Search results

article

Spektrometria mas - uniwersalna technika analityczna

M. Czerwicka, J. Kumirska, P. Stepnowski

Laboratorium - Przegląd Ogólnopolski > 2012 > nr 5-6 > 20--22

Spektrometria mas jest jedną z najpopularniejszych technik analitycznych. Umożliwia ona analizę jakościową i ilościową zarówno prostych związków, jak i wysokocząsteczkowych biomolekuł, a dzięki połączeniu spektrometrii mas z technikami chromatograficznymi także analizę skomplikowanych mieszanin. Najważniejsze aspekty tej techniki zostaną zaprezentowane w niniejszej pracy.

article

Stężenia glutarylkarnityny (C5DC) u noworodków z rozszczepem twarzoczaszki

Kamil K. Hozyasz, Mariusz Ołtarzewski, Ewa Jabłońska, Barbara Radomyska

Pediatria Polska > 2010 > 85 > 3 > 239-242

Metabolity talidomidu, np. pochodne kwasu glutarowego, działają teratogennie. Zwiększone wytwarzanie kwasu glutarowego skutkuje wzrostem stężenia glutarylkarnityny (C5DC). W badaniu przesiewowym noworodków w kierunku kwasicy glutarowej są wykorzystywane oznaczenia C5DC.Celem pracy była analiza stężenia C5DC u dzieci z rozszczepami twarzoczaszki.Retrospektywnie analizowano wyniki oznaczeń C5DC w badaniach...

article

Rückstände ausgewählter Humanarzneimittel in Oberflächenwasserkörpern im Einzugsgebiet Halle (Saale)

Daniel Kern, Wilhelm Lorenz

Environmental Sciences Europe > 2008 > 20 > 2 > 97-101

Im Rahmen dieser Studie wurde mittels Modifizierung von in der Literatur vorhandenen Methoden eine angepasste Methode zur Bestimmung von 16 ausgewählten Arzneimittelwirkstoffen mittels LC-MS/MS in Oberflächenwasser erarbeitet. Hierbei wurde für 13 von 16 Analyten eine Bestimmungsgrenze von weniger als 10 ng/L erreicht. Die Untersuchung von Stichproben aus der Saale und Seen um Halle zeigte, dass Carbamazepin...

article

Characterization of isomeric acetyl amino acids and di‐acetyl amino acids by LC/MS/MS

Addipilli Ramunaidu, Pallerla Pavankumar, Nagarjunachary Ragi, Rodda Ramesh, more

Journal of Mass Spectrometry > 58 > 12 > n/a - n/a

Acetylation of amino acids is important in the molecular biology and biochemistry because they are part of several metabolic pathways. N‐acetyl amino acids can form through degradation of N‐acetyl proteins or direct acetylation of amino acids by specific enzymes. Acetylation of α‐amino acids can be either on the alpha –NH₂ or on the side‐chain functional group, where both the acetyl products are isomeric...

article

LC–MS/MS methods for determination of venetoclax in human plasma and cerebrospinal fluid

Yan‐Ling Yang, Zhou‐Yi Qian, Yang Zhao, Xiang‐Long Chen, more

Biomedical Chromatography > 37 > 12 > n/a - n/a

We developed and validated sensitive MS/MS methods for the determination of venetoclax, an oral selective B‐cell lymphoma‐2 inhibitor, in human plasma and cerebrospinal fluid (CSF). Acetonitrile was used as protein precipitant. The mobile phase was 10 mM ammonium formate consisting of 0.1% formic acid and acetonitrile (40:60, v/v). The analytes were separated on an ACQUITY UPLC HSS T3 column (2.1...

article

Tandem mass spectrometry approaches for recognition of isomeric compounds mixtures

Sara Crotti, Marta Menicatti, Marco Pallecchi, Gianluca Bartolucci

Mass Spectrometry Reviews > 42 > 4 > 1244 - 1260

The present review aims to collect the published literature pertaining the recognition of isobaric compounds (isomers or stereoisomers) using the features of tandem mass spectrometry (MS) experiments without any chromatographic separation or chemical modification (derivatization or isotopic enrichment) of the analytes. MS/MS methods possess high selectivity, wide dynamic range and high throughput...

article

Quantification of monoamine biomarkers in cerebrospinal fluid: Comparison of a UHPLC–MS/MS method with a UHPLC coupled to fluorescence detection method

Ayoub Boulghobra, Taous Abar, Fathi Moussa, Bruno Baudin, more

Biomedical Chromatography > 36 > 12 > n/a - n/a

Inborn errors of monoamine neurotransmitter metabolism are rare genetic diseases classified as catecholamine and serotonin metabolism disorders or neurotransmitter transportopathies. To diagnose these orphan diseases, monoamine metabolites have been identified and validated as cerebrospinal fluid (CSF) biomarkers: 5‐hydroxy‐tryptophane, 5‐hydroxy‐indol‐acetic acid, 3‐ortho‐methyl‐DOPA, homovanillic...

article

Quantitation of the ataxia‐telangiectasia‐mutated and Rad3‐related inhibitor elimusertib (BAY‐1895344) in human plasma using LC–MS/MS

Brian F. Kiesel, Robert A. Parise, Anuradha Krishnamurthy, Steven Gore, more

Biomedical Chromatography > 36 > 11 > n/a - n/a

Ataxia‐telangiectasia‐mutated and Rad3‐related (ATR) is master regulator of the DNA‐damage response that, through multiple mechanisms, can promote cancer cell survival in response to replication stress from sources, including chemotherapy and radiation. Elimusertib (BAY‐1895344) is an orally available small‐molecule ATR inhibitor currently in preclinical and clinical development for cancer treatment...

article

Investigation of fragmentation pathways of protonated 2‐methoxypyrimidine derivatives

Chengli Zu, Nick X. Wang, Christopher J. Brown, Qiang Yang, more

Journal of Mass Spectrometry > 57 > 9 > n/a - n/a

Several representative pyrimidine derivatives were selected to undergo electrospray ionization (ESI) followed by collision‐induced dissociation tandem mass spectrometry (CID MS/MS) experiments. Two competitive pathways were found to govern the formation of major fragment ions from protonated species of these molecules. The pathways were largely affected by the 2‐O‐methyl group but not significantly...

article

MALDI‐MS/MS of N‐Terminal TMPP‐Acyl Peptides: A Worthwhile Tool to Decipher Protein N‐Termini

Bernard Fernandez, Jean Armengaud, Gilles Subra, Christine Enjalbal

European Journal of Organic Chemistry > 2022 > 21 > n/a - n/a

N‐terminal derivatization of proteins with permanently positive charged reagent constitutes a viable mass spectrometry bottom‐up strategy for systematic confident identification of protein N‐termini. Although shotgun nanoLC‐ESI‐MS/MS approaches are commonly applied in that context by dissociating multiply charged molecular ions upon low energy collision‐induced dissociations (CID), we were keen to...

article

Neutral loss scan in complement with high‐resolution MS/MS: Combination of detection methods for flavonoid and limonoid glycosides analysis

Rui Min Vivian Goh, Kim Huey Ee, Aileen Pua, Yunle Huang, more

Journal of Mass Spectrometry > 57 > 2 > n/a - n/a

In this study, neutral loss scan and high‐resolution MS/MS were used in combination to detect and tentatively identify various flavonoid and limonoid glycosides in navel orange albedo, juice, peel and pulp. These compound classes are of research interest due to their flavour and bioactive properties, and although flavonoid glycosides have been previously studied in other food matrices, to the best...

article

P‐97: Separation of Isomeric OLED Materials Using Ion Mobility‐Mass Spectrometry (IM‐MS)

Hirotaka Shioji, Azusa Uematsu, Motoshi Onoda, Keiko Matsuda, more

SID Symposium Digest of Technical Papers > 52 > 1 > 1444 - 1447

The separation of the structural isomers of OLED materials was carried out by using high performance liquid chromatography‐mass spectrometry (HPLC‐MS) and ion mobility‐mass spectrometry (IM‐MS). Almost all isomeric OLED materials were separated by using HPLC, however, some isomers were not distinguished with each other. On the other hand, by using IM, inseparable isomers by HPLC were separated and...

article

43‐2: Application of Liquid Extraction Surface Analysis (LESA)‐NanoESI‐Orbitrap‐MS to a Degradation Analysis of Organic EL Elements

Hikaru Takano, Tsuyoshi Akiyama, Hirotaka Shioji, Takahiro Shibamori, more

SID Symposium Digest of Technical Papers > 51 > 1 > 626 - 629

Liquid extraction surface analysis (LESA)‐NanoESI‐Orbitrap‐mass spectrometry is successfully applied to small‐molecular based OLEDs devices for the first time. It is revealed that NanoESI is possible to detect the molecular ion of unstable metal complexes and that LESA enables to detect deteriorated species of TPBi covered with the electrode.

article

QCMS² as a new method for providing insight into peptide fragmentation: The influence of the side‐chain and inter–side‐chain interactions

Julie Cautereels, Nils Van Hee, Sneha Chatterjee, Christian Van Alsenoy, more

Journal of Mass Spectrometry > 55 > 7 > n/a - n/a

The identification of peptides and proteins from tandem mass spectra is a difficult task and multiple tools have been developed to aid this identification. We present a new method called quantum chemical mass spectrometry for materials science (QCMS²), which is based on quantum chemical calculations of bond orders, reaction, and transition‐state energies at the DFT/B3LYP/6‐311+G* level of theory....

article

Bottom‐up proteomics of envelope proteins extracted from spinach chloroplast via high organic content CE‐MS

Jianhui Cheng, Gregg B. Morin, David D. Y. Chen

ELECTROPHORESIS > 41 > 5-6 > 370 - 378

A high organic content CE‐MS/MS (HOCE‐MS/MS) method was developed for the proteomic analysis of envelope proteins extracted from spinach leaves. Separation was performed in a 1‐m long hydroxypropyl cellulose coated capillary, using 8% (v/v) formic acid in 70% (v/v) methanol and 22% water as the BGE. A flow‐through microvial interface was used to couple the CE system with an Orbitrap Fusion Lumos mass...

article

ESI‐MS/MS analysis of protonated N‐methyl amino acids and their immonium ions

Pavankumar Pallerla, Sudarshana Reddy Bhumireddy, Sai Sachin Lingampally, Nagarjuna Chary Ragi, more

Journal of Mass Spectrometry > 54 > 9 > 761 - 771

Methylation is one of the important posttranslational modifications of biological systems. At the metabolite level, the methylation process is expected to convert bioactive compounds such as amino acids, fatty acids, lipids, sugars, and other organic acids into their methylated forms. A few of the methylated amino acids are identified and have been proved as potential biomarkers for several metabolic...

article

Bolt: a New Age Peptide Search Engine for Comprehensive MS/MS Sequencing Through Vast Protein Databases in Minutes

Amol Prakash, Shadab Ahmad, Swetaketu Majumder, Conor Jenkins, more

Journal of The American Society for Mass Spectrometry > 2019 > 30 > 11 > 2408-2418

Recent increases in mass spectrometry speed, sensitivity, and resolution now permit comprehensive proteomics coverage. However, the results are often hindered by sub-optimal data processing pipelines. In almost all MS/MS peptide search engines, users must limit their search space to a canonical database due to time constraints and q value considerations, but this typically does not reflect the individual...

article

Citrulline Effect Is a Characteristic Feature of Deiminated Peptides in Tandem Mass Spectrometry

Arnold Steckel, Gitta Schlosser

Journal of The American Society for Mass Spectrometry > 2019 > 30 > 9 > 1586-1591

Tandem mass spectrometry of peptides is of utmost importance in proteomics. Collision-induced dissociation usually generates y type fragment ion series from tryptic peptides, carrying information on their primary structure. Amino acid side chains or differences in their basicity could alter fragmentation processes considerably. The well-known proline effect is a cleavage preference at the N-terminus...

article

Automatic Analyte-Ion Recognition and Background Removal for Ambient Mass-Spectrometric Data Based on Cross-Correlation

Yi You, Sunil P. Badal, Jacob T. Shelley

Journal of The American Society for Mass Spectrometry > 2019 > 30 > 9 > 1720-1732

Ambient mass spectrometry is a powerful approach for rapid, high-throughput, and direct sample analysis. Due to the open-air desorption and ionization processes, random fluctuations of ambient conditions can lead to large variances in mass-spectral signals over time. The mass-spectral data also can be further complicated due to multiple analytes present in the sample, background-ion signals stemming...

article

19‐3: Examination in Application of TOF‐SIMS with MS/MS to a Degradation Analysis of OLED

Daichi Shirakura, Aki Suzuki, Shinji Okamura, Takeshi Akiyama, more

SID Symposium Digest of Technical Papers > 50 > 1 > 256 - 258

TOF‐SIMS with MS/MS was applied to degradation analyses of OLEDs. Photoluminescence and GCIB‐TOF‐SIMS revealed a degraded layer and molecular weights of degradation products. MS/MS by TOF‐SIMS gave more detailed structural information of degradation products than conventional TOF‐SIMS, which demonstrated effectiveness of TOF‐SIMS with MS/MS for degradation analyses of OLEDs.

INFONA - science communication portal

Search results

Spektrometria mas - uniwersalna technika analityczna

Stężenia glutarylkarnityny (C5DC) u noworodków z rozszczepem twarzoczaszki

Rückstände ausgewählter Humanarzneimittel in Oberflächenwasserkörpern im Einzugsgebiet Halle (Saale)

Characterization of isomeric acetyl amino acids and di‐acetyl amino acids by LC/MS/MS

LC–MS/MS methods for determination of venetoclax in human plasma and cerebrospinal fluid

Tandem mass spectrometry approaches for recognition of isomeric compounds mixtures

Quantification of monoamine biomarkers in cerebrospinal fluid: Comparison of a UHPLC–MS/MS method with a UHPLC coupled to fluorescence detection method

Quantitation of the ataxia‐telangiectasia‐mutated and Rad3‐related inhibitor elimusertib (BAY‐1895344) in human plasma using LC–MS/MS

Investigation of fragmentation pathways of protonated 2‐methoxypyrimidine derivatives

MALDI‐MS/MS of N‐Terminal TMPP‐Acyl Peptides: A Worthwhile Tool to Decipher Protein N‐Termini

Neutral loss scan in complement with high‐resolution MS/MS: Combination of detection methods for flavonoid and limonoid glycosides analysis

P‐97: Separation of Isomeric OLED Materials Using Ion Mobility‐Mass Spectrometry (IM‐MS)

43‐2: Application of Liquid Extraction Surface Analysis (LESA)‐NanoESI‐Orbitrap‐MS to a Degradation Analysis of Organic EL Elements

QCMS² as a new method for providing insight into peptide fragmentation: The influence of the side‐chain and inter–side‐chain interactions

Bottom‐up proteomics of envelope proteins extracted from spinach chloroplast via high organic content CE‐MS

ESI‐MS/MS analysis of protonated N‐methyl amino acids and their immonium ions

Bolt: a New Age Peptide Search Engine for Comprehensive MS/MS Sequencing Through Vast Protein Databases in Minutes

Citrulline Effect Is a Characteristic Feature of Deiminated Peptides in Tandem Mass Spectrometry

Automatic Analyte-Ion Recognition and Background Removal for Ambient Mass-Spectrometric Data Based on Cross-Correlation

19‐3: Examination in Application of TOF‐SIMS with MS/MS to a Degradation Analysis of OLED

Filter options

Publication date

Content availability

Publication type

Publication language

Keywords

Data set

INFONA - science communication portal

Search results

Add recipient

Sending message cancelled

Are you sure you want to cancel sending this message?

Send message

Filter options

Publication date

Date range setting

Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.

Content availability

Publication type

Publication language

Keywords

Data set

Reporting an error / abuse

Sending the report failed

Accessibility options