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article

Sex differences in neuronal activation during aversion‐resistant alcohol consumption

Miranda E. Arnold, Arielle N. Butts, Theresa R. Erlenbach, Kristen N. Amico, more

Alcoholism: Clinical and Experimental Research > 47 > 2 > 240 - 250

Background One of the DSM‐5 criteria for Alcohol Use Disorder is continued alcohol consumption despite negative consequences. This has been modeled in mice using adulteration of alcohol solution with the bitter tastant quinine. Mice that continue to consume alcohol despite this adulteration are considered aversion resistant. The limited number of studies dissecting the underlying neuronal mechanisms...

article

Adolescent‐ and adult‐initiated alcohol exposure in mice differentially promotes tumorigenesis and metastasis of breast cancer

Mei Xu, Hui Li, Danlei Chen, Huaxun Wu, more

Alcoholism: Clinical and Experimental Research > 47 > 2 > 251 - 262

Background Alcohol exposure increases the risk of breast cancer. Alcohol consumption by adolescents is a serious social and public health issue. This study investigated the impact of adolescent alcohol consumption on mammary tumorigenesis and progression and compared it to that of adult alcohol exposure in animal models. Methods Female adolescent (5 weeks) and adult (8 weeks) MMTV‐Wnt1 mice were...

article

Neuromuscular mechanisms of weakness in a mouse model of chronic alcoholic myopathy

Samantha E. Moser, Austin M. Brown, Brian C. Clark, W. David Arnold, more

Alcoholism: Clinical and Experimental Research > 46 > 9 > 1636 - 1647

Background Weakness is a common clinical symptom reported in individuals with chronic alcohol use disorder. However, it remains unclear whether low strength in these individuals is directly related to excessive ethanol intake, other deleterious factors (lifestyle, environment, genetics, etc.), or a combination of both. Therefore, we examined whether (and how) ethanol reduces the muscle’s force‐producing...

article

Chronic ethanol consumption plus an atherogenic diet cause metabolic steatohepatitis with advanced liver fibrosis in apolipoprotein E/low‐density lipoprotein receptor double‐knockout mice

Jinyao Liu, Yumiko Oba, Seiko Yamano

Alcoholism: Clinical and Experimental Research > 46 > 7 > 1192 - 1203

Background Nonalcoholic steatohepatitis is the inflammatory subtype of nonalcoholic fatty liver disease with a high risk of progression to liver fibrosis. We investigated metabolic steatohepatitis with advanced liver fibrosis in apolipoprotein E/low‐density lipoprotein receptor double‐knockout (AL) mice fed a co‐diet of ethanol with a low‐carbohydrate–high‐protein‐high‐fat atherogenic diet (AD) for...

article

The development, but not expression, of alcohol front‐loading in C57BL/6J mice maintained on LabDiet 5001 is abolished by maintenance on Teklad 2920x rodent diet

Nicole M. Maphis, Radcliff T. Huffman, David N. Linsenbardt

Alcoholism: Clinical and Experimental Research > 46 > 7 > 1321 - 1330

Background Excessive alcohol (ethanol) consumption, such as binge drinking, is extremely commonplace and represents a major health concern. Through modeling excessive drinking in rodents, we are beginning to uncover the neurobiological and neurobehavioral causes and consequences of this pattern of ethanol intake. One important factor for modeling binge drinking in mice is that they reliably drink...

article

COVID‐19 patients with documented alcohol use disorder or alcohol‐related complications are more likely to be hospitalized and have higher all‐cause mortality

Kristina L. Bailey, Harlan Sayles, James Campbell, Neha Khalid, more

Alcoholism: Clinical and Experimental Research > 46 > 6 > 1023 - 1035

Background Coronavirus Disease 2019 (COVID‐19) has affected every country globally, with hundreds of millions of people infected with the SARS‐CoV‐2 virus and over 6 million deaths to date. It is unknown how alcohol use disorder (AUD) affects the severity and mortality of COVID‐19. AUD is known to increase the severity and mortality of bacterial pneumonia and the risk of developing acute respiratory...

article

The impact of intermittent exercise on mouse ethanol drinking and abstinence‐associated affective behavior and physiology

Samuel W. Centanni, Sara Y. Conley, Joseph R. Luchsinger, Louise Lantier, more

Alcoholism: Clinical and Experimental Research > 46 > 1 > 114 - 128

Background Negative emotional states are associated with the initiation and maintenance of alcohol use and drive relapse to drinking during withdrawal and protracted abstinence. Physical exercise is correlated with decreased negative affective symptoms, although a direct relationship between drinking patterns and exercise level has not been fully elucidated. Methods We incorporated intermittent...

article

Chloride intracellular channel 4 (CLIC4) expression profile in the mouse medial prefrontal cortex and its regulation by ethanol

James W. Bogenpohl, Rory M. Weston, Taylor N. Foreman, Kaitlyn E. Kitchen, more

Alcoholism: Clinical and Experimental Research > 46 > 1 > 29 - 39

Background Chloride intracellular channel 4 (CLIC4) is a multifunctional metamorphic protein for which a growing body of evidence supports a major role in the brain's molecular and behavioral responses to ethanol (EtOH). Although key to understanding the functional biology underlying this role, little is known about the cellular and subcellular expression patterns of CLIC4 in brain and how they are...

article

Ethanol attenuates presentation of cytotoxic T‐lymphocyte epitopes on hepatocytes of HBV‐infected humanized mice

Murali Ganesan, Weimin Wang, Saumi Mathews, Edward Makarov, more

Alcoholism: Clinical and Experimental Research > 46 > 1 > 40 - 51

Background and Aims Approximately 3.5% of the global population is chronically infected with Hepatitis B Virus (HBV), which puts them at high risk of end‐stage liver disease, with the risk of persistent infection potentiated by alcohol consumption. However, the mechanisms underlying the effects of alcohol on HBV persistence remain unclear. Here, we aimed to establish in vivo/ex vivo evidence that...

article

Primed for addiction: A critical review of the role of microglia in the neurodevelopmental consequences of adolescent alcohol drinking

Jennifer K. Melbourne, Cassie M. Chandler, Catherine E. Van Doorn, Michael T. Bardo, more

Alcoholism: Clinical and Experimental Research > 45 > 10 > 1908 - 1926

Alcohol is one of the most widely used recreational substances worldwide, with drinking frequently initiated during adolescence. The developmental state of the adolescent brain makes it vulnerable to initiating alcohol use, often in high doses, and particularly susceptible to alcohol‐induced brain changes. Microglia, the brain parenchymal macrophages, have been implicated in mediating some of these...

article

Intoxication Effects on Impulsive Alcohol Choice in Heavy Drinkers: Correlation With Sensation Seeking and Differential Effects by Commodity

Brandon G. Oberlin, Claire R. Carron, Nolan E. Ramer, Martin H. Plawecki, more

Alcoholism: Clinical and Experimental Research > 45 > 1 > 204 - 214

Background The preference for immediate rewards and high sensation seeking are both potent risk factors for alcohol use disorder (AUD), but how they interact during intoxication is poorly understood. To model decision making linked to AUD risk, we tested heavy drinkers for impulsive choice (delay discounting with alcohol:money or money:money) and behavioral sensation seeking using a novel odor choice...

article

Proteomic Profiling Reveals Roles of Stress Response, Ca²⁺ Transient Dysregulation, and Novel Signaling Pathways in Alcohol‐Induced Cardiotoxicity

Rui Liu, Fangxu Sun, Parvin Forghani, Lawrence C. Armand, more

Alcoholism: Clinical and Experimental Research > 44 > 11 > 2187 - 2199

Background Alcohol use in pregnancy increases the risk of abnormal cardiac development, and excessive alcohol consumption in adults can induce cardiomyopathy, contractile dysfunction, and arrhythmias. Understanding molecular mechanisms underlying alcohol‐induced cardiac toxicity could provide guidance in the development of therapeutic strategies. Methods We have performed proteomic and bioinformatic...

article

Ethanol Alters Variability, But Not Rate, of Firing in Medial Prefrontal Cortex Neurons of Awake‐Behaving Rats

Mitchell D. Morningstar, David N. Linsenbardt, Christopher C. Lapish

Alcoholism: Clinical and Experimental Research > 44 > 11 > 2225 - 2238

Background The medial prefrontal cortex (mPFC) is a brain region involved in the evaluation and selection of motivationally relevant outcomes. Neural activity in mPFC is altered following acute ethanol (EtOH) use and, in rodent models, doses as low as 0.75 g/kg yield cognitive deficits. Deficits in decision making following acute EtOH are thought to be mediated, at least in part, by decreases in...

article

Chronic Voluntary Ethanol Drinking in Cynomolgus Macaques Elicits Gene Expression Changes in Prefrontal Cortical Area 46

Nicole A. R. Walter, Christina L. Zheng, Robert P. Searles, Shannon K. McWeeney, more

Alcoholism: Clinical and Experimental Research > 44 > 2 > 470 - 478

Background Genome‐wide profiling to examine brain transcriptional features associated with excessive ethanol (EtOH) consumption has been applied to a variety of species including rodents, nonhuman primates (NHPs), and humans. However, these data were obtained from cross‐sectional samples which are particularly vulnerable to individual variation when obtained from small outbred populations typical...

article

SNARE Complex–Associated Proteins and Alcohol

Joydip Das

Alcoholism: Clinical and Experimental Research > 44 > 1 > 7 - 18

Alcohol addiction causes major health problems throughout the world, causing numerous deaths and incurring a huge economic burden to society. To develop an intervention for alcohol addiction, it is necessary to identify molecular target(s) of alcohol and associated molecular mechanisms of alcohol action. The functions of many central and peripheral synapses are impacted by low concentrations of ethanol...

article

Voluntary Chronic Heavy Alcohol Consumption in Male Rhesus Macaques Suppresses Cancellous Bone Formation and Increases Bone Marrow Adiposity

Arianna M. Kahler‐Quesada, Kathleen A. Grant, Nicole A. R. Walter, Natali Newman, more

Alcoholism: Clinical and Experimental Research > 43 > 12 > 2494 - 2503

Background Chronic heavy alcohol consumption is an established risk factor for bone fracture, but comorbidities associated with alcohol intake may contribute to increased fracture rates in alcohol abusers. To address the specific effects of alcohol on bone, we used a nonhuman primate model and evaluated voluntary alcohol consumption on: (i) global markers of bone turnover in blood and (ii) cancellous...

article

F654A and K558Q Mutations in NMDA Receptor 1 Affect Ethanol‐Induced Behaviors in Drosophila

Benjamin Troutwine, Annie Park, Maria E. Velez‐Hernandez, Linda Lew, more

Alcoholism: Clinical and Experimental Research > 43 > 12 > 2480 - 2493

Background N‐methyl‐D‐aspartate (NMDA) receptors regulate synaptic plasticity and modulate a wide variety of behaviors. Mammalian NMDA receptors are inhibited by ethanol (EtOH) even at low concentrations. In mice, the F639A mutation in transmembrane domain (TMD) 3 of the NR1 subunit reduces EtOH sensitivity of the receptor and, in some paradigms, reduces behavioral EtOH sensitivity and increases...

article

Ethanol Exposure Impairs AMPK Signaling and Phagocytosis in Human Alveolar Macrophages: Role of Ethanol Metabolism

Lata Kaphalia, Mukund P. Srinivasan, Ramu D. Kakumanu, Bhupendra S. Kaphalia, more

Alcoholism: Clinical and Experimental Research > 43 > 8 > 1682 - 1694

Background Chronic alcohol consumption impairs alveolar macrophage's (AM) function and increases risk for developing lung infection and pneumonia. However, the mechanism and metabolic basis of alcohol‐induced AM dysfunction leading to lung infection are not well defined, but may include altered ethanol (EtOH) and reactive oxygen species metabolism and cellular energetics. Therefore, oxidative stress,...

article

Effects of Acute Ethanol Administration on Brain Oxidative Status: The Role of Acetaldehyde

Pablo Baliño, Ricard Romero-Cano, Juan Vicente Sánchez‐Andrés, Victoria Valls, more

Alcoholism: Clinical and Experimental Research > 43 > 8 > 1672 - 1681

Background Ethanol (EtOH), one of the most widely consumed substances of abuse, can induce brain damage and neurodegeneration. EtOH is centrally metabolized into acetaldehyde, which has been shown to be responsible for some of the neurophysiological and cellular effects of EtOH. Although some of the consequences of chronic EtOH administration on cell oxidative status have been described, the mechanisms...

article

Assessment of Extracellular Cytokines in the Hippocampus of the Awake Behaving Rat Using Large‐Molecule Microdialysis Combined with Multiplex Arrays After Acute and Chronic Ethanol Exposure

Anny Gano, Andrew S. Vore, Maryam N. Sammakia, Terrence Deak

Alcoholism: Clinical and Experimental Research > 43 > 4 > 640 - 654

Background Studies have demonstrated persistent changes in central nervous system (CNS) cytokine gene expression following ethanol (EtOH) exposure. However, the low endogenous expression and short half‐lives of cytokines in the CNS have made cytokine protein detection challenging. The goal of these studies was to establish parameters for use of large‐molecule microdialysis and sensitive multiplexing...

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Sex differences in neuronal activation during aversion‐resistant alcohol consumption

Adolescent‐ and adult‐initiated alcohol exposure in mice differentially promotes tumorigenesis and metastasis of breast cancer

Neuromuscular mechanisms of weakness in a mouse model of chronic alcoholic myopathy

Chronic ethanol consumption plus an atherogenic diet cause metabolic steatohepatitis with advanced liver fibrosis in apolipoprotein E/low‐density lipoprotein receptor double‐knockout mice

The development, but not expression, of alcohol front‐loading in C57BL/6J mice maintained on LabDiet 5001 is abolished by maintenance on Teklad 2920x rodent diet

COVID‐19 patients with documented alcohol use disorder or alcohol‐related complications are more likely to be hospitalized and have higher all‐cause mortality

The impact of intermittent exercise on mouse ethanol drinking and abstinence‐associated affective behavior and physiology

Chloride intracellular channel 4 (CLIC4) expression profile in the mouse medial prefrontal cortex and its regulation by ethanol

Ethanol attenuates presentation of cytotoxic T‐lymphocyte epitopes on hepatocytes of HBV‐infected humanized mice

Primed for addiction: A critical review of the role of microglia in the neurodevelopmental consequences of adolescent alcohol drinking

Intoxication Effects on Impulsive Alcohol Choice in Heavy Drinkers: Correlation With Sensation Seeking and Differential Effects by Commodity

Proteomic Profiling Reveals Roles of Stress Response, Ca²⁺ Transient Dysregulation, and Novel Signaling Pathways in Alcohol‐Induced Cardiotoxicity

Ethanol Alters Variability, But Not Rate, of Firing in Medial Prefrontal Cortex Neurons of Awake‐Behaving Rats

Chronic Voluntary Ethanol Drinking in Cynomolgus Macaques Elicits Gene Expression Changes in Prefrontal Cortical Area 46

SNARE Complex–Associated Proteins and Alcohol

Voluntary Chronic Heavy Alcohol Consumption in Male Rhesus Macaques Suppresses Cancellous Bone Formation and Increases Bone Marrow Adiposity

F654A and K558Q Mutations in NMDA Receptor 1 Affect Ethanol‐Induced Behaviors in Drosophila

Ethanol Exposure Impairs AMPK Signaling and Phagocytosis in Human Alveolar Macrophages: Role of Ethanol Metabolism

Effects of Acute Ethanol Administration on Brain Oxidative Status: The Role of Acetaldehyde

Assessment of Extracellular Cytokines in the Hippocampus of the Awake Behaving Rat Using Large‐Molecule Microdialysis Combined with Multiplex Arrays After Acute and Chronic Ethanol Exposure

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