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article

Pharmacological Sequestration of Mitochondrial Calcium Uptake Protects Neurons Against Glutamate Excitotoxicity

Plamena R. Angelova, Darya Vinogradova, Margarita E. Neganova, Tatiana P. Serkova, more

Molecular Neurobiology > 2019 > 56 > 3 > 2244-2255

Neuronal excitotoxicity which is induced by exposure to excessive extracellular glutamate is shown to be involved in neuronal cell death in acute brain injury and a number of neurological diseases. High concentration of glutamate induces calcium deregulation which results in mitochondrial calcium overload and mitochondrial depolarization that triggers the mechanism of cell death. Inhibition of mitochondrial...

article

La découverte des propriétés antidépressives de la kétamine

Pierre de Maricourt, Raphaël Gaillard

Annales M�dico-psychologiques, revue psychiatrique > 2017 > 175 > 7 > 665-669

Depression is a frequent disease with a significant medico-economic impact. Conventional antidepressants have a delayed action and are ineffective in one third of cases. Discovery of ketamine's antidepressant effects these last years opens new perspectives for treatment-resistant depression.This article reviews the discovery of the antidepressant effect of ketamine, the current state of knowledge...

article

Kétamine, dépression et suicide : vers une nouvelle classe d’antidépresseurs ?

Rémi Moirand, Sylvain Iceta, Emmanuel Poulet

Annales M�dico-psychologiques, revue psychiatrique > 2017 > 175 > 2 > 121-126

Major depressive disorder is a frequent and serious disease, which can result in suicide. Treatment resistance is frequent in this pathology and actual antidepressants need a few weeks before having a clinical efficacy. Ketamine is an NMDA antagonist used in anaesthesia for decades, and has shown since several years a fast and efficient antidepressant effect in patients with treatment-resistant depression...

article

Could glutamate spectroscopy differentiate bipolar depression from unipolar?

Matthew J. Taylor, M.J. Taylor

Journal of Affective Disorders > 2014 > 167 > Complete > 80-84

Background: Accurate differentiation of bipolar and unipolar depression is a key clinical challenge. A biological measure that could differentiate bipolar and unipolar depression might supplement clinical assessment. Magnetic Resonance Spectroscopy measurements of total glutamate and glutamine (Glx) in anterior cingulate cortex are one potential measure. The objective of this study was to assess the...

article

A study of oxidative stress, cytokines and glutamate in Wilson disease and their asymptomatic siblings

Jayantee Kalita, Vijay Kumar, Usha K. Misra, Abhay Ranjan, more

Journal of Neuroimmunology > 2014 > 274 > 1-2 > 141-148

Background: Free copper in Wilson disease (WD) is toxic and may reduce antioxidant, increase oxidative stress marker and thereby cytokine release and excitotoxic injury, but there is paucity of studies in humans. We report oxidative stress markers, cytokines and glutamate in neurologic WD and correlate these with their clinical severity, laboratory findings and extent of Magnetic resonance imaging...

article

Prefrontal grey and white matter neurometabolite changes after atomoxetine and methylphenidate in children with attention deficit/hyperactivity disorder: A 1H magnetic resonance spectroscopy study

Veronika Husarova, Michal Bittsansky, Igor Ondrejka, Dusan Dobrota, more

Psychiatry Research: Neuroimaging > 2014 > 222 > 1-2 > 75-83

Attention deficit/hyperactivity disorder (ADHD) is the most common neurobehavioral childhood disorder. Dysfunction of prefrontal neural circuits which are responsible for executive and attentional functions has been previously shown in ADHD. We investigated the neurometablite changes in areas included in dorsolateral prefrontal neural circuits after 2 months of long-acting methylphenidate or atomoxetine...

article

Oxidative Stress-Associated Neuroretinal Dysfunction and Nitrosative Stress in Diabetic Retinopathy

Lakshmi K. Mandal, Subhadip Choudhuri, Deep Dutta, Bhaskar Mitra, more

Canadian Journal of Diabetes > 2013 > 37 > 6 > 401-407

The present study was intended to investigate whether oxidative stress is the key regulator to alter neuroretinal biochemical homeostasis and in turn aggravate the process of diabetic retinopathy by inducing nitrosative stress in the retinal neurovascular unit.Peripheral blood mononuclear cell reactive oxygen species level was measured by flow cytometry along with spectrophotometric detection of malondialdehyde...

article

A novel series of metabotropic glutamate receptor 5 negative allosteric modulators based on a 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine core

Guillaume Duvey, Benjamin Perry, Emmanuel Le Poul, Sonia Poli, more

Bioorganic & Medicinal Chemistry Letters > 2013 > 23 > 16 > 4523-4527

A series of potent non-acetylinic negative allosteric modulators of the metabotropic glutamate receptor 5 (mGlu5 NAMs) was developed starting from HTS screening hit 1. Potency was improved via iterative SAR, and physicochemical properties were optimized to deliver orally bioavailable compounds acceptable for in vivo testing. A lead molecule from the series demonstrated dose-dependent activity in the...

article

Glutamate–glutamine cycling in Alzheimer's disease

Heather Scott Walton, Peter R. Dodd

Neurochemistry International > 2007 > 50 > 7-8 > 1052-1066

In addition to its definitive pathological characteristics, neuritic plaques and neurofibrillary tangles, Alzheimer's disease (AD) brain exhibits regionally variable neuronal loss and synaptic dysfunction that are likely to underlie the symptomatic memory loss and language abnormalities. A number of mechanisms that could give rise to this localized damage have been proposed, amongst which excitotoxicity...

article

Actualités et perspectives thérapeutiques de la maladie d'Alzheimer

F. Nourhashémi

La Revue de medecine interne > 2006 > 27 > 8 > 585-587

article

Stress oxydatif cérébral : les astrocytes sont-ils vulnérables aux faibles concentrations intracellulaires de glutamate ? Implications sur la survie neuronale

D.B. Ré, I. Nafia, A. Nieoullon, L. Kerkerian Le Goff, more

Annales francaises d'anesthesie et de reanimation > 2005 > 24 > 5 > 502-509

Cette revue comporte la description des substances oxygénées réactives (ROS), de leur mode de production et d'action et des différents systèmes de défenses contre le stress oxydatif, en particulier du glutathion, le principal antioxydant du système nerveux central dont la synthèse par les neurones semble dépendre de précurseurs astrocytaires. Elle fait également le point sur les différents mécanismes...

article

Role des recepteurs NMDA et des canaux calciques sur le taux de glutamate dans un modele in vitro d ischemie cerebrale.

Frédéric Robert, Lionel Bert, Luc Stoppini

Comptes rendus - Biologies > 2002 > 325 > 4 > 495-504

We have investigated the effects of various insults on extracellular glutamate and phosphoethanolamine levels as well as electrical activity alterations in the early period following these insults in organotypic hippocampal slice cultures. Cultures prepared from 7-day-old rats were maintained in vitro for 7-14 days and then metabolic inhibition was induced: cultures were briefly exposed to potassium...

article

Les modeles pharmacologiques dans la recherche sur la maladie d@⌀lzheimer

C. Gilles, S. Ertlé, J.P. Macher

Annales medico-psychologiques > 2001 > 159 > 1 > 54-62

Une utilisation plus large des modeles pharmacologiques faciliterait le developpement de nouveaux medicaments pour la maladie d'Alzheimer (MA). Les deux modeles principaux qui sont actuellement proposes (scopolamine et ketamine) sont bases respectivement sur les hypotheses cholinergique et glutamatergique de cette maladie. Bien qu'ils induisent certaines des alterations attentionnelles et mnesiques...

article

Energy conservation in aerobically grown Staphylococcus aureus

Zofia Tynecka, Zofia Szcześniak, Anna Malm, Renata Los

Research in Microbiology > 1999 > 150 > 8 > 555-566

The present studies provide new data on the involvement of menaquinol oxidases in substrate oxidation and energy conservation in aerobically grown, resting cells of Staphylococcus aureus 17810R, starved of endogenous energy reserves and supplemented with glutamate or L-lactate. These cells were energetically competent, since they oxidized both substrates, generated an electrochemical proton gradient...

article

Isoliensinine activated the Nrf2/GPX4 pathway to inhibit glutamate‐induced ferroptosis in HT‐22 cells

Hui‐Zhi Long, Feng‐Jiao Li, Li‐Chen Gao, Zi‐Wei Zhou, more

Journal of Biochemical and Molecular Toxicology > 38 > 9 > n/a - n/a

Isoliensinine (ISO), a natural compound, is a bibenzyl isoquinoline alkaloid monomer in lotus seed, which has strong antioxidant and free radical scavenging activities. The oxidative toxicity caused by glutamic acid overdose is one of the important mechanisms of nerve cell injury, and the oxidative toxicity caused by glutamic acid is related to ferroptosis. This study aims to establish a glutamate‐induced...

article

Co‐administration of sub‐effective doses of the constituents of Crocus sativus L. crocins with those of the antipsychotics clozapine and risperidone counteract memory deficits caused by blockade of the NMDA receptor in rats

Foteini Vartzoka, Maria Anastasia Parlantza, Petros A. Tarantilis, Nikolaos Pitsikas

Phytotherapy Research > 38 > 8 > 4140 - 4150

Experimental evidence indicates that the noncompetitive N‐methyl‐D‐aspartate (NMDA) receptor antagonists ketamine and MK‐801 induce schizophrenia‐like symptoms in rodents, including cognitive deficits. Crocins are among the active components of the plant Crocus sativus L. and were found to be effective in different models of psychiatric disorders comprising schizophrenia. The present study was designed...

article

Miniaturized Electrochemical Sensing Platforms for Quantitative Monitoring of Glutamate Dynamics in the Central Nervous System

Qi Wang, Chunyu Yang, Shulin Chen, Jinghua Li

Angewandte Chemie International Edition > 63 > 34 > n/a - n/a

Glutamate is one of the most important excitatory neurotransmitters within the mammalian central nervous system. The role of glutamate in regulating neural network signaling transmission through both synaptic and extra‐synaptic paths highlights the importance of the real‐time and continuous monitoring of its concentration and dynamics in living organisms. Progresses in multidisciplinary research have...

article

Miniaturized Electrochemical Sensing Platforms for Quantitative Monitoring of Glutamate Dynamics in the Central Nervous System

Qi Wang, Chunyu Yang, Shulin Chen, Jinghua Li

Angewandte Chemie > 136 > 34 > n/a - n/a

article

RNA‐sequencing reveals a shared neurotranscriptomic profile in the medial preoptic area of highly social songbirds and rats

Brandon J. Polzin, Changjiu Zhao, Sharon A. Stevenson, Stephen C. Gammie, more

Genes, Brain and Behavior > 23 > 4 > n/a - n/a

Rough‐and‐tumble play in juvenile rats and song in flocks of adult songbirds outside a breeding context (gregarious song) are two distinct forms of non‐sexual social behavior. Both are believed to play roles in the development of sociomotor skills needed for later life‐history events, including reproduction, providing opportunities for low‐stakes practice. Additionally, both behaviors are thought...

article

Astrocytic PAR1 and mGluR2/3 control synaptic glutamate time course at hippocampal CA1 synapses

Woo Suk Roh, Jae Hong Yoo, Shashank M. Dravid, Guido Mannaioni, more

Glia > 72 > 9 > 1707 - 1724

Astrocytes play an essential role in regulating synaptic transmission. This study describes a novel form of modulation of excitatory synaptic transmission in the mouse hippocampus by astrocytic G‐protein‐coupled receptors (GPCRs). We have previously described astrocytic glutamate release via protease‐activated receptor‐1 (PAR1) activation, although the regulatory mechanisms for this are complex. Through...

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Search results

Pharmacological Sequestration of Mitochondrial Calcium Uptake Protects Neurons Against Glutamate Excitotoxicity

La découverte des propriétés antidépressives de la kétamine

Kétamine, dépression et suicide : vers une nouvelle classe d’antidépresseurs ?

Could glutamate spectroscopy differentiate bipolar depression from unipolar?

A study of oxidative stress, cytokines and glutamate in Wilson disease and their asymptomatic siblings

Prefrontal grey and white matter neurometabolite changes after atomoxetine and methylphenidate in children with attention deficit/hyperactivity disorder: A 1H magnetic resonance spectroscopy study

Oxidative Stress-Associated Neuroretinal Dysfunction and Nitrosative Stress in Diabetic Retinopathy

A novel series of metabotropic glutamate receptor 5 negative allosteric modulators based on a 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine core

Glutamate–glutamine cycling in Alzheimer's disease

Actualités et perspectives thérapeutiques de la maladie d'Alzheimer

Stress oxydatif cérébral : les astrocytes sont-ils vulnérables aux faibles concentrations intracellulaires de glutamate ? Implications sur la survie neuronale

Role des recepteurs NMDA et des canaux calciques sur le taux de glutamate dans un modele in vitro d ischemie cerebrale.

Les modeles pharmacologiques dans la recherche sur la maladie d@⌀lzheimer

Energy conservation in aerobically grown Staphylococcus aureus

Isoliensinine activated the Nrf2/GPX4 pathway to inhibit glutamate‐induced ferroptosis in HT‐22 cells

Co‐administration of sub‐effective doses of the constituents of Crocus sativus L. crocins with those of the antipsychotics clozapine and risperidone counteract memory deficits caused by blockade of the NMDA receptor in rats

Miniaturized Electrochemical Sensing Platforms for Quantitative Monitoring of Glutamate Dynamics in the Central Nervous System

Miniaturized Electrochemical Sensing Platforms for Quantitative Monitoring of Glutamate Dynamics in the Central Nervous System

RNA‐sequencing reveals a shared neurotranscriptomic profile in the medial preoptic area of highly social songbirds and rats

Astrocytic PAR1 and mGluR2/3 control synaptic glutamate time course at hippocampal CA1 synapses

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