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Items from 1 to 20 out of 1,219 results

article

Development and validation of a liquid chromatography–tandem mass spectrometry method for simultaneous quantification of eight Xiakucao Oral liquid–related compounds in rat plasma and its application in pharmacokinetic study

Jingyi Jin, Xiaoqing Xu, Xinwei Wang, Biao Chen, more

Biomedical Chromatography > 38 > 9 > n/a - n/a

Xiakucao Oral Liquid (XKCOL) has been widely used for treating mammary gland hyperplasia and goiter in China. However, its pharmacokinetic data have been missing to date. To conduct its pharmacokinetic study, we established an LC–tandem mass spectrometry method for the simultaneous determination of eight XKCOL‐related compounds in rat plasma. Liquid–liquid extraction was used for the sampling process...

article

Association of Vancomycin AUC/MIC and Trough Concentration With Early Clinical Response in Enterococcus or Coagulase‐Negative Staphylococcus Infection: A Prospective Study

Chuleephorn Pitayakittiwong, Pakawadee Sermsappasuk, Atibordee Meesing, Siriluk Jaisue

The Journal of Clinical Pharmacology > 64 > 8 > 1006 - 1014

This study was condcuted to examine the association of area under the curve (AUC)/minimum inhibitory concentration (MIC) and trough concentration (C_trough) of vancomycin with treatment outcome and nephrotoxicity in infections caused by Enterococcus spp. and coagulase‐negative Staphylococci (CoNS). Peak and trough concentrations were used to calculate AUC in 89 patients receiving vancomycin for infections...

article

Diosmetin as a promising natural therapeutic agent: In vivo, in vitro mechanisms, and clinical studies

Zihao Sun, Kai Liu, Chuipeng Liang, Lin Wen, more

Phytotherapy Research > 38 > 7 > 3660 - 3694

Diosmetin, a natural occurring flavonoid, is primarily found in citrus fruits, beans, and other plants. Diosmetin demonstrates a variety of pharmacological activities, including anticancer, antioxidant, anti‐inflammatory, antibacterial, metabolic regulation, cardiovascular function improvement, estrogenic effects, and others. The process of literature search was done using PubMed, Web of Science and...

article

Antibody–Antibiotic Conjugates: A Comprehensive Review on Their Therapeutic Potentials Against BacterialInfections

Atieh Darbandi, Milad Abdi, Shirin Dashtbin, Sajad Yaghoubi, more

Journal of Clinical Laboratory Analysis > 38 > 10 > n/a - n/a

Introduction Antibodies are significant agents in the immune system and have proven to be effective in treating bacterial infections. With the advancement of antibody engineering in recent decades, antibody therapy has evolved widely. Aim This review aimed to investigate a new method as a therapeutic platform for the treatment of bacterial infections and explore the novel features of this method...

article

Pediatric Extrapolation Approach for U.S. Food and Drug Administration Approval of Brexpiprazole in Patients Aged 13 to 17 Years with Schizophrenia

Huixia Zhang, Jie Liu, Vishnu Sharma, Luning Zhuang, more

The Journal of Clinical Pharmacology > 64 > 7 > 771 - 778

A pharmacokinetic (PK) bridging approach was successfully employed to support the dosing regimen and approval of brexpiprazole in pediatric patients aged 13‐17 years with schizophrenia. Brexpiprazole was approved in 2015 for the treatment of schizophrenia and the adjunctive treatment of major depressive disorder in adults based on efficacy and safety data from clinical trials. On January 13, 2020,...

article

Ethosuximide lowers lamotrigine serum concentrations: Evidence for a clinically relevant interaction

Anne Hagemann, Arne Herting, Dennis Klimpel, Christian G. Bien, more

Epilepsia > 65 > 6 > e73 - e78

We investigated the effect of comedication with ethosuximide (ESM) on lamotrigine (LTG) blood levels. Based on observations from clinical practice, we hypothesized that ESM reduces the LTG serum concentration. We additionally evaluated this effect in the presence of concomitant valproic acid (VPA). We retrospectively analyzed samples of inpatients from our department who had been treated with a combination...

article

Formation and clearance of TNF–TNF inhibitor complexes during TNF inhibitor treatment

Lea Catharina Berkhout, Merel Jeanne I'Ami, Simone Kruithof, Erik Hans Vogelzang, more

British Journal of Pharmacology > 181 > 8 > 1165 - 1181

Background and Purpose Millions of patients with inflammatory diseases are treated with tumour necrosis factor (TNF) inhibitors (TNFi). Individual treatment response varies, in part related to variable drug clearance. The role of TNF–TNFi complexes in clearance of the different TNFi is controversial. Moreover, mechanistic insight into the structural aspects and biological significance of TNF–TNFi...

article

Pharmacokinetics, absolute bioavailability, and tissue distribution of WJ‐14, a novel N‐methyl‐d‐aspartate receptor antagonist, in rats by liquid chromatography–tandem mass spectrometry

Weiyin Huang, Yan Zhang, Lishou Yang, Yiwen Zhang, more

Biomedical Chromatography > 38 > 4 > n/a - n/a

To circumvent the limitations of current antidepressants, WJ‐14, a novel N‐methyl‐d‐aspartate receptor antagonist, was synthesized and demonstrated to have remarkable efficiency in the treatment of depression. To illustrate the pharmacokinetics, absolute bioavailability, and tissue distribution of WJ‐14 in rats, a rapid and sensitive liquid chromatography–tandem mass spectrometry–based analytical...

article

Peri‐operative desmopressin combined with pharmacokinetic‐guided factor VIII concentrate in non‐severe haemophilia A patients

Lorenzo G. R. Romano, Lisette M. Schütte, Reinier M. Hest, Karina Meijer, more

Haemophilia > 30 > 2 > 355 - 366

Introduction Non‐severe haemophilia A patient can be treated with desmopressin or factor VIII (FVIII) concentrate. Combining both may reduce factor consumption, but its feasibility and safety has never been investigated. Aim We assessed the feasibility and safety of combination treatment in nonsevere haemophilia A patients. Methods Non‐severe, desmopressin responsive, haemophilia A patients were...

article

Pharmacokinetic and Pharmacodynamic Analysis of Acetaminophen and Ibuprofen Dual Therapy for Patent Ductus Arteriosus Closure in Preterm Neonates at Less Than 29 Weeks of Gestation

Mohammed Almoslem, Sanket D. Shah, Valvanera Vozmediano, Serge Guzy, more

The Journal of Clinical Pharmacology > 64 > 3 > 312 - 322

Patent ductus arteriosus (PDA) is a blood vessel that critically supports fetal circulation. The ductus naturally closes within a few days after birth. However, it can stay open in premature neonates for an extended period of time, which is associated with increased mortality and various co‐morbidities. Ibuprofen and indomethacin are currently the only 2 drugs approved for inducing PDA closure, but...

article

Methadone pharmacokinetics in opioid agonist treatment: Influencing factors and clinical implications

Fatemeh Chalabianloo, Lars Thore Fadnes, Kjell Arne Johansson, Gudrun Høiseth, more

Basic & Clinical Pharmacology & Toxicology > 134 > 3 > 333 - 344

Background A considerable inter‐individual variability has been reported in the relationship between methadone doses applied and serum concentrations achieved in methadone maintenance treatment. However, the underlying causes for this variability are not fully understood. Objectives We investigated the influence of genetic, pathophysiological and pharmacological factors on serum methadone concentration‐to‐dose...

article

Model‐based dose optimization framework for bedaquiline, pretomanid and linezolid for the treatment of drug‐resistant tuberculosis

Krina Mehta, Tingjie Guo, Piet H. Graaf, J. G. Coen Hasselt

British Journal of Clinical Pharmacology > 90 > 2 > 463 - 474

Aims Bedaquiline, pretomanid and linezolid (BPaL) combination treatment against Mycobacterium tuberculosis is promising, yet safety and adherence concerns exist that motivate exploration of alternative dosing regimens. We developed a mechanistic modelling framework to compare the efficacy of the current and alternative BPaL treatment strategies. Methods Pharmacodynamic models for each drug in the...

article

Determination of flurbiprofen in rat plasma using ultra‐high performance liquid chromatography–tandem mass spectrometry and its application in a pharmacokinetic study

Xihong Zhao, Chunjing Lv, Hong Chen, Feng Qin, more

Biomedical Chromatography > 38 > 2 > n/a - n/a

A rapid and sensitive ultra‐high performance liquid chromatography–tandem mass spectrometry method was developed to determine flurbiprofen in rat plasma. A triple quadrupole tandem mass spectrometer equipped with an electrospray ionization (ESI) source was used in negative ion mode. Acetonitrile precipitation was selected to prepare samples. Flurbiprofen and internal standard flurbiprofen‐d₅ were...

article

Crystal structure of human serum albumin in complex with megabody reveals unique human and murine cross‐reactive binding site

Sofia De Felice, Zhanna Romanyuk, Monica Chinellato, Giulia Zoia, more

Protein Science > 33 > 2 > n/a - n/a

The pharmacokinetic properties of small biotherapeutics can be enhanced via conjugation to cross‐reactive albumin‐binding ligands in a process that improves their safety and accelerates testing through multiple pre‐clinical animal models. In this context, the small and stable heavy‐chain‐only nanobody NbAlb1, capable of binding both human and murine albumin, has recently been successfully applied...

article

Comparative pharmacokinetics of 11 major bioactive components between two dosage forms of Qixue Shuangbu Prescription in rats by ultra‐high‐performance liquid chromatography‐tandem mass spectrometry

Yong Jiang, Liu Xu, Nina Wei, Rui Chen, more

Journal of Separation Science > 47 > 1 > n/a - n/a

Although Qixue Shuangbu Prescription (QSP) is a classic Chinese medicine prescription for treating chronic heart failure. Low bioavailability due to the insolubility and poor biofilm permeability of the main bioactive ingredients of QSP is still a key factor limiting its efficacy. In this study, a novel self‐microemulsifying drug delivery system was proposed to effectively improve the bioavailability...

article

Pharmacokinetics of toltrazuril and its metabolite, toltrazuril sulfone, in suckling piglets following oral and intramuscular administrations

Ta‐Wei Yeh, Tirawat Rairat, Chao‐Ming Wang, Ching‐Fen Wu, more

Journal of Veterinary Pharmacology and Therapeutics > 47 > 1 > 36 - 47

Toltrazuril (TZR) is currently the only registered chemotherapeutic drug in the European Union for the treatment of Cystoisospora suis. This study investigated the comparative pharmacokinetics and tissue concentration‐time profiles of TZR and its active metabolite, toltrazuril sulfone (TZR‐SO₂), after oral (per os, p.o.) and intramuscular (i.m.) administration to suckling piglets. Following a single...

article

Metabolic regularity of bioactive compounds in Bufei Jianpi granule in rats using ultra‐high‐performance liquid chromatography coupled with triple quadrupole mass spectrometry analysis technology

Shuai Wang, Xin Xin Yang, Tian Jiao Li, Xiang Mu Tian, more

Biomedical Chromatography > 37 > 12 > n/a - n/a

Bufei Jianpi granule (BJG) is clinically effective for treating chronic obstructive pulmonary disease (COPD). At present, there is no report regarding the drug metabolism of BJG in vivo. This work developed an ultra‐high‐performance liquid chromatography coupled with triple quadrupole mass spectrometry method with high accuracy and sensitivity to determine drug metabolism of this compound in vivo...

article

Simultaneous determination of abrine, hypaphorine, schaftoside and soyasaponin Bb in rat plasma by UPLC–MS/MS and its application to a pharmacokinetic study after oral administration of Abrus cantoniensis Hance extract

Chengzhong Zhang, Qitao Bu, Chunyan Li, Pengfei Lu, more

Biomedical Chromatography > 37 > 10 > n/a - n/a

A simple and sensitive liquid chromatography tandem mass spectrometry method was established and validated for the quantitative determination of abrine, hypaphorine, schaftoside and soyasaponin Bb in rat plasma. After preparation by protein precipitation with acetonitrile, the analytes and internal standard were separated on a Waters CORTECS T3 column using acetonitrile containing 0.1% formic acid...

article

Pharmacokinetics of YK‐1169 in healthy subjects and pharmacokinetic/pharmacodynamic analysis by Monte Carlo simulation

You Li, Bingqian Yan, Siwei Guo, Miaomei Tian, more

British Journal of Clinical Pharmacology > 89 > 10 > 3067 - 3078

Objective This study (NCT05588531) aimed to evaluate the safety and pharmacokinetics of cefepime‐avibactam (YK‐1169) in healthy Chinese subjects and explore the optimal regimen for treating carbapenem‐resistant Klebsiella pneumoniae (CRKP) based on the pharmacokinetic/pharmacodynamic evaluation. Methods YK‐1169 single‐ascending doses (0.5, 1.25, 2.5 or 3.75 g, 2‐h infusion) and multiple doses (2...

article

Pharmacokinetic pharmacodynamic modeling of analgesics and sedatives in children

Maddlie Bardol, Shan Pan, Suellen M. Walker, Joseph F. Standing, more

Pediatric Anesthesia > 33 > 10 > 781 - 792

Pharmacokinetic pharmacodynamic modeling is an important tool which uses statistical methodology to provide a better understanding of the relationship between concentration and effect of drugs such as analgesics and sedatives. Pharmacokinetic pharmacodynamic models also describe between‐subject variability that allows identification of subgroups and dose adjustment for optimal pain management in individual...

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Development and validation of a liquid chromatography–tandem mass spectrometry method for simultaneous quantification of eight Xiakucao Oral liquid–related compounds in rat plasma and its application in pharmacokinetic study

Association of Vancomycin AUC/MIC and Trough Concentration With Early Clinical Response in Enterococcus or Coagulase‐Negative Staphylococcus Infection: A Prospective Study

Diosmetin as a promising natural therapeutic agent: In vivo, in vitro mechanisms, and clinical studies

Antibody–Antibiotic Conjugates: A Comprehensive Review on Their Therapeutic Potentials Against BacterialInfections

Pediatric Extrapolation Approach for U.S. Food and Drug Administration Approval of Brexpiprazole in Patients Aged 13 to 17 Years with Schizophrenia

Ethosuximide lowers lamotrigine serum concentrations: Evidence for a clinically relevant interaction

Formation and clearance of TNF–TNF inhibitor complexes during TNF inhibitor treatment

Pharmacokinetics, absolute bioavailability, and tissue distribution of WJ‐14, a novel N‐methyl‐d‐aspartate receptor antagonist, in rats by liquid chromatography–tandem mass spectrometry

Peri‐operative desmopressin combined with pharmacokinetic‐guided factor VIII concentrate in non‐severe haemophilia A patients

Pharmacokinetic and Pharmacodynamic Analysis of Acetaminophen and Ibuprofen Dual Therapy for Patent Ductus Arteriosus Closure in Preterm Neonates at Less Than 29 Weeks of Gestation

Methadone pharmacokinetics in opioid agonist treatment: Influencing factors and clinical implications

Model‐based dose optimization framework for bedaquiline, pretomanid and linezolid for the treatment of drug‐resistant tuberculosis

Determination of flurbiprofen in rat plasma using ultra‐high performance liquid chromatography–tandem mass spectrometry and its application in a pharmacokinetic study

Crystal structure of human serum albumin in complex with megabody reveals unique human and murine cross‐reactive binding site

Comparative pharmacokinetics of 11 major bioactive components between two dosage forms of Qixue Shuangbu Prescription in rats by ultra‐high‐performance liquid chromatography‐tandem mass spectrometry

Pharmacokinetics of toltrazuril and its metabolite, toltrazuril sulfone, in suckling piglets following oral and intramuscular administrations

Metabolic regularity of bioactive compounds in Bufei Jianpi granule in rats using ultra‐high‐performance liquid chromatography coupled with triple quadrupole mass spectrometry analysis technology

Simultaneous determination of abrine, hypaphorine, schaftoside and soyasaponin Bb in rat plasma by UPLC–MS/MS and its application to a pharmacokinetic study after oral administration of Abrus cantoniensis Hance extract

Pharmacokinetics of YK‐1169 in healthy subjects and pharmacokinetic/pharmacodynamic analysis by Monte Carlo simulation

Pharmacokinetic pharmacodynamic modeling of analgesics and sedatives in children

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