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Items from 1 to 20 out of 629 results

article

Whole‐blood transcriptome analysis reveals distinct gene expression signatures in paediatric patients with sickle cell anaemia before and after exercise

Abel Plaza‐Florido, Robert I. Liem, Fadia Haddad, Shlomit Radom‐Aizik

British Journal of Haematology > 205 > 1 > 320 - 328

Sickle cell anaemia (SCA) patients display elevated levels of circulating pro‐inflammatory cytokines and endothelial activation markers compared to healthy peers. The impact of exercise on the pro‐inflammatory state in SCA remains unclear. This study aimed to characterize the whole‐blood transcriptome profile in response to an acute bout of exercise in paediatric SCA patients. Twenty‐three SCA participants...

article

Novel electrical therapy to improve sleep disturbance in patients with autoimmune rheumatic diseases

Jiaoshi Zhao, Peili He, Qiujing Wei, Liuzhong Zhou, more

International Journal of Rheumatic Diseases > 27 > 6 > n/a - n/a

Objectives Sleep disturbance is common in autoimmune rheumatism diseases (ARD) and it plays an important role in activating disease and affects the quality of life. This study aims to evaluate the efficacy and acceptability of the novel electrical therapy on sleep disturbance in ARD patients and its effect on immunologic factors. Methods A total of 51 ARD patients (26 treatment group and 25 control...

article

Sex differences in systemic inflammation and immune function in diet‐induced obesity rodent models: A systematic review

Jenneffer Rayane Braga Tibaes, Maria Ines Barreto Silva, Bethany Wollin, Donna Vine, more

Obesity Reviews > 25 > 3 > n/a - n/a

Understanding sex differences in immunological responses in the context of obesity is important to improve health outcomes. This systematic review aimed to investigate sex differences in systemic inflammation, immune cell phenotype, and function in diet‐induced obesity (DIO) animal models. A systematic search in Medline, Embase, and CINAHL from inception to April 2023 was conducted, using a combination...

article

One carbon metabolism and its implication in health and immune functions

Shreya Dang, Arushi Jain, Garima Dhanda, Neetu Bhattacharya, more

Cell Biochemistry and Function > 42 > 1 > n/a - n/a

One carbon (1C) metabolism is critical for cellular viability and physiological homeostasis. Starting from its crucial involvement in purine biosynthesis to posttranslational modification of proteins, 1C metabolism contributes significantly to the development and cellular differentiation through methionine and folate cycles that are pivotal for cellular function. Genetic polymorphisms of several genes...

article

Effect of selection genotype on immune response to Brucella abortus RB51 in Holstein cattle

Kaitlyn M. Sarlo Davila, Paola Boggiatto, Steven Olsen, John D. Lippolis, more

Animal Genetics > 55 > 1 > 47 - 54

Genetic selection for milk production traits in US Holsteins has affected numerous genes associated with reproduction and immunity. This study compares the transcriptomic response of peripheral blood mononuclear cells to an in vitro Brucella abortus strain RB51 (RB51) bacterial challenge between contemporary Holsteins and Holsteins that have not been selected for milk production traits since the mid‐1960s...

article

Induction of IL‐32 in the immune response of keratinocytes to Mycobacterium marinum infection

Xu Sang, Xiaotong Xue, Zihao Mi, Zhenzhen Wang, more

Experimental Dermatology > 32 > 9 > 1451 - 1458

Keratinocytes are the predominant cell type in the skin epidermis, and they not only protect the skin from the influence of external physical factors but also function as an immune barrier against microbial invasion. However, little is known regarding the immune defence mechanisms of keratinocytes against mycobacteria. Here, we performed single‐cell RNA sequencing (scRNA‐seq) on skin biopsy samples...

article

Exposure to ultraviolet‐B radiation increases the susceptibility of mosquitoes to infection with dengue virus

Lesley A. Alton, Mario Novelo, Julian E. Beaman, Pieter A. Arnold, more

Global Change Biology > 29 > 19 > 5540 - 5551

By 2100, greenhouse gases are predicted to reduce ozone and cloud cover over the tropics causing increased exposure of organisms to harmful ultraviolet‐B radiation (UVBR). UVBR damages DNA and is an important modulator of immune function and disease susceptibility in humans and other vertebrates. The effect of UVBR on invertebrate immune function is largely unknown, but UVBR together with ultraviolet‐A...

article

miR‐126‐5p expression in the plasma of patients with sepsis‐induced acute lung injury and its correlation with inflammation and immune function

Xiaoyong Mao, Yiping Wu, Weifeng Xu

The Clinical Respiratory Journal > 17 > 7 > 629 - 637

Objective This work was implemented to elucidate the miR‐126‐5p expression in the plasma of patients with sepsis‐induced acute lung injury (ALI) and its correlation with inflammation and immune function. Methods The peripheral blood of patients with sepsis‐induced ALI was obtained, and the levels of inflammatory factors (interleukin‐6 [IL‐6], C‐reactive protein [CRP], and procalcitonin [PCT]) were...

article

Carryover effects from environmental change in early life: An overlooked driver of the amphibian extinction crisis?

Niclas U. Lundsgaard, Coen Hird, Kathleen A. Doody, Craig E. Franklin, more

Global Change Biology > 29 > 14 > 3857 - 3868

Ecological carryover effects, or delayed effects of the environment on an organism's phenotype, are central predictors of individual fitness and a key issue in conservation biology. Climate change imposes increasingly variable environmental conditions that may be challenging to early life‐history stages in animals with complex life histories, leading to detrimental physiological and fitness effects...

article

Dietary supplementation with probiotics increases growth performance, improves the intestinal mucosal barrier and activates the Wnt/β‐catenin pathway activity in chicks

Di‐qing Tong, Zhu‐jin Lu, Nan Zeng, Xiu‐qi Wang, more

Journal of the Science of Food and Agriculture > 103 > 9 > 4649 - 4659

Background Probiotics comprise effective feed additives that can replace antibiotics in animal livestock production. However, mono‐strain probiotics appear less effective because of their instability. Therefore, the present study aimed to investigate dietary supplementation with compound probiotics (CPP) on growth performance, diarrhea rate and intestinal mucosal barrier, as well as the possible...

article

Effects of sheep whey protein combined with Fu brick tea polysaccharides and stachyose on immune function and intestinal metabolites of cyclophosphamide‐treated mice

Nan Wang, Daoyuan Ren, Li Zhang, Ning Han, more

Journal of the Science of Food and Agriculture > 103 > 7 > 3402 - 3413

BACKGROUND Sheep whey protein (SWP), Fu brick tea polysaccharides (FBTP) and stachyose (STA) have been shown to improve immunity, but little is known about the regulatory effect of SWP, FBTP, STA and their combined formula (CF) on immune function and intestinal metabolism of immunosuppressed mice induced by cyclophosphamide (CTX). RESULTS Administration of SWP, FBTP, STA or CF restored the levels...

article

Eucalyptol antagonized the apoptosis and immune dysfunction of grass carp hepatocytes induced by tetrabromobisphenol A by regulating ROS/ASK1/JNK pathway

Wenying Sun, Huanyi Liu, Huijun Zhu, Meichen Gao, more

Environmental Toxicology > 38 > 4 > 820 - 832

Tetrabromobisphenol A (TBBPA) is a common environmental pollutant which has multi‐organ toxicity to mammals. Eucalyptol (EUC) has super antioxidant biological activity. However, in this experimental study, we probed into the mechanism of toxic of TBBPA exposure on Grass carp hepatocytes (L8824 cells) and the antagonistic impact of EUC on TBBPA. We treated L8824 cells with 8 μg/ml TBBPA and/or 20 μM...

article

Circadian rhythms of hosts and their gut microbiomes: Implications for animal physiology and ecology

Dominik W. Schmid, Pablo Capilla‐Lasheras, Davide M. Dominoni, Nadine Müller‐Klein, more

Functional Ecology > 37 > 3 > 476 - 487

Daily light–dark cycles shape the circadian physiology and behaviour of nearly all organisms, with variation in circadian phenotypes having cascading effects on individual fitness, species interactions and species co‐evolution. Recent evidence that circadian rhythms in host immunity and metabolism are synchronised by the gut microbiota suggest that the circadian dynamics of gut microbes are a...

article

Dietary β‐sitosterol supplementation enhanced intestinal immune function of large yellow croaker (Larimichthys crocea) infected with Aeromonas hydrophila

Yan Song, ZhiYuan Lu, XiaoFang Zhang, Jing Xu, more

Aquaculture Research > 53 > 18 > 6545 - 6561

An 80‐day feeding trial was performed to investigate the effect of dietary β‐sitosterol supplementation on intestinal immune function in large yellow croaker. 540 fish (initial average weight: 189.74 ± 0.31 g) were fed six diets containing graded levels of β‐sitosterol (0.0%, 0.5%, 1.0%, 1.5%, 2.0% and 2.5%) and then challenged with Aeromonas hydrophila for 10 days. Results demonstrated that dietary...

article

Effects of supplementing with Humulus scandens on the growth performance and gut microbiota in piglets

Lihong Hao, Cheng Wang, Huaizhong Wang, Jiancai Wang, more

Journal of Applied Microbiology > 133 > 6 > 3546 - 3557

Aims This study was conducted to evaluate the effects of feeding Humulus scandens (Hu) on growth performance and gut microbiota in piglets. Methods and Results A total of 120 piglets were allocated to four dietary treatments (1) CON, basal diet; (2) T1, basal diet + 2.0% Hu; (3) T2, basal diet + 2.8% Hu and (4) T3, basal diet + 3.6% Hu. The results showed that dietary H. scandens supplementation...

article

Effects of the methionine hydroxyl analog chelated microminerals on growth performance, antioxidant status, and immune response of growing–finishing pigs

Juan Chen, Huakai Wang, Yongxi Ma, Yawei Zhang, more

Animal Science Journal > 93 > 1 > n/a - n/a

This study aimed to investigate the effects of methionine hydroxyl analog chelated microminerals (MHA‐M) replacing inorganic microminerals (ITMs) on the growth performance, fecal microminerals concentrations, immune function, and antioxidant status in growing‐finishing pigs; 253 pigs (average 33.68 kg body weight) were randomly assigned to six treatments with six replicates each treatment: (1) ITM:...

article

Immune functions of phagocytic blood cells in teleost

Wentao Zhu, Jianguo Su

Reviews in Aquaculture > 14 > 2 > 630 - 646

Phagocytosis is a fundamental immune function against foreign microorganisms and abnormal cells, and it is also a bridge between innate and adaptive immunity. Blood as the direct living environment of various immune cells is a crucial site for phagocytosis. In this review, we firstly summarized the morphological structure and cytochemical characteristics of teleost peripheral blood cells, divided...

article

Dietary foods containing nitric oxide donors can be early curators of SARS‐CoV‐2 infection: A possible role in the immune system

S Swathi Krishna, Arumugam Thennavan, S K Kanthlal

Journal of Food Biochemistry > 46 > 3 > n/a - n/a

Severe acute respiratory syndrome coronavirus 2 (SARS CoV‐2) is a lethal virus that causes COVID‐19 (Coronavirus disease 2019), the respiratory illness that has caused the COVID‐19 pandemic. Even though multiple pharmacological trials are ongoing, there is no proof that any treatment will effectively cure or prevent COVID‐19. Currently, COVID‐19‐infected patients are being managed with non‐specific...

article

Effects of L‐carnitine supplementation on growth performance, histomorphology, antioxidant and immune function of Rhynchocypris lagowskii fed dietary fish oil replaced with corn oil

Sen Wang, Qi Yao, Ning Wang, Dongming Zhang, more

Aquaculture Research > 53 > 5 > 1981 - 1994

The effects of L‐carnitine (LC) and dietary lipid on the growth and health of farmed fish are still conflicting. This study aimed to explore the effects of LC supplementation and dietary fish oil replacement by corn oil on growth performance, antioxidant, immune function and histomorphology of Rhynchocypris Lagowskii. Six diets were evaluated as follows: dietary fish oil as 50% and 100% replacement...

article

Introduction to biological rhythms: A brief history of chronobiology and its relevance to parasite immunology

Louise Madeleine Ince

Parasite Immunology > 44 > 3 > n/a - n/a

Almost every living organism on earth is exposed to a fluctuating environment, for example, light:dark cycles, food availability and seasonal photoperiods. Most species have therefore evolved internal timing mechanisms allowing them to anticipate these rhythmic environmental changes, obtaining a survival advantage. Circadian (24 h) rhythms, in particular, regulate multiple aspects of physiology, including...

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Search results

Whole‐blood transcriptome analysis reveals distinct gene expression signatures in paediatric patients with sickle cell anaemia before and after exercise

Novel electrical therapy to improve sleep disturbance in patients with autoimmune rheumatic diseases

Sex differences in systemic inflammation and immune function in diet‐induced obesity rodent models: A systematic review

One carbon metabolism and its implication in health and immune functions

Effect of selection genotype on immune response to Brucella abortus RB51 in Holstein cattle

Induction of IL‐32 in the immune response of keratinocytes to Mycobacterium marinum infection

Exposure to ultraviolet‐B radiation increases the susceptibility of mosquitoes to infection with dengue virus

miR‐126‐5p expression in the plasma of patients with sepsis‐induced acute lung injury and its correlation with inflammation and immune function

Carryover effects from environmental change in early life: An overlooked driver of the amphibian extinction crisis?

Dietary supplementation with probiotics increases growth performance, improves the intestinal mucosal barrier and activates the Wnt/β‐catenin pathway activity in chicks

Effects of sheep whey protein combined with Fu brick tea polysaccharides and stachyose on immune function and intestinal metabolites of cyclophosphamide‐treated mice

Eucalyptol antagonized the apoptosis and immune dysfunction of grass carp hepatocytes induced by tetrabromobisphenol A by regulating ROS/ASK1/JNK pathway

Circadian rhythms of hosts and their gut microbiomes: Implications for animal physiology and ecology

Dietary β‐sitosterol supplementation enhanced intestinal immune function of large yellow croaker (Larimichthys crocea) infected with Aeromonas hydrophila

Effects of supplementing with Humulus scandens on the growth performance and gut microbiota in piglets

Effects of the methionine hydroxyl analog chelated microminerals on growth performance, antioxidant status, and immune response of growing–finishing pigs

Immune functions of phagocytic blood cells in teleost

Dietary foods containing nitric oxide donors can be early curators of SARS‐CoV‐2 infection: A possible role in the immune system

Effects of L‐carnitine supplementation on growth performance, histomorphology, antioxidant and immune function of Rhynchocypris lagowskii fed dietary fish oil replaced with corn oil

Introduction to biological rhythms: A brief history of chronobiology and its relevance to parasite immunology

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