amino‐acid...

article

Base-Resolution Mapping Reveals Distinct m1A Methylome in Nuclear- and Mitochondrial-Encoded Transcripts

Xiaoyu Li, Xushen Xiong, Meiling Zhang, Kun Wang, more

Molecular Cell > 2017 > 68 > 5 > 993-1005.e9

Gene expression can be post-transcriptionally regulated via dynamic and reversible RNA modifications. N¹-methyladenosine (m¹A) is a recently identified mRNA modification; however, little is known about its precise location and biogenesis. Here, we develop a base-resolution m¹A profiling method, based on m¹A-induced misincorporation during reverse transcription, and report distinct classes of m¹A methylome...

article

Synthesis of RNA Containing 5‐Hydroxymethyl‐, 5‐Formyl‐, and 5‐Carboxycytidine

Iacovos N. Michaelides, Nobuhiro Tago, Bastien Viverge, Thomas Carell

Chemistry – A European Journal > 23 > 63 > 15894 - 15898

5‐Hydroxymethyl‐, 5‐formyl‐, and 5‐carboxy‐2′‐deoxycytidine are new epigenetic bases (hmdC, fdC, cadC) that were recently discovered in the DNA of higher eukaryotes. The same bases (5‐hydroxymethyl‐, 5‐formyl‐, and 5‐carboxycytidine; hmC, fC, and caC) have now also been detected in mammalian RNA with a high abundance in mRNA. While DNA phosphoramidites (PAs) that allow the synthesis of xdC‐containing...

article

Regulation of Peripheral Myelination through Transcriptional Buffering of Egr2 by an Antisense Long Non-coding RNA

Margot Martinez-Moreno, Timothy Mark O’Shea, John P. Zepecki, Alexander Olaru, more

Cell Reports > 2017 > 20 > 8 > 1950-1963

Precise regulation of Egr2 transcription is fundamentally important to the control of peripheral myelination. Here, we describe a long non-coding RNA antisense to the promoter of Egr2 (Egr2-AS-RNA). During peripheral nerve injury, the expression of Egr2-AS-RNA is increased and correlates with decreased Egr2 transcript and protein levels. Ectopic expression of Egr2-AS-RNA in dorsal root ganglion (DRG)...

article

Regulatory mechanisms of RNA function: emerging roles of DNA repair enzymes

Laure Jobert, Hilde Nilsen

Cellular and Molecular Life Sciences > 2014 > 71 > 13 > 2451-2465

The acquisition of an appropriate set of chemical modifications is required in order to establish correct structure of RNA molecules, and essential for their function. Modification of RNA bases affects RNA maturation, RNA processing, RNA quality control, and protein translation. Some RNA modifications are directly involved in the regulation of these processes. RNA epigenetics is emerging as a mechanism...

chapter

Unveiling the dynamics in RNA epigenetic regulations

Jia Meng, Xiaodong Cui, Hui Liu, Lin Zhang, more

2013 IEEE International Conference on Bioinformatics and Biomedicine > 139 - 144

2013 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)

Despite the prevalent studies of DNA/Chromatin related epigenetics, such as, histone modifications and DNA methylation, RNA epigenetics did not receive deserved attention due to the lack of high throughput approach for profiling epitranscriptome. Recently, a new affinity-based sequencing approach MeRIPseq was developed and applied to survey the global mRNA N6-methyladenosine (m⁶A) in mammalian cells...

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