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Items from 1 to 20 out of 391 results

article

HAp Thermosensitive Nanohydrogel Cavities Act as Brood Pouches to Incubate and Control‐Release NSCs for Rapid Spinal Cord Injury Therapy

Min Hao, Dapeng Zhang, Wenhan Wang, Zhijian Wei, more

Advanced Functional Materials > 32 > 31 > n/a - n/a

Limitations such as the cell life span, cellular activity, and cellular diffusion outside the lesion make the direct repair of spinal cord injury (SCI) by neural stem cell (NSC) transplantation challenging. Here, an injectable hydroxyapatite (HAp) thermosensitive nanohydrogel is proposed to achieve stem cell storage and release, as well as fate regulation, for therapy. The cavities formed in situ...

article

Multivalent Polyanionic 2D Nanosheets Functionalized Nanofibrous Stem Cell‐based Neural Scaffolds

Yi Xia, Hua Yang, Shuang Li, Suqiong Zhou, more

Advanced Functional Materials > 31 > 20 > n/a - n/a

Because developed neural cells are no longer regenerative and proliferative, achieving neural regenerations by using induced pluripotent stem cells (IPS cells) for nerve diseases have recently attracted much attention. Since the IPS cells’ growth and differentiation can be manipulated by different physical and chemicals cues, scaffolds combining the beneficial nanostructures and extracellular matrix...

article

Glucocorticoids attenuate interleukin‐6‐induced c‐Fos and Egr1 expression and impair neuritogenesis in PC12 cells

Hannes Bongartz, Elena Anne Seiß, Jörg Bock, Fred Schaper

Journal of Neurochemistry > 157 > 3 > 532 - 549

Interleukin‐6 (IL‐6) is a cytokine primarily known for immune regulation. There is also growing evidence that IL‐6 triggers neurogenesis and impacts neural development, both life‐long occurring processes that can be impaired by early‐life and adult stress. Stress induces the release of glucocorticoids by activation of the hypothalamic–pituitary–adrenal (HPA) axis. On the cellular level, glucocorticoids...

article

Neural induction: Historical views and application to pluripotent stem cells

Noriaki Sasai, Minori Kadoya, Agnes Ong Lee Chen

Development, Growth & Differentiation > 63 > 1 > 26 - 37

Embryonic stem (ES) cells are a useful experimental material to recapitulate the differentiation steps of early embryos, which are usually invisible and inaccessible from outside of the body, especially in mammals. ES cells have greatly facilitated the analyses of gene expression profiles and cell characteristics. In addition, understanding the mechanisms during neural differentiation is important...

article

Defining the role of 17β‐estradiol in human endometrial stem cells differentiation into neuron‐like cells

Elham Hasanzadeh, Somayeh Ebrahimi‐Barough, Narges Mahmoodi, Amir Mellati, more

Cell Biology International > 45 > 1 > 140 - 153

Human endometrial stem cells (hEnSCs) that can be differentiated into various neural cell types have been regarded as a suitable cell population for neural tissue engineering and regenerative medicine. Considering different interactions between hormones, growth factors, and other factors in the neural system, several differentiation protocols have been proposed to direct hEnSCs towards specific neural...

article

Novel approach for neuronal stem cell differentiation using aqueous two‐phase systems in 3D cultures

Karolina Chairez‐Cantu, Mirna González‐González, Marco Rito‐Palomares

Journal of Chemical Technology & Biotechnology > 96 > 1 > 8 - 13

Stem cell therapy has emerged as a promising alternative for replacing lost cells involved in neurodegenerative diseases. High efficiency of differentiation and full cell viability are actual challenges to achieve the translation of cell therapies to the clinic. To address this, the construction of aqueous two‐phase systems in three‐dimensional (ATPS‐3D) cultures has been proposed. This technique...

article

Black‐Phosphorus‐Incorporated Hydrogel as a Conductive and Biodegradable Platform for Enhancement of the Neural Differentiation of Mesenchymal Stem Cells

Chao Xu, Yin Xu, Ming Yang, Yukai Chang, more

Advanced Functional Materials > 30 > 39 > n/a - n/a

Conductive hydrogel scaffolds have important applications for electroactive tissue repairs. However, the development of conductive hydrogel scaffolds tends to incorporate nonbiodegradable conductive nanomaterials that will remain in the human body as foreign matters. Herein, a biodegradable conductive hybrid hydrogel is demonstrated based on the integration of black phosphorus (BP) nanosheets into...

article

Control the fate of human umbilical cord mesenchymal stem cells with dual‐enzymatically cross‐linked gelatin hydrogels for potential applications in nerve regeneration

Jinrui Li, Feng Gao, Shanshan Ma, Yanting Zhang, more

Journal of Tissue Engineering and Regenerative Medicine > 14 > 9 > 1261 - 1271

Stem‐cell‐based therapy is a promising strategy to treat challenging neurological diseases, while its application is hindered primarily by the low viability and uncontrolled differentiation of stem cell. Hydrogel can be properly engineered to share similar characteristics with the target tissue, thus promoting cell viability and directing cell differentiation. In this study, we proposed a new dual‐enzymatically...

article

The effect of magnetic stimulation on differentiation of human induced pluripotent stem cells into neuron

Gang Liu, Xiu Ming Li, Shan Tian, Rong Rong Lu, more

Journal of Cellular Biochemistry > 121 > 10 > 4130 - 4141

The effect of stem cell transplantation in the treatment of neural lesions is so far not satisfactory. Magnetic stimulation is a feasible exogenous interference to improve transplantation outcome. However, the effect of magnetic stimulation on the differentiation of induced pluripotent stem cells (iPSCs) into neuron has not been studied. In this experiment, an in vitro neuron differentiation system...

article

3D Bioprinting: Lipid‐Bilayer‐Supported 3D Printing of Human Cerebral Cortex Cells Reveals Developmental Interactions (Adv. Mater. 31/2020)

Linna Zhou, Anne C. Wolfes, Yichen Li, Danny C. W. Chan, more

Advanced Materials > 32 > 31 > n/a - n/a

Current understanding of brain development, derived from suboptimal in vitro and animal models, is rudimentary. In article number 2002183, Francis G. Szele, Hagan Bayley, and co‐workers introduce a means to print human neural cells in a soft, biocompatible extracellular matrix. The approach provides precise, customizable construction of natural and unnatural patterns of cells, and yields important...

article

Lipid‐Bilayer‐Supported 3D Printing of Human Cerebral Cortex Cells Reveals Developmental Interactions

Linna Zhou, Anne C. Wolfes, Yichen Li, Danny C. W. Chan, more

Advanced Materials > 32 > 31 > n/a - n/a

Current understanding of human brain development is rudimentary due to suboptimal in vitro and animal models. In particular, how initial cell positions impact subsequent human cortical development is unclear because experimental spatial control of cortical cell arrangement is technically challenging. 3D cell printing provides a rapid customized approach for patterning. However, it has relied on materials...

article

Construction of multifunctional fusion proteins with a laminin‐derived short peptide to promote neural differentiation of mouse induced pluripotent stem cells

Afroza Sharmin, Nihad Adnan, Amranul Haque, Yasumasa Mashimo, more

Journal of Biomedical Materials Research Part B: Applied Biomaterials > 108 > 6 > 2691 - 2698

There is growing interest in the functional roles of the extracellular matrix (ECM) in regulating the fate of pluripotent stem cells (PSCs). An artificially bioengineered ECM provides an excellent model for studying the molecular mechanisms underlying self‐renewal and differentiation of PSCs, without multiple unknown and variable factors associated with natural substrates. Here, we have engineered...

article

Surface Topography and Electrical Signaling: Single and Synergistic Effects on Neural Differentiation of Stem Cells

Behnaz Sadat Eftekhari, Mahnaz Eskandari, Paul A. Janmey, Ali Samadikuchaksaraei, more

Advanced Functional Materials > 30 > 25 > n/a - n/a

Incomplete regeneration and restoration of function in damaged nerves is a major clinical challenge. In this regard, stem cells hold much promise in nerve tissue engineering, with advantages such as prevention of scar‐tissue ingrowth and guidance of axonal regrowth. Engineering 3D and patterned microenvironments using biomaterials with chemical and mechanical characteristics close to those of normal...

article

MicroRNA‐7 promotes neural differentiation of trabecular meshwork mesenchymal stem cell on nanofibrous scaffold

Behrouz Jedari, Ali Rahmani, Mahmood Naderi, Samad Nadri

Journal of Cellular Biochemistry > 121 > 4 > 2818 - 2827

The purpose of this study was to investigate miR‐7 overexpression effects on neural differentiation of mesenchymal stem cells (MSCs) on both two‐dimensional (2D) and three‐dimensional (3D) culture systems. We upregulated miR‐7 through lentiviral vector in trabecular meshwork MSCs (TMMSCs) and polymers of poly l‐lactic acid/polycaprolactone fibrous scaffold were fabricated by electrospinning and characterized...

article

Regulating Electrical Cue and Mechanotransduction in Topological Gradient Structure Modulated Piezoelectric Scaffolds to Predict Neural Cell Response

Jeong In Kim, Tae In Hwang, Jeong Chan Lee, Chan Hee Park, more

Advanced Functional Materials > 30 > 3 > n/a - n/a

Neural cells respond to topographical cues with alterations in cell growth and neurite sprouting mediated by changes in cell behavior. The interaction of fiber topography with cell adhesion receptors affects how the cells adhere to the surface of fibers and defines cell fate through alterations in the biochemistry, physiology, and morphology of neural cells. Although previous studies suggest topographical...

article

Mechanotransduction: Regulating Electrical Cue and Mechanotransduction in Topological Gradient Structure Modulated Piezoelectric Scaffolds to Predict Neural Cell Response (Adv. Funct. Mater. 3/2020)

Jeong In Kim, Tae In Hwang, Jeong Chan Lee, Chan Hee Park, more

Advanced Functional Materials > 30 > 3 > n/a - n/a

In article number 1907330, Chan Hee Park, Cheol Sang Kim, and co‐workers develop tunable topography modulated piezoelectric fibrous scaffolds that can regulate electrical cues and mechanotransduction to predict neural cell response. YAP translocation in cells provide clues to how cells respond to topological gradient structure‐modulated piezoelectric scaffolds. Such pleiotropic regulations could fine‐tune...

article

Bioluminescence‐driven optogenetic activation of transplanted neural precursor cells improves motor deficits in a Parkinson's disease mouse model

Jessica R. Zenchak, Brandon Palmateer, Nicolai Dorka, Tariq M. Brown, more

Journal of Neuroscience Research > 98 > 3 > 458 - 468

The need to develop efficient therapies for neurodegenerative diseases is urgent, especially given the increasing percentages of the population living longer, with increasing chances of being afflicted with conditions like Parkinson's disease (PD). A promising curative approach toward PD and other neurodegenerative diseases is the transplantation of stem cells to halt and potentially reverse neuronal...

article

MFN2 silencing promotes neural differentiation of embryonic stem cells via the Akt signaling pathway

Siqi Yi, Chenghao Cui, Xiaotian Huang, Xiaohui Yin, more

Journal of Cellular Physiology > 235 > 2 > 1051 - 1064

Mitofusin 2 (MFN2) is a regulatory protein participating in mitochondria dynamics, cell proliferation, death, differentiation, and so on. This study aims at revealing the functional role of MFN2 in the pluripotency maintenance and primitive differetiation of embryonic stem cell (ESCs). A dox inducible silencing and routine overexpressing approach was used to downregulate and upregulate MFN2 expression,...

article

Improved neural differentiation of normal and abnormal induced pluripotent stem cell lines in the presence of valproic acid

Sophia Fernandes, Rajesh Vinnakota, Janesh Kumar, Vaijayanti Kale, more

Journal of Tissue Engineering and Regenerative Medicine > 13 > 8 > 1482 - 1496

During the generation of induced pluripotent stem cell (iPSC) lines from cord blood CD34⁺ cells, a line having complete trisomy of Chromosome 1 and deletion of q23 to qTer of Chromosome 11 was accidentally developed in our lab. The abnormality was consistently detected even at higher passages. These chromosomal anomalies are known to manifest neurological developmental defects. In order to examine...

article

The Flot2 component of the lipid raft changes localization during neural differentiation of P19C6 cells

Kei Hanafusa, Nobuhiro Hayashi

BMC Molecular and Cell Biology > 2019 > 20 > 1 > 1-9

Background Flotillin-2 (Flot2) is a lipid raft scaffold protein that is thought to be related to neural differentiation. Flot2 is phosphorylated by Fyn, a Src kinase, and causes raft-dependent endocytosis; however, the exact role of Flot2 in neural differentiation remains unclear. To reveal the roles of lipid raft-associated proteins during neural differentiation, we tried to analyze the expression...

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Search results

HAp Thermosensitive Nanohydrogel Cavities Act as Brood Pouches to Incubate and Control‐Release NSCs for Rapid Spinal Cord Injury Therapy

Multivalent Polyanionic 2D Nanosheets Functionalized Nanofibrous Stem Cell‐based Neural Scaffolds

Glucocorticoids attenuate interleukin‐6‐induced c‐Fos and Egr1 expression and impair neuritogenesis in PC12 cells

Neural induction: Historical views and application to pluripotent stem cells

Defining the role of 17β‐estradiol in human endometrial stem cells differentiation into neuron‐like cells

Novel approach for neuronal stem cell differentiation using aqueous two‐phase systems in 3D cultures

Black‐Phosphorus‐Incorporated Hydrogel as a Conductive and Biodegradable Platform for Enhancement of the Neural Differentiation of Mesenchymal Stem Cells

Control the fate of human umbilical cord mesenchymal stem cells with dual‐enzymatically cross‐linked gelatin hydrogels for potential applications in nerve regeneration

The effect of magnetic stimulation on differentiation of human induced pluripotent stem cells into neuron

3D Bioprinting: Lipid‐Bilayer‐Supported 3D Printing of Human Cerebral Cortex Cells Reveals Developmental Interactions (Adv. Mater. 31/2020)

Lipid‐Bilayer‐Supported 3D Printing of Human Cerebral Cortex Cells Reveals Developmental Interactions

Construction of multifunctional fusion proteins with a laminin‐derived short peptide to promote neural differentiation of mouse induced pluripotent stem cells

Surface Topography and Electrical Signaling: Single and Synergistic Effects on Neural Differentiation of Stem Cells

MicroRNA‐7 promotes neural differentiation of trabecular meshwork mesenchymal stem cell on nanofibrous scaffold

Regulating Electrical Cue and Mechanotransduction in Topological Gradient Structure Modulated Piezoelectric Scaffolds to Predict Neural Cell Response

Mechanotransduction: Regulating Electrical Cue and Mechanotransduction in Topological Gradient Structure Modulated Piezoelectric Scaffolds to Predict Neural Cell Response (Adv. Funct. Mater. 3/2020)

Bioluminescence‐driven optogenetic activation of transplanted neural precursor cells improves motor deficits in a Parkinson's disease mouse model

MFN2 silencing promotes neural differentiation of embryonic stem cells via the Akt signaling pathway

Improved neural differentiation of normal and abnormal induced pluripotent stem cell lines in the presence of valproic acid

The Flot2 component of the lipid raft changes localization during neural differentiation of P19C6 cells

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