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article

The storage lesions: From past to future

J.-D. Tissot, M. Bardyn, G. Sonego, M. Abonnenc, more

Transfusion Clinique et Biologique > 2017 > 24 > 3 > 277-284

Red blood cell (RBC) concentrates are stored in additive solutions at 4^oC for up to 42 days, whereas platelets concentrates (PCs) are stored at 22^oC with continuous agitation for up to 5 to 7 days, according national regulations, and the use or not of pathogen inactivation procedures. Storage induces cellular lesion and alters either RBC or platelet metabolism, and is associated with protein alterations...

article

Multistage magnetic particle separator

Paul Todd, Ryan P. Cooper, John F. Doyle, Scott Dunn, more

Journal of Magnetism and Magnetic Materials > 2001 > 225 > 1-2 > 294-300

Significant motion of a particle suspended in a fluid in a magnetic field requires steep gradients and hence short migration distances. Recognizing this constraint a magnetic particle separator was designed to classify particles on the basis of magnetophoretic mobility. Multiple short migration paths were achieved by using a multistage extractor, which draws particles out of a feed cuvette using an...

article

Advances in metformin‐delivery systems for diabetes and obesity management

Mehrnaz Abbasi, Braeden Heath, Lauren McGinness

Diabetes, Obesity and Metabolism > 26 > 9 > 3513 - 3529

Metformin is a medication that is commonly prescribed to manage type 2 diabetes. It has been used for more than 60 years and is highly effective in lowering blood glucose levels. Recent studies indicate that metformin may have additional medical benefits beyond treating diabetes, revealing its potential therapeutic uses. Oral medication is commonly used to administer metformin because of its convenience...

article

Chronic exposure to TiO₂ micro‐ and nano particles: A biochemical and histopathological experimental study

Mariela Gisele Domingo, Melisa Kurtz, Guillermo Maglione, Maximiliano Martin, more

Journal of Biomedical Materials Research Part B: Applied Biomaterials > 112 > 7 > n/a - n/a

The aim of this work was to analyze the effects of long‐term exposure to titanium dioxide (TiO₂) micro‐ (MPs) and nanoparticles (NPs) (six and 12 months) on the biochemical and histopathological response of target organs using a murine model. Male Wistar rats were intraperitoneally injected with a suspension of TiO₂ NPs (5 nm; TiO₂‐NP5 group) or MPs (45 μm; TiO₂‐NP5 group); the control group was injected...

article

Injectable Mesocellular Foam Silica Microparticles with a Dual Role of Cell‐Recruiting Scaffolds and Intracellular Delivery Vehicles for Enhanced Cancer Vaccine

Jihye Im, Youngjin Choi, Thanh Loc Nguyen, Min Kyung Kim, more

Advanced Functional Materials > 34 > 25 > n/a - n/a

The cancer vaccine is one of the potent cancer immunotherapies based on provoking antigen‐specific adaptive immune responses in patients. Activating host antigen‐presenting cells by delivering antigens and adjuvants is one of the most important requirements to enhance cancer vaccine efficacy. This study proposes an effective cancer vaccine platform based on injectable mesocellular foam (MCF) silica...

article

A Quantitative Analysis of Microplastics in the Gastrointestinal Tracts of Odontocetes in the Southeast Region of the United States

Julia M. Courville, Rose Borkowski, Lucy Sonnenberg, Gretchen K. Bielmyer‐Fraser

Environmental Toxicology and Chemistry > 43 > 6 > 1260 - 1273

Microplastics (<5 mm in diameter) are ubiquitous in the oceanic environment, yet microplastic accumulation in marine mammals is vastly understudied. In recent years, efforts have been made to document microplastic profiles in odontocetes. The objective of the present study was to describe and quantify microplastics in the gastrointestinal (GI) tracts of deceased odontocetes that stranded in the...

article

Transcriptomic analysis and fusion gene identifications of midbody remnants released from colorectal cancer cells reveals they are molecularly distinct from exosomes and microparticles

Wittaya Suwakulsiri, Rong Xu, Alin Rai, Maoshan Chen, more

PROTEOMICS > 24 > 11 > n/a - n/a

Previously, we reported that human primary (SW480) and metastatic (SW620) colorectal (CRC) cells release three classes of membrane‐encapsulated extracellular vesicles (EVs); midbody remnants (MBRs), exosomes (Exos), and microparticles (MPs). We reported that MBRs were molecularly distinct at the protein level. To gain further biochemical insights into MBRs, Exos, and MPs and their emerging role in...

article

Comparative proteomic analysis of three major extracellular vesicle classes secreted from human primary and metastatic colorectal cancer cells: Exosomes, microparticles, and shed midbody remnants

Wittaya Suwakulsiri, Rong Xu, Alin Rai, Adnan Shafiq, more

PROTEOMICS > 24 > 11 > n/a - n/a

Cell‐derived extracellular vesicles (EVs) are evolutionary‐conserved secretory organelles that, based on their molecular composition, are important intercellular signaling regulators. At least three classes of circulating EVs are known based on mechanism of biogenesis: exosomes (sEVs/Exos), microparticles (lEVs/MPs), and shed midbody remnants (lEVs/sMB‐Rs). sEVs/Exos are of endosomal pathway origin,...

article

Microencapsulation of pyriproxyfen using the particles from gas‐saturated solutions process as a controlled‐release system

Tanjina Sharmin, Hiroyuki Tashiro, Hiroki Sakai, Kouichiro Shibata, more

Asia‐Pacific Journal of Chemical Engineering > 19 > 3 > n/a - n/a

The purpose of this investigation was to determine whether pyriproxyfen (PPF), a synthetic juvenile hormone analog (JHA), could be encapsulated in supercritical carbon dioxide (scCO₂) using the process particles from the gas‐saturated solutions (PGSS) for a controlled‐release system. The PGSS process represents a promising two‐step production system especially suited for the encapsulation and controlled‐release...

article

Microstructure change and functional characteristic promotion: the structural manipulation of soy protein microparticles through pH

Yufeng Lin, Weiqian Luo, Beibei Xiong, Jian Guo, more

International Journal of Food Science & Technology > 59 > 6 > 3823 - 3833

In this work, soy protein isolates (SPIs) were subjected to microparticulation, turning soy protein ingredients into microparticles with improved thermal stability which could be used in high‐protein foods. The pH is a critical determinant in microparticulation. Our work is mainly to investigate the effect of pH on the formation and properties of protein microparticles. To clarify the effects of pH...

article

Numerical and experimental investigation of the deviation of microparticles inside the microchannel using the vortices caused by the ICEK phenomenon

Seyed Mohammad Ehsan Ghadamgahi, Mohammad Mohsen Shahmardan, Mohsen Nazari, Hamed Mansouri, more

ELECTROPHORESIS > 45 > 7-8 > 720 - 734

One field of study in microfluidics is the control, trapping, and separation of microparticles suspended in fluid. Some of its applications are related to cell handling, virus detection, and so on. One of the new methods in this field is using ICEK phenomena and dielectrophoresis forces. In the present study, considering the ICEK phenomena, the microparticles inside the fluid are deviated in the desired...

article

Plant‐produced Der p 2‐bearing bioparticles activate Th1/Treg‐related activation patterns in dendritic cells irrespective of the allergic background

Stefanie Busold, Lorenz Aglas, Charlotte Menage, Réjean Desgagnés, more

Clinical & Experimental Allergy > 54 > 4 > 300 - 303

article

Three EHDA Processes from a Detachable Spinneret for Fabricating Drug Fast Dissolution Composites

Shu Chen, Jianfeng Zhou, Boya Fang, Yue Ying, more

Macromolecular Materials and Engineering > 309 > 4 > n/a - n/a

In this study, three kinds of electrohydrodynamic atomization (EHDA) processes (electrospraying, electrospinning, and coaxial electrospinning) are implemented to create hydroxypropyl methylcellulose (HPMC) based ultra‐thin products for providing the fast dissolution of a poorly water‐soluble drug ketoprofen (KET). An EHDA apparatus, characterized by a novel spinneret, is homemade for conducting the...

article

Injectable MSC Spheroid and Microgel Granular Composites for Engineering Tissue

Nikolas Di Caprio, Matthew D. Davidson, Andrew C. Daly, Jason A. Burdick

Advanced Materials > 36 > 14 > n/a - n/a

Many cell types require direct cell–cell interactions for differentiation and function; yet, this can be challenging to incorporate into 3‐dimensional (3D) structures for the engineering of tissues. Here, a new approach is introduced that combines aggregates of cells (spheroids) with similarly‐sized hydrogel particles (microgels) to form granular composites that are injectable, undergo interparticle...

article

Enrichment of a fruit‐based smoothie beverage with omega‐3 fatty acids from microencapsulated chia seed oil

Claudia N. Copado, Vanesa Y. Ixtaina, Mabel C. Tomás

Journal of the Science of Food and Agriculture > 104 > 6 > 3352 - 3360

BACKGROUND Omega‐3 fatty acids are known for their various health benefits. Chia is the richest vegetable source of omega‐3 fatty acids. However, its oil is highly susceptible to oxidative deterioration and should be protected for incorporation into food matrices. This work aimed to study the incorporation of different chia oil microcapsules in a powdered beverage, analyzing the effect on the physicochemical...

article

Biological effects of molybdenum(IV) sulfide nanoparticles and microparticles in the rat after repeated intratracheal administration

Z. Sobańska, K. Sitarek, J. Gromadzińska, R. Świercz, more

Journal of Applied Toxicology > 44 > 4 > 595 - 608

In this study, molybdenum(IV) sulfide (MoS₂) nanoparticles (97 ± 32 nm) and microparticles (1.92 ± 0.64 μm) stabilized with poly (vinylpolypyrrolidone) (PVP) were administered intratracheally to male and female rats (dose of 1.5 or 5 mg/kg bw), every 14 days for 90 days (seven administrations in total). Blood parameters were assessed during and at the end of the study (hematology, biochemistry including...

article

Plugging the Leak of Nanoparticles by Interfacial Polymer Adsorption Enables an Efficient Protein and Peptide Encapsulation

Qingqing Huo, Yue Gao, Wenbo Wu, Shuai Hu, more

Advanced Functional Materials > 34 > 6 > n/a - n/a

Encapsulation is a promising technology to enhance the pharmacokinetic properties of proteins and peptides, particularly addressing their short half‐life. Despite its potential, this method has limitations, such as low encapsulation efficiency, a minimal mass fraction of therapeutic agents, and the potential loss of biological activity. In this study, the pivotal role of amphiphilic polymers in achieving...

article

Impact of splenectomy on circulating microparticles in patients with sickle cell anemia

Mohamed‐Rachid Boulassel, Khoula Al‐Rubkhi, Jamal Al‐Qasabi, Islam El‐Ghamry, more

International Journal of Laboratory Hematology > 46 > 1 > 141 - 147

Introduction Circulating microparticles (MP) are being described as potential biomarkers for disease activity in a variety of conditions including sickle cell anemia (SCA). However, relatively little is known about the influence of spleen status on MP levels in patients with SCA. Methods Using a prospective study design we characterize circulating MP in 144 patients with SCA in steady state by...

article

The use of LA-ICP-MS as an auxiliary tool to assess the pulmonary toxicity of molybdenum(IV) sulfide (MoS₂) nano- and microparticles

Renata Kuraś, Maciej Stępnik, Katarzyna Domeradzka-Gajda, Beata Janasik

International Journal of Occupational Medicine and Environmental Health > 2023 > 37 > 1 > 18-33

Objectives Laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) has considerable applicative potential for both qualitative and quantitative analyses of elemental spatial distribution and concentration. It provides high resolutions at pg-level detection limits. These qualities make it very useful for analyzing biological samples. The present study responds to the growing demand...

article

Permittivity‐Based Microparticle Classification by the Integration of Impedance Cytometry and Microwave Resonators

Uzay Tefek, Burak Sari, Hashim Z. Alhmoud, Mehmet S. Hanay

Advanced Materials > 35 > 46 > n/a - n/a

Permittivity of microscopic particles can be used as a classification parameter for applications in materials and environmental sciences. However, directly measuring the permittivity of individual microparticles has proven to be challenging due to the convoluting effect of particle size on capacitive signals. To overcome this challenge, a sensing platform is built to independently obtain both the...

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Search results

The storage lesions: From past to future

Multistage magnetic particle separator

Advances in metformin‐delivery systems for diabetes and obesity management

Chronic exposure to TiO₂ micro‐ and nano particles: A biochemical and histopathological experimental study

Injectable Mesocellular Foam Silica Microparticles with a Dual Role of Cell‐Recruiting Scaffolds and Intracellular Delivery Vehicles for Enhanced Cancer Vaccine

A Quantitative Analysis of Microplastics in the Gastrointestinal Tracts of Odontocetes in the Southeast Region of the United States

Transcriptomic analysis and fusion gene identifications of midbody remnants released from colorectal cancer cells reveals they are molecularly distinct from exosomes and microparticles

Comparative proteomic analysis of three major extracellular vesicle classes secreted from human primary and metastatic colorectal cancer cells: Exosomes, microparticles, and shed midbody remnants

Microencapsulation of pyriproxyfen using the particles from gas‐saturated solutions process as a controlled‐release system

Microstructure change and functional characteristic promotion: the structural manipulation of soy protein microparticles through pH

Numerical and experimental investigation of the deviation of microparticles inside the microchannel using the vortices caused by the ICEK phenomenon

Plant‐produced Der p 2‐bearing bioparticles activate Th1/Treg‐related activation patterns in dendritic cells irrespective of the allergic background

Three EHDA Processes from a Detachable Spinneret for Fabricating Drug Fast Dissolution Composites

Injectable MSC Spheroid and Microgel Granular Composites for Engineering Tissue

Enrichment of a fruit‐based smoothie beverage with omega‐3 fatty acids from microencapsulated chia seed oil

Biological effects of molybdenum(IV) sulfide nanoparticles and microparticles in the rat after repeated intratracheal administration

Plugging the Leak of Nanoparticles by Interfacial Polymer Adsorption Enables an Efficient Protein and Peptide Encapsulation

Impact of splenectomy on circulating microparticles in patients with sickle cell anemia

The use of LA-ICP-MS as an auxiliary tool to assess the pulmonary toxicity of molybdenum(IV) sulfide (MoS₂) nano- and microparticles

Permittivity‐Based Microparticle Classification by the Integration of Impedance Cytometry and Microwave Resonators

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