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Items from 1 to 20 out of 716 results

article

Efficacy of vitamin E and N-acetylcysteine in the prevention of contrast induced kidney injury in patients with chronic kidney disease: a double blind, randomized controlled trial

Thomas M. Kitzler, Aala Jaberi, Gerald Sendlhofer, Peter Rehak, more

Wiener klinische Wochenschrift > 2012 > 124 > 9-10 > 312-319

Summary Background Contrast induced acute kidney injury is one of the most frequent causes of hospital acquired acute kidney injury. The present study aims to investigate the efficacy of vitamin E or N-acetylcysteine as an adjunct to current standard therapy in the prevention of this clinical predicament. We tested the hypothesis that vitamin E or N-acetylcysteine added to standard therapy with 0...

article

N-acetylcysteine modulates effect of the iron isomaltoside on peritoneal mesothelial cells

M. Misian, E. Baum, A. Breborowicz

Journal of Physiology and Pharmacology > 2020 > 71 > 3

article

ENACT: a protocol for a randomised placebo-controlled trial investigating the efficacy and mechanisms of action of adjunctive N-acetylcysteine for first-episode psychosis

S. M. Cotton, M. Berk, A. Watson, S. Wood, more

Trials > 2019 > 20 > 1 > 1-14

Background First-episode psychosis (FEP) may lead to a progressive, potentially disabling and lifelong chronic illness; however, evidence suggests that the illness course can be improved if appropriate treatments are given at the early stages. Nonetheless, the efficacy of antipsychotic medications is suboptimal, particularly for negative and cognitive symptoms, and more efficacious and benign treatments...

article

Hepatoprotective effects of Tribulus terrestris, Ashwagandha and N-acetylcysteine on liver fibrosis in carbon tetrachloride-induced rats

Derya Altay, Yasar Dogan, Cemal Orhan, Mehmet Tuzcu, more

Acta Poloniae Pharmaceutica - Drug Research > 2019 > 76 > 5 > 805-813

Background and Aim: Fibrosis, which develops during the progression of liver damage, is the previous stage of cirrhosis. Carbon tetrachloride is one of the most commonly used hepatic toxins in experimental animal models of liver fibrosis. It was investigated the hepatoprotective effects of Tribulus terrestris, Ashwagandha and N-acetylcysteine in an experimental model of liver fibrosis induced by carbon...

article

Effect of Orally Administered N-Acetylcysteine on Chronic Bronchitis: A Meta-analysis

Jia Wei, Cai-shuang Pang, Juan Han, Hao Yan

Advances in Therapy > 2019 > 36 > 12 > 3356-3367

Introduction The effect of N-acetylcysteine (NAC) treatment for patients with chronic bronchitis (CB) is controversial. To better understand the role of NAC in CB treatment, we performed a meta-analysis to provide a more accurate estimation of the importance of NAC treatment. Methods PubMed, Embase, and CNKI were systematically searched. The pooled relative risk (RR) and 95% confidence intervals...

article

N-acetylcysteine for cessation of tobacco smoking: rationale and study protocol for a randomised controlled trial

Lauren Arancini, Chiara C. Bortolasci, Seetal Dodd, Olivia M. Dean, more

Trials > 2019 > 20 > 1 > 1-7

Background Tobacco smoking is a highly prevalent, addictive behaviour and a key public health priority. However available cessation therapies have low quit and high relapse rates, indicating an urgent need for more effective treatments. Predicated on promising preclinical and pilot clinical data, this paper presents a rationale and protocol for the trial of N-acetylcysteine (NAC) as a novel anti-craving...

article

The radioprotective effect of N-acetylcysteine against x-radiation-induced renal injury in rats

Tolga Mercantepe, Atilla Topcu, Sema Rakici, Levent Tumkaya, more

Environmental Science and Pollution Research > 2019 > 26 > 28 > 29085- 29094

The purpose of this study was therefore to investigate the effects of radiotherapy on the kidney and the potential use of agents such as N-acetylcysteine (NAC) in developing a future therapeutic protocol for radiation-induced nephrotoxicity at the histopathological and biochemical levels. Our study consisted of three groups: control (oral saline solution only; group 1), irradiation (IR; group 2),...

article

Antioxidants protect against diabetes by improving glucose homeostasis in mouse models of inducible insulin resistance and obesity

Leon G. Straub, Vissarion Efthymiou, Gerald Grandl, Miroslav Balaz, more

Diabetologia > 2019 > 62 > 11 > 2094-2105

Aims/hypothesis In the context of diabetes, the health benefit of antioxidant treatment has been widely debated. In this study, we investigated the effect of antioxidant treatment during the development of insulin resistance and hyperphagia in obesity and partial lipodystrophy. Methods We studied the role of antioxidants in the regulation of insulin resistance using the tamoxifen-inducible fat-specific...

article

Therapeutic effects of N-acetylcysteine against malathion-induced hepatotoxicity

Heba Mohamed Aboubakr, Eman Abdelfattah Elzohairy, Abla Abdelrahman Ali, Laila Ahmed Rashed, more

Egyptian Journal of Forensic Sciences > 2019 > 9 > 1 > 1-9

Background The wide unregulated use of malathion has produced severe health hazards. N-acetylcysteine (NAC) is a known glutathione precursor, and there is a growing attention concerning its beneficial effects against pesticide-induced toxicity. The present study was designed to investigate the therapeutic effects of NAC against malathion-induced hepatotoxicity, oxidative stress, genotoxicity, immunotoxicity,...

article

The antioxidants resveratrol and N-acetylcysteine enhance anthelmintic activity of praziquantel and artesunate against Schistosoma mansoni

Maria João Gouveia, Paul J. Brindley, Carlos Azevedo, Fátima Gärtner, more

Parasites & Vectors > 2019 > 12 > 1 > 1-12

Background Treatment of schistosomiasis has relied on the anthelmintic drug praziquantel (PZQ) for more than a generation. Despite its celebrated performance for treatment and control of schistosomiasis and other platyhelminth infections, praziquantel has some shortcomings and the inability of this drug to counteract disease sequelae prompts the need for novel therapeutic strategies. Methods Using...

article

Curcumin induced oxidative stress attenuation by N-acetylcysteine co-treatment: a fibroblast and epithelial cell in-vitro study in idiopathic pulmonary fibrosis

L. R. Rodriguez, S. N. Bui, R. T. Beuschel, E. Ellis, more

Molecular Medicine > 2019 > 25 > 1 > 1-12

Background Idiopathic Pulmonary Fibrosis (IPF) is a fatal lung disease of unknown etiology with only two federally approved drug options. Given the complex molecular pathogenesis of IPF involving multiple cell types and multiple pathways, we explore the effects of a potential antifibrotic and antioxidant drug combination. Curcumin is a polyphenolic compound derived from turmeric with significant biological...

article

A study protocol for the N-ICE trial: A randomised double-blind placebo-controlled study of the safety and efficacy of N-acetyl-cysteine (NAC) as a pharmacotherapy for methamphetamine (“ice”) dependence

Rebecca McKetin, Olivia M. Dean, Alyna Turner, Peter J. Kelly, more

Trials > 2019 > 20 > 1 > 1-11

Background There are currently no approved pharmacotherapies for managing methamphetamine dependence. N-acetylcysteine (NAC) has been found to reduce the craving for methamphetamine and other drugs, but its effect on methamphetamine use and other clinically related endpoints are uncertain. The N-ICE trial is evaluating the safety and efficacy of NAC as a take-home pharmacotherapy for methamphetamine...

article

Efficacy and safety profile of mucolytic/antioxidant agents in chronic obstructive pulmonary disease: a comparative analysis across erdosteine, carbocysteine, and N-acetylcysteine

Paola Rogliani, Maria Gabriella Matera, Clive Page, Ermanno Puxeddu, more

Respiratory Research > 2019 > 20 > 1 > 1-11

Background To date there are no head-to-head studies comparing different mucolytic/antioxidant agents. Considering the inconsistent evidence resulting from the pivotal studies on mucolytic/antioxidant agents tested in chronic obstructive pulmonary disease (COPD), and the recent publication of Reducing Exacerbations and Symptoms by Treatment with ORal Erdosteine in COPD (RESTORE) study, we have performed...

article

Potential role of N-acetylcysteine on chlorpyrifos-induced neurotoxicity in rats

Sahar M. Mahmoud, Ahmed E. Abdel Moneim, Marwa M. Qayed, Nabil A. El-Yamany

Environmental Science and Pollution Research > 2019 > 26 > 20 > 20731- 20741

Chlorpyrifos (CPF) is a widely used organophosphate insecticide with several harmful effects. N-acetylcysteine (NAC) represents an ideal antixenobiotic; it can directly enter endogenous biochemical processes and is used as adjunctive treatment for psychiatric disorders. We aimed to evaluate the neuroprotective effect of NAC as an antioxidant drug against CPF-induced neurotoxicity in adult male albino...

article

N-Acetylcysteine Prevents Post-embolization Syndrome in Patients with Hepatocellular Carcinoma Following Transarterial Chemoembolization

Sith Siramolpiwat, Thanachai Punjachaipornpon, Bubpha Pornthisarn, Ratha-korn Vilaichone, more

Digestive Diseases and Sciences > 2019 > 64 > 11 > 3337-3345

Background Post-embolization syndrome is a common complication after transarterial chemoembolization (TACE) for hepatocellular carcinoma (HCC). N-acetylcysteine (NAC) is known to ameliorate liver damage from several causes. Aim To determine the efficacy of intravenous NAC in the prevention of post-embolization syndrome in HCC patients following TACE. Methods In this study, patients with HCC admitted...

article

Effect of N-acetylcysteine on exacerbations of bronchiectasis (BENE): a randomized controlled trial

Qian Qi, Yirepanjaing Ailiyaer, Ruijuan Liu, Yan Zhang, more

Respiratory Research > 2019 > 20 > 1 > 1-10

Background N-acetylcysteine is a classic mucolytic agent. This study aimed to investigate the efficacy of N-acetylcysteine on reducing the risk of exacerbations in bronchiectasis patients. Methods A prospective, randomized, controlled trial was conducted between April 1, 2014 and December 31, 2016 in five general hospitals in Shandong Province, China. Adult bronchiectasis patients with at least...

article

Effects of chronic cocaine self-administration and N-acetylcysteine on learning, cognitive flexibility, and reinstatement in nonhuman primates

Brian D. Kangas, Rachel J. Doyle, Stephen J. Kohut, Jack Bergman, more

Psychopharmacology > 2019 > 236 > 7 > 2143-2153

Rationale Cocaine use disorder (CUD) is associated with cognitive deficits that have been linked to poor treatment outcomes. An improved understanding of cocaine’s deleterious effects on cognition may help optimize pharmacotherapies. Emerging evidence implicates abnormalities in glutamate neurotransmission in CUD and drugs that normalize glutamatergic homeostasis (e.g., N-acetylcysteine [NAC]) may...

article

THE EFFECTS OF SULFUR-CONTAINING COMPOUNDS ON REDOX STATUS IN HOMOCYSTEINE-TREATED RATS

Tanja S. Sobot, Vladimir I. Zivkovic, Ivan M. Srejovic, Jovana N. Jeremic, more

Acta Poloniae Pharmaceutica - Drug Research > 2019 > 76 > 1 > 147-157

There is growing interest in the activity of sulfur-containing compounds on redox balance in physiological and pathological conditions, considering that some of these compounds have not only antioxidative but also pro-oxidative activities. Aim of this study was to assess possible differences in the effects of various sulfur-containing compounds on redox balance of cardiovascular system in its physiological...

article

Antioxidant and cytoprotective effects of N-acetylcysteine against subchronic oral glyphosate-based herbicide-induced oxidative stress in rats

Ruhi Turkmen, Yavuz Osman Birdane, Hasan Huseyin Demirel, Hidayet Yavuz, more

Environmental Science and Pollution Research > 2019 > 26 > 11 > 11427- 11437

It is claimed that oxidative stress has a prominent role in the mechanism of toxic effects formed by glyphosate-based herbicide (GBH) in living systems. A strong thiol compound, N-acetylcysteine (NAC), has antioxidative and cytoprotective properties. The objective in this subchronic toxicity study was to identify the prophylactic effect of NAC over histopathological changes and oxidative stress induced...

article

Identification of biosynthetic genes for the β-carboline alkaloid kitasetaline and production of the fluorinated derivatives by heterologous expression

Shohei Ueda, Haruo Ikeda, Takushi Namba, Yukinori Ikejiri, more

Journal of Industrial Microbiology & Biotechnology > 2019 > 46 > 5 > 739-750

β-Carboline alkaloids exhibit a broad spectrum of pharmacological and biological activities and are widely distributed in nature. Genetic information on the biosynthetic mechanism of β-carboline alkaloids has not been accumulated in bacteria, because there are only a few reports on the microbial β-carboline compounds. We previously isolated kitasetaline, a mercapturic acid derivative of a β-carboline...

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N-ACETYLCYSTEINE (716)
OXIDATIVE STRESS (127)
GLUTATHIONE (96)
FREE RADICALS (46)
APOPTOSIS (42)
REACTIVE OXYGEN SPECIES (37)
ANTIOXIDANTS (34)
ANTIOXIDANT (32)
ACETAMINOPHEN (30)
INFLAMMATION (26)
RAT (26)
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MITOCHONDRIA (19)
HEPATOTOXICITY (17)
NITRIC OXIDE (17)
CYSTEINE (14)
ASCORBIC ACID (13)
HYDROGEN PEROXIDE (13)
PARACETAMOL (13)
CONTRAST-INDUCED NEPHROPATHY (12)
LIVER (12)
CATALASE (11)
DEFEROXAMINE (11)
DIABETES (11)
HOMOCYSTEINE (11)
CHRONIC OBSTRUCTIVE PULMONARY DISEASE (10)
CYTOTOXICITY (10)
LIPOPOLYSACCHARIDE (9)
VITAMIN E (9)
BRAIN (8)
GENE EXPRESSION (8)
N-ACETYLCYSTEIN (8)
SUPEROXIDE DISMUTASE (8)
VITAMIN C (8)
AGING (7)
MALONDIALDEHYDE (7)
MELATONIN (7)
MICE (7)
NF-ΚB (7)
RENAL FAILURE (7)
ACUTE KIDNEY INJURY (6)
ACUTE LUNG INJURY (6)
COMET ASSAY (6)
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DITHIOTHREITOL (6)
DNA DAMAGE (6)
EBSELEN (6)
FREE RADICAL (6)
HEART (6)
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NEPHROTOXICITY (6)
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NICOTINE (6)
PARKINSON'S DISEASE (6)
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ANTIOXIDANT ENZYMES (5)
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CHRONIC KIDNEY DISEASE (5)
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Search results

Efficacy of vitamin E and N-acetylcysteine in the prevention of contrast induced kidney injury in patients with chronic kidney disease: a double blind, randomized controlled trial

N-acetylcysteine modulates effect of the iron isomaltoside on peritoneal mesothelial cells

ENACT: a protocol for a randomised placebo-controlled trial investigating the efficacy and mechanisms of action of adjunctive N-acetylcysteine for first-episode psychosis

Hepatoprotective effects of Tribulus terrestris, Ashwagandha and N-acetylcysteine on liver fibrosis in carbon tetrachloride-induced rats

Effect of Orally Administered N-Acetylcysteine on Chronic Bronchitis: A Meta-analysis

N-acetylcysteine for cessation of tobacco smoking: rationale and study protocol for a randomised controlled trial

The radioprotective effect of N-acetylcysteine against x-radiation-induced renal injury in rats

Antioxidants protect against diabetes by improving glucose homeostasis in mouse models of inducible insulin resistance and obesity

Therapeutic effects of N-acetylcysteine against malathion-induced hepatotoxicity

The antioxidants resveratrol and N-acetylcysteine enhance anthelmintic activity of praziquantel and artesunate against Schistosoma mansoni

Curcumin induced oxidative stress attenuation by N-acetylcysteine co-treatment: a fibroblast and epithelial cell in-vitro study in idiopathic pulmonary fibrosis

A study protocol for the N-ICE trial: A randomised double-blind placebo-controlled study of the safety and efficacy of N-acetyl-cysteine (NAC) as a pharmacotherapy for methamphetamine (“ice”) dependence

Efficacy and safety profile of mucolytic/antioxidant agents in chronic obstructive pulmonary disease: a comparative analysis across erdosteine, carbocysteine, and N-acetylcysteine

Potential role of N-acetylcysteine on chlorpyrifos-induced neurotoxicity in rats

N-Acetylcysteine Prevents Post-embolization Syndrome in Patients with Hepatocellular Carcinoma Following Transarterial Chemoembolization

Effect of N-acetylcysteine on exacerbations of bronchiectasis (BENE): a randomized controlled trial

Effects of chronic cocaine self-administration and N-acetylcysteine on learning, cognitive flexibility, and reinstatement in nonhuman primates

THE EFFECTS OF SULFUR-CONTAINING COMPOUNDS ON REDOX STATUS IN HOMOCYSTEINE-TREATED RATS

Antioxidant and cytoprotective effects of N-acetylcysteine against subchronic oral glyphosate-based herbicide-induced oxidative stress in rats

Identification of biosynthetic genes for the β-carboline alkaloid kitasetaline and production of the fluorinated derivatives by heterologous expression

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