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article

Elucidation of the Microwave‐Assisted Synthesis and Characterization of Heteronuclear Complexes of Bisbenzimidazole Derivatives and Their Biological Activities by In Vitro and In Silico Assays

Esra Kaplan, Ziya Erdem Koc, Ahmet Uysal, Abdullahi Ibrahim Uba, more

Chemical Biology & Drug Design > 104 > 3 > n/a - n/a

A novel and efficient protocol for the microwave‐assisted synthesis of diversely substituted 2,2′‐bisbenzimidazol‐5,6′‐dicarboxylic acid (BIMCA) from the reaction of 3,4‐diaminobenzoic acid with oxalic acid has been developed, which proceeds through sequential nucleophilic addition and electrophilic substitution in accordance with the Philips method. The synthetic utility of this strategy was demonstrated...

article

Urinary mutagenicity and bladder cancer risk in northern New England

Jason Y. Y. Wong, Alexander H. Fischer, Dalsu Baris, Laura E. Beane Freeman, more

Environmental and Molecular Mutagenesis > 65 > 1-2 > 47 - 54

The etiology of bladder cancer among never smokers without occupational or environmental exposure to established urothelial carcinogens remains unclear. Urinary mutagenicity is an integrative measure that reflects recent exposure to genotoxic agents. Here, we investigated its potential association with bladder cancer in rural northern New England. We analyzed 156 bladder cancer cases and 247 cancer‐free...

article

In vitro Genotoxicity and In silico Docking Analyses of the Essential Oils of Thuja orientalis

Sedat BOZARI

Chemistry & Biodiversity > 21 > 2 > n/a - n/a

Two main objectives were pursued to assess the reliability of Thuja orientalis essential oils (TOEO). The first objective was to extract TOEO, analyze them by GC‐MS, and determine their in vitro genotoxicity against selected plants using the RAPD‐PCR method. The second objective was to evaluate the in‐silico toxicity of TOEO. The binding sites and energies of each content was calculated against B‐DNA...

article

Mutagenicity assessment of high‐power 1.6‐THz pulse laser radiation

Midori Shirato, Yuma Takida, Taro Kanno, Hiroshi Matsuura, more

Photochemistry and Photobiology > 100 > 1 > 146 - 158

The effect of terahertz (THz) radiation has been studied in medicine. However, there is a lack of scientific information regarding its possible mutagenicity. Therefore, the present study aimed to assess the mutagenicity of 1.6 THz laser irradiation. The Ames test was conducted using five bacterial tester strains. The bacteria were subjected to (i) 1.6 THz laser irradiation at 3.8 mW/cm² for 60 min...

article

Effectiveness of metal and metal oxide nanoparticles against bacterial biofilms: Perspectives and limitations

Dipro Mukherjee, Moumita Sil, Arunava Goswami, Dibyajit Lahiri, more

Journal of Basic Microbiology > 63 > 9 > 971 - 985

In the last few years, there has been a necessary demand in the pharmaceutical industries for finding a treatment against biofilms formed by different bacterial species. We are aware of the fact that classical processes, which are already there for the removal of bacterial biofilms gives a very low efficiency and consequently antimicrobial resistance makes it even worse. To cope up with the cited...

article

In vitro genotoxicity potential investigation of 7 oxy‐PAHs

Adeline Clergé, Jérémie Le Goff, Emilie Brotin, Edwige Abeillard, more

Environmental and Molecular Mutagenesis > 64 > 3 > 176 - 186

Air pollutants include many compounds among them oxygenated polycyclic aromatic hydrocarbons (oxy‐PAHs). As they are suspected to generate DNA damage and mutagenicity, an understanding of their mode of action could highlight a carcinogenic potential risk in exposed population. In this article, a prospective study on seven oxy‐PAHs selected in terms of occurrence in the environment was conducted on...

article

Mutagenicity of the organic fraction of World Trade Center dust

David M. DeMarini, Sarah H. Warren, Lance R. Brooks

Environmental and Molecular Mutagenesis > 64 > 1 > 16 - 25

Most studies of the health effects and chemical characterization of the dust resulting from the catastrophic collapse of the World Trade Center (WTC) on September 11, 2001, have focused on the large inorganic fraction of the dust; however, chemical analyses have identified mutagens and carcinogens in the smaller organic fraction. Here, we determined the mutagenicity of the organic fraction of WTC...

article

Establishing a quantitative framework for regulatory interpretation of genetic toxicity dose–response data: Margin of exposure case study of 48 compounds with both in vivo mutagenicity and carcinogenicity dose–response data

Nikolai Chepelev, Alexandra S. Long, Marc Beal, Tara Barton‐Maclaren, more

Environmental and Molecular Mutagenesis > 64 > 1 > 4 - 15

Quantitative relationships between carcinogenic potency and mutagenic potency have been previously examined using a benchmark dose (BMD)‐based approach. We extended those analyses by using human exposure data for 48 compounds to calculate carcinogenicity‐derived and genotoxicity‐derived margin of exposure values (MOEs) that can be used to prioritize substances for risk management. MOEs for 16 of the...

article

In vitro and in vivo assessments of the genotoxic potential of 3‐chloroallyl alcohol

Aisling Redmond, Fagen Zhang, WanYun Cheng, B. Bhaskar Gollapudi

Environmental and Molecular Mutagenesis > 64 > 1 > 26 - 38

3‐Chloroallyl alcohol (3‐CAA) can be found in the environment following the application of plant protection products. 3‐CAA is formed in groundwater following the injection of 1,3‐dichloropropene, a fumigant used to control nematodes. 3‐CAA is also formed, in leafy crops, as a glycoside conjugate following application of the herbicide, clethodim. Human exposure may occur from groundwater used as drinking...

article

Genotoxicity testing of nanomaterials

Robert Landsiedel, Naveed Honarvar, Svenja Berit Seiffert, Barbara Oesch, more

Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology > 14 > 6 > n/a - n/a

Nanomaterials have outstanding and unprecedented advantageous material properties but may also cause adverse effects in humans upon exposure. Testing nanomaterials for genotoxic properties is challenging because traditional testing methods were designed for small, soluble molecules and may not be easily applicable without modifications. This review critically examines available genotoxicity tests...

article

Development and application of the Ames test using a direct‐exposure module: The assessment of mutagenicity of incense and sidestream cigarette smoke

Po‐Wen Chen, Hung‐Fu Lu, Zhen‐Shu Liu

Indoor Air > 32 > 10 > n/a - n/a

We had previously developed an improved Ames module to directly determine the mutagenicity of gaseous formaldehyde (HCHO) and toluene without liquid extraction. This study further evaluated the suitability and sensitivity of this module on whole and real polluted air samples. For this, two common brands of stick incense (A and B) and cigarettes (A and B) were harvested, and various types of incense...

article

Safety evaluation of mutagenicity, genotoxicity, and cytotoxicity of Lactobacillus spp. isolates as probiotic candidates

Atieh Darbandi, Shiva Mirkalantari, Rezvan Golmoradi Zadeh, Maryam Esghaei, more

Journal of Clinical Laboratory Analysis > 36 > 7 > n/a - n/a

Background Probiotics promote a healthy balance of gut bacteria and have many beneficial effects on human digestive physiology. Although, few side effects of probiotics have been reported. This study aimed to assess the safety of five probiotic candidate Lactobacillus strains isolated from healthy individuals by examining mutagenicity, genotoxicity, and oral toxic effects. Methods Five selected...

article

Microsatellite mutation frequencies in river otters (Lontra Canadensis) from the Athabasca Oil Sands region are correlated to polycyclic aromatic compound tissue burden

Helina Gyasi, Jory Curry, Jared Browning, Kelsey Ha, more

Environmental and Molecular Mutagenesis > 63 > 4 > 172 - 183

Mining activities in the Athabasca oil sands region (AOSR) have contributed to an increase of polycyclic aromatic compounds (PACs) locally. However, many PACs found in the AOSR, and the combined effects of PAC mixtures have not been evaluated for genotoxicity in wildlife. Here, we examine whether mutation frequencies in AOSR river otters are correlated to PAC tissue burdens. We used single‐molecule...

article

Mutagenicity and carcinogenicity of combustion emissions are impacted more by combustor technology than by fuel composition: A brief review

David M. DeMarini, William P. Linak

Environmental and Molecular Mutagenesis > 63 > 3 > 135 - 150

Studies during the past 50 years have characterized the carcinogenicity and mutagenicity of extractable organic material (EOM) of particulate matter (PM) in ambient air and from combustion emissions. We have summarized conclusions from these studies and present data supporting those conclusions for 50 combustion emissions, including carcinogenic potencies on mouse skin (papillomas/mouse/mg EOM), mutagenic...

article

A critical analysis of research methods and experimental models to study biocompatibility of endodontic materials

Sepanta Hosseinpour, Alexis Gaudin, Ove A. Peters

International Endodontic Journal > 55 > S2 > 346 - 369

Materials used for endodontics and with direct contact to tissues have a wide range of indications, from vital pulpal treatments to root filling materials and those used in endodontic surgery. In principle, interaction with dental materials may result in damage to tissues locally or systemically. Thus, a great variety of test methods are applied to evaluate a materials' potential risk of adverse biological...

article

The impact of differential lignin S/G ratios on mutagenicity and chicken embryonic toxicity

Xinwen Zhang, Delphis F. Levia, Elvis Osamudiamhen Ebikade, Jeffrey Chang, more

Journal of Applied Toxicology > 42 > 3 > 423 - 435

Lignin and lignin‐based materials have received considerable attention in various fields due to their promise as sustainable feedstocks. Guaiacol (G) and syringol (S) are two primary monolignols that occur in different ratios for different plant species. As methoxyphenols, G and S have been targeted as atmospheric pollutants and their acute toxicity examined. However, there is a rare understanding...

article

Utility of a next‐generation framework for assessment of genomic damage: A case study using the pharmaceutical drug candidate etoposide

John Nicolette, Mirjam Luijten, Jennifer C. Sasaki, Laura Custer, more

Environmental and Molecular Mutagenesis > 62 > 9 > 512 - 525

We present a hypothetical case study to examine the use of a next‐generation framework developed by the Genetic Toxicology Technical Committee of the Health and Environmental Sciences Institute for assessing the potential risk of genetic damage from a pharmaceutical perspective. We used etoposide, a genotoxic carcinogen, as a representative pharmaceutical for the purposes of this case study. Using...

article

Polyphenols as anticancer agents: Toxicological concern to healthy cells

Badar ul Islam, Mohd Suhail, Mohammed Kaleem Khan, Torki A. Zughaibi, more

Phytotherapy Research > 35 > 11 > 6063 - 6079

Polyphenols are a group of diverse chemical compounds present in a wide range of plants. Various biological properties such as antiallergic, antiviral, antibacterial, anticarcinogenic, antiinflammatory, antithrombotic, vasodilatory, and hepatoprotective effect of different polyphenols have been reported in the scientific literature. The major classes of polyphenols are flavonoids, stilbenoids, lignans,...

article

Hazard characterization of carcinogenicity, mutagenicity, and reproductive toxicity for short chain primary nitroalkanes

Lindsey Garnick, Caroline Gillie, Jordan Kozal, Andy Monnot, more

Journal of Applied Toxicology > 41 > 12 > 1910 - 1936

Nitroalkanes are organic aliphatic hydrocarbon compounds with a nitro moiety that are commonly used as solvents or intermediates to synthesize a variety of organic compounds due to their inherent reactivity. In June 2020, a harmonized classification and labeling (CLH) proposal was submitted to the European Chemicals Agency (ECHA) for the following harmonized carcinogenicity, mutagenicity, and reproductive...

article

Assessment of the mutagenicity of two common indoor air pollutants, formaldehyde and toluene

Po‐Wen Chen, Tai‐Chen Kuo, Zhen‐Shu Liu, Hung‐Fu Lu

Indoor Air > 31 > 5 > 1353 - 1363

Traditionally, direct‐reading instruments have been used to directly determine the concentrations of indoor air pollutants that may exceed the regulation limits. However, these instruments cannot directly assess the potential health hazards of these pollutants to humans. In this study, we developed and improved a bacterial reverse mutation assay (Ames test) by using a direct gas exposure module to...

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Search results

Elucidation of the Microwave‐Assisted Synthesis and Characterization of Heteronuclear Complexes of Bisbenzimidazole Derivatives and Their Biological Activities by In Vitro and In Silico Assays

Urinary mutagenicity and bladder cancer risk in northern New England

In vitro Genotoxicity and In silico Docking Analyses of the Essential Oils of Thuja orientalis

Mutagenicity assessment of high‐power 1.6‐THz pulse laser radiation

Effectiveness of metal and metal oxide nanoparticles against bacterial biofilms: Perspectives and limitations

In vitro genotoxicity potential investigation of 7 oxy‐PAHs

Mutagenicity of the organic fraction of World Trade Center dust

Establishing a quantitative framework for regulatory interpretation of genetic toxicity dose–response data: Margin of exposure case study of 48 compounds with both in vivo mutagenicity and carcinogenicity dose–response data

In vitro and in vivo assessments of the genotoxic potential of 3‐chloroallyl alcohol

Genotoxicity testing of nanomaterials

Development and application of the Ames test using a direct‐exposure module: The assessment of mutagenicity of incense and sidestream cigarette smoke

Safety evaluation of mutagenicity, genotoxicity, and cytotoxicity of Lactobacillus spp. isolates as probiotic candidates

Microsatellite mutation frequencies in river otters (Lontra Canadensis) from the Athabasca Oil Sands region are correlated to polycyclic aromatic compound tissue burden

Mutagenicity and carcinogenicity of combustion emissions are impacted more by combustor technology than by fuel composition: A brief review

A critical analysis of research methods and experimental models to study biocompatibility of endodontic materials

The impact of differential lignin S/G ratios on mutagenicity and chicken embryonic toxicity

Utility of a next‐generation framework for assessment of genomic damage: A case study using the pharmaceutical drug candidate etoposide

Polyphenols as anticancer agents: Toxicological concern to healthy cells

Hazard characterization of carcinogenicity, mutagenicity, and reproductive toxicity for short chain primary nitroalkanes

Assessment of the mutagenicity of two common indoor air pollutants, formaldehyde and toluene

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