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article

Estrogen receptor β and oxytocin interact to modulate anxiety-like behavior and neuroendocrine stress reactivity in adult male and female rats

Andrea E. Kudwa, Robert F. McGivern, Robert J. Handa, A.E. Kudwa, more

Physiology & Behavior > 2014 > 129 > Complete > 287-296

The hypothalamic–pituitary–adrenal (HPA) axis is activated in response to stressors and is controlled by neurons residing in the paraventricular nucleus of the hypothalamus (PVN). Although gonadal steroid hormones can influence HPA reactivity to stressors, the exact mechanism of action is not fully understood. It is known, however, that estrogen receptor β (ERβ) inhibits HPA reactivity and decreases...

article

Depressive symptoms are associated with allostatic load among community-dwelling older adults

Roni W. Kobrosly, Edwin van Wijngaarden, Christopher L. Seplaki, Deborah A. Cory-Slechta, more

Physiology & Behavior > 2014 > 123 > Complete > 223-230

The allostatic load model has been used to quantify the physiological costs of the body's response to repeated stressful demands and may provide a useful, integrative perspective on the various correlates of late-life depressive symptoms. We interviewed 125 Rochester, NY adults, ranging in age from 67 to 94years. We employed an allostatic load score as a measure of multisystem dysfunction in hypothalamic–pituitary–adrenal...

article

Dysregulated responses to emotions among abstinent heroin users: Correlation with childhood neglect and addiction severity

G. Gerra, L. Somaini, M. Manfredini, M.A. Raggi, more

Progress in Neuropsychopharmacology & Biological Psychiatry > 2014 > 48 > Complete > 220-228

The aim of this paper was to investigate the subjective responses of abstinent heroin users to both neutral and negative stimuli and the related hypothalamus-pituitary-adrenal reactions to emotional experience in relationship to their perception of childhood adverse experiences. Thirty male abstinent heroin dependents were included in the study. Emotional responses and childhood neglect perception...

article

Mild early‐life stress exaggerates the impact of acute stress on corticolimbic resting‐state functional connectivity

Huan Wang, Judith M. C. Leeuwen, Lycia D. Voogd, Robbert‐Jan Verkes, more

European Journal of Neuroscience > 55 > 9-10 > 2122 - 2141

Abundant evidence shows that early‐life stress (ELS) predisposes for the development of stress‐related psychopathology when exposed to stressors later in life, but the underlying mechanisms remain unclear. To study predisposing effects of mild ELS on stress sensitivity, we examined in a healthy human population the impact of a history of ELS on acute stress‐related changes in corticolimbic circuits...

article

Methyl‐CpG binding protein 2 dysfunction provides stress vulnerability with sex‐ and zygosity‐dependent outcomes

Livia Cosentino, Fabio Bellia, Nicole Pavoncello, Daniele Vigli, more

European Journal of Neuroscience > 55 > 9-10 > 2766 - 2776

Stress vulnerability is a critical factor for the development of trauma‐related disorders; however, its biological underpinnings are not clear. We demonstrated that dysfunctions in the X‐linked epigenetic factor methyl‐CpG binding protein 2 (MeCP2) provide trauma vulnerability in male mice. Given the prominent role of sex in stress outcomes, we explored the effects of MeCP2 hypofunctionality in females...

article

Neuroendocrine and neuroimmune responses in male and female rats: evidence for functional immaturity of the neuroimmune system during early adolescence

Paige Marsland, Allissa Parrella, Maya Orlofsky, Dennis F. Lovelock, more

European Journal of Neuroscience > 55 > 9-10 > 2311 - 2325

Adolescence is a developmental period characterized by rapid behavioral and physiological changes, including enhanced vulnerability to stress. Recent studies using rodent models of adolescence have demonstrated age differences in neuroendocrine responses and blunted neuroimmune responding to pharmacological challenges. The present study was designed to test whether this neuroimmune insensitivity would...

article

Tenuifolin ameliorates chronic restraint stress‐induced cognitive impairment in C57BL/6J mice

Haixia Wang, Hong Huang, Ning Jiang, Yiwen Zhang, more

Phytotherapy Research > 36 > 3 > 1402 - 1412

The general consensus is that stress affects the central nervous system and can lead to cognitive problems. The root of Polygala tenuifolia (P. tenuifolia) is a well‐known traditional Chinese medicine used for improving brain function. Tenuifolin (TEN) is the major constituent of P. tenuifolia and has a promising neuroprotective property. The purpose of this study was to investigate the alleviating...

article

Long‐term consequences of alcohol use in early adolescent mice: Focus on neuroadaptations in GR, CRF and BDNF

Patricia Sampedro‐Piquero, Román D. Moreno‐Fernández, Azucena Begega, Matías López, more

Addiction Biology > 27 > 2 > n/a - n/a

Our aim was to assess the cognitive and emotional state, as well as related‐changes in the glucocorticoid receptor (GR), the corticotropin‐releasing factor (CRF) and the brain‐derived neurotrophic factor (BDNF) expression of adolescent C57BL/6J male mice after a 5‐week two‐bottle choice protocol (postnatal day [pd]21 to pd52). Additionally, we wanted to analyse whether the behavioural and neurobiological...

article

Suppression of adult cytogenesis in the rat brain leads to sex‐differentiated disruption of the HPA axis activity

Tiago Silveira‐Rosa, António Mateus‐Pinheiro, Joana Sofia Correia, Joana Margarida Silva, more

Cell Proliferation > 55 > 2 > n/a - n/a

Objectives The action of stress hormones, mainly glucocorticoids, starts and coordinates the systemic response to stressful events. The HPA axis activity is predicated on information processing and modulation by upstream centres, such as the hippocampus where adult‐born neurons (hABN) have been reported to be an important component in the processing and integration of new information. Still, it remains...

article

The role of nucleus of the solitary tract glucagon‐like peptide‐1 and prolactin‐releasing peptide neurons in stress: anatomy, physiology and cellular interactions

Marie K. Holt, Linda Rinaman

British Journal of Pharmacology > 179 > 4 > 642 - 658

Neuroendocrine, behavioural and autonomic responses to stressful stimuli are orchestrated by complex neural circuits. The caudal nucleus of the solitary tract (cNTS) in the dorsomedial hindbrain is uniquely positioned to integrate signals of both interoceptive and psychogenic stress. Within the cNTS, glucagon‐like peptide‐1 (GLP‐1) and prolactin‐releasing peptide (PrRP) neurons play crucial roles...

article

Chronic stress facilitates bursting electrical activity in pituitary corticotrophs

Peter J. Duncan, Mehran Fazli, Nicola Romanò, Paul Le Tissier, more

The Journal of Physiology > 600 > 2 > 313 - 332

Abstract Coordination of an appropriate stress response is dependent upon anterior pituitary corticotroph excitability in response to hypothalamic secretagogues and glucocorticoid negative feedback. A key determinant of corticotroph excitability is large conductance calcium‐ and voltage‐activated (BK) potassium channels that are critical for promoting corticotrophin‐releasing hormone (CRH)‐induced...

article

Chronic stress induces NPD‐like behavior in APPPS1 and WT mice with subtle differences in gene expression

Amalie Clement, Mads M. Pedersen, Allan Stensballe, Ove Wiborg, more

Genes, Brain and Behavior > 20 > 8 > n/a - n/a

Neuropsychiatric disturbances (NPDs) are considered hallmarks of Alzheimer's disease (AD). Nevertheless, treatment of these symptoms has proven difficult and development of safe and effective treatment options is hampered by the limited understanding of the underlying pathophysiology. Thus, robust preclinical models are needed to increase knowledge of NPDs in AD and develop testable hypotheses and...

article

3‐O‐Acetyl‐11‐keto‐β‐boswellic acid ameliorates chronic unpredictable mild stress induced HPA axis dysregulation in relation with glutamate/GABA aberration in depressive rats

Venkatesh Gunasekaran, Anitta Augustine, Jinu Avarachan, Abdul Khayum, more

Clinical and Experimental Pharmacology and Physiology > 48 > 12 > 1633 - 1641

Overt expression of brain glucocorticoid receptor (GR) leads to elevation of glutamate release causes cerebral excitotoxicity which in turn produce neuropsychological disorders. The aim of our work is to study the consequence of 3‐O‐Acetyl‐11‐keto‐β‐boswellic acid (AKBA) on chronic unpredictable mild stress (CUMS) induced HPA axis dysregulation in relative to glutamate and GABA irregularity in depressive...

article

Orcinol glucoside improves the depressive‐like behaviors of perimenopausal depression mice through modulating activity of hypothalamic–pituitary–adrenal/ovary axis and activating BDNF‐ TrkB‐CREB signaling pathway

Junlong Li, Pingya He, Jian Zhang, Ning Li

Phytotherapy Research > 35 > 10 > 5795 - 5807

Orcinol Glucoside (OG), a phenolic glucoside isolated from C. orchioides, showed the antidepressant‐like effect on chronic unpredictable mild stress (CUMS)‐induced rats previously. This study was designed to determine whether OG could improve the depressive‐like symptoms of perimenopausal depression (PMD) and the possible mechanisms involved. This research was performed on a PMD mice model established...

article

Dietary EPA‐Enriched Phospholipids Alleviate Chronic Stress and LPS‐Induced Depression‐ and Anxiety‐Like Behavior by Regulating Immunity and Neuroinflammation

Cheng‐Cheng Wang, Lei Du, Hao‐Hao Shi, Lin Ding, more

Molecular Nutrition & Food Research > 65 > 17 > n/a - n/a

Scope A growing number of studies have reported the effects of eicosapentaenoic acid (EPA) and terrestrial phospholipids on ameliorating mood disorders. Marine‐derived EPA‐enriched phospholipids (EPA‐PL) exhibit the structural characteristics of EPA and phospholipids. However, the effect of dietary EPA‐PL, and the differences between amphiphilic EPA‐PL and lyophobic EPA on mood disorders had not...

article

T3 is linked to stress‐associated reduction of prolactin in lactating women

Safia Bibi, Mohsin Shah, Muhammad Omar Malik, Ki Ann Goosens

Journal of Neuroendocrinology > 33 > 8 > n/a - n/a

The relationship between stress responses and lactation is bidirectional. Breastfeeding confers many benefits to maternal health, including attenuated hypothalamic‐pituitary‐adrenal axis responsiveness to stress. However, increased stress burden can impair lactation. The mechanisms that underlie these relationships are poorly understood. The present study aimed to compare breastfeeding habits, as...

article

Maternal experiences of childhood maltreatment moderate patterns of mother–infant cortisol regulation under stress

Jennifer E. Khoury, Joseph Beeney, Ilana Shiff, Michelle Bosquet Enlow, more

Developmental Psychobiology > 63 > 5 > 1309 - 1321

The relation between maternal and infant cortisol responses has been a subject of intense research over the past decade. Relatedly, it has been hypothesized that maternal history of childhood maltreatment (MCM) impacts stress regulation across generations. The current study employed four statistical approaches to determine how MCM influences the cortisol responses of 150 mothers and their 4‐month‐old...

article

Towards an understanding of neurophysiological self‐regulation in early childhood: A heuristic and a new approach

Steven J. Holochwost, Jacek Kolacz, W. Roger Mills‐Koonce

Developmental Psychobiology > 63 > 4 > 734 - 752

Self‐regulation in early childhood encompasses both “top down,” volitional processes, as well as the “bottom up” activity of three neurophysiological systems: the parasympathetic nervous system (PNS), the sympathetic nervous system (SNS), and the hypothalamic‐pituitary‐adrenal (HPA) axis. In this paper we briefly review the structure, function, and early development of each of these systems and then...

article

Maternal psychological distress during gestation is associated with infant food allergy

Minna Lukkarinen, Emma Puosi, Eeva‐Leena Kataja, Laura S. Korhonen, more

Pediatric Allergy and Immunology > 32 > 4 > 787 - 792

article

Impaired hypothalamic feedback dysregulates brain glucocorticoid signaling in genetically‐selected Marchigian Sardinian alcohol‐preferring rats

Luis A. Natividad, Michael Q. Steinman, M. Adrienne McGinn, Suhas Sureshchandra, more

Addiction Biology > 26 > 3 > n/a - n/a

Genetically‐selected Marchigian Sardinian alcohol‐preferring (msP) rats display comorbid symptoms of increased alcohol preference and elevated anxiety‐like behavior. Heightened stress sensitivity in msPs is influenced by genetic polymorphisms of the corticotropin‐releasing factor receptor in the central nucleus of the amygdala (CeA), as well as reduced influence of anti‐stress mechanisms that normally...

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Search results

Estrogen receptor β and oxytocin interact to modulate anxiety-like behavior and neuroendocrine stress reactivity in adult male and female rats

Depressive symptoms are associated with allostatic load among community-dwelling older adults

Dysregulated responses to emotions among abstinent heroin users: Correlation with childhood neglect and addiction severity

Mild early‐life stress exaggerates the impact of acute stress on corticolimbic resting‐state functional connectivity

Methyl‐CpG binding protein 2 dysfunction provides stress vulnerability with sex‐ and zygosity‐dependent outcomes

Neuroendocrine and neuroimmune responses in male and female rats: evidence for functional immaturity of the neuroimmune system during early adolescence

Tenuifolin ameliorates chronic restraint stress‐induced cognitive impairment in C57BL/6J mice

Long‐term consequences of alcohol use in early adolescent mice: Focus on neuroadaptations in GR, CRF and BDNF

Suppression of adult cytogenesis in the rat brain leads to sex‐differentiated disruption of the HPA axis activity

The role of nucleus of the solitary tract glucagon‐like peptide‐1 and prolactin‐releasing peptide neurons in stress: anatomy, physiology and cellular interactions

Chronic stress facilitates bursting electrical activity in pituitary corticotrophs

Chronic stress induces NPD‐like behavior in APPPS1 and WT mice with subtle differences in gene expression

3‐O‐Acetyl‐11‐keto‐β‐boswellic acid ameliorates chronic unpredictable mild stress induced HPA axis dysregulation in relation with glutamate/GABA aberration in depressive rats

Orcinol glucoside improves the depressive‐like behaviors of perimenopausal depression mice through modulating activity of hypothalamic–pituitary–adrenal/ovary axis and activating BDNF‐ TrkB‐CREB signaling pathway

Dietary EPA‐Enriched Phospholipids Alleviate Chronic Stress and LPS‐Induced Depression‐ and Anxiety‐Like Behavior by Regulating Immunity and Neuroinflammation

T3 is linked to stress‐associated reduction of prolactin in lactating women

Maternal experiences of childhood maltreatment moderate patterns of mother–infant cortisol regulation under stress

Towards an understanding of neurophysiological self‐regulation in early childhood: A heuristic and a new approach

Maternal psychological distress during gestation is associated with infant food allergy

Impaired hypothalamic feedback dysregulates brain glucocorticoid signaling in genetically‐selected Marchigian Sardinian alcohol‐preferring rats

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