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Items from 1 to 20 out of 5,925 results

article

Urinary and Plasma Metabolomics Identify the Distinct Metabolic Profile of Disease State in Chronic Mouse Model of Multiple Sclerosis

J. Singh, M. Cerghet, L. M. Poisson, I. Datta, more

Journal of Neuroimmune Pharmacology > 2019 > 14 > 2 > 241-250

Identification of non-invasive biomarkers of disease progression in multiple sclerosis (MS) is critically needed for monitoring the disease progression and for effective therapeutic interventions. Urine is an attractive source for non-invasive biomarkers because it is easily obtained in the clinic. In search of a urine metabolite signature of progression in chronic experimental autoimmune encephalomyelitis...

article

New insights from a β-glucan human intervention study using NMR metabolomics

Mette Skau Mikkelsen, Francesco Savorani, Morten Arendt Rasmussen, Birthe Møller Jespersen, more

Food Research International > 2014 > 63 > Part B > 210-217

This study investigates the plasma metabolic effectiveness from 3.3g mixed linkage barley or oat β-glucan fibre per day by ¹ H NMR spectroscopy on plasma samples and multivariate data analysis. Three large-scale extracted, equally sized but structurally different β-glucans were tested in a blinded randomised cross-over design using young healthy adults, where the β-glucans were compared to...

article

Metabolomics analysis of postharvest ripening heterogeneity of ‘Hass’ avocadoes

Romina Pedreschi, Pablo Muñoz, Paula Robledo, Cecilia Becerra, more

Postharvest Biology and Technology > 2014 > 92 > Complete > 172-179

The complex physiology of ‘Hass’ avocado renders its postharvest ripening heterogeneous and unpredictable. Several approaches have previously been undertaken to broaden our understanding of the causes of this postharvest ripening heterogeneity but without much success. In this study, a fruit biopsy methodology was undertaken to sample mesocarp tissue from a series of individual avocado fruit while...

article

Metabolomics and transcriptomics demonstrate severe oxidative stress in both localized chemotherapy-treated and bystander tumors

Daniel Morvan, Aicha Demidem, D. Morvan, A. Demidem

BBA - General Subjects > 2014 > 1840 > 3 > 1092-1104

Background: Localized radiotherapy is long known to cause damages to not only targeted but also non-targeted cells, the so-called bystander (BS) effect. Recently, BS effect was demonstrated in response to chemotherapy. To get further insight into the mechanism of chemotherapy-induced BS effect in vivo, we investigated the response of normal tissues and untreated BS melanomas, at distance from localized...

article

Metabolomics in diabetes

Ai-hua Zhang, Shi Qiu, Hong-ying Xu, Hui Sun, more

Clinica Chimica Acta > 2014 > 429 > Complete > 106-110

Characterization of metabolic changes is key to early detection, treatment, and understanding molecular mechanisms of diabetes. Diabetes represents one of the most important global health problems. Approximately 90% of diabetics have type 2 diabetes. Identification of effective screening markers is critical for early treatment and intervention that can delay and/or prevent complications associated...

article

Gynäkologische Endokrinologie und Reproduktionsmedizin

M. Ludwig, M. Montag, F. Nawroth, T. Strowitzki, more

Der Gynäkologe > 2014 > 47 > 9 > 627-633

Themen der gynäkologischen Endokrinologie und Reproduktionsmedizin betreffen viele Bereiche der gynäkologischen Tätigkeit. Wir haben in diesem Beitrag 2 Punkte exemplarisch herausgegriffen, die uns relevant und diskussionswürdig erschienen. Das Thema „habituelle Aborte“ beschäftigt sich mit der evidenzbasierten Diagnostik, um für die Praxis eine sinnvolle Beratungsbasis zu gewährleisten. Bezüglich...

article

Differential metabolic responses of clam Ruditapes philippinarum to Vibrio anguillarum and Vibrio splendidus challenges

Xiaoli Liu, Chenglong Ji, Jianmin Zhao, Huifeng Wu, more

Fish and Shellfish Immunology > 2013 > 35 > 6 > 2001-2007

Clam Ruditapes philippinarum is one of the important marine aquaculture species in North China. However, pathogens can often cause diseases and lead to massive mortalities and economic losses of clam. In this work, we compared the metabolic responses induced by Vibrio anguillarum and Vibrio splendidus challenges towards hepatopancreas of clam using NMR-based metabolomics. Metabolic responses suggested...

article

Molekulares Profiling und prädiktive Signaturen

C. Denkert

Der Pathologe > 2008 > 29 > 2 > 168-171

Das Ovarialkarzinom ist ein Tumor mit einer sehr ungünstigen Prognose. Zur genauen Planung der Therapie ist es wichtig, Biomarker im Tumorgewebe zu identifizieren, die eine Information über das Ansprechen auf eine Therapie bzw. die Entwicklung von Resistenzen zulassen. Diese Biomarker können auf verschiedenen biologischen Ebenen gemessen werden. Auf Proteinebene können prognostische Biomarker im Tumorgewebe...

article

Molecular fingerprint by omics‐based approaches in saliva from patients affected by SARS‐CoV‐2 infection

Gabriella Pinto, Monica Gelzo, Gustavo Cernera, Mariapia Esposito, more

Journal of Mass Spectrometry > 59 > 9 > n/a - n/a

Clinical expression of coronavirus disease 2019 (COVID‐19) infectionis widely variable including fatal cases and patients with mild symptoms and a rapid resolution. We studied saliva from 63 hospitalized COVID‐19 patients and from 30 healthy controls by integrating large‐scale proteomics, peptidomics and targeted metabolomics to assess the biochemical alterations following the infection and to obtain...

article

The unique metabolome of clear cell ovarian carcinoma

Jennifer X Ji, Lien N Hoang, Dawn R Cochrane, Amy Lum, more

The Journal of Pathology > 264 > 2 > 160 - 173

Clear cell ovarian carcinoma (CCOC) is an aggressive malignancy affecting younger women. Despite ovarian cancer subtypes having diverse molecular and clinical characteristics, the mainstay of treatment for advanced stage disease remains cytotoxic chemotherapy. Late stage CCOC is resistant to conventional chemotherapy, which means a suboptimal outcome for patients affected. Despite detailed genomic,...

article

Fecal microbiota from patients with Parkinson's disease intensifies inflammation and neurodegeneration in A53T mice

Huijia Yang, Yaping Shao, Yiying Hu, Jin Qian, more

CNS Neuroscience & Therapeutics > 30 > 8 > n/a - n/a

Aims We evaluated the potential of Parkinson's disease (PD) fecal microbiota transplantation to initiate or exacerbate PD pathologies and investigated the underlying mechanisms. Methods We transplanted the fecal microbiota from PD patients into mice by oral gavage and assessed the motor and intestinal functions, as well as the inflammatory and pathological changes in the colon and brain. Furthermore,...

article

Plasma metabolites and inflammatory proteins profiling predict outcome of Fufang Duzhong Jiangu granules treating Kashin–Beck disease

Xingxing Deng, Hui Niu, Qian Zhang, Jinfeng Wen, more

Biomedical Chromatography > 38 > 9 > n/a - n/a

To investigate predictive biomarkers that could be used to identify patients’ response to treatment, plasma metabolomics and proteomics analyses were performed in Kashin–Beck disease (KBD) patients treated with Fufang Duzhong Jiangu Granules (FDJG). Plasma was collected from 12 KBD patients before treatment and 1 month after FDJG treatment. LC–MS and olink proteomics were employed for obtaining plasma...

article

Cellular metabolomics study of the antitumor mechanism of Sijunzi decoction combined with mitomycin C

Zhiru Zhang, Yu Chen, Yanggang Bian, Tian Tian Wang, more

Biomedical Chromatography > 38 > 9 > n/a - n/a

Mitomycin C (MMC) has an antitumor effect and is considered as a broad‐spectrum antibiotic. Sijunzi Decoction (SJZD), a well‐known ancient Chinese prescription, is widely used in the treatment of cancer when combined with chemotherapy drugs. Studies have shown that SJZD can be combined with other drugs to enhance the therapeutic effect against cancer and inhibit the toxicity of chemotherapy drugs,...

article

Revealing the material basis and mechanism for the inhibition of intestinal peristalsis by Zingiber officinale Roscoe through integrated metabolomics, serum pharmacochemistry, and network pharmacology

Lewen Xiong, Jing Xuan, Hongwei Zhao, Zhaoyu Zhang, more

Biomedical Chromatography > 38 > 9 > n/a - n/a

Abnormal relaxation and contraction of intestinal smooth muscle can cause various intestinal diseases. Diarrhea is a common and important public health problem worldwide in epidemiology. Zingiber officinale Roscoe (fresh ginger) has been found to treat diarrhea, but the material basis and mechanism of action that inhibits intestinal peristalsis remain unclear. Metabolomics and serum pharmacology were...

article

Straightforward Creation of Multishell Hollow Hybrids for an Integrated Metabolic Monitoring System in Disease Management

Man Zhang, Fangying Shi, Yijie Chen, Chenyu Yang, more

Small > 20 > 33 > n/a - n/a

Multidimensional metabolic analysis has become a new trend in establishing efficient disease monitoring systems, as the constraints associated with relying solely on a single dimension in refined monitoring are increasingly pronounced. Here, coordination polymers are employed as derivative precursors to create multishell hollow hybrids, developing an integrated metabolic monitoring system. Briefly,...

article

Metabolomics and cellular altered pathways in cancer biology: A review

Jitender Kumar Bhardwaj, Anshu Siwach, Som Nath Sachdeva

Journal of Biochemical and Molecular Toxicology > 38 > 9 > n/a - n/a

Cancer is a deadly disease that affects a cell's metabolism and surrounding tissues. Understanding the fundamental mechanisms of metabolic alterations in cancer cells would assist in developing cancer treatment targets and approaches. From this perspective, metabolomics is a great analytical tool to clarify the mechanisms of cancer therapy as well as a useful tool to investigate cancer from a distinct...

article

Metabolomic characterization of monoclonal antibody‐producing Chinese hamster lung (CHL)‐YN cells in glucose‐controlled serum‐free fed‐batch operation

Puriwat Sukwattananipaat, Hirotaka Kuroda, Noriko Yamano‐Adachi, Takeshi Omasa

Biotechnology and Bioengineering > 121 > 9 > 2848 - 2867

The fast‐growing Chinese hamster lung (CHL)‐YN cell line was recently developed for monoclonal antibody production. In this study, we applied a serum‐free fed‐batch cultivation process to immunoglobulin (Ig)G1‐producing CHL‐YN cells, which were then used to design a dynamic glucose supply system to stabilize the extracellular glucose concentration based on glucose consumption. Glucose consumption...

article

Plasma metabolomic profile of adiposity and body composition in childhood: The Genetics of Glucose regulation in Gestation and Growth cohort

Zhila Semnani‐Azad, Mohammad L. Rahman, Melina Arguin, Myriam Doyon, more

Pediatric Obesity > 19 > 9 > n/a - n/a

Objective This study identified metabolite modules associated with adiposity and body fat distribution in childhood using gold‐standard measurements. Methods We used cross‐sectional data from 329 children at mid‐childhood (age 5.3 ± 0.3 years; BMI 15.7 ± 1.5 kg/m²) from the Genetics of Glucose regulation in Gestation and Growth (Gen3G), a prospective pre‐birth cohort. We quantified 1038 plasma...

article

Comparative analysis of sipeimine content, metabolome and chloroplast genome in cultivated and wild varieties of Fritillaria taipaiensis

Yue Xu, Cun Chen, Jing Cai, Ling Lin, more

Journal of the Science of Food and Agriculture > 104 > 12 > 7271 - 7280

BACKGROUND The wild variety Fritillaria taipaiensis E.B (EB) is known for its superior therapeutic effects, but its limited production cannot meet demand. As a result, the cultivated variety F. taipaiensis P. Y. Li (PY) has been widely grown. In this study, we conducted a comprehensive analysis comparing EB and PY in terms of external features, sipeimine content, metabolome and chloroplast genome...

article

Metabolic fingerprinting by nuclear magnetic resonance of hepatocellular carcinoma cells during p53 reactivation‐induced senescence

Philipp Knopf, Jesus Pacheco‐Torres, Laimdota Zizmare, Noriko Mori, more

NMR in Biomedicine > 37 > 9 > n/a - n/a

Cellular senescence is characterized by stable cell cycle arrest. Senescent cells exhibit a senescence‐associated secretory phenotype that can promote tumor progression. The aim of our study was to identify specific nuclear magnetic resonance (NMR) spectroscopy‐based markers of cancer cell senescence. For metabolic studies, we employed murine liver carcinoma Harvey Rat Sarcoma Virus (H‐Ras) cells,...

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Search results

Urinary and Plasma Metabolomics Identify the Distinct Metabolic Profile of Disease State in Chronic Mouse Model of Multiple Sclerosis

New insights from a β-glucan human intervention study using NMR metabolomics

Metabolomics analysis of postharvest ripening heterogeneity of ‘Hass’ avocadoes

Metabolomics and transcriptomics demonstrate severe oxidative stress in both localized chemotherapy-treated and bystander tumors

Metabolomics in diabetes

Gynäkologische Endokrinologie und Reproduktionsmedizin

Differential metabolic responses of clam Ruditapes philippinarum to Vibrio anguillarum and Vibrio splendidus challenges

Molekulares Profiling und prädiktive Signaturen

Molecular fingerprint by omics‐based approaches in saliva from patients affected by SARS‐CoV‐2 infection

The unique metabolome of clear cell ovarian carcinoma

Fecal microbiota from patients with Parkinson's disease intensifies inflammation and neurodegeneration in A53T mice

Plasma metabolites and inflammatory proteins profiling predict outcome of Fufang Duzhong Jiangu granules treating Kashin–Beck disease

Cellular metabolomics study of the antitumor mechanism of Sijunzi decoction combined with mitomycin C

Revealing the material basis and mechanism for the inhibition of intestinal peristalsis by Zingiber officinale Roscoe through integrated metabolomics, serum pharmacochemistry, and network pharmacology

Straightforward Creation of Multishell Hollow Hybrids for an Integrated Metabolic Monitoring System in Disease Management

Metabolomics and cellular altered pathways in cancer biology: A review

Metabolomic characterization of monoclonal antibody‐producing Chinese hamster lung (CHL)‐YN cells in glucose‐controlled serum‐free fed‐batch operation

Plasma metabolomic profile of adiposity and body composition in childhood: The Genetics of Glucose regulation in Gestation and Growth cohort

Comparative analysis of sipeimine content, metabolome and chloroplast genome in cultivated and wild varieties of Fritillaria taipaiensis

Metabolic fingerprinting by nuclear magnetic resonance of hepatocellular carcinoma cells during p53 reactivation‐induced senescence

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